Development of a dog microdialysis model for determining synovial fluid pharmacokinetics of anti-arthritis compounds exemplified by methotrexate

Pharmaceutical Research

Volumn 20, Issue 4, 2003, Pages 605-610

  Qian, Mingxin ^a   West, Wanda ^a   Wu, Jing Tao ^a,b   Lu, Bing ^a   Christ, David D ^a  

^a BRISTOL MYERS SQUIBB   (United States)

^b MILLENNIUM PHARMACEUTICALS INC   (United States)

Author keywords

Methotrexate; Microdialysis; Rheumatoid arthritis; Synovial fluid pharmacokinetics

Indexed keywords

METHOTREXATE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTHROCENTESIS; ARTICLE; CALIBRATION; CONTAMINATION; CONTROLLED STUDY; DOG; DRUG BLOOD LEVEL; DRUG DISPOSITION; DRUG DISTRIBUTION; DRUG SYNOVIAL FLUID LEVEL; EXPERIMENTAL MODEL; IMPLANTATION; IN VITRO STUDY; INFUSION PUMP; MALE; MASS SPECTROMETRY; MICRODIALYSIS; NONHUMAN; PRIORITY JOURNAL; VALIDATION PROCESS;

ANIMALS; ANTIRHEUMATIC AGENTS; DOGS; FEASIBILITY STUDIES; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; MALE; METHOTREXATE; MICRODIALYSIS; MODELS, ANIMAL; PARACENTESIS; SYNOVIAL FLUID;

EID: 12444346409     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1023246832321     Document Type: Article

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