Determination of sinomenine sustained-release capsules in healthy Chinese volunteers by liquid chromatography-tandem mass spectrometry

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 889-890, Issue , 2012, Pages 39-43

  Su, Meng Xiang ^a   Song, Min ^a   Sun, De Zhu ^a   Zhao, Hua ^a   Gu, Xiao ^a   Zhu, Ling ^b   Zhan, Xiao Le ^b   Xu, Zhong Nan ^b   Wen, Ai Dong ^c   Hang, Tai Jun ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b Jiangsu Chia tai Tianqing Pharmaceutical Co Ltd   (China)

^c FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

LC MS MS; Pharmacokinetics; Sinomenine; Sustained release capsules

Indexed keywords

AMMONIUM ACETATE; HUMAN PLASMAS; INTERNAL STANDARDS; LC/MS/MS; LINEAR GRADIENT ELUTION; LINEAR RANGE; LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY; MASS DATA; METRONIDAZOLE; MOBILE PHASE; MULTIPLE REACTION MONITORING; MULTIPLE-DOSE; ORAL ADMINISTRATION; PLASMA SAMPLES; POSITIVE ION MODE; SINGLE-DOSE; SINOMENINE; SUSTAINED-RELEASE CAPSULES; TANDEM MASS SPECTROMETRIC;

AMMONIUM COMPOUNDS; MASS SPECTROMETRY; METHANOL; PHARMACOKINETICS; POSITIVE IONS;

LIQUID CHROMATOGRAPHY;

METHANOL; METRONIDAZOLE; SINOMENINE; SINOMENINE HYDROCHLORIDE; UNCLASSIFIED DRUG;

ADULT; AREA UNDER THE CURVE; ARTICLE; BLOOD SAMPLING; CHINESE; DRUG CAPSULE; DRUG DETERMINATION; DRUG RELEASE; DRUG STRUCTURE; FEMALE; HUMAN; HUMAN EXPERIMENT; LIQUID CHROMATOGRAPHY; NORMAL HUMAN; PRIORITY JOURNAL; SINGLE DRUG DOSE; TANDEM MASS SPECTROMETRY; TIME TO MAXIMUM PLASMA CONCENTRATION;

ADULT; AREA UNDER CURVE; CHINA; CHROMATOGRAPHY, LIQUID; DELAYED-ACTION PREPARATIONS; DRUG STABILITY; HUMANS; LEAST-SQUARES ANALYSIS; MALE; MORPHINANS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY;

EID: 84862799073     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2012.01.027     Document Type: Article

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