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1
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84893843447
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Prognosis of untreated strokes due to anterior circulation proximal intracranial arterial occlusions detected by use of computed tomography angiography
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COI: 1:CAS:528:DC%2BC2cXhtFCrtr%2FN, PID: 24323077
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Lima FO, Furie KL, Silva GS, Lev MH, Camargo ECS, Singhal AB, et al. Prognosis of untreated strokes due to anterior circulation proximal intracranial arterial occlusions detected by use of computed tomography angiography. JAMA Neurol. 2014;71(2):151–7.
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Lima, F.O.1
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Camargo, E.C.S.5
Singhal, A.B.6
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2
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84920502575
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A randomized trial of intraarterial treatment for acute ischemic stroke
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PID: 25517348, These five contemporary trials (references 2-6) comparing intra-arterial therapy to best medical care represent a landmark in acute stroke care. They converge in some critical aspects: the high recanalization rates, the careful selection of eligible patients, the emphasis on early intervention, and the remarkably high effect size of benefit
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Berkhemer OA, Fransen PSS, Beumer D, van den Berg LA, Lingsma HF, Yoo AJ, et al. A randomized trial of intraarterial treatment for acute ischemic stroke. N Engl J Med. 2014;372(1):11–20. These five contemporary trials (references 2-6) comparing intra-arterial therapy to best medical care represent a landmark in acute stroke care. They converge in some critical aspects: the high recanalization rates, the careful selection of eligible patients, the emphasis on early intervention, and the remarkably high effect size of benefit.
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N Engl J Med
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Berkhemer, O.A.1
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Beumer, D.3
van den Berg, L.A.4
Lingsma, H.F.5
Yoo, A.J.6
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3
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84924663845
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Endovascular therapy for ischemic stroke with perfusion-imaging selection
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COI: 1:CAS:528:DC%2BC2MXlt1Gru7s%3D, PID: 25671797, The EXTEND-IA was the smallest of the recent trials and showed benefit of IAT using a perfusion based selection paradigm
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Campbell BCV, Mitchell PJ, Kleinig TJ, Dewey HM, Churilov L, Yassi N, et al. Endovascular therapy for ischemic stroke with perfusion-imaging selection. N Engl J Med. 2015;372(11):1009–18. The EXTEND-IA was the smallest of the recent trials and showed benefit of IAT using a perfusion based selection paradigm.
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N Engl J Med
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Campbell, B.C.V.1
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Kleinig, T.J.3
Dewey, H.M.4
Churilov, L.5
Yassi, N.6
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4
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84924691962
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Randomized assessment of rapid endovascular treatment of ischemic stroke
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COI: 1:CAS:528:DC%2BC2MXkvV2kt7w%3D, PID: 25671798, The ESCAPE trial was characterized by using collateral assessment to aid the selection of eligible patients and by the emphasis on shortening times from admission to reperfusion in enrolling sites
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Goyal M, Demchuk AM, Menon BK, Eesa M, Rempel JL, Thornton J, et al. Randomized assessment of rapid endovascular treatment of ischemic stroke. N Engl J Med. 2015;372(11):1019–30. The ESCAPE trial was characterized by using collateral assessment to aid the selection of eligible patients and by the emphasis on shortening times from admission to reperfusion in enrolling sites.
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(2015)
N Engl J Med
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Goyal, M.1
Demchuk, A.M.2
Menon, B.K.3
Eesa, M.4
Rempel, J.L.5
Thornton, J.6
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5
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84930814840
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Stent-retriever thrombectomy after intravenous t-PA vs. t-PA alone in stroke
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SWIFT-PRIME used penumbral mismatch for the first 71 patients enrolled, and then a “small core” criterion for eligibility. Only patients who had received IV TPA were eligible. SWIFT PRIME presented the highest reperfusion rate of these positive trials
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Saver JL, Goyal M, Bonafe A, Diener H-C, Levy EI, Pereira VM, et al. Stent-retriever thrombectomy after intravenous t-PA vs. t-PA alone in stroke. N Engl J Med. 2015. doi:10.1056/NEJMoa1415061. SWIFT-PRIME used penumbral mismatch for the first 71 patients enrolled, and then a “small core” criterion for eligibility. Only patients who had received IV TPA were eligible. SWIFT PRIME presented the highest reperfusion rate of these positive trials.
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(2015)
N Engl J Med
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Saver, J.L.1
Goyal, M.2
Bonafe, A.3
Diener, H.-C.4
Levy, E.I.5
Pereira, V.M.6
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6
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84929454086
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Thrombectomy within 8 hours after symptom onset in ischemic stroke
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REVASCAT also used a simple small core neuroimaging criterion for including patients, and had a 8 hour window of eligibility
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Jovin TG, Chamorro A, Cobo E, de Miquel MA, Molina CA, Rovira A, et al. Thrombectomy within 8 hours after symptom onset in ischemic stroke. N Engl J Med. 2015. doi:10.1056/NEJMoa1503780. REVASCAT also used a simple small core neuroimaging criterion for including patients, and had a 8 hour window of eligibility.
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(2015)
N Engl J Med
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Jovin, T.G.1
Chamorro, A.2
Cobo, E.3
de Miquel, M.A.4
Molina, C.A.5
Rovira, A.6
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7
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0019582748
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Thresholds of focal cerebral ischemia in awake monkeys
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FitzGibbon, S.J.5
DeGirolami, U.6
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8
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0019822988
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Thresholds in cerebral ischemia—the ischemic penumbra
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COI: 1:STN:280:DyaL38%2Fmt1Orsg%3D%3D, PID: 6272455
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Astrup J, Siesjo BK, Symon L. Thresholds in cerebral ischemia—the ischemic penumbra. Stroke. 1981;12(6):723–5.
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Astrup, J.1
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9
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0023912077
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Local intra-arterial fibrinolytic therapy in acute carotid territory stroke. A pilot study
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PID: 3354013
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Del Zoppo GJ, Ferbert A, Otis S, Brückmann H, Hacke W, Zyroff J, et al. Local intra-arterial fibrinolytic therapy in acute carotid territory stroke. A pilot study. Stroke. 1988;19(3):307–13.
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Hacke, W.5
Zyroff, J.6
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10
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0020513399
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Thrombolytic therapy for thromboembolism of vertebrobasilar artery
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COI: 1:STN:280:DyaL3szgs1OitQ%3D%3D, PID: 6614585
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Nenci GG, Gresele P, Taramelli M, Agnelli G, Signorini E. Thrombolytic therapy for thromboembolism of vertebrobasilar artery. Angiology. 1983;34(9):561–71.
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11
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0031984356
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PROACT: a phase II randomized trial of recombinant pro-urokinase by direct arterial delivery in acute middle cerebral artery stroke. PROACT Investigators. Prolyse in Acute Cerebral Thromboembolism
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PID: 9445320
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Del Zoppo GJ, Higashida RT, Furlan AJ, Pessin MS, Rowley HA, Gent M. PROACT: a phase II randomized trial of recombinant pro-urokinase by direct arterial delivery in acute middle cerebral artery stroke. PROACT Investigators. Prolyse in Acute Cerebral Thromboembolism. Stroke. 1998;29(1):4–11.
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Del Zoppo, G.J.1
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Furlan, A.J.3
Pessin, M.S.4
Rowley, H.A.5
Gent, M.6
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12
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0033486107
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Intra-arterial prourokinase for acute ischemic stroke. The PROACT II study: a randomized controlled trial. Prolyse in Acute Cerebral Thromboembolism
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COI: 1:CAS:528:DC%2BD3cXhtFek, PID: 10591382
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Furlan A, Higashida R, Wechsler L, Gent M, Rowley H, Kase C, et al. Intra-arterial prourokinase for acute ischemic stroke. The PROACT II study: a randomized controlled trial. Prolyse in Acute Cerebral Thromboembolism. JAMA. 1999;282(21):2003–11.
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Furlan, A.1
Higashida, R.2
Wechsler, L.3
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Rowley, H.5
Kase, C.6
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13
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41149121206
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Mechanical thrombectomy for acute ischemic stroke: final results of the Multi MERCI trial
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PID: 18309168
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Smith WS, Sung G, Saver J, Budzik R, Duckwiler G, Liebeskind DS, et al. Mechanical thrombectomy for acute ischemic stroke: final results of the Multi MERCI trial. Stroke. 2008;39(4):1205–12.
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Smith, W.S.1
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Duckwiler, G.5
Liebeskind, D.S.6
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14
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22044433673
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Safety and efficacy of mechanical embolectomy in acute ischemic stroke: results of the MERCI trial
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PID: 15961709
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Smith WS, Sung G, Starkman S, Saver JL, Kidwell CS, Gobin YP, et al. Safety and efficacy of mechanical embolectomy in acute ischemic stroke: results of the MERCI trial. Stroke. 2005;36(7):1432–8.
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Smith, W.S.1
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Starkman, S.3
Saver, J.L.4
Kidwell, C.S.5
Gobin, Y.P.6
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15
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84874734317
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Endovascular therapy after intravenous t-PA versus t-PA alone for stroke
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COI: 1:CAS:528:DC%2BC3sXjvFChsro%3D, PID: 23390923, The IMS III trial (together with MR RESCUE and SYNTHESIS, following marked references), provided lessons that proved to be fundamental for the design of the contemporary, positive trials. In the IMS III trial, the lack of proof of a target vessel occlusion at baseline and the low reperfusion rates were critical for its negative outcome
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Broderick JP, Palesch YY, Demchuk AM, Yeatts SD, Khatri P, Hill MD, et al. Endovascular therapy after intravenous t-PA versus t-PA alone for stroke. N Engl J Med. 2013;368(10):893–903. The IMS III trial (together with MR RESCUE and SYNTHESIS, following marked references), provided lessons that proved to be fundamental for the design of the contemporary, positive trials. In the IMS III trial, the lack of proof of a target vessel occlusion at baseline and the low reperfusion rates were critical for its negative outcome.
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(2013)
N Engl J Med
, vol.368
, Issue.10
, pp. 893-903
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Broderick, J.P.1
Palesch, Y.Y.2
Demchuk, A.M.3
Yeatts, S.D.4
Khatri, P.5
Hill, M.D.6
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16
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84874751053
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A trial of imaging selection and endovascular treatment for ischemic stroke
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COI: 1:CAS:528:DC%2BC3sXjvFChsrg%3D, PID: 23394476, MR RESCUE combined the purposes of testing IAT for patients with proximal occlusions and whether neuroimaging could help define likelihood to benefit from IAT. Reperfusion rates were unsatisfactory and time to reperfusion was relatively late
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Kidwell CS, Jahan R, Gornbein J, Alger JR, Nenov V, Ajani Z, et al. A trial of imaging selection and endovascular treatment for ischemic stroke. N Engl J Med. 2013;368(10):914–23. MR RESCUE combined the purposes of testing IAT for patients with proximal occlusions and whether neuroimaging could help define likelihood to benefit from IAT. Reperfusion rates were unsatisfactory and time to reperfusion was relatively late.
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(2013)
N Engl J Med
, vol.368
, Issue.10
, pp. 914-923
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Kidwell, C.S.1
Jahan, R.2
Gornbein, J.3
Alger, J.R.4
Nenov, V.5
Ajani, Z.6
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17
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84908664180
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Recanalization and clinical outcome of occlusion sites at baseline CT angiography in the Interventional Management of Stroke III trial
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PID: 24895878
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Demchuk AM, Goyal M, Yeatts SD, Carrozzella J, Foster LD, Qazi E, et al. Recanalization and clinical outcome of occlusion sites at baseline CT angiography in the Interventional Management of Stroke III trial. Radiology. 2014;273(1):202–10.
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Radiology
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Demchuk, A.M.1
Goyal, M.2
Yeatts, S.D.3
Carrozzella, J.4
Foster, L.D.5
Qazi, E.6
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18
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84879076054
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Endovascular treatment for acute ischemic stroke
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COI: 1:CAS:528:DC%2BC3sXjvFChsrs%3D, PID: 23387822, The SYNTHESIS trial tested IAT alone versus IV TPA. Reperfusion rates were nor reported
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Ciccone A, Valvassori L, Nichelatti M, Sgoifo A, Ponzio M, Sterzi R, et al. Endovascular treatment for acute ischemic stroke. N Engl J Med. 2013;368(10):904–13. The SYNTHESIS trial tested IAT alone versus IV TPA. Reperfusion rates were nor reported.
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N Engl J Med
, vol.368
, Issue.10
, pp. 904-913
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Ciccone, A.1
Valvassori, L.2
Nichelatti, M.3
Sgoifo, A.4
Ponzio, M.5
Sterzi, R.6
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19
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84888301222
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IMS-III and SYNTHESIS expansion trials of endovascular therapy in acute ischemic stroke: how can we improve?
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PID: 24114453, A thorough critical reappraisal of the negative trials in intra-arterial therapy
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Nogueira RG, Gupta R, Davalos A. IMS-III and SYNTHESIS expansion trials of endovascular therapy in acute ischemic stroke: how can we improve? Stroke. 2013;44(11):3272–4. A thorough critical reappraisal of the negative trials in intra-arterial therapy.
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Stroke
, vol.44
, Issue.11
, pp. 3272-3274
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Nogueira, R.G.1
Gupta, R.2
Davalos, A.3
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20
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84904559401
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Evaluation of interval times from onset to reperfusion in patients undergoing endovascular therapy in the Interventional Management of Stroke III trial
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COI: 1:CAS:528:DC%2BC2cXhtFynsLfK, PID: 24815501, This work detailed the impact of treatment delay in the IMS III trial, one of the major lessons from this negative trial
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Goyal M, Almekhlafi MA, Fan L, Menon BK, Demchuk AM, Yeatts SD, et al. Evaluation of interval times from onset to reperfusion in patients undergoing endovascular therapy in the Interventional Management of Stroke III trial. Circulation. 2014;130(3):265–72. This work detailed the impact of treatment delay in the IMS III trial, one of the major lessons from this negative trial.
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(2014)
Circulation
, vol.130
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, pp. 265-272
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Goyal, M.1
Almekhlafi, M.A.2
Fan, L.3
Menon, B.K.4
Demchuk, A.M.5
Yeatts, S.D.6
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21
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84867072741
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Solitaire flow restoration device versus the Merci Retriever in patients with acute ischaemic stroke (SWIFT): a randomised, parallel-group, non-inferiority trial
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PID: 22932715, The SWIFT and TREVO (next reference) trials established the use of retrievable stents as the state of the art for reperfusion of large vessel occlusion in stroke by comparing reperfusion rates and clinical outcomes in a head-to-head comparison of the stent retrievers versus the Merci device. Here, the complete reperfusion rate achieved with the Solitaire device was 61 %, versus 24 % with Merci
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Saver JL, Jahan R, Levy EI, Jovin TG, Baxter B, Nogueira RG, et al. Solitaire flow restoration device versus the Merci Retriever in patients with acute ischaemic stroke (SWIFT): a randomised, parallel-group, non-inferiority trial. Lancet. 2012;380(9849):1241–9. The SWIFT and TREVO (next reference) trials established the use of retrievable stents as the state of the art for reperfusion of large vessel occlusion in stroke by comparing reperfusion rates and clinical outcomes in a head-to-head comparison of the stent retrievers versus the Merci device. Here, the complete reperfusion rate achieved with the Solitaire device was 61 %, versus 24 % with Merci.
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(2012)
Lancet
, vol.380
, Issue.9849
, pp. 1241-1249
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Saver, J.L.1
Jahan, R.2
Levy, E.I.3
Jovin, T.G.4
Baxter, B.5
Nogueira, R.G.6
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22
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84867064449
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Trevo versus Merci retrievers for thrombectomy revascularisation of large vessel occlusions in acute ischaemic stroke (TREVO 2): a randomised trial
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PID: 22932714, In TEVO, a trial with similar design as SWIFT, the Trevo device yielded a reperfusion rate of 85 %, versus 60 % with Merci
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Nogueira RG, Lutsep HL, Gupta R, Jovin TG, Albers GW, Walker GA, et al. Trevo versus Merci retrievers for thrombectomy revascularisation of large vessel occlusions in acute ischaemic stroke (TREVO 2): a randomised trial. Lancet. 2012;380(9849):1231–40. In TEVO, a trial with similar design as SWIFT, the Trevo device yielded a reperfusion rate of 85 %, versus 60 % with Merci.
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Lancet
, vol.380
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, pp. 1231-1240
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Nogueira, R.G.1
Lutsep, H.L.2
Gupta, R.3
Jovin, T.G.4
Albers, G.W.5
Walker, G.A.6
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23
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67650066675
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Temporal trends in public awareness of stroke: warning signs, risk factors, and treatment
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PID: 19498187
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Kleindorfer D, Khoury J, Broderick JP, Rademacher E, Woo D, Flaherty ML, et al. Temporal trends in public awareness of stroke: warning signs, risk factors, and treatment. Stroke. 2009;40(7):2502–6.
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Woo, D.5
Flaherty, M.L.6
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24
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84867563573
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Endovascular recanalization in acute ischemic stroke: regionalized organization of care
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PID: 23008408
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Saver JL. Endovascular recanalization in acute ischemic stroke: regionalized organization of care. Neurology. 2012;79(13 Suppl 1):S3–4.
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Neurology
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Saver, J.L.1
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25
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49849091548
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A brief prehospital stroke severity scale identifies ischemic stroke patients harboring persisting large arterial occlusions
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PID: 18556587
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Nazliel B, Starkman S, Liebeskind DS, Ovbiagele B, Kim D, Sanossian N, et al. A brief prehospital stroke severity scale identifies ischemic stroke patients harboring persisting large arterial occlusions. Stroke. 2008;39(8):2264–7.
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Ovbiagele, B.4
Kim, D.5
Sanossian, N.6
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26
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22044445060
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Recommendations for comprehensive stroke centers: a consensus statement from the Brain Attack Coalition
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PID: 15961715
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Alberts MJ, Latchaw RE, Selman WR, Shephard T, Hadley MN, Brass LM, et al. Recommendations for comprehensive stroke centers: a consensus statement from the Brain Attack Coalition. Stroke. 2005;36(7):1597–616.
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Hadley, M.N.5
Brass, L.M.6
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27
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79958283156
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Transfer delay is a major factor limiting the use of intra-arterial treatment in acute ischemic stroke
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COI: 1:CAS:528:DC%2BC3MXmslalur4%3D, PID: 21527756
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Prabhakaran S, Ward E, John S, Lopes DK, Chen M, Temes RE, et al. Transfer delay is a major factor limiting the use of intra-arterial treatment in acute ischemic stroke. Stroke. 2011;42(6):1626–30.
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28
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84898776150
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Effect of the use of ambulance-based thrombolysis on time to thrombolysis in acute ischemic stroke: a randomized clinical trial
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COI: 1:CAS:528:DC%2BC2cXhsFems73I, PID: 24756512
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Ebinger M, Winter B, Wendt M, Weber JE, Waldschmidt C, Rozanski M, et al. Effect of the use of ambulance-based thrombolysis on time to thrombolysis in acute ischemic stroke: a randomized clinical trial. JAMA. 2014;311(16):1622–31.
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29
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84963785337
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Stagnation of treatment times over a decade: results of a pooled analysis from the MERCI registry, MERCI, TREVO, and TREVO 2 trials
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Gupta R, Xiang B, Ge S, Sun C-HJ, Yoo AJ, Mehta BP. Stagnation of treatment times over a decade: results of a pooled analysis from the MERCI registry, MERCI, TREVO, and TREVO 2 trials. J Neurointerv Surg. 2015. doi:10.1136/neurintsurg-2014-011626.
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Gupta, R.1
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30
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79952103979
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Metrics for measuring quality of care in comprehensive stroke centers: detailed follow-up to Brain Attack Coalition comprehensive stroke center recommendations: a statement for healthcare professionals from the American Heart Association/American Stroke A
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PID: 21233469
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Leifer D, Bravata DM, Connors JJB, Hinchey JA, Jauch EC, Johnston SC, et al. Metrics for measuring quality of care in comprehensive stroke centers: detailed follow-up to Brain Attack Coalition comprehensive stroke center recommendations: a statement for healthcare professionals from the American Heart Association/American Stroke A. Stroke. 2011;42(3):849–77.
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Johnston, S.C.6
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31
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79953065842
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A multicenter analysis of “time to microcatheter” for endovascular therapy in acute ischemic stroke
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PID: 19811609
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Miley JT, Memon MZ, Hussein HM, Valenta DA, Suri MFK, Vazquez G, et al. A multicenter analysis of “time to microcatheter” for endovascular therapy in acute ischemic stroke. J Neuroimaging. 2011;21(2):159–64.
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Vazquez, G.6
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32
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80555149163
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Achieving faster recanalization times by IA thrombolysis in acute ischemic stroke: where should we direct our efforts?
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COI: 1:STN:280:DC%2BC3MnivVShsA%3D%3D, PID: 21696664
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Eesa M, Menon BK, Hill MD, Demchuk A, Goyal M. Achieving faster recanalization times by IA thrombolysis in acute ischemic stroke: where should we direct our efforts? Interv Neuroradiol. 2011;17(2):228–34.
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