Epigenetic control of interferon-gamma expression in CD8 T cells

Journal of Immunology Research

Volumn 2015, Issue , 2015, Pages

  De Araujo Souza, Patrícia S ^a,b   Hanschke, Steffi C H ^a   Viola, Joaõ P B ^a  

^a INSTITUTO NACIONAL DE CÂNCER   (Brazil)

^b FLUMINENSE FEDERAL UNIVERSITY   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOSINE; DINUCLEOTIDE; DNA; GAMMA INTERFERON; HISTONE; STAT4 PROTEIN; T LYMPHOCYTE RECEPTOR; CHROMATIN;

AUTOCRINE EFFECT; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELLULAR IMMUNITY; CHROMATIN; CPG ISLAND; CYTOTOXIC T LYMPHOCYTE; DNA METHYLATION; EPIGENETICS; GENE EXPRESSION REGULATION; HISTONE MODIFICATION; HUMAN; IMMUNOGENETICS; IMMUNOMODULATION; INTERFERON PRODUCTION; LYMPHOCYTE DIFFERENTIATION; NONHUMAN; PARACRINE SIGNALING; PROMOTER REGION; PROTEIN FUNCTION; PROTEIN PROCESSING; REVIEW; SIGNAL TRANSDUCTION; TH1 CELL; BIOSYNTHESIS; CELL DIFFERENTIATION; CYTOLOGY; GENETIC EPIGENESIS; GENETICS; IMMUNOLOGICAL MEMORY; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; METABOLISM;

CD4-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; CHROMATIN; CPG ISLANDS; DNA METHYLATION; EPIGENESIS, GENETIC; GENE EXPRESSION REGULATION; HUMANS; IMMUNOLOGIC MEMORY; INTERFERON-GAMMA; LYMPHOCYTE ACTIVATION; PROMOTER REGIONS, GENETIC; T-LYMPHOCYTES, CYTOTOXIC;

EID: 84929340452     PISSN: 23148861     EISSN: 23147156     Source Type: Journal    
DOI: 10.1155/2015/849573     Document Type: Review

References (47)

1. K. Schroder, P. J. Hertzog, T. Ravasi, and D. A. Hume, "Interferon-: an overview of signals, mechanisms and functions, " Journal of Leukocyte Biology, vol. 75, no. 2, pp. 163-189, 2004.
2. D. H. Kaplan, V. Shankaran, A. S. Dighe et al., "Demonstration of an interferon gamma-dependent tumor surveillance system in immunocompetent mice, " Proceedings of the National Academy of Sciences of the United States of America, vol. 95, no. 13, pp. 7556-7561, 1998.
3. V. Shankaran, H. Ikeda, A. T. Bruce et al., "IFN, and lymphocytes prevent primary tumour development and shape tumour immunogenicity, " Nature, vol. 410, no. 6832, pp. 1107-1111, 2001.
4. R. L. Rutishauser and S. M. Kaech, "Generating diversity: transcriptional regulation of effector and memory CD8+ T-cell differentiation, " Immunological Reviews, vol. 235, no. 1, pp. 219-233, 2010.
5. A. E. Denton, B. E. Russ, P. C. Doherty, S. Rao, and S. J. Turner, "Differentiation-dependent functional and epigenetic landscapes for cytokine genes in virus-specific CD8+ T cells, " Proceedings of the National Academy of Sciences of the United States of America, vol. 108, no. 37, pp. 15306-15311, 2011.
6. V. P. Badovinac, A. R. Tvinnereim, and J. T. Harty, "Regulation of antigen-specific CD8+ T cell homeostasis by perforin and interferon-, " Science, vol. 290, no. 5495, pp. 1354-1357, 2000.
7. F. Rodriguez, S. Harkins, M. K. Slifka, and J. L. Whitton, "Immunodominance in virus-induced CD8(+) T-cell responses is dramatically modified by DNA immunization and is regulated by gamma interferon, " Journal of Virology, vol. 76, no. 9, pp. 4251-4259, 2002.
8. F. Liu, J. L. Whitton, and M. K. Slifka, "The rapidity with which virus-specific CD8+ T cells initiate IFN-synthesis increases markedly over the course of infection and correlates with immunodominance, " Journal of Immunology, vol. 173, no. 1, pp. 456-462, 2004.
9. B. S. Reis, D. P. H. van Konijnenburg, S. I. Grivennikov, and D. Mucida, "Transcription factor T-bet regulates intraepithelial lymphocyte functional maturation, " Immunity, vol. 41, no. 2, pp. 244-256, 2014.
10. J. K. Whitmire, B. Eam, N. Benning, and J. L. Whitton, "Direct interferon-signaling dramatically enhances CD4+ and CD8+ T cell memory, " Journal of Immunology, vol. 179, no. 2, pp. 1190-1197, 2007.
11. J. K. Whitmire, J. T. Tan, and J. L. Whitton, "Interferon-acts directly on CD8+ T cells to increase their abundance during virus infection, "The Journal of Experimental Medicine, vol. 201, no. 7, pp. 1053-1059, 2005.
12. O. Sercan, G. J. Hämmerling, B. Arnold, and T. Schüler, "Cutting edge: innate immune cells contribute to the IFN-dependent regulation of antigen-specific CD8+ T cell homeostasis, " The Journal of Immunology, vol. 176, no. 2, pp. 735-739, 2006.
13. T. A. Fong and T. R. Mosmann, "Alloreactive murine CD8+ T cell clones secrete the Th1 pattern of cytokines, " Journal of Immunology, vol. 144, no. 5, pp. 1744-1752, 1990.
14. R. E. Tascon, E. Stavropoulos, K. V. Lukacs, andM. J. Colston, "Protection against Mycobacterium tuberculosis infection by CD8+ T cells requires the production of gamma interferon, " Infection and Immunity, vol. 66, no. 2, pp. 830-834, 1998.
15. A. Billiau and P. Matthys, "Interferon-gamma: a historical perspective, " Cytokine and Growth Factor Reviews, vol. 20, no. 2, pp. 97-113, 2009.
16. M. R. Betts, M. C. Nason, S. M. West et al., "HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+ T cells, " Blood, vol. 107, no. 12, pp. 4781-4789, 2006.
17. G. Gasteiger and A. Y. Rudensky, "Interactions between innate and adaptive lymphocytes, "Nature Reviews Immunology, vol. 14, no. 9, pp. 631-639, 2014.
18. A. Srikiatkhachorn and T. J. Braciale, "Virus-specific CD8+ T lymphocytes downregulate T helper cell type 2 cytokine secretion and pulmonary eosinophilia during experimental murine respiratory syncytial virus infection, " The Journal of Experimental Medicine, vol. 186, no. 3, pp. 421-432, 1997.
19. G. Das, S. Sheridan, and Jr. Janeway C. A., "The source of early IFN-that plays a role in Th1 priming, " The Journal of Immunology, vol. 167, no. 4, pp. 2004-2010, 2001.
20. J. E. Uzonna, K. L. Joyce, and P. Scott, "Low dose Leishmania major promotes a transient T helper cell type 2 response that is down-regulated by interferon-producing CD8+ T cells, " Journal of ExperimentalMedicine, vol. 199, no. 11, pp. 1559-1566, 2004.
21. L. K. Teixeira, B. P. F. Fonseca, A. Vieira-De-Abreu et al., "IFN-gamma production by CD8+ T cells depends on NFAT1 transcription factor and regulatesThdifferentiation, " Journal of Immunology, vol. 175, no. 9, pp. 5931-5939, 2005.
22. J. M. Curtsinger, P. Agarwal, D. C. Lins, and M. F. Mescher, "Autocrine IFN-promotes naiveCD8 T cell differentiation and synergizes with IFN-to stimulate strong function, " Journal of Immunology, vol. 189, no. 2, pp. 659-668, 2012.
23. J. S. Haring, G. A. Corbin, and J. T. Harty, "Dynamic regulation of IFN-signaling in antigen-specific CD8+ T cells responding to infection, " The Journal of Immunology, vol. 174, no. 11, pp. 6791-6802, 2005.
24. L. L. Carter and K. M. Murphy, "Lineage-specific requirement for signal transducer and activator of transcription (Stat)4 in interferon production from CD4+ versus CD8+ T cells, " The Journal of ExperimentalMedicine, vol. 189, no. 8, pp. 1355-1360, 1999.
25. S. J. Szabo, S. T. Kim, G. L. Costa, X. Zhang, C. G. Fathman, and L. H. Glimcher, "A novel transcription factor, T-bet, directs Th1 lineage commitment, " Cell, vol. 100, no. 6, pp. 655-669, 2000.
26. E. L. Pearce, A. C. Mullen, G. A. Martins et al., "Control of effector CD8+ T cell function by the transcription factor Eomesodermin, " Science, vol. 302, no. 5647, pp. 1041-1043, 2003.
27. S. M. Kaech and W. Cui, "Transcriptional control of effector and memory CD8+ T cell differentiation, " Nature Reviews Immunology, vol. 12, no. 11, pp. 749-761, 2012.
28. S. M. Kaech and E. J. Wherry, "Heterogeneity and cell-fate decisions in effector and memory CD8+ T cell differentiation during viral infection, " Immunity, vol. 27, no. 3, pp. 393-405, 2007.
29. S. M. Kaech, S. Hemby, E. Kersh, and R. Ahmed, "Molecular and functional profiling ofmemory CD8 T cell differentiation, " Cell, vol. 111, no. 6, pp. 837-851, 2002.
30. P. A. Jones, "Functions of DNA methylation: islands, start sites, gene bodies and beyond, " Nature Reviews Genetics, vol. 13, no. 7, pp. 484-492, 2012.
31. D. R. Fitzpatrick, K. M. Shirley, L. E. McDonald, H. Bielefeldt-Ohmann, G. F. Kay, and A. Kelso, "Distinct methylation of the interferon gamma (IFN-gamma) and interleukin 3 (IL-3) genes in newly activated primary CD8+ T lymphocytes: regional IFNgamma promoter demethylation and mRNA expression are heritable in CD44( high)CD8+ T cells, " Journal of Experimental Medicine, vol. 188, no. 1, pp. 103-117, 1998.
32. E. N. Kersh, D. R. Fitzpatrick, K. Murali-Krishna et al., "Rapid demethylation of the IFN-gene occurs in memory but not naive CD8 T cells, " The Journal of Immunology, vol. 176, no. 7, pp. 4083-4093, 2006.
33. B. R. Winders, R. H. Schwartz, and D. Bruniquel, "A distinct region of the murine IFN-promoter is hypomethylated from early T cell development through mature naive and Th1 cell differentiation, but is hypermethylated inTh2cells, " The Journal of Immunology, vol. 173, no. 12, pp. 7377-7384, 2004.
34. J. K. Northrop, R. M. Thomas, A. D. Wells, and H. Shen, "Epigenetic remodeling of the IL-2 and IFN-loci in memory CD8 T cells is influenced by CD4 T cells, " The Journal of Immunology, vol. 177, no. 2, pp. 1062-1069, 2006.
35. K. W. Makar and C. B. Wilson, "DNA methylation is a nonredundant repressor of theTh2 effector program, " The Journal of Immunology, vol. 173, no. 7, pp. 4402-4406, 2004.
36. B. Jones and J. Chen, "Inhibition of IFN-transcription by sitespecific methylation during T helper cell development, " EMBO Journal, vol. 25, no. 11, pp. 2443-2452, 2006.
37. T. M. Aune, L. A. Penix, M. R. Rincón, and R. A. Flaveel, "Differential transcription directed by discrete gamma interferon promoter elements in naive and memory (effector) CD4 T cells and CD8 T cells, " Molecular and Cellular Biology, vol. 17, no. 1, pp. 199-208, 1997.
38. V. W. Zhou, A. Goren, and B. E. Bernstein, "Charting histone modifications and the functional organization of mammalian genomes, " Nature Reviews Genetics, vol. 12, no. 1, pp. 7-18, 2011.
39. V. P. Zediak, J. B. Johnnidis, E. J. Wherry, and S. L. Berger, "Cutting edge: persistently open chromatin at effector gene loci in restingmemory CD8+ T cells independent of transcriptional status, " The Journal of Immunology, vol. 186, no. 5, pp. 2705-2709, 2011.
40. S. Bandyopadhyay, H. Z. Qui, and A. J. Adler, "In vitro and in vivo differentiated effectorCD8 T cells display divergent histone acetylation patterns within the Ifng locus, " Immunology Letters, vol. 122, no. 2, pp. 214-218, 2009.
41. H. A. Young, K. L. Komschlies, V. Ciccarone et al., "Expression of human IFN-genomicDNA in transgenic mice, " The Journal of Immunology, vol. 143, no. 7, pp. 2389-2394, 1989.
42. H. Zhu, J. Yang, T. L. Murphy et al., "Unexpected characteristics of the IFN-reporters in nontransformed T cells, " The Journal of Immunology, vol. 167, no. 2, pp. 855-865, 2001.
43. M. Soutto, W. Zhou, and T. M. Aune, "Cutting edge: distal regulatory elements are required to achieve selective expression of IFN-in Th1/Tc1 effector cells, " Journal of Immunology, vol. 169, no. 12, pp. 6664-6667, 2002.
44. M. Shnyreva, W. M. Weaver, M. Blanchette et al., "Evolutionarily conserved sequence elements that positively regulate IFN-expression in T cells, " Proceedings of the National Academy of Sciences of the United States of America, vol. 101, no. 34, pp. 12622-12627, 2004.
45. D. U. Lee, O. Avni, L. Chen, and A. Rao, "A distal enhancer in the interferon-gamma (IFN-gamma) locus revealed by genome sequence comparison, " Journal of Biological Chemistry, vol. 279, no. 6, pp. 4802-4810, 2004.
46. R. D. Hatton, L. E. Harrington, R. J. Luther et al., "A distal conserved sequence element controls Ifng gene expression by T cells and NK cells, " Immunity, vol. 25, no. 5, pp. 717-729, 2006.
47. J. R. Schoenborn, M. O. Dorschner, M. Sekimata et al., "Comprehensive epigenetic profiling identifies multiple distal regulatory elements directing transcription of the gene encoding interferon-gamma, " Nature Immunology, vol. 8, no. 7, pp. 732-742, 2007.