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Volumn 131, Issue 14, 2015, Pages 1260-1268

O-linked β-N-acetylglucosamine transferase directs cell proliferation in idiopathic pulmonary arterial hypertension

Author keywords

Biosynthetic pathways; Hexosamines; Host cell factor C1; Pulmonary hypertension; Smooth muscle; UDP N acetylglucosamine peptide beta N acetylglucosaminyltransferase

Indexed keywords

HEXOSAMINE; HOST CELL FACTOR 1; HYDROLASE; O LINKED BETA N ACETYLGLUCOSAMINE HYDROLASE; O LINKED BETA N ACETYLGLUCOSAMINE TRANSFERASE; TRANSCRIPTION FACTOR; TRANSFERASE; UNCLASSIFIED DRUG; ALLOXAN; GLUCOSE; HCFC1 PROTEIN, HUMAN; HOST CELL FACTOR C1; N ACETYLGLUCOSAMINYLTRANSFERASE; UDP-N-ACETYLGLUCOSAMINE-PEPTIDE BETA-N-ACETYLGLUCOSAMINYLTRANSFERASE;

EID: 84929335104     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.114.013878     Document Type: Article
Times cited : (46)

References (55)
  • 1
    • 84871211326 scopus 로고    scopus 로고
    • Pathobiology of pulmonary arterial hypertension and right ventricular failure
    • Voelkel NF, Gomez-Arroyo J, Abbate A, Bogaard HJ, Nicolls MR. Pathobiology of pulmonary arterial hypertension and right ventricular failure. Eur Respir J. 2012;40:1555-1565. doi: 10.1183/09031936.00046612.
    • (2012) Eur Respir J , vol.40 , pp. 1555-1565
    • Voelkel, N.F.1    Gomez-Arroyo, J.2    Abbate, A.3    Bogaard, H.J.4    Nicolls, M.R.5
  • 2
    • 84902968590 scopus 로고    scopus 로고
    • The metabolic theory of pulmonary arterial hypertension
    • Paulin R, Michelakis ED. The metabolic theory of pulmonary arterial hypertension. Circ Res. 2014;115:148-164. doi: 10.1161/CIRCRESAHA.115.301130.
    • (2014) Circ Res , vol.115 , pp. 148-164
    • Paulin, R.1    Michelakis, E.D.2
  • 4
    • 84902980316 scopus 로고    scopus 로고
    • The genetics of pulmonary arterial hypertension
    • Austin ED, Loyd JE. The genetics of pulmonary arterial hypertension. Circ Res. 2014;115:189-202. doi: 10.1161/CIRCRESAHA.115.303404.
    • (2014) Circ Res , vol.115 , pp. 189-202
    • Austin, E.D.1    Loyd, J.E.2
  • 8
    • 33644874204 scopus 로고    scopus 로고
    • The hexosamine signaling pathway: Deciphering the "O-GlcNAc code"
    • Love DC, Hanover JA. The hexosamine signaling pathway: deciphering the "O-GlcNAc code". Sci STKE. 2005;2005:re13. doi: 10.1126/stke.3122005re13.
    • (2005) Sci STKE , vol.2005 , pp. re13
    • Love, D.C.1    Hanover, J.A.2
  • 9
    • 0025855139 scopus 로고
    • Discovery of a metabolic pathway mediating glucose-induced desensitization of the glucose transport system. Role of hexosamine biosynthesis in the induction of insulin resistance
    • Marshall S, Bacote V, Traxinger RR. Discovery of a metabolic pathway mediating glucose-induced desensitization of the glucose transport system. Role of hexosamine biosynthesis in the induction of insulin resistance. J Biol Chem. 1991;266:4706-4712.
    • (1991) J Biol Chem , vol.266 , pp. 4706-4712
    • Marshall, S.1    Bacote, V.2    Traxinger, R.R.3
  • 10
    • 0037300799 scopus 로고    scopus 로고
    • A role for N-acetylglucosamine as a nutrient sensor and mediator of insulin resistance
    • Wells L, Vosseller K, Hart GW. A role for N-acetylglucosamine as a nutrient sensor and mediator of insulin resistance. Cell Mol Life Sci. 2003;60:222-228.
    • (2003) Cell Mol Life Sci , vol.60 , pp. 222-228
    • Wells, L.1    Vosseller, K.2    Hart, G.W.3
  • 12
    • 34247583996 scopus 로고    scopus 로고
    • Cycling of O-linked beta-N-acetylglucosamine on nucleocytoplasmic proteins
    • Hart GW, Housley MP, Slawson C. Cycling of O-linked beta-N-acetylglucosamine on nucleocytoplasmic proteins. Nature. 2007;446:1017-1022. doi: 10.1038/nature05815.
    • (2007) Nature , vol.446 , pp. 1017-1022
    • Hart, G.W.1    Housley, M.P.2    Slawson, C.3
  • 13
    • 79959381299 scopus 로고    scopus 로고
    • Cross talk between O-GlcNAcylation and phosphorylation: Roles in signaling, transcription, and chronic disease
    • Hart GW, Slawson C, Ramirez-Correa G, Lagerlof O. Cross talk between O-GlcNAcylation and phosphorylation: roles in signaling, transcription, and chronic disease. Annu Rev Biochem. 2011;80:825-858. doi: 10.1146/annurev-biochem-060608-102511.
    • (2011) Annu Rev Biochem , vol.80 , pp. 825-858
    • Hart, G.W.1    Slawson, C.2    Ramirez-Correa, G.3    Lagerlof, O.4
  • 14
    • 0030959555 scopus 로고    scopus 로고
    • Dynamic glycosylation of nuclear and cytosolic proteins. Cloning and characterization of a unique O-GlcNAc transferase with multiple tetratricopeptide repeats
    • Kreppel LK, Blomberg MA, Hart GW. Dynamic glycosylation of nuclear and cytosolic proteins. Cloning and characterization of a unique O-GlcNAc transferase with multiple tetratricopeptide repeats. J Biol Chem. 1997;272:9308-9315.
    • (1997) J Biol Chem , vol.272 , pp. 9308-9315
    • Kreppel, L.K.1    Blomberg, M.A.2    Hart, G.W.3
  • 15
    • 0030944105 scopus 로고    scopus 로고
    • O-Linked GlcNAc transferase is a conserved nucleocytoplasmic protein containing tetratricopeptide repeats
    • Lubas WA, Frank DW, Krause M, Hanover JA. O-Linked GlcNAc transferase is a conserved nucleocytoplasmic protein containing tetratricopeptide repeats. J Biol Chem. 1997;272:9316-9324.
    • (1997) J Biol Chem , vol.272 , pp. 9316-9324
    • Lubas, W.A.1    Frank, D.W.2    Krause, M.3    Hanover, J.A.4
  • 16
    • 0035971182 scopus 로고    scopus 로고
    • Dynamic O-glycosylation of nuclear and cytosolic proteins: Cloning and characterization of a neutral, cytosolic beta-N-acetylglucosaminidase from human brain
    • Gao Y, Wells L, Comer FI, Parker GJ, Hart GW. Dynamic O-glycosylation of nuclear and cytosolic proteins: cloning and characterization of a neutral, cytosolic beta-N-acetylglucosaminidase from human brain. J Biol Chem. 2001;276:9838-9845. doi: 10.1074/jbc.M010420200.
    • (2001) J Biol Chem , vol.276 , pp. 9838-9845
    • Gao, Y.1    Wells, L.2    Comer, F.I.3    Parker, G.J.4    Hart, G.W.5
  • 17
    • 0037127198 scopus 로고    scopus 로고
    • Dynamic O-glycosylation of nuclear and cytosolic proteins: Further characterization of the nucleocytoplasmic beta-N-acetylglucosaminidase, O-GlcNAcase
    • Wells L, Gao Y, Mahoney JA, Vosseller K, Chen C, Rosen A, Hart GW. Dynamic O-glycosylation of nuclear and cytosolic proteins: further characterization of the nucleocytoplasmic beta-N-acetylglucosaminidase, O-GlcNAcase. J Biol Chem. 2002;277:1755-1761.
    • (2002) J Biol Chem , vol.277 , pp. 1755-1761
    • Wells, L.1    Gao, Y.2    Mahoney, J.A.3    Vosseller, K.4    Chen, C.5    Rosen, A.6    Hart, G.W.7
  • 20
    • 84896785101 scopus 로고    scopus 로고
    • Modification of hyaluronan by heavy chains of inter-alpha-inhibitor in idiopathic pulmonary arterial hypertension
    • Lauer ME, Aytekin M, Comhair SA, Loftis J, Tian L, Farver CF, Hascall VC, Dweik RA. Modification of hyaluronan by heavy chains of inter-alpha-inhibitor in idiopathic pulmonary arterial hypertension. J Biol Chem. 2014;289:6791-6798. doi: 10.1074/jbc.M113.512491.
    • (2014) J Biol Chem , vol.289 , pp. 6791-6798
    • Lauer, M.E.1    Aytekin, M.2    Comhair, S.A.3    Loftis, J.4    Tian, L.5    Farver, C.F.6    Hascall, V.C.7    Dweik, R.A.8
  • 24
    • 77954308587 scopus 로고    scopus 로고
    • Increased expression of beta-N-acetylglucosaminidase in erythrocytes from individuals with pre-diabetes and diabetes
    • Park K, Saudek CD, Hart GW. Increased expression of beta-N-acetylglucosaminidase in erythrocytes from individuals with pre-diabetes and diabetes. Diabetes. 2010;59:1845-1850. doi: 10.2337/db09-1086.
    • (2010) Diabetes , vol.59 , pp. 1845-1850
    • Park, K.1    Saudek, C.D.2    Hart, G.W.3
  • 26
    • 77951220191 scopus 로고    scopus 로고
    • A proposed mitochondrial-metabolic mechanism for initiation and maintenance of pulmonary arterial hypertension in fawn-hooded rats: The Warburg model of pulmonary arterial hypertension
    • Rehman J, Archer SL. A proposed mitochondrial-metabolic mechanism for initiation and maintenance of pulmonary arterial hypertension in fawn-hooded rats: the Warburg model of pulmonary arterial hypertension. Adv Exp Med Biol. 2010;661:171-185. doi: 10.1007/978-1-60761-500-2-11.
    • (2010) Adv Exp Med Biol , vol.661 , pp. 171-185
    • Rehman, J.1    Archer, S.L.2
  • 28
    • 42549105111 scopus 로고    scopus 로고
    • The GLUT-1 XbaI gene polymorphism is associated with vascular calcifications in nondiabetic uremic patients
    • Rufino M, Hernández D, Barrios Y, Salido E. The GLUT-1 XbaI gene polymorphism is associated with vascular calcifications in nondiabetic uremic patients. Nephron Clin Pract. 2008;108:c182-c187. doi: 10.1159/000118940.
    • (2008) Nephron Clin Pract , vol.108 , pp. c182-c187
    • Rufino, M.1    Hernández, D.2    Barrios, Y.3    Salido, E.4
  • 29
    • 84894076239 scopus 로고    scopus 로고
    • Overexpression of O-GlcNAc by prostate cancer cells is significantly associated with poor prognosis of patients
    • Kamigaito T, Okaneya T, Kawakubo M, Shimojo H, Nishizawa O, Nakayama J. Overexpression of O-GlcNAc by prostate cancer cells is significantly associated with poor prognosis of patients. Prostate Cancer Prostatic Dis. 2014;17:18-22. doi: 10.1038/pcan.2013.56.
    • (2014) Prostate Cancer Prostatic Dis , vol.17 , pp. 18-22
    • Kamigaito, T.1    Okaneya, T.2    Kawakubo, M.3    Shimojo, H.4    Nishizawa, O.5    Nakayama, J.6
  • 30
    • 84859484538 scopus 로고    scopus 로고
    • Critical role of O-Linked β-N-acetylglucosamine transferase in prostate cancer invasion, angiogenesis, and metastasis
    • Lynch TP, Ferrer CM, Jackson SR, Shahriari KS, Vosseller K, Reginato MJ. Critical role of O-Linked β-N-acetylglucosamine transferase in prostate cancer invasion, angiogenesis, and metastasis. J Biol Chem. 2012;287:11070-11081. doi: 10.1074/jbc.M111.302547.
    • (2012) J Biol Chem , vol.287 , pp. 11070-11081
    • Lynch, T.P.1    Ferrer, C.M.2    Jackson, S.R.3    Shahriari, K.S.4    Vosseller, K.5    Reginato, M.J.6
  • 32
    • 12444279265 scopus 로고
    • On the origin of cancer cells
    • Warburg O. On the origin of cancer cells. Science. 1956;123:309-314.
    • (1956) Science , vol.123 , pp. 309-314
    • Warburg, O.1
  • 33
    • 80054046029 scopus 로고    scopus 로고
    • Aerobic glycolysis: Meeting the metabolic requirements of cell proliferation
    • Lunt SY, Vander Heiden MG. Aerobic glycolysis: meeting the metabolic requirements of cell proliferation. Annu Rev Cell Dev Biol. 2011;27:441-464. doi: 10.1146/annurev-cellbio-092910-154237.
    • (2011) Annu Rev Cell Dev Biol , vol.27 , pp. 441-464
    • Lunt, S.Y.1    Vander Heiden, M.G.2
  • 34
    • 79953684503 scopus 로고    scopus 로고
    • The Warburg and Crabtree effects: On the origin of cancer cell energy metabolism and of yeast glucose repression
    • Diaz-Ruiz R, Rigoulet M, Devin A. The Warburg and Crabtree effects: On the origin of cancer cell energy metabolism and of yeast glucose repression. Biochim Biophys Acta. 2011;1807:568-576. doi: 10.1016/j.bbabio.2010.08.010.
    • (2011) Biochim Biophys Acta , vol.1807 , pp. 568-576
    • Diaz-Ruiz, R.1    Rigoulet, M.2    Devin, A.3
  • 35
    • 84878225772 scopus 로고    scopus 로고
    • Hyper-O-GlcNAcylation is anti-apoptotic and maintains constitutive NF-κB activity in pancreatic cancer cells
    • Ma Z, Vocadlo DJ, Vosseller K. Hyper-O-GlcNAcylation is anti-apoptotic and maintains constitutive NF-κB activity in pancreatic cancer cells. J Biol Chem. 2013;288:15121-15130. doi: 10.1074/jbc.M113.470047.
    • (2013) J Biol Chem , vol.288 , pp. 15121-15130
    • Ma, Z.1    Vocadlo, D.J.2    Vosseller, K.3
  • 36
    • 34249090239 scopus 로고    scopus 로고
    • A sugar-coated switch for cellular growth and arrest
    • Taniguchi N. A sugar-coated switch for cellular growth and arrest. Nat Chem Biol. 2007;3:307-309. doi: 10.1038/nchembio0607-307.
    • (2007) Nat Chem Biol , vol.3 , pp. 307-309
    • Taniguchi, N.1
  • 39
    • 84896322689 scopus 로고    scopus 로고
    • Functional O-GlcNAc modifications: Implications in molecular regulation and pathophysiology
    • Vaidyanathan K, Durning S, Wells L. Functional O-GlcNAc modifications: implications in molecular regulation and pathophysiology. Crit Rev Biochem Mol Biol. 2014;49:140-163. doi: 10.3109/10409238.2014.884535.
    • (2014) Crit Rev Biochem Mol Biol , vol.49 , pp. 140-163
    • Vaidyanathan, K.1    Durning, S.2    Wells, L.3
  • 40
  • 41
    • 0037117511 scopus 로고    scopus 로고
    • Elevated nucleocytoplasmic glycosylation by O-GlcNAc results in insulin resistance associated with defects in Akt activation in 3T3-L1 adipocytes
    • Vosseller K, Wells L, Lane MD, Hart GW. Elevated nucleocytoplasmic glycosylation by O-GlcNAc results in insulin resistance associated with defects in Akt activation in 3T3-L1 adipocytes. Proc Natl Acad Sci U S A. 2002;99:5313-5318. doi: 10.1073/pnas.072072399.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 5313-5318
    • Vosseller, K.1    Wells, L.2    Lane, M.D.3    Hart, G.W.4
  • 42
    • 3042534011 scopus 로고    scopus 로고
    • Dynamic O-GlcNAc modification of nucleocytoplasmic proteins in response to stress. A survival response of mammalian cells
    • Zachara NE, O'Donnell N, Cheung WD, Mercer JJ, Marth JD, Hart GW. Dynamic O-GlcNAc modification of nucleocytoplasmic proteins in response to stress. A survival response of mammalian cells. J Biol Chem. 2004;279:30133-30142. doi: 10.1074/jbc.M403773200.
    • (2004) J Biol Chem , vol.279 , pp. 30133-30142
    • Zachara, N.E.1    O'Donnell, N.2    Cheung, W.D.3    Mercer, J.J.4    Marth, J.D.5    Hart, G.W.6
  • 43
    • 34250823511 scopus 로고    scopus 로고
    • E2F activation of S phase promoters via association with HCF-1 and the MLL family of histone H3K4 methyl-transferases
    • Tyagi S, Chabes AL, Wysocka J, Herr W. E2F activation of S phase promoters via association with HCF-1 and the MLL family of histone H3K4 methyl-transferases. Mol Cell. 2007;27:107-119. doi: 10.1016/j.molcel.2007.05.030.
    • (2007) Mol Cell , vol.27 , pp. 107-119
    • Tyagi, S.1    Chabes, A.L.2    Wysocka, J.3    Herr, W.4
  • 44
    • 0038242360 scopus 로고    scopus 로고
    • Proteolytic processing is necessary to separate and ensure proper cell growth and cytokinesis functions of HCF-1
    • Julien E, Herr W. Proteolytic processing is necessary to separate and ensure proper cell growth and cytokinesis functions of HCF-1. EMBO J. 2003;22:2360-2369. doi: 10.1093/emboj/cdg242.
    • (2003) EMBO J , vol.22 , pp. 2360-2369
    • Julien, E.1    Herr, W.2
  • 46
    • 84872503697 scopus 로고    scopus 로고
    • Impact of O-GlcNAc on cardioprotection by remote ischaemic preconditioning in non-diabetic and diabetic patients
    • Jensen RV, Zachara NE, Nielsen PH, Kimose HH, Kristiansen SB, Bøtker HE. Impact of O-GlcNAc on cardioprotection by remote ischaemic preconditioning in non-diabetic and diabetic patients. Cardiovasc Res. 2013;97:369-378. doi: 10.1093/cvr/cvs337.
    • (2013) Cardiovasc Res , vol.97 , pp. 369-378
    • Jensen, R.V.1    Zachara, N.E.2    Nielsen, P.H.3    Kimose, H.H.4    Kristiansen, S.B.5    Bøtker, H.E.6
  • 47
    • 84875221904 scopus 로고    scopus 로고
    • Post-translational protein modification by O-linked N-acetyl-glucosamine: Its role in mediating the adverse effects of diabetes on the heart
    • McLarty JL, Marsh SA, Chatham JC. Post-translational protein modification by O-linked N-acetyl-glucosamine: its role in mediating the adverse effects of diabetes on the heart. Life Sci. 2013;92:621-627. doi: 10.1016/j.lfs.2012.08.006.
    • (2013) Life Sci , vol.92 , pp. 621-627
    • McLarty, J.L.1    Marsh, S.A.2    Chatham, J.C.3
  • 48
    • 78649990012 scopus 로고    scopus 로고
    • O-GlcNAc modification, insulin signaling and diabetic complications
    • Issad T, Masson E, Pagesy P. O-GlcNAc modification, insulin signaling and diabetic complications. Diabetes Metab. 2010;36(6 pt 1):423-435. doi: 10.1016/j.diabet.2010.09.001.
    • (2010) Diabetes Metab , vol.36 , Issue.6 , pp. 423-435
    • Issad, T.1    Masson, E.2    Pagesy, P.3
  • 49
    • 40449128605 scopus 로고    scopus 로고
    • Hepatic glucose sensing via the CREB coactivator CRTC2
    • Dentin R, Hedrick S, Xie J, Yates J 3rd, Montminy M. Hepatic glucose sensing via the CREB coactivator CRTC2. Science. 2008;319:1402-1405. doi: 10.1126/science.1151363.
    • (2008) Science , vol.319 , pp. 1402-1405
    • Dentin, R.1    Hedrick, S.2    Xie, J.3    Yates, J.4    Montminy, M.5
  • 50
    • 33644698706 scopus 로고    scopus 로고
    • Identification of the major site of O-linked beta-N-acetylglucosamine modification in the C terminus of insulin receptor substrate-1
    • Ball LE, Berkaw MN, Buse MG. Identification of the major site of O-linked beta-N-acetylglucosamine modification in the C terminus of insulin receptor substrate-1. Mol Cell Proteomics. 2006;5:313-323. doi: 10.1074/mcp.M500314-MCP200.
    • (2006) Mol Cell Proteomics , vol.5 , pp. 313-323
    • Ball, L.E.1    Berkaw, M.N.2    Buse, M.G.3
  • 52
    • 77949295164 scopus 로고    scopus 로고
    • The hexosamine signaling pathway: O-GlcNAc cycling in feast or famine
    • Hanover JA, Krause MW, Love DC. The hexosamine signaling pathway: O-GlcNAc cycling in feast or famine. Biochim Biophys Acta. 2010;1800:80-95. doi: 10.1016/j.bbagen.2009.07.017.
    • (2010) Biochim Biophys Acta , vol.1800 , pp. 80-95
    • Hanover, J.A.1    Krause, M.W.2    Love, D.C.3
  • 55
    • 33947731898 scopus 로고    scopus 로고
    • Pulmonary arterial hypertension is linked to insulin resistance and reversed by peroxisome proliferator-activated receptor-gamma activation
    • Hansmann G, Wagner RA, Schellong S, Perez VA, Urashima T, Wang L, Sheikh AY, Suen RS, Stewart DJ, Rabinovitch M. Pulmonary arterial hypertension is linked to insulin resistance and reversed by peroxisome proliferator-activated receptor-gamma activation. Circulation. 2007;115:1275-1284. doi: 10.1161/CIRCULATIONAHA.106.663120.
    • (2007) Circulation , vol.115 , pp. 1275-1284
    • Hansmann, G.1    Wagner, R.A.2    Schellong, S.3    Perez, V.A.4    Urashima, T.5    Wang, L.6    Sheikh, A.Y.7    Suen, R.S.8    Stewart, D.J.9    Rabinovitch, M.10


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