The effects of anti-obesity intervention with orlistat and sibutramine on microvascular endothelial function

Clinical Hemorheology and Microcirculation

Volumn 59, Issue 4, 2015, Pages 323-334

  Al Tahami, Belqes Abdullah Mohammad ^a   Ismail, Ab Aziz Al Safi ^a   Bee, Yvonne Tee Get ^b   Awang, Siti Azima ^b   Rani, Wan Rimei Salha Wan Abdul ^b   Sanip, Zulkefli ^a   Rasool, Aida Hanum Ghulam ^a  

^a SCHOOL OF MEDICAL SCIENCES   (Malaysia)

^b SCHOOL OF PHYSICS   (Malaysia)

Author keywords

Microvascular endothelial function; obesity; orlistat; sibutramine

Indexed keywords

ACETYLCHOLINE; ATENOLOL; CHOLESTEROL; LIPID; LOW DENSITY LIPOPROTEIN CHOLESTEROL; NITROPRUSSIDE SODIUM; SIBUTRAMINE; TETRAHYDROLIPSTATIN; ANTIOBESITY AGENT; CYCLOBUTANE DERIVATIVE; LACTONE;

ADULT; AGED; ANTHROPOMETRY; ARTICLE; BLOOD PRESSURE; BODY MASS; BODY WEIGHT; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG EFFECT; DRUG EFFICACY; FEMALE; HEART RATE; HUMAN; HYPERTENSION; IONTOPHORESIS; LASER DOPPLER FLUXIMETRY; MAJOR CLINICAL STUDY; MALE; NON INVASIVE PROCEDURE; OBESITY; OUTCOME ASSESSMENT; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; TREATMENT OUTCOME; VASCULAR ENDOTHELIUM; VASODILATATION; ADOLESCENT; DRUG EFFECTS; LASER DOPPLER FLOWMETRY; METABOLISM; MICROVASCULATURE; MIDDLE AGED; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; ANTHROPOMETRY; ANTI-OBESITY AGENTS; BLOOD PRESSURE; CHOLESTEROL; CYCLOBUTANES; ENDOTHELIUM, VASCULAR; FEMALE; HEART RATE; HUMANS; LACTONES; LASER-DOPPLER FLOWMETRY; MALE; MICROVESSELS; MIDDLE AGED; OBESITY; PROSPECTIVE STUDIES; YOUNG ADULT;

EID: 84929333511     PISSN: 13860291     EISSN: 18758622     Source Type: Journal    
DOI: 10.3233/CH-131765     Document Type: Article

References (53)

1. C.J. Abularrage, A.N. Sidawy, G. Aidinian, N. Singh, J.M. Weiswasser and S. Arora, Evaluation of the microcirculation in vascular disease, J Vasc Surg 42 (2005), 574-581.
2. B.A. Al-Tahami, Y.-T.G. Bee, A.A.A.-S. Ismail and A.H.G. Rasool, Impaired microvascular endothelial function in relatively young obese humans is associated with altered metabolic and inflammatory markers, Clin Hemorheol Microcirc 47 (2011), 87-97.
3. B.A. Al-Tahami, G.B. Yvonne-Tee, A.S. Halim, A.A. Ismail, and A.H.G. Rasool, Reproducibility of Laser Doppler fluximetry and the process of iontophoresis in assessing microvascular endothelial function using low current strength, Methods Find Exp Clin Pharmacol 32 (2010), 181-185.
4. T.J. Anderson, E. Elstein, H. Haber and F. Charbonneau, Comparative study of ACE-inhibition, angiotensin II antagonism, and calcium channel blockade on flow-mediated vasodilation in patients with coronary disease (BANFF study), J Am Coll Cardiol 35 (2000), 60-66.
5. Anonymous, Ethical guidelines for publication in Clinical Hemorheology and Microcirculation, Clin Hemorheol Microcirc 44 (2010), 1-2.
6. A.T. Belqes Abdullah, T.G.B. Yvonne, S.H. Ahmad, A.S.I. Abdul Aziz and H.G.R. Aida, Method optimization on the process of iontophoresis with laser Doppler fluximetry in the assessment of microvascular endothelial function, Malays J Med Health Sci 7 (2011), 35-40.
7. R. Bergholm, M. Tiikkainen, S. Vehkavaara, M. Tamminen, K. Teramo, A. Rissanen and H. Yki-Järvinen, Lowering of LDL cholesterol rather than moderate weight loss improves endothelium-dependent vasodilatation in obese women with previous gestational diabetes, Diabetes Care 26 (2003), 1667-1672.
8. S.V. Brodsky, F. Zhang, A. Nasjletti and M.S. Goligorsky, Endothelium-derived microparticles impair endothelial function in vitro, Am J Physiol Heart Circ Physiol 286 (2004), H1910-H1915.
9. J.F. Brun, E. Varlet-Marie, E. Raynaud de Mauverger and J. Mercier, Both overall adiposity and abdominal adiposity increase blood viscosity by separate mechanisms, Clin Hemorheol Microcirc 48 (2011), 257-263.
10. J.P. Crowley, J. Metzger, A. Assaf, R.C. Carleton, E. Merrill and C.R. Valeri, Low density lipoprotein cholesterol and whole blood viscosity, Ann Clin Lab Sci 24 (1994), 533-541.
11. A. Damaske, S. Muxel, F. Fasola, M., C. Radmacher, S. Schaefer, A. Jabs, D. Orphal, P. Wild, J.D. Parker, M. Fineschi, T. Munzel, S. Forconi and T. Gori, Peripheral hemorheological and vascular correlates of coronary blood flow, Clin Hemorheol Microcirc 49 (2011), 261-269.
12. P.E. de Jong, J.C. Verhave, S.J. Pinto-Sietsma and H.L. Hillege, Obesity and target organ damage: The kidney, Int J Obes Relat Metab Disord 26 (2002), S21-S24.
13. R.T. de Jongh, E.H. Serné, R.G. IJzerman, G. de Vries and C.D. Stehouwer, Impaired microvascular function in obesity: Implications for obesity-associated microangiopathy, hypertension, and insulin resistance, Circulation 109 (2004), 2529-2535.
14. J.J. Durussel, M.F. Berthault, G. Guiffant and J. Dufaux, Effects of red blood cell hyperaggregation on the rat microcirculation blood flow, Acta Physiol Scand 163 (1998), 25-32.
15. K. Egashira, Y. Hirooka, H. Kai, M. Sugimachi, K. Suzuki, T. Inou and A. Takeshita, Reduction serum cholesterol with pravastatin improves endothelium-dependent coronary vasomotion in patients with hypercholesterolemia, Circulation 89 (1994), 2159-2524.
16. S. Engel, J. Bohnte and K. Gorzelniiak, Weight loss and the renine-angiotensin-aldosteron system, Hypertension 45 (2005), 356-362.
17. M. Ercan, C. Koksal, D. Konukoglu, A.K. Bozkurt and S. Onen, Impaired plasma viscosity via increased cholesterol levels in peripheral occlusive arterial disease, Clin Hemorheol Microcirc 29 (2003), 3-9.
18. M. Esler, N. Strazniky, N. Gikeli, K. Masuo, G. Lambert and E. Lambert, Mechanisms of sympathetic activation in obesity-related hypertension, Hypertension 48 (2006), 787-796.
19. W.T. Friedewald, R.I. Levy, R.I. and D.S. Fredrickson, Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge, Clin Chem 18 (1972), 499-502.
20. V.H. Goh, C.F. Tain, T.Y. Tong, H.P. Mok, M.T. Wong and Are, BMI and other anthropometric measures appropriate as indices for obesity? A study in an Asian population, J Lipid Res 45 (2004), 1892-1898.
21. J.E. Hall, The kidney, hypertension, and obesity, Hypertension 41 (2003), 625-633.
22. O. Hamdy, S. Ledbury, C. Mullooly, C. Jarema, S. Porter, K. Ovalle, A. Moussa, A. Caselli, A.E. Caballero, P.A. Economides, A. Veves and E.S. Horton, Lifestyle modification improves endothelial function in obese subjects with the insulin resistance syndrome, Diabetes Care 26 (2003), 2119-2125.
23. B. Hornig, U. Landmesser, C. Kohler, D. Ahlersmann, S. Spiekermann, A. Christoph, H. Tatge and H. Drexter, Comparative effect of ace inhibition and angiotensin II type 1 receptor antagonism on bioavailability of nitric oxide in patients with coronary artery disease: Role of superoxide dismutase, Circulation 103 (2001), 799-805.
24. H. Hubert, M. Feinleib and P. McNamara, Obesity as an independent risk factor for cardiovascular disease: A 26-year follow-up of participants in the Framingham Heart Study, Circulation 67 (1983), 968-977.
25. W.P.T. James, A. Astrup, N. Finer, J. Hilsted, P. Kopelman, S. Rössner, W.H.M. Saris and L.F. Van Gaal, Effect of sibutramine on weight maintenance after weight loss: A randomised trial, Lancet 356 (2000), 2119-2125.
26. W.P.T. James, I.D. Caterson, W. Coutinho, N. Finer, L.F. Van Gaal, A.P. Maggioni, C. Torp-Pedersen, A.M. Sharma, G.M. Shepherd, R.A. Rode and C.L. Renz, Effect of Sibutramine on Cardiovascular Outcomes in Overweight and Obese Subjects, N Engl J Med 363 (2010), 905-917.
27. S. Kenchaiah, J.C. Evan, D. Levy, P.W. Wilson, E.J. Benjamin, M.G. Larson, W.B. Kannel and R.S. Vasan, Obesity and the risk of heart failure, N Engl J Med 347 (2002), 305-313.
28. L.A Harker, S.M. Schwartz and R. Ross, Endothelium and arteriosclerosis, Clin Haematol 10 (1981), 283-296.
29. J. Manson, G. Colditz and M. Tampfer, A prospective study of obesity and risk of coronary heart disease in women, N Engl J Med 322 (1990), 882-889.
30. J. Martínez-González, B. Raposo, C. Rodríguez and L. Badimon, 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibition prevents endothelial NO synthase downregulation by atherogenic levels of native LDLs: Balance between transcriptional and posttranscriptional regulation, Arterioscler Thromb Vasc Biol 21 (2001), 804-809.
31. A. Masumoto, Y. Hirooka, K. Hironaga, K. Eshima, S. Setoguchi, K. Egashira and A. Takeshita, Effect of pravastatin on endothelial function in patients with coronary artery disease (cholesterol-independent effect of pravastatin), Am J Cardiol 88 (2001), 1291-1294.
32. K.J. Mather, S. Verma and T.J. Anderson, Improved endothelial function with metformin in type 2 diabetes mellitus, J Am Coll Cardiol 37 (2001), 1344-1350.
33. J.M. Miles, L. Leiter, P. Hollander, T. Wadden, J.W. Anderson, M. Doyle, J. Foreyt, L. Aronne and S. Klein, Effect of orlistat in overweight and obese patients with type 2 diabetes treated with metformin, Diabetes Care 25 (2002), 1123-1128.
34. B. Mittendorfer, R.E. Ostlund, B.W. Patterson and S. Kleon, Orlistat inhibit dietary cholesterol absorption, Obes Res 9 (2001), 599-604.
35. H.J. Montoye, H.C.G. Kemper, W.H.M. Saris and R.A. Washburn Measuring Physical Activity and Energy Expenditure, Human Kinetics Publishers, Champaign, Illinois 1996.
36. E. Muls, J. Kolanowski, A. Scheen and L. Van Gaal, The effect of orlistat on weight and serum lipid in obese patients with hypercholesterolemia: A randomized-double-blinded, placebo-controlled, multicentre study, International J of Obesity 25 (2001), 1713-1721.
37. S.J. Pinto-Sietsma, G. Navis, W.M. Janssen, D. de Zeeuw, R.O. Gans, and P.E. de Jong, A central body fat distribution is related to renal function impairment, even in lean subjects, Am J Kidney Dis 41 (2003), 733-741.
38. S. Rabkin, F. Mathewson and P. Hsu, Relation of body weight to development of ischemic heart disease in a cohort of young North American men after a 26 year observation period: The Manitoba Study, Am J Cardiol 39 (1997), 452-458.
39. R. Ross, Atherosclerosis-an inflammatory disease, N Engl J Med 340 (1999), 115-126.
40. M. Rossi, M. Nannipieri, M. Anselmino, D. Guarino, F. Franzoni and M. Pesce, Subcutaneous adipose tissue blood flow and vasomotion in morbidly obese patients: Long term effect of gastric bypass surgery, Clin Hemorheol Microcirc 51 (2012), 159-167.
41. B. Sandhagen and L. Lind, Whole blood viscosity and erythrocyte deformability are related to endothelium-dependent vasodilation and coronary risk in the elderly. The prospective investigation of the vasculature in Uppsala seniors (PIVUS) study, Clin Hemorheol Microcirc 50 (2012), 301-311.
42. M. Shechter, R. Beigel, D. Freimark, S. Matetzky and M.S. Feinberg, Short-term sibutramine therapy is associated with weight loss and improved endothelial function in obese patients with coronary artery disease, Am J Cardiol 97 (2006), 1650-1653.
43. H. Shimokawa, Primary endothelial dysfunction: Atherosclerosis, J Mol Cell Cardiol 31 (1999), 23-37.
44. J.H. Stein, C.M. Carlsson, K. Papcke-Benson, S.E. Aeschlimann, A. Bodemer, M. Carnes and P.E. Mc Bride, The effects of lipid-lowering and antioxidant vitamin therapies on flow-mediated vasodilation of the brachial artery in older adults with hypercholesterolemia, J Am Coll Cardiol 38 (2001), 1806-1813.
45. H.O. Steinberg, B. Bayazeed, G. Hook, A. Johnson, J. Cronin and A.D. Baron, Endothelial dysfunction is associated with cholesterol levels in the high normal range in humans, Circulation 96 (1997), 3287-3293.
46. N.E. Strazniky, E.A. Lambert, G.W. Lambert, K. Masuo, M.D. Esler and P.J. Nestel, Effects of dietary weight loss on sympathetic activity and cardiovascular risk factors associated with metabolic syndrome, J Clin Endocrinal Metab 90 (2005), 5998-6005.
47. U.S. Food Drug Administration and FDA. Drug Safety Communication: Recommends against the continued use of Meridia (sibutramine), URL http://www.fda.gov/Drugs/DrugSafety/ucm228746.htm (2010).
48. P. Ulker, F. Gunduz, H.J. Meiselman and O.K. Baskurt, Nitric oxide generated by red blood cells following exposure to shear stress dilates isolated small mesenteric arteries under hypoxic conditions, Clin Hemorheol Microcirc (2012), DOI: 10.3233/CH-2012-1618.
49. H.A. Van Leiden, J.M. Dekker, A.C. Moll, G. Nijpels, R.J. Heine, L.M. Bouter, C.D. Stehouwer and B.C. Polak, Blood pressure, lipids, and obesity are associated with retinopathy: The Hoorn study, Diabetes Care 25 (2002), 1320-1325.
50. A. Vayá, A. Hernández-Mijares, M. Suescun, E. Solá, R. Cámara, M. Romagnoli, D. Bautista and B. Laiz, Metabolic alterations in morbid obesity. Influence on the haemorheological profile, Clin Hemorheol Microcirc 48 (2011), 247-255.
51. S. Wassmann, U. Laufs, A.T. Bäumer, K. Müller, K. Ahlbory, W. Linz, G. Itter, R. Rösen, M. Böhm and G. Nickenig, HMGCoA reductase inhibitors improve endothelial dysfunction in normocholesterolemic hypertension via reduced production of reactive oxygen species, Hypertension 37 (2001), 1450-1457.
52. M. Wiewiora, K. Sosada, M. Wylezol, L. Slowinska and W. Zurawinski, Red blood cell aggregation and deformability among patients qualified for bariatric surgery, Obes Surg 17 (2007), 365-371.
53. J. Wilding, Science, medicine, and the future: Obesity treatment, BMJ 315 (1997), 997-1000.