Endothelial dysfunction is associated with cholesterol levels in the high normal range in humans

Circulation

Volumn 96, Issue 10, 1997, Pages 3287-3293

  Steinberg, Helmut O ^a   Bayazeed, Basel ^a   Hook, Ginger ^a   Johnson, Ann ^a   Cronin, Jessica ^a   Baron, Alain D ^a,b  

^a Department of Surgical Pathology   (United States)

^b INDIANA UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Cholesterol; Endothelium; Methacholine; Sodium nitroprusside; Vasodilation

Indexed keywords

CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; METHACHOLINE CHLORIDE; NITROPRUSSIDE SODIUM;

ADULT; ARTICLE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DOSE RESPONSE; ENDOTHELIUM; FEMALE; FEMORAL ARTERY; HUMAN; HUMAN EXPERIMENT; HYPERCHOLESTEROLEMIA; INFUSION; INTRAARTERIAL DRUG ADMINISTRATION; LEG BLOOD FLOW; MALE; PRIORITY JOURNAL; VASCULAR DISEASE; VASODILATATION;

EID: 0030729184     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.96.10.3287     Document Type: Article

References (41)

1. Multiple Risk Factor Intervention Trial Group. Multiple Risk Factor Intervention Trial: risk factor changes and mortality results. JAMA. 1982;248:1465-1477.
2. Kannel WB, Castelli WP, Gordon T, McNamara PM. Serum cholesterol, lipoproteins, and the risk of coronary heart disease: the Framingham Study. Ann Intern Med. 1971;74:1-12.
3. Kannel WB, Castelli WP, Gordon T. Cholesterol in the prediction of atherosclerotic disease. Ann Intern Med. 1979;90:85-91.
4. Creager MA, Cooke JP, Mendelsohn MP, Gallagher SJ, Coleman SM, Loscalzo J, Dzau VJ. Impaired vasodilation of forearm resistance vessels in hypercholesterolemic humans. J Clin Invest. 1990;86:228-234.
5. Casino PR, Kilcoyne CM, Quyyumi AA, Hoeg JM, Panza JA. The role of nitric oxide in endothelium-dependent vasodilation of hypercholesterolemic patients. Circulation. 1993;88:2541-2547.
6. Casino PR, Kilcoyne CM, Cannon RO, Quyyumi AA, Panza JA. Impaired endothelium-dependent vascular relaxation in patients with hypercholesterolemia extends beyond the muscarinic receptor. Am J Cardiol. 1995;75:40-44.
7. Gilligan DM, Guetta V, Panza JA, Garcia CE, Quyyumi AA, Cannon RO. Selective loss of microvascular endothelial function in human hypercholesterolemia. Circulation. 1994;90:35-41
8. Vita JA Treasure CB, Nabel EG, McLenachan JM, Fish DR, Yeung AC, Vekshtein VI, Selwyn AP, Ganz P. Coronary vasomotor responses to acetylcholine relates to risk factors for coronary artery disease. Circulation. 1990;81:491-497.
9. Moncada S, Palmer RMJ, Higgs EA. The discovery of nitric oxide as the endogenous vasodilator. Hypertension. 1988;12:365-372.
10. Vallance P, Collier J, Moncada S. Effects of endothelium-derived nitric oxide on peripheral arteriolar tone in man. Lancet. 1989;2:997-1000.
11. Garg UC, Hassid A. Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells. J Clin Invest. 1989;83:1774-1777.
12. Kopalkov V, Gordon D, Kulik TJ. Nitric oxide-generating compounds inhibit total protein and collagen synthesis in cultured vascular smooth muscle cells. Circ Res. 1995;76:305-309.
13. Bruckdorfer KR, Jacobs MJ, Rice-Evans C. Endothelium-derived relaxing factor (nitric oxide), lipoprotein oxidation and atherosclerosis. Biochem Soc Trans. 1990;18:1061-1063.
14. Hogg N, Kalyanaraman B, Joseph J, Struck A, Parthasarathy S. Inhibition of low-density lipoprotein oxidation by nitric oxide. Fed Eur Biochem Soc. 1993;334:170-174.
15. National Cholesterol Education Program. Second Report of the Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel II). Circulation. 1994;89:1329-1445.
16. National Diabetes Data Group. Classification and diagnosis of diabetes mellitus and other categories of glucose intolerance. Diabetes. 1979;28:1039-1057.
17. Baron AD, Brechtel G, Wallace P, Edelman SV. Rates and tissue sites of non-insulin and insulin-mediated glucose uptake in humans. Am J Physiol. 1988;255:E769-E-774.
18. Friedewald WT, Levy RT, Fredrickson DS. Estimation of the concentration of low density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem. 1972;18:499-502.
19. Novak M. Colorimetric ultramicro method for the determination of free fatty acids. J Lipid Res. 1965;6:431-433.
20. Moncada S, Radomski MW, Palmer RMJ. Endothelium derived relaxing factor: identification as nitric oxide and role in the control of vascular tone and platelet function. Biochem Pharmacol. 1988;37:2495-2501.
21. Panza JA, Quyyumy A, Brush JE, Epstein SE. Abnormal endothelium dependent vascular relaxation in patients with essential hypertension. New Engl J Med. 1990;323:22-27.
22. Taddei S, Virdis A, Mattei P, Salvetti A. Vasodilation to acetylcholine in primary and secondary forms of human hypertension. Hypertension. 1993;21:929-933.
23. Taddei S, Virdis A, Matei P, Ghiadoni L, Gennari A, Fasolo CB, Sudano I, Salvetti A. Aging and endothelial function in normotensive subjects and patients with essential hypertension. Circulation. 1995;91:1981-1987.
24. Petrie JR, Ueda S, Webb DJ, Elliott HL, Connell JMC. Endothelial nitric oxide production and insulin sensitivity: a physiological link with implications for pathogenesis of cardiovascular disease. Circulation. 1996;93:1331-1333.
25. Steinberg HO, Chaker H, Leaming R, Johnson A, Brechtel G, Baron AD. Obesity/insulin resistance is associated with endothelial dysfunctionL implications for the syndrome of insulin resistance. J Clin Invest. 1996;97:2601-2610.
26. Tare M, Parkington HC, Coleman HA, Neild TO, Dusting GJ. Hyperpolarization and relaxation of arterial smooth muscle caused by nitric oxide derived from the endothelium. Nature. 1990;346:69-71.
27. Mombouli J-V, Illiano S, Nagao T, Scott-Burden T, Vanhoutte PM. Potentiation of endothelium-dependent relaxations to bradykinin by angiotensin I converting enzyme inhibitors in canine coronary artery involves both endothelium-derived relaxing and hyperpolarizing factors. Circ Res. 1992;71:137-144.
28. Brayden JE. Membrane hyperpolarization is a mechanism of endothelium-dependent cerebral vasodilation. Am J Physiol. 1990;259:H669-H673.
29. Bank N, Aynedjian HS. Role of thromboxane in impaired renal vasodilation response to acetylcholine in hypercholesterolemic rats. J Clin Invest. 1992;89:1636-1642.
30. 2 as an endothelium-derived contracting factor in diabetic state. Diabetes. 1993;42:1246-1252.
31. Minor RLJ, Myers PR, Guerra RJ, Bates JN, Harrison DG. Diet-induced atherosclerosis increases the release of nitrogen oxides from rabbit aortas. J Clin Invest. 1990;86:2109-2116.
32. Mugge A, Brandes RP, Boger FH, Dwnger A, Bode-Boger S, Kienke S, Frolich JC, Lichtlen PR. Vascular release of superoxide radicals is enhanced in hypercholesterolemic rabbits. J Cardiovasc Pharmac. 1994;24:994-998.
33. Ohara Y, Petersen TE, Harrison DG. Hypercholesterolemia increases endothelial superoxide anion production. J Clin Invest. 1993;91:2546-2551.
34. Linder L, Kiowski W, Buehler FR, Luescher TF. Indirect evidence for release of endothelium-derived relaxing factor in human forearm circulation in vivo. Circulation. 1990;81:1762-1767.
35. Sheu W H-H, Shieh S-M, Fuh M M-T, Shen D D-C, Jeng C-Y, Chen Y-D I, Reaven GM Insulin resistance, glucose intolerance and hyperinsulinemia: hypertriglyceridemia versus hypercholesterolemia. Arterioscler Thromb. 1993;13:367-370.
36. Karhapaa P, Voutilainen E, Kovanen PT, Laakso M. Insulin resistance in familial and nonfamilial hypercholesterolemia. Arterioscler Thromb. 1993;13:41-47.
37. Stroes ESG, Koomans HA, de Bruin TWA, Rabelink TJ. Vascular function in the forearm of hypercholesterolaemic patients off and on lipid-lowering medication. Lancet. 1995;346:467-471.
38. Vogel RA, Coretti Mc, Plotnik GD. Changes in flow mediated brachial artery vasoactivity with lowering of desirable cholesterol levels in healthy middle-aged men. Am J Cardiol. 1996;77:37-40.
39. Sacks FM, Pfeffer MA, Noye LA, Rouleau JL, Rutherford JD, Cole TG, Brown L, Warnica W, Arnold JMO, Wun C-C, Davis BR, Braunwald E. The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels. N Engl J Med. 1996;335:1001-1009.
40. Leung W-H, Lau C-P, Wong C-K. Beneficial effect of cholesterol-lowering therapy on coronary endothelium-dependent relaxation in hypercholesterolaemic patients. Lancet. 1993;341:1496-1500
41. Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Summary of the Second Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel II). JAMA. 1993;269:3015-3023.