Science, medicine, and the future: Obesity treatment

British Medical Journal

Volumn 315, Issue 7114, 1997, Pages 997-1000

  Wilding, John ^a  

^a UNIVERSITY HOSPITAL AINTREE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BETA 3 ADRENERGIC RECEPTOR STIMULATING AGENT; CHOLECYSTOKININ RECEPTOR STIMULATING AGENT; DEXFENFLURAMINE; GLUCAGON LIKE PEPTIDE 1; LEPTIN; NEUROPEPTIDE Y; NEUROPEPTIDE Y RECEPTOR ANTAGONIST; NEUROTRANSMITTER; RECOMBINANT PROTEIN; SIBUTRAMINE; TETRAHYDROLIPSTATIN;

BODY WEIGHT; CLINICAL TRIAL; DIABETES MELLITUS; DIETARY INTAKE; ENERGY BALANCE; GASTROINTESTINAL DISEASE; GENETIC MODEL; HEART DISEASE; HUMAN; HYPERTENSION; HYPOTHALAMUS; LIFESTYLE; LOW CALORY DIET; NONHUMAN; OBESITY; PRIORITY JOURNAL; SHORT SURVEY; WEIGHT REDUCTION;

EID: 0030763001     PISSN: 09598146     EISSN: None     Source Type: Journal    
DOI: 10.1136/bmj.315.7114.997     Document Type: Short Survey

References (19)

1. Jung RT Obesity as a disease. Br Med Bull 1997;53:307-21.
2. Wing R. Behavioral treatment of severe obesity. Aw J clin Nutr 1992;55:545-548
3. Skender MI., Godrick K, Del Junco DJ. Comparison of 2-year weight loss trends in behavioral treatments of obesity: diet, exercise and combination interventions. Am J Clin Nutr 1996;96:1115-23.
4. Connolly HM, Crary JL, McGoon MD, Hensrud DD, Edwards BS, Edwards WD, et al. Valvular heart disease associated with fenfluraminephemermine. N Engl J Med 1997;337:581-8.
5. Sjostrom I,. The natural history of massive obesity. Obesity 1995;3:317.
6. Wilding JPH, Widdowson PS, Williams G. Neurobiology, Br Med Bull 1997;53:286-306.
7. Ballinger A, Mclougblin I., Medbak S, Clark M, Cholecystokinin is a satiey hormone in humans at physiological postprandial plasmaconcentrations. Clin Sci 1995;89:375-81.
8. Turton MD, O'shea D, Gunn I, Beak SA, Edwards CMB, Meeran K, et al. A role for glucagon-like Peptide-1 in the central control of leeding. Nature 1996;379:69-72.
9. Lu D, Willard D, Patel IR, Kadwell S, Overton L, et al. Agouti Protein is an antagonist of the melanocyte-stimulating-hormone receptor. Nature 1994;371:799-802.
10. Naggerr JK, Fricker LD, Varlamon O, Nishina PM, Rouille Y, Steiner DF, et al. Hyperproinsulinaetmia in obese fat/fat mice associated with a carboxypeptidase E mutation which reduces enzyme activity. Nat Genet 1995;10:135-42.
11. Jackson RS, Greemers JWM, Ohagi S, Raffin Sanson MI, Sanders L, Montague CT, et al. Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase I gene. Nat Genet 1997;16:303-6.
12. Zhang Y, Proenca R, Matlei M, Barone M, Leopold L, Fridman JM. Positional cloning of the mouse obese gene and its human homologue. Nature 1994;372:425-32.
13. Wang Q, Bing C, Al-Barazanji K, Mossakowaska DE, Wang X, McBay D, et al. Interactions between leptin and hypothalamic neuropeptide Y. neurones in the control of food intake and energy homeostasis in the rat. Diabetes 1997;46:335-41.
14. Montage CT, Far̈ooqi IS, Whitehead JP, Soos MA, Wareham NJ, et al. Congenital leptin deficiency is associated with serve early-onset obesity in humans. Nature 1997;387:903-8.
15. Erickson JC, Hollopeter G, Palmiter RD, Attenuation of the obesity syndrome of ob/ob mice by the loss of neuropeptide-Y Science 1996,274:1704-7.
16. Bouchard C, Tremblay A, Despres JP, Nadeau A, Lupien PJ, Theriault G, et al. The response to long-term overfeeding in identical-twins. N Engl J Med1995;322:1477-82.
17. Clement K, Vaisse C, Manning BS, Basdevant A, Guygrand B. Ruiz J, et al. Genetic-variation in the beta(3)-adrenergic receptor and an increased capacity to gain weight in patients with morbid-obesity. N Engl J Med 1995;333:352-4.
18. Fleury C, Neverova M, Collins S, Raimbault S, Champigny O, Levi Meyrueis C, et al. Uncoupling Protein-2: a novel gene linked to obesity and hyperinsulinaetinia. Nat Genet 1997;15:269-72.
19. VidalPuig A, Solanes G, Grujic D, Flier JS, Lowell BB. Ucp3: an uncoupling protein homologue expressed preferentially and abundantly in skeletal muscle and brown adipose tissue. Biochem Biophys Res Common 1997;235:79-82.