Impaired microvascular endothelial function in relatively young obese humans is associated with altered metabolic and inflammatory markers

Clinical Hemorheology and Microcirculation

Volumn 47, Issue 2, 2011, Pages 87-97

  Al Tahami, Belqes Abdullah ^a   Bee, Yvonne Tee Get ^b   Ismail, Abdul Aziz Al Safi ^b   Rasool, Aida Hanum Ghulam ^a  

^a SCHOOL OF MEDICAL SCIENCES   (Malaysia)

^b SCHOOL OF HEALTH SCIENCES   (Malaysia)

Author keywords

adiponectin; metabolic markers; microvascular endothelial function; Obesity

Indexed keywords

ACETYLCHOLINE; ADIPONECTIN; C REACTIVE PROTEIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; NITROPRUSSIDE SODIUM;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DIASTOLIC BLOOD PRESSURE; ENDOTHELIAL DYSFUNCTION; FEMALE; GLUCOSE BLOOD LEVEL; HUMAN; INFLAMMATION; LASER DOPPLER FLOWMETRY; LIPID BLOOD LEVEL; MALE; METABOLISM; MICROVASCULATURE; OBESITY; SYSTOLIC BLOOD PRESSURE; TRIACYLGLYCEROL BLOOD LEVEL; VASODILATATION;

ADIPONECTIN; ADULT; BLOOD GLUCOSE; BLOOD PRESSURE; C-REACTIVE PROTEIN; ENDOTHELIAL CELLS; FEMALE; HUMANS; LIPIDS; MALE; MICROVESSELS; OBESITY;

EID: 79952132924     PISSN: 13860291     EISSN: 18758622     Source Type: Journal    
DOI: 10.3233/CH-2010-1370     Document Type: Article

References (38)

1. Y. Arita, S. Kihara, N. Ouchi, M. Takahashi, K. Maeda, J. Miyagawa, K. Hotta, I. Shimomura, T. Nakamura, K. Miyaoka, H. Kuriyama, M. Nishida, S. Yamashita, K. Okubo, K. Matsubara, M. Muraguchi, Y. Ohmoto, T. Funahashi and Y Matsuzawa, Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity, Biochem Biophys Res Commun 257 (1999), 79-83. (Pubitemid 29299050)
2. J.V. Castell, M.J. Gomez-Lechbn, M. David, T. Hirano, T. Kishimoto, C Peter and PC Heirnich, Recombinant human interleukin-6 (IL-6/BSF-2/HSF) regulates the synthesis of acute phase proteins in human hepatocytes, Federation of European Biochemical Societies 23(2) (1998), 347-350.
3. T.P. Combs, A.H. Berg, S. Obici, PE. Scherer and L. Rossetti, Endogenous glucose production is inhibited by the adipose-derived protein Acrp30, J Clin Invest 108 (2001), 1875-1881. (Pubitemid 34015133)
4. S. Czernichow, J.R. Greenfield, P. Galan, J.P. Bastard, N. Charnaux, K. Samaras, M. Safar, J. Blacher, S. Hercberg and B. Levy, Microvascular dysfunction in healthy insulin-sensitive overweight individuals, Journal of Hypertension 28(2) (2010), 325-332.
5. PE. De Jong, J.C. Verhave, SJ. Pinto-Sietsma and H.L. Hillege, Obesity and target organ damage: The kidney, Int J Obes RelatMetab Disord26(4) (2002), 21-24.
6. R.T. De Jongh, E.H. Serné, R.I. IJzerman, H.T. Jørstad and C.A. Stehouwer, Impaired local microvascular vasodilatory effects of insulin and reduced skin microvascular vasomotion in obese women, MicrovascularResearch 75 (2008), 256-262. (Pubitemid 351240937)
7. T.R. De Jongh, H.E. Serné, R.G. IJzerman, G. de Vries and D.A. Stehouwer, Impaired microvascular function in obe-sity: Implications for obesity-associated microangiopathy, hypertension, and insulin resistance, Circulation 109 (2004), 2529-2535. (Pubitemid 38720552)
8. V.H. Goh, C.F Tain, T.Y Tong, M.P. Helen and M.T. Wong, Are BMI and other anthropometric measures appropriate as indices for obesity? A study in an Asian population, Journal ofLipid Research 45 (2004), 1892-1898. (Pubitemid 40990882)
9. I. Jialal, S. Devaraj and S.K. Venugopal, C-Reactive protein: Risk marker or mediator in atherothrombosis? Hypertension 44 (2004), 6-11. (Pubitemid 38823477)
10. S. Kenchaiah, J.C. Evans, D. Levy, PW. Wilson, EJ. Benjamin, M.G. Larson, W.B. Kannel and R.S. Vasan, Obesity and the risk of heart failure, NEngl JMed 347 (2002), 305-313. (Pubitemid 34815352)
11. PK. Kern, G.B. Di Gregorio, T. Lu, N. Rassouli and G. Ranganathan, Adiponectin expression from human adipose tissue relation to obesity, insulin resistance, and tumor necrosis factor expression, Diabetes 52 (2003), 1779-1785. (Pubitemid 36792470)
12. B.I. Levy, G. Ambrosio, A.R. Pries and H.A. Struijker-Boudier, Microcirculation in hypertension: A new target for treatment? Circulation 104 (2001), 736-741.
13. P. Libby, Inflammation in atherosclerosis, Nature 420 (2002), 868-874. (Pubitemid 36019640)
14. J.E. Manson, MJ. Stampfer, G.A. Colditz, W.C. Willett, B. Rosner, F.E. Speizer and C.H. HenneKens, Aprospective study of obesity and risk of coronary heartdisease in women, N Engl JMed 322 (1990), 882-889. (Pubitemid 20108377)
15. K.L. Margolis, J.E. Manson, P. Greenland, RJ. Rodabough, PF. Bray, M. Safford, R.HJ. Grimm and R. Prentice, Leukocyte count as a predictor of cardiovascular events and mortality in postmenopausal women, Arch Intern Med 165 (2005), 500-508.
16. J.P. Noon, B.R. Walker, DJ. Webb, A.C. Shore, D.W. Holton, H.V. Edwards and G.C. Watt, Impaired microvascular dilatation band capillary rarefaction in young adults with a predisposition to high blood pressure, J Clin Invest 99 (1997), 1873-1879. (Pubitemid 27175934)
17. N. Ouchi, M. Ohishi, S. Kihara, T. Funahashi, T. Tadashi Nakamura, H. Nagaretani, M. Kumada, K. Ohashi, Y Okamoto, H. Nishizawa, K. Kishida, N. Maeda, A. Nagasawa, H. Kobayashi, H. Hiraoka, N. Komai, M. Kaibe, H. Rakugi, T. Ogihara and Y Matsuzawa, Association of hypoadiponectinemia with impaired vasoreactivity, Hypertension 42 (2003), 231-234. (Pubitemid 37093465)
18. N. Ouchi, S. Kihara and Y Arita, Novelmodulatorforendothelial adhesion molecules: Adipocyte-derivedplasmaprotein adiponectin, Circulation 100 (1999), 2473-2476. (Pubitemid 30005109)
19. N. Ouchi, S. Kihara, Y. Arita, M. Nishida,A. Matsuyama, Y. Okamoto, M. Ishigami, H. Kuriyama, K. Kishida, H. Nishizawa, K. Hotta, M. Muraguchi, Y. Ohmoto, S. Yamashita, T. Funahashi and Y Matsuzawa, Adipocyte-derived plasma pro-tein, adiponectin, suppresses lipid accumulation and class A scavenger receptor expression in human monocyte-derived macrophages, Circulation 103 (2001), 1057-1063. (Pubitemid 32200177)
20. S.J. Pinto-Sietsma, G. Navis, W.M. Janssen, D. de Zeeuw, R.O. Gans and P.E. de Jong, A central body fat distribution is related to renal function impairment, even in lean subjects, AJKidney Dis 41 (2003), 733-741. (Pubitemid 36401550)
21. S.W. Rabkin, F.A. Mathewson andP.H. Hsu, Relationofbodyweightto developmentofischemicheartdiseasein acohort of young North American men after a 26 year observation period: The Manitoba Study, Am J Cardiol 39 (1997), 452-458.
22. C Rask-Madsen, H. Domínguez, N. Ihlemann, T. Hermann, L. Køber and C Torp-Pedersen, Tumor necrosis factor-inhibits insulin's stimulating effect on glucose uptake and endotheliumdependent vasodilation in humans, Circulation 108 (2003), 1815-1821. (Pubitemid 37296090)
23. A. Ross, Atherosclerosis: An inflammatory disease, NEngl JMed 340 (1999), 115-126.
24. D. Samocha-Bonet, D. Justo, O. Rogowski, N. Saar, S. Abu-Abeid, G. Shenkerman, I. Shapira, S. Berlinr and A. Tomer, Platelet counts and platelet activation markers in obese subjects, Mediators of Inflammation 2008 (2007), 1-6, doi:10.1155/2008/834153
25. V. Schachinger, MB. Britten and A.M. Zeiher, Prognostic impact of coronary vasodilator dysfunction on adverse long-term outcome of coronary heart disease, Circulation 101 (2000), 1899-1906. (Pubitemid 30225269)
26. M. Shimabukuro, N. Higa, T. Asahi, Y Oshiro, N. Takasu, T. Tagawa, S. Ueda, I. Shimomura, T. Funahashi and Y Matsuzawa, Hypoadiponectinemia is closely linked to endothelial dysfunction in man, J Clin Endocrinol Metab 88 (2003), 3236-3240. (Pubitemid 36877499)
27. H.O. Steinberg, G. Paradisi, G. Hook, K. Crowder, J. Cronin and A.D. Baron, Free fatty acid elevation impairs insulin-mediated vasodilation and nitric oxide production, Diabetes 49 (2000), 1231-1238. (Pubitemid 30439100)
28. H.O. Steinberg, H. Chaker, R. Leaming, A. Johnson, G. Brechtel and A.D. Baron, Obesity/insulin resistance is associated with endothelial dysfunction: Implications for the syndrome of insulin resistance, J Clin Invest 97 (1996), 2601-2610.
29. J.A. Suwaidi, S. Hamasaki, S.T. Higano, R.A. Nishimura, D.R. Holmes and A. Lerman, Long-term follow-up of patients with mild coronary artery disease and endothelial dysfunction, Circulation 101 (2000), 948-954. (Pubitemid 30131694)
30. CJ. Tack, M.E. Ong, Lutterman and J.P. Smits, Insulin-induced vasodilatation and endothelial function in obesity/insulin resistance. Effects of troglitazone, Diabetologia 41 (1998), 569-576. (Pubitemid 28206828)
31. H.A. Van Leiden, J.M. Dekker, A.C. Moll, G. Nijpels, RJ. Heine, L.M. Bouter, C.D. Stehouwer and B.C. Polak, Blood pressure, lipids, and obesity are associated with retinopathy: The Hoorn study, Diabetes Care 25 (2002), 1320-1325. (Pubitemid 41071139)
32. G.R. Warnick, R.H. Knopp, V. Fitzpatrick and L. Branson, Estimating low-density lipoprotein cholesterol by the Friedewald equation is adequate for classifying patients on the basis of nationally recommended cutpoints, Clinical Chemistry 36 (1990), 15-19.
33. C Weyer, T. Funahashi, S. Tanaka, K. Hotta, Y Matsuzawa, R.E. Pratley and PA. Tataranni, Hypoadiponectinemia in obesity and type 2 diabetes: Close association with insulin resistance and hyperinsulinemia, J Clin Endocrinol Metab 86 (2001), 1930-1935. (Pubitemid 32472900)
34. World Health Organization, Physical status: The use and interpretation of anthropometry, Report of WHO Expert Committee Geneva, 1999.
35. World Health Organization, Obesity: Preventing and Managing the Global Epidemic, World Health Organization Report Series, 2000.
36. T. Yamauchi, J. Kamon, H. Waki, Y Terauchi, N. Kubota, K. Hara, Y Mori, T. Ide, K. Murakami, N. Tsuboyama-Kasaoka, O. Ezaki, Y Akanuma, O. Gavrilova, C Vinson, M.L. Reitman, H. Kagechika, K. Shudo, M. Yoda, Y Nakano, K. Tobe, R. Nagai, S. Kimura, M. Tomita, P. Froguel and T. Kadowaki, The fat derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity,NatMed7 (2001), 941-946. (Pubitemid 32756432)
37. W.S. Yang, WJ. Lee, T. Funahashi, S. Tanaka, Y Matsuzawa, C.L. Chao, C.L. Chen, T.Y Tai and L.M. Chuang, Weight reduction increases plasma levels of anadipose-derived anti-inflammatory protein, adiponectin, J Clin Endocrinol Metab 86 (2001), 3815-3819. (Pubitemid 32755982)
38. F. Zaldivar, R.G. McMurra, D. Nemet, P. Galassetti, PJ. Mills and D.M. Cooper, Body fat and circulating leukocytes in children, International Journal ofObesity 30 (2006), 906-911. (Pubitemid 43801189)