MTHFR deficiency or reduced intake of folate or choline in pregnant mice results in impaired short-term memory and increased apoptosis in the hippocampus of wild-type offspring

Neuroscience

Volumn 300, Issue , 2015, Pages 1-9

  Jadavji, N M ^a   Deng, L ^a   Malysheva, O ^b   Caudill, M A ^b   Rozen, R ^a  

^a RESEARCH INSTITUTE OF THE MCGILL UNIVERSITY HEALTH CENTRE   (Canada)

^b Department of Obstetrics Gynecology

Author keywords

Apoptosis; Maternal choline deficiency; Maternal folate deficiency; MTHFR deficiency; Short term memory

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); CHOLINE; FOLIC ACID; HOMOCYSTEINE; CHOLINE ACETYLTRANSFERASE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2);

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BODY WEIGHT; BRAIN REGION; BRAIN SIZE; CELL COUNT; CELL PROLIFERATION; CONTROLLED STUDY; DENTATE GYRUS; DIETARY INTAKE; HIPPOCAMPAL CA1 REGION; HIPPOCAMPAL CA2 REGION; HIPPOCAMPUS; MATERNAL NUTRITION; MEMORY DISORDER; MOUSE; NONHUMAN; NUTRITIONAL DISORDER; PREGNANCY; PRIORITY JOURNAL; PROGENY; PROTEIN BLOOD LEVEL; SHORT TERM MEMORY; ANIMAL; BLOOD; DEFICIENCY; DISEASE MODEL; FEMALE; FOLIC ACID DEFICIENCY; GROWTH, DEVELOPMENT AND AGING; HOMOCYSTINURIA; MALE; MAZE TEST; MEMORY DISORDERS; METABOLISM; NERVOUS SYSTEM DEVELOPMENT; ORGAN SIZE; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; PREGNANCY COMPLICATION; PSYCHOSIS; RECOGNITION; SPASTICITY; TRANSGENIC MOUSE; VITAMIN DEFICIENCY;

ANIMALS; APOPTOSIS; BODY WEIGHT; CHOLINE DEFICIENCY; CHOLINE O-ACETYLTRANSFERASE; DISEASE MODELS, ANIMAL; FEMALE; FOLIC ACID DEFICIENCY; HIPPOCAMPUS; HOMOCYSTEINE; HOMOCYSTINURIA; MALE; MATERNAL NUTRITIONAL PHYSIOLOGICAL PHENOMENA; MAZE LEARNING; MEMORY DISORDERS; MEMORY, SHORT-TERM; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); MICE, TRANSGENIC; MUSCLE SPASTICITY; NEUROGENESIS; ORGAN SIZE; PREGNANCY; PREGNANCY COMPLICATIONS; PSYCHOTIC DISORDERS; RECOGNITION (PSYCHOLOGY);

EID: 84929316985     PISSN: 03064522     EISSN: 18737544     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2015.04.067     Document Type: Article

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