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Volumn 11, Issue 6, 2015, Pages 763-769

Stem cell therapies for systemic lupus erythematosus: Current progress and established evidence

Author keywords

hematopoietic stem cells; immunomodulation; mesenchymal stem cells; systemic lupus erythematosus; transplantation

Indexed keywords

ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION; ALLOGENEIC MESENCHYMAL STEM CELL TRANSPLANTATION; AUTOLOGOUS HEMATOPOIETIC STEM CELL TRANSPLANTATION; CLINICAL TRIAL (TOPIC); HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; IMMUNOMODULATION; MESENCHYMAL STEM CELL TRANSPLANTATION; PHASE 1 CLINICAL TRIAL (TOPIC); PHASE 2 CLINICAL TRIAL (TOPIC); RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; STEM CELL TRANSPLANTATION; SYSTEMIC LUPUS ERYTHEMATOSUS; ANIMAL; BIOLOGICAL THERAPY; DRUG RESISTANCE; HEMATOPOIETIC STEM CELL; LUPUS ERYTHEMATOSUS, SYSTEMIC; MESENCHYMAL STROMA CELL; PHYSIOLOGY;

EID: 84929310579     PISSN: 1744666X     EISSN: 17448409     Source Type: Journal    
DOI: 10.1586/1744666X.2015.1037741     Document Type: Review
Times cited : (10)

References (63)
  • 1
    • 84898876959 scopus 로고    scopus 로고
    • Optimizing outcome in SLE: Treating-To-Target and definition of treatment goals
    • Doria A, Gatto M, Zen M, et al. Optimizing outcome in SLE: treating-To-Target and definition of treatment goals. Autoimmun Rev 2014;13:770-7
    • (2014) Autoimmun Rev , vol.13 , pp. 770-777
    • Doria, A.1    Gatto, M.2    Zen, M.3
  • 2
    • 84877821946 scopus 로고    scopus 로고
    • Emerging and critical issues in the pathogenesis of lupus
    • Gatto M, Zen M, Ghirardello A, et al. Emerging and critical issues in the pathogenesis of lupus. Autoimmun Rev 2013;12:523-36
    • (2013) Autoimmun Rev , vol.12 , pp. 523-536
    • Gatto, M.1    Zen, M.2    Ghirardello, A.3
  • 3
    • 78649751475 scopus 로고    scopus 로고
    • Azathioprine versus mycophenolate mofetil for long-Term immunosuppression in lupus nephritis: Results from the Maintain Nephritis Trial
    • Houssiau FA, D'Cruz D, Sangle S, et al. Azathioprine versus mycophenolate mofetil for long-Term immunosuppression in lupus nephritis: results from the Maintain Nephritis Trial. Ann Rheum Dis 2010;69: 2083-9
    • (2010) Ann Rheum Dis , vol.69 , pp. 2083-2089
    • Houssiau, F.A.1    D'cruz, D.2    Sangle, S.3
  • 4
    • 74849138379 scopus 로고    scopus 로고
    • Nonrenal disease activity following mycophenolate mofetil or intravenous cyclophosphamide as induction treatment for lupus nephritis: Findings in a multicenter, prospective, randomized, open-label, parallel-group clinical trial
    • Ginzler EM, Wofsy D, Isenberg D, et al. Nonrenal disease activity following mycophenolate mofetil or intravenous cyclophosphamide as induction treatment for lupus nephritis: findings in a multicenter, prospective, randomized, open-label, parallel-group clinical trial. Arthritis Rheum 2010;62:211-21
    • (2010) Arthritis Rheum , vol.62 , pp. 211-221
    • Ginzler, E.M.1    Wofsy, D.2    Isenberg, D.3
  • 5
    • 84902547534 scopus 로고    scopus 로고
    • Hydroxychloroquine: A multifaceted treatment in lupus
    • Costedoat-Chalumeau N, Dunogue-B, Morel N, et al. Hydroxychloroquine: a multifaceted treatment in lupus. Presse Med 2014;43:e167-80
    • (2014) Presse Med , vol.43 , pp. e167-e180
    • Costedoat-Chalumeau, N.1    Dunogue, B.2    Morel, N.3
  • 7
    • 79952070370 scopus 로고    scopus 로고
    • Efficacy and safety of belimumab in patients with active systemic lupus erythematosus: A randomised, placebo-controlled, phase 3 trial
    • Navarra SV, Guzman RM, Gallacher AE, et al. Efficacy and safety of belimumab in patients with active systemic lupus erythematosus: a randomised, placebo-controlled, phase 3 trial. Lancet 2011;377:721-31
    • (2011) Lancet , vol.377 , pp. 721-731
    • Navarra, S.V.1    Guzman, R.M.2    Gallacher, A.E.3
  • 8
    • 84889657510 scopus 로고    scopus 로고
    • Efficacy and safety of epratuzumab in patients with moderate/severe active systemic lupus erythematosus: Results from EMBLEM, a phase IIb, randomised, double-blind, placebo-controlled, multicentre study
    • Wallace DJ, Kalunian K, Petri MA, et al. Efficacy and safety of epratuzumab in patients with moderate/severe active systemic lupus erythematosus: results from EMBLEM, a phase IIb, randomised, double-blind, placebo-controlled, multicentre study. Ann Rheum Dis 2014;73:183-90
    • (2014) Ann Rheum Dis , vol.73 , pp. 183-190
    • Wallace, D.J.1    Kalunian, K.2    Petri, M.A.3
  • 9
    • 84875697484 scopus 로고    scopus 로고
    • Sifalimumab, a human anti-interferon-A monoclonal antibody, in systemic lupus erythematosus: A phase i randomized, controlled, dose-escalation study
    • Petri M, Wallace DJ, Spindler A, et al. Sifalimumab, a human anti-interferon-A monoclonal antibody, in systemic lupus erythematosus: a phase I randomized, controlled, dose-escalation study. Arthritis Rheum 2013;65:1011-21
    • (2013) Arthritis Rheum , vol.65 , pp. 1011-1021
    • Petri, M.1    Wallace, D.J.2    Spindler, A.3
  • 10
    • 84918584175 scopus 로고    scopus 로고
    • Stem cell-based therapies for age-related macular degeneration: Current status and prospects
    • Mu Y, Zhao M, Su G. Stem cell-based therapies for age-related macular degeneration: current status and prospects. Int J Clin Exp Med 2014;7:3843-52
    • (2014) Int J Clin Exp Med , vol.7 , pp. 3843-3852
    • Mu, Y.1    Zhao, M.2    Su, G.3
  • 11
    • 84895098346 scopus 로고    scopus 로고
    • Mesenchymal stem cell treatments in rheumatology: A glass half full?
    • Tyndall A. Mesenchymal stem cell treatments in rheumatology: a glass half full?. Nat Rev Rheumatol 2014;10:117-24
    • (2014) Nat Rev Rheumatol , vol.10 , pp. 117-124
    • Tyndall, A.1
  • 12
    • 0030828395 scopus 로고    scopus 로고
    • Autologous marrow stem cell transplantation for severe systemic lupus erythematosus of long duration
    • Marmont AM, van Lint MT, Gualandi F, et al. Autologous marrow stem cell transplantation for severe systemic lupus erythematosus of long duration. Lupus 1997;6:545-8
    • (1997) Lupus , vol.6 , pp. 545-548
    • Marmont, A.M.1    Van Lint, M.T.2    Gualandi, F.3
  • 13
    • 0036847280 scopus 로고    scopus 로고
    • Hematopoietic stem cell transplantation for severe and refractory lupus. Analysis after five years and fifteen patients
    • Traynor AE, Barr WG, Rosa RM, et al. Hematopoietic stem cell transplantation for severe and refractory lupus. Analysis after five years and fifteen patients. Arthritis Rheum 2002;46:2917-23
    • (2002) Arthritis Rheum , vol.46 , pp. 2917-2923
    • Traynor, A.E.1    Barr, W.G.2    Rosa, R.M.3
  • 14
    • 0034718372 scopus 로고    scopus 로고
    • Treatment of severe systemic lupus erythematosus with high-dose chemotherapy and haemopoietic stem-cell transplantation: A phase i study
    • Traynor AE, Schroeder J, Rosa RM, et al. Treatment of severe systemic lupus erythematosus with high-dose chemotherapy and haemopoietic stem-cell transplantation: a phase I study. Lancet 2000;356:701-7
    • (2000) Lancet , vol.356 , pp. 701-707
    • Traynor, A.E.1    Schroeder, J.2    Rosa, R.M.3
  • 15
    • 32044473487 scopus 로고    scopus 로고
    • Nonmyeloablative hematopoietic stem cell transplantation for systemic lupus erythematosus
    • Burt RK, Traynor A, Statkute L, et al. Nonmyeloablative hematopoietic stem cell transplantation for systemic lupus erythematosus. JAMA 2006;295:527-35
    • (2006) JAMA , vol.295 , pp. 527-535
    • Burt, R.K.1    Traynor, A.2    Statkute, L.3
  • 16
    • 78649742723 scopus 로고    scopus 로고
    • Stem cell transplantation: Progress in Asia
    • Sun L. Stem cell transplantation: progress in Asia. Lupus 2010;19:1468-73
    • (2010) Lupus , vol.19 , pp. 1468-1473
    • Sun, L.1
  • 17
    • 84874424391 scopus 로고    scopus 로고
    • Autologous haematopoietic stem cell transplantation for systemic lupus erythematosus: Data from the European Group for Blood and Marrow Transplantation registry
    • Alchi B, Jayne D, Labopin M, et al. Autologous haematopoietic stem cell transplantation for systemic lupus erythematosus: data from the European Group for Blood and Marrow Transplantation registry. Lupus 2013;22: 245-53
    • (2013) Lupus , vol.22 , pp. 245-253
    • Alchi, B.1    Jayne, D.2    Labopin, M.3
  • 18
    • 0036228253 scopus 로고    scopus 로고
    • Stem cell transplantation for autoimmune disease: Progress and problems
    • Furst DE. Stem cell transplantation for autoimmune disease: progress and problems. Curr Opin Rheumatol 2002;14:220-4
    • (2002) Curr Opin Rheumatol , vol.14 , pp. 220-224
    • Furst, D.E.1
  • 19
    • 84890426974 scopus 로고    scopus 로고
    • Long-Term follow-up of autologous stem cell transplantation for severe pediatric systemic lupus erythematosus
    • Su G, Luan Z, Wu F, et al. Long-Term follow-up of autologous stem cell transplantation for severe pediatric systemic lupus erythematosus. Clin Rheumatol 2013;32:1727-34
    • (2013) Clin Rheumatol , vol.32 , pp. 1727-1734
    • Su, G.1    Luan, Z.2    Wu, F.3
  • 20
    • 80855128856 scopus 로고    scopus 로고
    • Immune recovery after autologous PBSC transplantation without in vitro graft manipulation for refractory systemic lupus erythematosus
    • Wada H, Terasako K, Kamiya Y, et al. Immune recovery after autologous PBSC transplantation without in vitro graft manipulation for refractory systemic lupus erythematosus. Bone Marrow Transplant 2011;46:1450-4
    • (2011) Bone Marrow Transplant , vol.46 , pp. 1450-1454
    • Wada, H.1    Terasako, K.2    Kamiya, Y.3
  • 21
    • 59449092041 scopus 로고    scopus 로고
    • Depletion of autoreactive immunologic memory followed by autologous hematopoietic stem cell transplantation in patients with refractory SLE induces long-Term remission through de novo generation of a juvenile and tolerant immune system
    • Alexander T, Thiel A, Rosen O, et al. Depletion of autoreactive immunologic memory followed by autologous hematopoietic stem cell transplantation in patients with refractory SLE induces long-Term remission through de novo generation of a juvenile and tolerant immune system. Blood 2009;113:214-23
    • (2009) Blood , vol.113 , pp. 214-223
    • Alexander, T.1    Thiel, A.2    Rosen, O.3
  • 22
    • 76349096767 scopus 로고    scopus 로고
    • Regulatory T cell (Treg) subsets return in patients with refractory lupus following stem cell transplantation, and TGF-beta-producing CD8+ Treg cells are associated with immunological remission of lupus
    • Zhang L, Bertucci AM, Ramsey-Goldman R, et al. Regulatory T cell (Treg) subsets return in patients with refractory lupus following stem cell transplantation, and TGF-beta-producing CD8+ Treg cells are associated with immunological remission of lupus. J Immunol 2009;183:6346-58
    • (2009) J Immunol , vol.183 , pp. 6346-6358
    • Zhang, L.1    Bertucci, A.M.2    Ramsey-Goldman, R.3
  • 23
    • 80052529432 scopus 로고    scopus 로고
    • Hematopoietic stem cell transplant for systemic lupus erythematosus: Interferon regulatory factor 7 activation correlates with the IFN signature and recurrent disease
    • Sweeney SE. Hematopoietic stem cell transplant for systemic lupus erythematosus: Interferon regulatory factor 7 activation correlates with the IFN signature and recurrent disease. Lupus 2011;20:975-80
    • (2011) Lupus , vol.20 , pp. 975-980
    • Sweeney, S.E.1
  • 24
    • 80051482080 scopus 로고    scopus 로고
    • Autologous haemopoietic stem cell transplantation for autoimmune diseases
    • Zeher M, Papp G, Szodoray P. Autologous haemopoietic stem cell transplantation for autoimmune diseases. Expert Opin Biol Ther 2011;11:1193-201
    • (2011) Expert Opin Biol Ther , vol.11 , pp. 1193-1201
    • Zeher, M.1    Papp, G.2    Szodoray, P.3
  • 25
    • 11144357974 scopus 로고    scopus 로고
    • Autologous stem cell transplantation for systemic lupus erythematosus
    • Jayne D, Passweg J, Marmont A, et al. Autologous stem cell transplantation for systemic lupus erythematosus. Lupus 2004;13:168-76
    • (2004) Lupus , vol.13 , pp. 168-176
    • Jayne, D.1    Passweg, J.2    Marmont, A.3
  • 26
    • 84877619326 scopus 로고    scopus 로고
    • The function of hematopoietic stem cells is altered by both genetic and inflammatory factors in lupus mice
    • Niu H, Fang G, Tang Y, et al. The function of hematopoietic stem cells is altered by both genetic and inflammatory factors in lupus mice. Blood 2013;121: 1986-94
    • (2013) Blood , vol.121 , pp. 1986-1994
    • Niu, H.1    Fang, G.2    Tang, Y.3
  • 27
    • 38349090187 scopus 로고    scopus 로고
    • The use of stem cells for the treatment of autoimmune diseases
    • Rosa SB, Voltarelli JC, Chies JA, et al. The use of stem cells for the treatment of autoimmune diseases. Braz J Med Biol Res 2007;40:1579-97
    • (2007) Braz J Med Biol Res , vol.40 , pp. 1579-1597
    • Rosa, S.B.1    Voltarelli, J.C.2    Chies, J.A.3
  • 28
    • 36248958730 scopus 로고    scopus 로고
    • Abnormal surface markers expression on bone marrow CD34+ cells and correlation with disease activity in patients with systemic lupus erythematosus
    • Sun LY, Zhou KX, Feng XB, et al. Abnormal surface markers expression on bone marrow CD34+ cells and correlation with disease activity in patients with systemic lupus erythematosus. Clin Rheumatol 2007;26:2073-9
    • (2007) Clin Rheumatol , vol.26 , pp. 2073-2079
    • Sun, L.Y.1    Zhou, K.X.2    Feng, X.B.3
  • 29
    • 84877806000 scopus 로고    scopus 로고
    • Stem cells in autoimmune diseases: Implications for pathogenesis and future trends in therapy
    • Cipriani P, Carubbi F, Liakouli V, et al. Stem cells in autoimmune diseases: Implications for pathogenesis and future trends in therapy. Autoimmun Rev 2013;12:709-16
    • (2013) Autoimmun Rev , vol.12 , pp. 709-716
    • Cipriani, P.1    Carubbi, F.2    Liakouli, V.3
  • 30
    • 21344463992 scopus 로고    scopus 로고
    • Haematopoietic stem cell transplantation in the treatment of severe autoimmune disease: Results from phase I/II studies, prospective randomized trials and future directions
    • Tyndall A, Saccardi R. Haematopoietic stem cell transplantation in the treatment of severe autoimmune disease: results from phase I/II studies, prospective randomized trials and future directions. Clin Exp Immunol 2005;141:1-9
    • (2005) Clin Exp Immunol , vol.141 , pp. 1-9
    • Tyndall, A.1    Saccardi, R.2
  • 31
    • 34548040947 scopus 로고    scopus 로고
    • Reversal of autoimmune disease in lupus-prone New Zealand black/New Zealand white mice by nonmyeloablative transplantation of purified allogeneic hematopoietic stem cells
    • Smith-Berdan S, Gille D, Weissman IL, et al. Reversal of autoimmune disease in lupus-prone New Zealand black/New Zealand white mice by nonmyeloablative transplantation of purified allogeneic hematopoietic stem cells. Blood 2007;110: 1370-8
    • (2007) Blood , vol.110 , pp. 1370-1378
    • Smith-Berdan, S.1    Gille, D.2    Weissman, I.L.3
  • 32
    • 34247133789 scopus 로고    scopus 로고
    • Hematopoietic stem cell transplantation in autoimmune diseases: The Ahmedabad experience
    • Vanikar AV, Modi PR, Patel RD, et al. Hematopoietic stem cell transplantation in autoimmune diseases: the Ahmedabad experience. Transplant Proc 2007;39:703-8
    • (2007) Transplant Proc , vol.39 , pp. 703-708
    • Vanikar, A.V.1    Modi, P.R.2    Patel, R.D.3
  • 33
    • 67651092045 scopus 로고    scopus 로고
    • Allogeneic hematopoietic SCT for patients with autoimmune diseases
    • Daikeler T, Hugle T, Farge D, et al. Allogeneic hematopoietic SCT for patients with autoimmune diseases. Bone Marrow Transplant 2009;44:27-33
    • (2009) Bone Marrow Transplant , vol.44 , pp. 27-33
    • Daikeler, T.1    Hugle, T.2    Farge, D.3
  • 34
    • 0029871565 scopus 로고    scopus 로고
    • Haemopoietic stem and progenitor cells in the treatment of severe autoimmune diseases
    • Tyndall A, Gratwohl A. Haemopoietic stem and progenitor cells in the treatment of severe autoimmune diseases. Ann Rheum Dis 1996;55:149-51
    • (1996) Ann Rheum Dis , vol.55 , pp. 149-151
    • Tyndall, A.1    Gratwohl, A.2
  • 35
    • 33847374613 scopus 로고    scopus 로고
    • Abnormality of bone marrow-derived mesenchymal stem cells in patients with systemic lupus erythematosus
    • Sun LY, Zhang HY, Feng XB, et al. Abnormality of bone marrow-derived mesenchymal stem cells in patients with systemic lupus erythematosus. Lupus 2007;16:121-8
    • (2007) Lupus , vol.16 , pp. 121-128
    • Sun, L.Y.1    Zhang, H.Y.2    Feng, X.B.3
  • 36
    • 77952921223 scopus 로고    scopus 로고
    • Defective phenotype of mesenchymal stem cells in patients with systemic lupus erythematosus
    • Nie Y, Lau C, Lie A, et al. Defective phenotype of mesenchymal stem cells in patients with systemic lupus erythematosus. Lupus 2010;19:850-9
    • (2010) Lupus , vol.19 , pp. 850-859
    • Nie, Y.1    Lau, C.2    Lie, A.3
  • 37
    • 84865722353 scopus 로고    scopus 로고
    • Enhanced apoptosis and senescence of bone-marrow-derived mesenchymal stem cells in patients with systemic lupus erythematosus
    • Li X, Liu L, Meng D, et al. Enhanced apoptosis and senescence of bone-marrow-derived mesenchymal stem cells in patients with systemic lupus erythematosus. Stem Cells Dev 2012;21: 2387-94
    • (2012) Stem Cells Dev , vol.21 , pp. 2387-2394
    • Li, X.1    Liu, L.2    Meng, D.3
  • 38
    • 84893818867 scopus 로고    scopus 로고
    • Wnt/betacatenin signaling mediates the senescence of bone marrow-mesenchymal stem cells from systemic lupus erythematosus patients through the p53/p21 pathway
    • Gu Z, Tan W, Feng G, et al. Wnt/betacatenin signaling mediates the senescence of bone marrow-mesenchymal stem cells from systemic lupus erythematosus patients through the p53/p21 pathway. Mol Cell Biochem 2014;387:27-37
    • (2014) Mol Cell Biochem , vol.387 , pp. 27-37
    • Gu, Z.1    Tan, W.2    Feng, G.3
  • 39
    • 84910006143 scopus 로고    scopus 로고
    • High level of reactive oxygen species impaired mesenchymal stem cell migration via over polymerization of F-Actin cytoskeleton in systemic lupus erythematosus
    • Shi D, Li X, Chen H, et al. High level of reactive oxygen species impaired mesenchymal stem cell migration via over polymerization of F-Actin cytoskeleton in systemic lupus erythematosus. Pathol Biol (Paris) 2014;62(6):382-90
    • (2014) Pathol Biol (Paris) , vol.62 , Issue.6 , pp. 382-390
    • Shi, D.1    Li, X.2    Chen, H.3
  • 40
    • 84866095966 scopus 로고    scopus 로고
    • Gene expression profile reveals abnormalities of multiple signaling pathways in mesenchymal stem cell derived from patients with systemic lupus erythematosus
    • Tang Y, Ma X, Zhang H, et al. Gene expression profile reveals abnormalities of multiple signaling pathways in mesenchymal stem cell derived from patients with systemic lupus erythematosus. Clin Dev Immunol 2012;2012:826182
    • (2012) Clin Dev Immunol , vol.2012 , pp. 826182
    • Tang, Y.1    Ma, X.2    Zhang, H.3
  • 41
    • 84873365843 scopus 로고    scopus 로고
    • Activated NF-kappaB in bone marrow mesenchymal stem cells from systemic lupus erythematosus patients inhibits osteogenic differentiation through downregulating Smad signaling
    • Tang Y, Xie H, Chen J, et al. Activated NF-kappaB in bone marrow mesenchymal stem cells from systemic lupus erythematosus patients inhibits osteogenic differentiation through downregulating Smad signaling. Stem Cells Dev 2013;22: 668-78
    • (2013) Stem Cells Dev , vol.22 , pp. 668-678
    • Tang, Y.1    Xie, H.2    Chen, J.3
  • 42
    • 84904993611 scopus 로고    scopus 로고
    • A CD8 T cell/indoleamine 2, 3-dioxygenase axis is required for mesenchymal stem cell suppression of human systemic lupus erythematosus
    • Wang D, Feng X, Lu L, et al. A CD8 T cell/indoleamine 2, 3-dioxygenase axis is required for mesenchymal stem cell suppression of human systemic lupus erythematosus. Arthritis Rheumatol 2014;66:2234-45
    • (2014) Arthritis Rheumatol , vol.66 , pp. 2234-2245
    • Wang, D.1    Feng, X.2    Lu, L.3
  • 43
    • 84912004805 scopus 로고    scopus 로고
    • Restored immunosuppressive effect of mesenchymal stem cells on B cells after OAZ downregulation in patients with systemic lupus erythematosus
    • Feng X, Che N, Liu Y, et al. Restored immunosuppressive effect of mesenchymal stem cells on B cells after OAZ downregulation in patients with systemic lupus erythematosus. Arthritis Rheumatol 2014;66:3413-23
    • (2014) Arthritis Rheumatol , vol.66 , pp. 3413-3423
    • Feng, X.1    Che, N.2    Liu, Y.3
  • 44
    • 84867905846 scopus 로고    scopus 로고
    • Differential effect of allogeneic versus syngeneic mesenchymal stem cell transplantation in MRL/lpr and (NZB/NZW) F1 mice
    • Gu F, Molano I, Ruiz P, et al. Differential effect of allogeneic versus syngeneic mesenchymal stem cell transplantation in MRL/lpr and (NZB/NZW) F1 mice. Clin Immunol 2012;145:142-52
    • (2012) Clin Immunol , vol.145 , pp. 142-152
    • Gu, F.1    Molano, I.2    Ruiz, P.3
  • 45
    • 77749279645 scopus 로고    scopus 로고
    • Autologous mesenchymal stem cell treatment increased T regulatory cells with no effect on disease activity in two systemic lupus erythematosus patients
    • Carrion F, Nova E, Ruiz C, et al. Autologous mesenchymal stem cell treatment increased T regulatory cells with no effect on disease activity in two systemic lupus erythematosus patients. Lupus 2010;19:317-22
    • (2010) Lupus , vol.19 , pp. 317-322
    • Carrion, F.1    Nova, E.2    Ruiz, C.3
  • 46
    • 67649604299 scopus 로고    scopus 로고
    • Mesenchymal stem cell transplantation reverses multiorgan dysfunction in systemic lupus erythematosus mice and humans
    • Sun L, Akiyama K, Zhang H, et al. Mesenchymal stem cell transplantation reverses multiorgan dysfunction in systemic lupus erythematosus mice and humans. Stem Cells 2009;27:1421-32
    • (2009) Stem Cells , vol.27 , pp. 1421-1432
    • Sun, L.1    Akiyama, K.2    Zhang, H.3
  • 47
    • 62449102751 scopus 로고    scopus 로고
    • Transplantation of human bone marrow mesenchymal stem cell ameliorates the autoimmune pathogenesis in MRL/lpr mice
    • Zhou K, Zhang H, Jin O, et al. Transplantation of human bone marrow mesenchymal stem cell ameliorates the autoimmune pathogenesis in MRL/lpr mice. Cell Mol Immunol 2008;5:417-24
    • (2008) Cell Mol Immunol , vol.5 , pp. 417-424
    • Zhou, K.1    Zhang, H.2    Jin, O.3
  • 48
    • 78649245336 scopus 로고    scopus 로고
    • Transplantation of umbilical cord mesenchymal stem cells alleviates lupus nephritis in MRL/lpr mice
    • Gu Z, Akiyama K, Ma X, et al. Transplantation of umbilical cord mesenchymal stem cells alleviates lupus nephritis in MRL/lpr mice. Lupus 2010;19: 1502-14
    • (2010) Lupus , vol.19 , pp. 1502-1514
    • Gu, Z.1    Akiyama, K.2    Ma, X.3
  • 49
    • 79955402680 scopus 로고    scopus 로고
    • Therapeutic effects of umbilical cord blood-derived mesenchymal stem cell transplantation in experimental lupus nephritis
    • Chang JW, Hung SP, Wu HH, et al. Therapeutic effects of umbilical cord blood-derived mesenchymal stem cell transplantation in experimental lupus nephritis. Cell Transplant 2011;20:245-57
    • (2011) Cell Transplant , vol.20 , pp. 245-257
    • Chang, J.W.1    Hung, S.P.2    Wu, H.H.3
  • 50
    • 84855267258 scopus 로고    scopus 로고
    • Reversal of serologic, immunologic, and histologic dysfunction in mice with systemic lupus erythematosus by long-Term serial adipose tissue-derived mesenchymal stem cell transplantation
    • Choi EW, Shin IS, Park SY, et al. Reversal of serologic, immunologic, and histologic dysfunction in mice with systemic lupus erythematosus by long-Term serial adipose tissue-derived mesenchymal stem cell transplantation. Arthritis Rheum 2012;64: 243-53
    • (2012) Arthritis Rheum , vol.64 , pp. 243-253
    • Choi, E.W.1    Shin, I.S.2    Park, S.Y.3
  • 51
    • 77955451557 scopus 로고    scopus 로고
    • Allogenic mesenchymal stem cells transplantation in refractory systemic lupus erythematosus: A pilot clinical study
    • Liang J, Zhang H, Hua B, et al. Allogenic mesenchymal stem cells transplantation in refractory systemic lupus erythematosus: a pilot clinical study. Ann Rheum Dis 2010;69:1423-9
    • (2010) Ann Rheum Dis , vol.69 , pp. 1423-1429
    • Liang, J.1    Zhang, H.2    Hua, B.3
  • 52
    • 77955361735 scopus 로고    scopus 로고
    • Umbilical cord mesenchymal stem cell transplantation in severe and refractory systemic lupus erythematosus
    • Sun L, Wang D, Liang J, et al. Umbilical cord mesenchymal stem cell transplantation in severe and refractory systemic lupus erythematosus. Arthritis Rheum 2010;62: 2467-75
    • (2010) Arthritis Rheum , vol.62 , pp. 2467-2475
    • Sun, L.1    Wang, D.2    Liang, J.3
  • 53
    • 84879160785 scopus 로고    scopus 로고
    • Allogeneic mesenchymal stem cell transplantation in severe and refractory systemic lupus erythematosus: 4 years of experience
    • Wang D, Zhang H, Liang J, et al. Allogeneic mesenchymal stem cell transplantation in severe and refractory systemic lupus erythematosus: 4 years of experience. Cell Transplant 2013;22: 2267-77
    • (2013) Cell Transplant , vol.22 , pp. 2267-2277
    • Wang, D.1    Zhang, H.2    Liang, J.3
  • 54
    • 84919354336 scopus 로고    scopus 로고
    • Allogeneic mesenchymal stem cell transplantation for lupus nephritis patients refractory to conventional therapy
    • Gu F, Wang D, Zhang H, et al. Allogeneic mesenchymal stem cell transplantation for lupus nephritis patients refractory to conventional therapy. Clin Rheumatol 2014;33:1611-19
    • (2014) Clin Rheumatol , vol.33 , pp. 1611-1619
    • Gu, F.1    Wang, D.2    Zhang, H.3
  • 55
    • 84863724904 scopus 로고    scopus 로고
    • Allogeneic transplantation of umbilical cord-derived mesenchymal stem cells for diffuse alveolar hemorrhage in systemic lupus erythematosus
    • Shi D, Wang D, Li X, et al. Allogeneic transplantation of umbilical cord-derived mesenchymal stem cells for diffuse alveolar hemorrhage in systemic lupus erythematosus. Clin Rheumatol 2012;31: 841-6
    • (2012) Clin Rheumatol , vol.31 , pp. 841-846
    • Shi, D.1    Wang, D.2    Li, X.3
  • 56
    • 84876420786 scopus 로고    scopus 로고
    • Mesenchymal SCT ameliorates refractory cytopenia in patients with systemic lupus erythematosus
    • Li X, Wang D, Liang J, et al. Mesenchymal SCT ameliorates refractory cytopenia in patients with systemic lupus erythematosus. Bone Marrow Transplant 2013;48:544-50
    • (2013) Bone Marrow Transplant , vol.48 , pp. 544-550
    • Li, X.1    Wang, D.2    Liang, J.3
  • 57
    • 84899563126 scopus 로고    scopus 로고
    • Umbilical cord mesenchymal stem cell transplantation in active and refractory systemic lupus erythematosus: A multicenter clinical study
    • Wang D, Li J, Zhang Y, et al. Umbilical cord mesenchymal stem cell transplantation in active and refractory systemic lupus erythematosus: a multicenter clinical study. Arthritis Res Ther 2014;16:R79
    • (2014) Arthritis Res Ther , vol.16 , pp. R79
    • Wang, D.1    Li, J.2    Zhang, Y.3
  • 58
    • 77956302939 scopus 로고    scopus 로고
    • Not a process of simple vicariousness, the differentiation of human adipose-derived mesenchymal stem cells to renal tubular epithelial cells plays an important role in acute kidney injury repairing
    • Li K, Han Q, Yan X, et al. Not a process of simple vicariousness, the differentiation of human adipose-derived mesenchymal stem cells to renal tubular epithelial cells plays an important role in acute kidney injury repairing. Stem Cells Dev 2010;19:1267-75
    • (2010) Stem Cells Dev , vol.19 , pp. 1267-1275
    • Li, K.1    Han, Q.2    Yan, X.3
  • 59
    • 84861364704 scopus 로고    scopus 로고
    • Mesenchymal stem cell transplantation inhibits abnormal activation of Akt/GSK3beta signaling pathway in T cells from systemic lupus erythematosus mice
    • Ji S, Guo Q, Han Y, et al. Mesenchymal stem cell transplantation inhibits abnormal activation of Akt/GSK3beta signaling pathway in T cells from systemic lupus erythematosus mice. Cell Physiol Biochem 2012;29:705-12
    • (2012) Cell Physiol Biochem , vol.29 , pp. 705-712
    • Ji, S.1    Guo, Q.2    Han, Y.3
  • 60
    • 84890402540 scopus 로고    scopus 로고
    • Allogenic mesenchymal stem cell transplantation ameliorates nephritis in lupus mice via inhibition of B-cell activation
    • Ma X, Che N, Gu Z, et al. Allogenic mesenchymal stem cell transplantation ameliorates nephritis in lupus mice via inhibition of B-cell activation. Cell Transplant 2013;22:2279-90
    • (2013) Cell Transplant , vol.22 , pp. 2279-2290
    • Ma, X.1    Che, N.2    Gu, Z.3
  • 61
    • 77956371047 scopus 로고    scopus 로고
    • Interferon-gamma-dependent inhibition of B cell activation by bone marrow-derived mesenchymal stem cells in a murine model of systemic lupus erythematosus
    • Schena F, Gambini C, Gregorio A, et al. Interferon-gamma-dependent inhibition of B cell activation by bone marrow-derived mesenchymal stem cells in a murine model of systemic lupus erythematosus. Arthritis Rheum 2010;62:2776-86
    • (2010) Arthritis Rheum , vol.62 , pp. 2776-2786
    • Schena, F.1    Gambini, C.2    Gregorio, A.3
  • 62
    • 84864948206 scopus 로고    scopus 로고
    • Double allogenic mesenchymal stem cells transplantations could not enhance therapeutic effect compared with single transplantation in systemic lupus erythematosus
    • Wang D, Akiyama K, Zhang H, et al. Double allogenic mesenchymal stem cells transplantations could not enhance therapeutic effect compared with single transplantation in systemic lupus erythematosus. Clin Dev Immunol 2012;2012:273291
    • (2012) Clin Dev Immunol , vol.2012 , pp. 273291
    • Wang, D.1    Akiyama, K.2    Zhang, H.3
  • 63
    • 84871026987 scopus 로고    scopus 로고
    • Real-world costs of autologous and allogeneic stem cell transplantations for haematological diseases: A multicentre study
    • Blommestein HM, Verelst SG, Huijgens PC, et al. Real-world costs of autologous and allogeneic stem cell transplantations for haematological diseases: a multicentre study. Ann Hematol 2012;91:1945-52
    • (2012) Ann Hematol , vol.91 , pp. 1945-1952
    • Blommestein, H.M.1    Verelst, S.G.2    Huijgens, P.C.3


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