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Volumn 7, Issue 11, 2014, Pages 3843-3852

Stem cell-based therapies for age-relatedmacular degeneration: Current status and prospects

Author keywords

Age related macular degeneration; Clinical trial; Retinal pigment epithelium; Stem cell

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; 4 [4 (1,3 BENZODIOXOL 5 YL) 5 (2 PYRIDINYL) 1H IMIDAZOL 2 YL]BENZAMIDE; BRAIN DERIVED NEUROTROPHIC FACTOR; DICKKOPF 1 PROTEIN; ERYTHROPOIETIN; FRACTALKINE; NEURONAL APOPTOSIS INHIBITORY PROTEIN; NEUROTROPHIN 4; NOGGIN; RHODOPSIN; SOMATOMEDIN C;

EID: 84918584175     PISSN: None     EISSN: 19405901     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (21)

References (66)
  • 3
    • 50249172959 scopus 로고    scopus 로고
    • Age-period-cohort effect on the incidence of age-related macular degeneration: The Beaver Dam Eye Study
    • Klein R, Knudtson MD, Lee KE, Gangnon RE, Klein BE. Age-period-cohort effect on the incidence of age-related macular degeneration: the Beaver Dam Eye Study. Ophthalmology 2008; 115: 1460-1467.
    • (2008) Ophthalmology , vol.115 , pp. 1460-1467
    • Klein, R.1    Knudtson, M.D.2    Lee, K.E.3    Gangnon, R.E.4    Klein, B.E.5
  • 4
    • 33748957970 scopus 로고    scopus 로고
    • Changes in visual acuity in a population over a 15-year period: The Beaver Dam Eye Study
    • Klein R, Klein BE, Lee KE, Cruickshanks KJ, Gangnon RE. Changes in visual acuity in a population over a 15-year period: the Beaver Dam Eye Study. Am J Ophthalmol 2006; 142: 539-549.
    • (2006) Am J Ophthalmol , vol.142 , pp. 539-549
    • Klein, R.1    Klein, B.E.2    Lee, K.E.3    Cruickshanks, K.J.4    Gangnon, R.E.5
  • 5
    • 26844508345 scopus 로고    scopus 로고
    • Enhanced efficacy associated with early treatment of neovascular age-related macular degeneration with pegaptanib sodium: An exploratory analysis
    • VEGF Inhibition Study in Ocular Neovascularization (V.I.S.I.O.N.) Clinical Trial Group
    • Gonzales CR; VEGF Inhibition Study in Ocular Neovascularization (V.I.S.I.O.N.) Clinical Trial Group. Enhanced efficacy associated with early treatment of neovascular age-related macular degeneration with pegaptanib sodium: an exploratory analysis. Retina 2005; 25: 815-827.
    • (2005) Retina , vol.25 , pp. 815-827
    • Gonzales, C.R.1
  • 6
    • 46949111802 scopus 로고    scopus 로고
    • Ranibizumab and pegaptanib for the treatment of age-related macular degeneration: A systematic review and economic evaluation
    • ix-201
    • Colquitt JL, Jones J, Tan SC, Takeda A, Clegg AJ, Price A. Ranibizumab and pegaptanib for the treatment of age-related macular degeneration: a systematic review and economic evaluation. Health Technol Assess 2008; 12: iii-iv, ix-201.
    • (2008) Health Technol Assess , vol.12 , pp. iii-iv
    • Colquitt, J.L.1    Jones, J.2    Tan, S.C.3    Takeda, A.4    Clegg, A.J.5    Price, A.6
  • 7
    • 57949094834 scopus 로고    scopus 로고
    • Ranibi-zumab versus verteporfin photodynamic therapy for neovascular age-related macular degeneration: Two-year results of the ANCHOR study
    • ANCHOR Study Group
    • Brown DM, Michels M, Kaiser PK, Heier JS, Sy JP, Ianchulev T; ANCHOR Study Group. Ranibi-zumab versus verteporfin photodynamic therapy for neovascular age-related macular degeneration: Two-year results of the ANCHOR study. Ophthalmology 2009; 116: 57-65.
    • (2009) Ophthalmology , vol.116 , pp. 57-65
    • Brown, D.M.1    Michels, M.2    Kaiser, P.K.3    Heier, J.S.4    Sy, J.P.5    Ianchulev, T.6
  • 9
    • 66849127769 scopus 로고    scopus 로고
    • Photoreceptors repair by autologous transplantation of retinal pigment epithelium and partial-thickness choroid graft in rabbits
    • Zhang T, Hu Y, Li Y, Wu J, Zhao L, Wang C, Liu Y, Yin Z, Ma Z. Photoreceptors repair by autologous transplantation of retinal pigment epithelium and partial-thickness choroid graft in rabbits. Invest Ophthalmol Vis Sci 2009; 50: 2982-2988.
    • (2009) Invest Ophthalmol Vis Sci , vol.50 , pp. 2982-2988
    • Zhang, T.1    Hu, Y.2    Li, Y.3    Wu, J.4    Zhao, L.5    Wang, C.6    Liu, Y.7    Yin, Z.8    Ma, Z.9
  • 10
    • 66849103887 scopus 로고    scopus 로고
    • Autologous transplantation of retinal pigment epithelium-Bruch’s membrane complex for hemorrhagic age-related macular degeneration
    • Ma Z, Han L, Wang C, Dou H, Hu Y, Feng X, Xu Y, Wang Z, Yin Z, Liu Y. Autologous transplantation of retinal pigment epithelium-Bruch’s membrane complex for hemorrhagic age-related macular degeneration. Invest Ophthalmol Vis Sci 2009; 50: 2975-2981.
    • (2009) Invest Ophthalmol Vis Sci , vol.50 , pp. 2975-2981
    • Ma, Z.1    Han, L.2    Wang, C.3    Dou, H.4    Hu, Y.5    Feng, X.6    Xu, Y.7    Wang, Z.8    Yin, Z.9    Liu, Y.10
  • 11
    • 48249112154 scopus 로고    scopus 로고
    • Autologous transplantation of RPE with partial-thickness choroid after mechanical debridement of Bruch membrane in the rabbit
    • Hu Y, Zhang T, Wu J, Li Y, Lu X, Qian F, Yin Z, Ma Z. Autologous transplantation of RPE with partial-thickness choroid after mechanical debridement of Bruch membrane in the rabbit. Invest Ophthalmol Vis Sci 2008; 49: 3185-3192.
    • (2008) Invest Ophthalmol Vis Sci , vol.49 , pp. 3185-3192
    • Hu, Y.1    Zhang, T.2    Wu, J.3    Li, Y.4    Lu, X.5    Qian, F.6    Yin, Z.7    Ma, Z.8
  • 13
    • 6344287506 scopus 로고    scopus 로고
    • Derivation and comparative assessment of retinal pigment epithelium from human embryonic stem cells using transcriptomics
    • Klimanskaya I, Hipp J, Rezai KA, West M, Atala A, Lanza R. Derivation and comparative assessment of retinal pigment epithelium from human embryonic stem cells using transcriptomics. Cloning Stem Cells 2004; 6: 217-245.
    • (2004) Cloning Stem Cells , vol.6 , pp. 217-245
    • Klimanskaya, I.1    Hipp, J.2    Rezai, K.A.3    West, M.4    Atala, A.5    Lanza, R.6
  • 14
    • 70349873363 scopus 로고    scopus 로고
    • Long-term safety and function of RPE from human embryonic stem cells in preclinical models of macular degeneration
    • Lu B, Malcuit C, Wang S, Girman S, Francis P, Lemieux L, Lanza R, Lund R. Long-term safety and function of RPE from human embryonic stem cells in preclinical models of macular degeneration. Stem Cells 2009; 27: 2126-2135.
    • (2009) Stem Cells , vol.27 , pp. 2126-2135
    • Lu, B.1    Malcuit, C.2    Wang, S.3    Girman, S.4    Francis, P.5    Lemieux, L.6    Lanza, R.7    Lund, R.8
  • 22
    • 78149260595 scopus 로고    scopus 로고
    • Cone and rod photoreceptor transplantation in models of the childhood retinopathy Leber congenital amaurosis using flow-sorted Crx-positive donor cells
    • Lakowski J, Baron M, Bainbridge J, Barber AC, Pearson RA, Ali RR, Sowden JC. Cone and rod photoreceptor transplantation in models of the childhood retinopathy Leber congenital amaurosis using flow-sorted Crx-positive donor cells. Hum Mol Genet 2010; 19: 4545-4559.
    • (2010) Hum Mol Genet , vol.19 , pp. 4545-4559
    • Lakowski, J.1    Baron, M.2    Bainbridge, J.3    Barber, A.C.4    Pearson, R.A.5    Ali, R.R.6    Sowden, J.C.7
  • 23
    • 70349347145 scopus 로고    scopus 로고
    • In vitro differentiation of retinal cells from human pluripotent stem cells by small-molecule induction
    • Osakada F, Jin ZB, Hirami Y, Ikeda H, Danjyo T, Watanabe K, Sasai Y, Takahashi M. In vitro differentiation of retinal cells from human pluripotent stem cells by small-molecule induction. J Cell Sci 2009; 122: 3169-3179.
    • (2009) J Cell Sci , vol.122 , pp. 3169-3179
    • Osakada, F.1    Jin, Z.B.2    Hirami, Y.3    Ikeda, H.4    Danjyo, T.5    Watanabe, K.6    Sasai, Y.7    Takahashi, M.8
  • 24
    • 33748086466 scopus 로고    scopus 로고
    • Efficient generation of retinal progenitor cells from human embryonic stem cells
    • Lamba DA, Karl MO, Ware CB, Reh TA. Efficient generation of retinal progenitor cells from human embryonic stem cells. Proc Natl Acad Sci U S A 2006; 103: 12769-12774.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 12769-12774
    • Lamba, D.A.1    Karl, M.O.2    Ware, C.B.3    Reh, T.A.4
  • 25
    • 58049200677 scopus 로고    scopus 로고
    • Transplantation of human embryonic stem cell-derived photoreceptors restores some visual function in Crx deficient mice
    • Lamba DA, Gust J, Reh TA. Transplantation of human embryonic stem cell-derived photoreceptors restores some visual function in Crx deficient mice. Cell Stem Cell 2009; 4: 73-79.
    • (2009) Cell Stem Cell , vol.4 , pp. 73-79
    • Lamba, D.A.1    Gust, J.2    Reh, T.A.3
  • 29
    • 84872869816 scopus 로고    scopus 로고
    • Three-dimensional neuroepithelial culture from human embryonic stem cells and its use for quantitative conversion to retinal pigment epithelium
    • Zhu Y, Carido M, Meinhardt A, Kurth T, Karl MO, Ader M, Tanaka EM. Three-dimensional neuroepithelial culture from human embryonic stem cells and its use for quantitative conversion to retinal pigment epithelium. PLoS One 2013; 8: e54552.
    • (2013) PLoS One , vol.8
    • Zhu, Y.1    Carido, M.2    Meinhardt, A.3    Kurth, T.4    Karl, M.O.5    Ader, M.6    Tanaka, E.M.7
  • 30
    • 33747195353 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
    • Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 2006; 126: 663-676.
    • (2006) Cell , vol.126 , pp. 663-676
    • Takahashi, K.1    Yamanaka, S.2
  • 31
    • 74049111551 scopus 로고    scopus 로고
    • Induced pluripotent stem cell therapies for retinal disease
    • Comyn O, Lee E, MacLaren RE. Induced pluripotent stem cell therapies for retinal disease. Curr Opin Neurol 2010; 23: 4-9.
    • (2010) Curr Opin Neurol , vol.23 , pp. 4-9
    • Comyn, O.1    Lee, E.2    Maclaren, R.E.3
  • 32
    • 77951881724 scopus 로고    scopus 로고
    • Induced pluripotent stem cells for retinal degenerative diseases: A new perspective on the challenges
    • Jin ZB, Okamoto S, Mandai M, Takahashi M. Induced pluripotent stem cells for retinal degenerative diseases: a new perspective on the challenges. J Genet 2009; 88: 417-424.
    • (2009) J Genet , vol.88 , pp. 417-424
    • Jin, Z.B.1    Okamoto, S.2    Mandai, M.3    Takahashi, M.4
  • 33
    • 77951016970 scopus 로고    scopus 로고
    • Induced pluripotent stem cells generate both retinal ganglion cells and photoreceptors: Ther apeutic implications in degenerative changes in glaucoma and age-related macular degeneration
    • Parameswaran S, Balasubramanian S, Babai N, Qiu F, Eudy JD, Thoreson WB, Ahmad I. Induced pluripotent stem cells generate both retinal ganglion cells and photoreceptors: ther apeutic implications in degenerative changes in glaucoma and age-related macular degeneration. Stem Cells 2010; 28: 695-703.
    • (2010) Stem Cells , vol.28 , pp. 695-703
    • Parameswaran, S.1    Balasubramanian, S.2    Babai, N.3    Qiu, F.4    Eudy, J.D.5    Thoreson, W.B.6    Ahmad, I.7
  • 36
    • 79955396129 scopus 로고    scopus 로고
    • Human induced pluripotent stem-derived retinal pigment epithelium (RPE) cells exhibit ion transport, membrane potential, polarized vascular endothelial growth factor secretion, and gene expression pattern similar to native RPE
    • Kokkinaki M, Sahibzada N, Golestaneh N. Human induced pluripotent stem-derived retinal pigment epithelium (RPE) cells exhibit ion transport, membrane potential, polarized vascular endothelial growth factor secretion, and gene expression pattern similar to native RPE. Stem Cells 2011; 29: 825-835.
    • (2011) Stem Cells , vol.29 , pp. 825-835
    • Kokkinaki, M.1    Sahibzada, N.2    Golestaneh, N.3
  • 38
    • 84862935591 scopus 로고    scopus 로고
    • Combination of retinal pigment epithelium cell-conditioned medium and photoreceptor outer segments stimulate mesenchymal stem cell differentiation toward a functional retinal pigment epithelium cell phenotype
    • Huang C, Zhang J, Ao M, Li Y, Zhang C, Xu Y, Li X, Wang W. Combination of retinal pigment epithelium cell-conditioned medium and photoreceptor outer segments stimulate mesenchymal stem cell differentiation toward a functional retinal pigment epithelium cell phenotype. J Cell Biochem 2012; 113: 590-598.
    • (2012) J Cell Biochem , vol.113 , pp. 590-598
    • Huang, C.1    Zhang, J.2    Ao, M.3    Li, Y.4    Zhang, C.5    Xu, Y.6    Li, X.7    Wang, W.8
  • 39
    • 55649098337 scopus 로고    scopus 로고
    • Differentiation of rat mesenchymal stem cells transplanted into the subretinal space of sodium iodate-injected rats
    • Gong L, Wu Q, Song B, Lu B, Zhang Y. Differentiation of rat mesenchymal stem cells transplanted into the subretinal space of sodium iodate-injected rats. Clin Experiment Ophthalmol 2008; 36: 666-671.
    • (2008) Clin Experiment Ophthalmol , vol.36 , pp. 666-671
    • Gong, L.1    Wu, Q.2    Song, B.3    Lu, B.4    Zhang, Y.5
  • 41
    • 67649645214 scopus 로고    scopus 로고
    • Retinal incorporation and differentiation of mesenchymal stem cells intravitreally injected in the injured retina of rats
    • Castanheira P, Torquetti L, Nehemy MB, Goes AM. Retinal incorporation and differentiation of mesenchymal stem cells intravitreally injected in the injured retina of rats. Arq Bras Oftalmol 2008; 71: 644-650.
    • (2008) Arq Bras Oftalmol , vol.71 , pp. 644-650
    • Castanheira, P.1    Torquetti, L.2    Nehemy, M.B.3    Goes, A.M.4
  • 45
    • 77955646411 scopus 로고    scopus 로고
    • Adult ciliary epithelial cells, previously identified as retinal stem cells with potential for retinal repair, fail to differentiate into new rod photoreceptors
    • Gualdoni S, Baron M, Lakowski J, Decembrini S, Smith AJ, Pearson RA, Ali RR, Sowden JC. Adult ciliary epithelial cells, previously identified as retinal stem cells with potential for retinal repair, fail to differentiate into new rod photoreceptors. Stem Cells 2010; 28: 1048-1059.
    • (2010) Stem Cells , vol.28 , pp. 1048-1059
    • Gualdoni, S.1    Baron, M.2    Lakowski, J.3    Decembrini, S.4    Smith, A.J.5    Pearson, R.A.6    Ali, R.R.7    Sowden, J.C.8
  • 46
    • 34347361689 scopus 로고    scopus 로고
    • Late-stage neuronal progenitors in the retina are radial Müller glia that function as retinal stem cells
    • Bernardos RL, Barthel LK, Meyers JR, Raymond PA. Late-stage neuronal progenitors in the retina are radial Müller glia that function as retinal stem cells. J Neurosci 2007; 27: 7028-7040.
    • (2007) J Neurosci , vol.27 , pp. 7028-7040
    • Bernardos, R.L.1    Barthel, L.K.2    Meyers, J.R.3    Raymond, P.A.4
  • 47
    • 84883584025 scopus 로고    scopus 로고
    • Atoh7 promotes the differentiation of retinal stem cells derived from Müller cells into retinal ganglion cells by inhibiting Notch signaling
    • Song WT, Zhang XY, Xia XB. Atoh7 promotes the differentiation of retinal stem cells derived from Müller cells into retinal ganglion cells by inhibiting Notch signaling. Stem Cell Res Ther 2013; 4: 94.
    • (2013) Stem Cell Res Ther , vol.4 , pp. 94
    • Song, W.T.1    Zhang, X.Y.2    Xia, X.B.3
  • 48
    • 78651513390 scopus 로고    scopus 로고
    • Possible mechanisms of retinal function recovery with the use of cell therapy with bone marrow-derived stem cells
    • Siqueira RC, Voltarelli JC, Messias AM, Jorge R. Possible mechanisms of retinal function recovery with the use of cell therapy with bone marrow-derived stem cells. Arq Bras Oftalmol 2010; 73: 474-479.
    • (2010) Arq Bras Oftalmol , vol.73 , pp. 474-479
    • Siqueira, R.C.1    Voltarelli, J.C.2    Messias, A.M.3    Jorge, R.4
  • 49
    • 34447645326 scopus 로고    scopus 로고
    • Subretinal transplantation of bone marrow mesenchymal stem cells delays retinal degeneration in the RCS rat model of retinal degeneration
    • Inoue Y, Iriyama A, Ueno S, Takahashi H, Kondo M, Tamaki Y, Araie M, Yanagi Y. Subretinal transplantation of bone marrow mesenchymal stem cells delays retinal degeneration in the RCS rat model of retinal degeneration. Exp Eye Res 2007; 85: 234-241.
    • (2007) Exp Eye Res , vol.85 , pp. 234-241
    • Inoue, Y.1    Iriyama, A.2    Ueno, S.3    Takahashi, H.4    Kondo, M.5    Tamaki, Y.6    Araie, M.7    Yanagi, Y.8
  • 50
    • 77955844750 scopus 로고    scopus 로고
    • Effects of bone marrow mesenchymal stem cell transplantation on light-damaged retina
    • Zhang Y, Wang W. Effects of bone marrow mesenchymal stem cell transplantation on light-damaged retina. Invest Ophthalmol Vis Sci 2010; 51: 3742-3748.
    • (2010) Invest Ophthalmol Vis Sci , vol.51 , pp. 3742-3748
    • Zhang, Y.1    Wang, W.2
  • 51
    • 84886400360 scopus 로고    scopus 로고
    • Basic fibroblast growth factor expression is implicated in mesenchymal stem cells response to light-induced retinal injury
    • Xu W, Wang X, Xu G, Guo J. Basic fibroblast growth factor expression is implicated in mesenchymal stem cells response to light-induced retinal injury. Cell Mol Neurobiol 2013; 33: 1171-1179.
    • (2013) Cell Mol Neurobiol , vol.33 , pp. 1171-1179
    • Xu, W.1    Wang, X.2    Xu, G.3    Guo, J.4
  • 52
    • 84883162905 scopus 로고    scopus 로고
    • Light-induced retinal injury enhanced neurotrophins secretion and neurotrophic effect of mesenchymal stem cells in vitro
    • Xu W, Wang X, Xu G, Guo J. Light-induced retinal injury enhanced neurotrophins secretion and neurotrophic effect of mesenchymal stem cells in vitro. Arq Bras Oftalmol 2013; 76: 105-110.
    • (2013) Arq Bras Oftalmol , vol.76 , pp. 105-110
    • Xu, W.1    Wang, X.2    Xu, G.3    Guo, J.4
  • 55
    • 33947095602 scopus 로고    scopus 로고
    • Transplantation of bone marrow-derived mesenchymal stem cells rescue photoreceptor cells in the dystrophic retina of the rhodopsin knockout mouse
    • Arnhold S, Absenger Y, Klein H, Addicks K, Schraermeyer U. Transplantation of bone marrow-derived mesenchymal stem cells rescue photoreceptor cells in the dystrophic retina of the rhodopsin knockout mouse. Graefes Arch Clin Exp Ophthalmol 2007; 245: 414-422.
    • (2007) Graefes Arch Clin Exp Ophthalmol , vol.245 , pp. 414-422
    • Arnhold, S.1    Absenger, Y.2    Klein, H.3    Addicks, K.4    Schraermeyer, U.5
  • 56
    • 65349155750 scopus 로고    scopus 로고
    • Human umbilical cord blood-derived mesenchymal stem cells do not differentiate into neural cell types or integrate into the retina after intravitreal grafting in neonatal rats
    • Hill AJ, Zwart I, Tam HH, Chan J, Navarrete C, Jen LS, Navarrete R. Human umbilical cord blood-derived mesenchymal stem cells do not differentiate into neural cell types or integrate into the retina after intravitreal grafting in neonatal rats. Stem Cells Dev 2009; 18: 399-409.
    • (2009) Stem Cells Dev , vol.18 , pp. 399-409
    • Hill, A.J.1    Zwart, I.2    Tam, H.H.3    Chan, J.4    Navarrete, C.5    Jen, L.S.6    Navarrete, R.7
  • 58
    • 79955063380 scopus 로고    scopus 로고
    • Intravitreal injections of neurotrophic factors secreting mesenchymal stem cells are neuroprotective in rat eyes following optic nerve transection
    • Levkovitch-Verbin H, Sadan O, Vander S, Rosner M, Barhum Y, Melamed E, Offen D, Melamed S. Intravitreal injections of neurotrophic factors secreting mesenchymal stem cells are neuroprotective in rat eyes following optic nerve transection. Invest Ophthalmol Vis Sci 2010; 51: 6394-6400.
    • (2010) Invest Ophthalmol Vis Sci , vol.51 , pp. 6394-6400
    • Levkovitch-Verbin, H.1    Sadan, O.2    Vander, S.3    Rosner, M.4    Barhum, Y.5    Melamed, E.6    Offen, D.7    Melamed, S.8
  • 59
    • 84879758608 scopus 로고    scopus 로고
    • Transplantation of CX3CL1-expressing mesenchymal stem cells provides neuroprotective and immunomodulatory effects in a rat model of retinal degeneration
    • Huang L, Xu W, Xu G. Transplantation of CX3CL1-expressing mesenchymal stem cells provides neuroprotective and immunomodulatory effects in a rat model of retinal degeneration. Ocul Immunol Inflamm 2013; 21: 276-285.
    • (2013) Ocul Immunol Inflamm , vol.21 , pp. 276-285
    • Huang, L.1    Xu, W.2    Xu, G.3
  • 60
    • 79953207886 scopus 로고    scopus 로고
    • Use of autologous bone marrow derived stem cells for rehabilitation of patients with dry age related macular degeneration and retinitis pigmentosa: Phase-1 clinical trial
    • Kumar A, Pahwa VK, Tandon R, Kumar L, Mohanty S. Use of autologous bone marrow derived stem cells for rehabilitation of patients with dry age related macular degeneration and retinitis pigmentosa: phase-1 clinical trial. Indian J Med Paediatr Oncol 2005; 26 Suppl 3: 12-14.
    • (2005) Indian J Med Paediatr Oncol , vol.26 , pp. 12-14
    • Kumar, A.1    Pahwa, V.K.2    Tandon, R.3    Kumar, L.4    Mohanty, S.5
  • 61
    • 77952871361 scopus 로고    scopus 로고
    • Intravitreal autologous bone-marrow-derived mononuclear cell transplantation
    • Jonas JB, Witzens-Harig M, Arseniev L, Ho AD. Intravitreal autologous bone-marrow-derived mononuclear cell transplantation. Acta Oph-thalmol 2010; 88: e131-2.
    • (2010) Acta Oph-thalmol , vol.88 , pp. e131-e132
    • Jonas, J.B.1    Witzens-Harig, M.2    Arseniev, L.3    Ho, A.D.4
  • 62
    • 79958284018 scopus 로고    scopus 로고
    • Intravitreal injection of autologous bone marrow-derived mononuclear cells for hereditary retinal dystrophy: A phase I trial
    • Siqueira RC, Messias A, Voltarelli JC, Scott IU, Jorge R. Intravitreal injection of autologous bone marrow-derived mononuclear cells for hereditary retinal dystrophy: a phase I trial. Retina 2011; 31: 1207-1214.
    • (2011) Retina , vol.31 , pp. 1207-1214
    • Siqueira, R.C.1    Messias, A.2    Voltarelli, J.C.3    Scott, I.U.4    Jorge, R.5
  • 63
    • 84887982515 scopus 로고    scopus 로고
    • Subretinal transplantation of rat MSCs and erythropoietin gene modified rat MSCs for protecting and rescuing degenerative retina in rats
    • Guan Y, Cui L, Qu Z, Lu L, Wang F, Wu Y, Zhang J, Gao F, Tian H, Xu L, Xu G, Li W, Jin Y, Xu GT. Subretinal transplantation of rat MSCs and erythropoietin gene modified rat MSCs for protecting and rescuing degenerative retina in rats. Curr Mol Med 2013; 13: 1419-1431.
    • (2013) Curr Mol Med , vol.13 , pp. 1419-1431
    • Guan, Y.1    Cui, L.2    Qu, Z.3    Lu, L.4    Wang, F.5    Wu, Y.6    Zhang, J.7    Gao, F.8    Tian, H.9    Xu, L.10    Xu, G.11    Li, W.12    Jin, Y.13    Xu, G.T.14
  • 65
    • 84864768429 scopus 로고    scopus 로고
    • Stem cell-based delivery of brain-derived neurotrophic factor gene in the rat retina
    • Park HY, Kim JH, Sun Kim H, Park CK. Stem cell-based delivery of brain-derived neurotrophic factor gene in the rat retina. Brain Res 2012; 1469: 10-23.
    • (2012) Brain Res , vol.1469 , pp. 10-23
    • Park, H.Y.1    Kim, J.H.2    Sun Kim, H.3    Park, C.K.4


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