The association of GSDMB and ORMDL3 gene polymorphisms with asthma: A meta-analysis

Allergy, Asthma and Immunology Research

Volumn 7, Issue 2, 2014, Pages 175-185

  Zhao, Chun Ni ^a   Fan, Ye ^a   Huang, Jian Jun ^b   Zhang, Hai Xia ^a   Gao, Tao ^c   Wang, Cong ^a   Wang, Tong ^a   Hou, Li Fang ^a,c  

^a SHANXI MEDICAL UNIVERSITY   (China)

^b General Hospital of Datong Coal Mining Group   (China)

^c NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Asthma; Gsdmb; Meta analysis; Ormdl3; Polymorphism

Indexed keywords

GASDERMIN B; MEMBRANE PROTEIN; ORM1 LIKE 3 PROTEIN; UNCLASSIFIED DRUG;

ALLELE; ARTICLE; ASTHMA; CASE CONTROL STUDY; CONFIDENCE INTERVAL; DATA ANALYSIS SOFTWARE; DATA EXTRACTION; FAMILY; GENE EXPRESSION; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HERITABILITY; HUMAN; LINEAR REGRESSION ANALYSIS; MEDLINE; META ANALYSIS; MULTICENTER STUDY (TOPIC); PUBLISHING; SAMPLE SIZE; SENSITIVITY ANALYSIS; SINGLE NUCLEOTIDE POLYMORPHISM; STATISTICAL MODEL; SYSTEMATIC REVIEW;

EID: 84929305761     PISSN: 20927355     EISSN: 20927363     Source Type: Journal    
DOI: 10.4168/aair.2015.7.2.175     Document Type: Article

References (56)

1. Lemanske RF Jr, Busse WW. Asthma: clinical expression and mo-lecular mechanisms. J Allergy Clin Immunol 2010;125:S95-102.
2. Laitinen LA, Heino M, Laitinen A, Kava T, Haahtela T. Damage of the airway epithelium and bronchial reactivity in patients with asthma. Am Rev Respir Dis 1985;131:599-606.
3. Koppelman GH, Los H, Postma DS. Genetic and environment in asthma: the answer of twin studies. Eur Respir J 1999;13:2-4.
4. Zhang G, Goldblatt J, LeSouëf P. The era of genome-wide associa-tion studies: opportunities and challenges for asthma genetics. J Hum Genet 2009;54:624-8.
5. Breslow DK, Collins SR, Bodenmiller B, Aebersold R, Simons K, Shevchenko A, et al. Orm family proteins mediate sphingolipid ho-meostasis. Nature 2010;463:1048-53.
6. Cantero-Recasens G, Fandos C, Rubio-Moscardo F, Valverde MA, Vicente R. The asthma-associated ORMDL3 gene product regu-lates endoplasmic reticulum-mediated calcium signaling and cel-lular stress. Hum Mol Genet 2010;19:111-21.
7. Yang FF, Huang Y, Li QB, Dai JH, Fu Z. Single nucleotide polymor-phisms in the ORM1-like 3 gene associated with childhood asthma in a Chinese population. Genet Mol Res 2012;11:4646-53.
8. Galanter J, Choudhry S, Eng C, Nazario S, Rodríguez-Santana JR, Casal J, et al. ORMDL3 gene is associated with asthma in three eth-nically diverse populations. Am J Respir Crit Care Med 2008;177:1194-200.
9. Hrdlickova B, Holla LI. Relationship between the 17q21 locus and adult asthma in a Czech population. Hum Immunol 2011;72:921-5.
10. Li FX, Tan JY, Yang XX, Wu YS, Wu D, Li M. Genetic variants on 17q21 are associated with asthma in a Han Chinese population. Genet Mol Res 2012;11:340-7.
11. Leung TF, Sy HY, Ng MC, Chan IH, Wong GW, Tang NL, et al. Asth-ma and atopy are associated with chromosome 17q21 markers in Chinese children. Allergy 2009;64:621-8.
12. Moffatt MF, Kabesch M, Liang L, Dixon AL, Strachan D, Heath S, et al. Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma. Nature 2007;448:470-3.
13. Tamura M, Tanaka S, Fujii T, Aoki A, Komiyama H, Ezawa K, et al. Members of a novel gene family, Gsdm, are expressed exclusively in the epithelium of the skin and gastrointestinal tract in a highly tissue-specific manner. Genomics 2007;89:618-29.
14. Carl-McGrath S, Schneider-Stock R, Ebert M, Röcken C. Differen-tial expression and localisation of gasdermin-like (GSDML), a nov-el member of the cancer-associated GSDMDC protein family, in neoplastic and non-neoplastic gastric, hepatic, and colon tissues. Pathology 2008;40:13-24.
15. Zhang Y, Moffatt MF, Cookson WO. Genetic and genomic ap-proaches to asthma: new insights for the origins. Curr Opin Pulm Med 2012;18:6-13.
16. Tavendale R, Macgregor DF, Mukhopadhyay S, Palmer CN. A poly-morphism controlling ORMDL3 expression is associated with asthma that is poorly controlled by current medications. J Allergy Clin Immunol 2008;121:860-3.
17. Karunas AS, Iunusbaev BB, Fedorova I, Gimalova GF, Ramazanova NN, Gur'eva LL, et al. Genome-wide association study of bronchial asthma in the Volga-Ural region of Russia. Mol Biol (Mosk) 2011;45:992-1003.
18. Yu J, Kang MJ, Kim BJ, Kwon JW, Song YH, Choi WA, et al. Polymor-phisms in GSDMA and GSDMB are associated with asthma sus-ceptibility, atopy and BHR. Pediatr Pulmonol 2011;46:701-8.
19. Binia A, Khorasani N, Bhavsar PK, Adcock I, Brightling CE, Chung KF, et al. Chromosome 17q21 SNP and severe asthma. J Hum Gen-et 2011;56:97-8.
20. Ferreira MA, McRae AF, Medland SE, Nyholt DR, Gordon SD, Wright MJ, et al. Association between ORMDL3, IL1RL1 and a de-letion on chromosome 17q21 with asthma risk in Australia. Eur J Hum Genet 2011;19:458-64.
21. Hirota T, Harada M, Sakashita M, Doi S, Miyatake A, Fujita K, et al. Genetic polymorphism regulating ORM1-like 3 (Saccharomyces cerevisiae) expression is associated with childhood atopic asthma in a Japanese population. J Allergy Clin Immunol 2008;121:769-70.
22. Verlaan DJ, Berlivet S, Hunninghake GM, Madore AM, Larivière M, Moussette S, et al. Allele-specific chromatin remodeling in the ZPBP2/GSDMB/ORMDL3 locus associated with the risk of asthma and autoimmune disease. Am J Hum Genet 2009;85:377-93.
23. Lander ES, Schork NJ. Genetic dissection of complex traits. Science 1994;265:2037-48.
24. Mantel N, Haenszel W. Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst 1959;22:719-48.
25. DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials 1986;7:177-88.
26. Deeks JJ, Altman DG, Bradburn MJ. Chapter 15. Statistical methods for examining heterogeneity and combining results from several studies in meta-analysis. In: Egger M, Smith GD, Altman DG, editors. Systematic reviews in health care: meta-analysis in context. 2nd ed. London: BMJ; 2001. 285-312.
27. Egger M, Davey Smith G, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ 1997;315:629-34.
28. Kazeem GR, Farrall M. Integrating case-control and TDT studies. Ann Hum Genet 2005;69:329-35.
29. Nicodemus KK. Catmap: case-control and TDT meta-analysis package. BMC Bioinformatics 2008;9:130.
30. Rogers AJ, Raby BA, Lasky-Su JA, Murphy A, Lazarus R, Klander-man BJ, et al. Assessing the reproducibility of asthma candidate gene associations, using genome-wide data. Am J Respir Crit Care Med 2009;179:1084-90.
31. Wu H, Romieu I, Sienra-Monge JJ, Li H, del Rio-Navarro BE, Lon-don SJ. Genetic variation in ORM1-like 3 (ORMDL3) and gasder-min-like (GSDML) and childhood asthma. Allergy 2009;64:629-35.
32. Madore AM, Tremblay K, Hudson TJ, Laprise C. Replication of an association between 17q21 SNPs and asthma in a French-Canadi-an familial collection. Hum Genet 2008;123:93-5.
33. Marinho S, Custovic A, Marsden P, Smith JA, Simpson A. 17q12-21 variants are associated with asthma and interact with active smok-ing in an adult population from the United Kingdom. Ann Allergy Asthma Immunol 2012;108:402-411.e9.
34. Flory JH, Sleiman PM, Christie JD, Annaiah K, Bradfield J, Kim CE, et al. 17q12-21 variants interact with smoke exposure as a risk fac-tor for pediatric asthma but are equally associated with early-onset versus late-onset asthma in North Americans of European ances-try. J Allergy Clin Immunol 2009;124:605-7.
35. Smit LA, Bouzigon E, Pin I, Siroux V, Monier F, Aschard H, et al. 17q21 variants modify the association between early respiratory infections and asthma. Eur Respir J 2010;36:57-64.
36. Moffatt MF, Gut IG, Demenais F, Strachan DP, Bouzigon E, Heath S, et al. A large-scale, consortium-based genomewide association study of asthma. N Engl J Med 2010;363:1211-21.
37. Halapi E, Gudbjartsson DF, Jonsdottir GM, Bjornsdottir US, Thor-leifsson G, Helgadottir H, et al. A sequence variant on 17q21 is as-sociated with age at onset and severity of asthma. Eur J Hum Genet 2010;18:902-8.
38. Wan YI, Shrine NR, Soler Artigas M, Wain LV, Blakey JD, Moffatt MF, et al. Genome-wide association study to identify genetic deter-minants of severe asthma. Thorax 2012;67:762-8.
39. Kang MJ, Yu HS, Seo JH, Kim HY, Jung YH, Kim YJ, et al. GSDMB/ORMDL3 variants contribute to asthma susceptibility and eosino-phil-mediated bronchial hyperresponsiveness. Hum Immunol 2012;73:954-9.
40. Sleiman PM, Annaiah K, Imielinski M, Bradfield JP, Kim CE, Frack-elton EC, et al. ORMDL3 variants associated with asthma suscepti-bility in North Americans of European ancestry. J Allergy Clin Im-munol 2008;122:1225-7.
41. Sterne JA, Gavaghan D, Egger M. Publication and related bias in meta-analysis: power of statistical tests and prevalence in the liter-ature. J Clin Epidemiol 2000;53:1119-29.
42. Willemsen G, van Beijsterveldt TC, van Baal CG, Postma D, Boomsma DI. Heritability of self-reported asthma and allergy: a study in adult Dutch twins, siblings and parents. Twin Res Hum Genet 2008;11:132-42.
43. Fagnani C, Annesi-Maesano I, Brescianini S, D'Ippolito C, Medda E, Nisticò L, et al. Heritability and shared genetic effects of asthma and hay fever: an Italian study of young twins. Twin Res Hum Genet 2008;11:121-31.
44. Bouzigon E, Corda E, Aschard H, Dizier MH, Boland A, Bousquet J, et al. Effect of 17q21 variants and smoking exposure in early-onset asthma. N Engl J Med 2008;359:1985-94.
45. Saeki N, Kuwahara Y, Sasaki H, Satoh H, Shiroishi T. Gasdermin (Gsdm) localizing to mouse Chromosome 11 is predominantly ex-pressed in upper gastrointestinal tract but significantly suppressed in human gastric cancer cells. Mamm Genome 2000;11:718-24.
46. Saeki N, Usui T, Aoyagi K, Kim DH, Sato M, Mabuchi T, et al. Dis-tinctive expression and function of four GSDM family genes (GSD-MA-D) in normal and malignant upper gastrointestinal epitheli-um. Genes Chromosomes Cancer 2009;48:261-71.
47. Hjelmqvist L, Tuson M, Marfany G, Herrero E, Balcells S, Gonzàlez-Duarte R. ORMDL proteins are a conserved new family of endo-plasmic reticulum membrane proteins. Genome Biol 2002;3:RE-SEARCH0027.
48. Heinemeyer T, Wingender E, Reuter I, Hermjakob H, Kel AE, Kel OV, et al. Databases on transcriptional regulation: TRANSFAC, TRRD and COMPEL. Nucleic Acids Res 1998;26:362-7.
49. Ellenberger T, Fass D, Arnaud M, Harrison SC. Crystal structure of transcription factor E47: e-box recognition by a basic region helix-loop-helix dimer. Genes Dev 1994;8:970-80.
50. Quong MW, Romanow WJ, Murre C. E protein function in lympho-cyte development. Annu Rev Immunol 2002;20:301-22.
51. Murre C. Helix-loop-helix proteins and lymphocyte development. Nat Immunol 2005;6:1079-86.
52. Tomita K, Sakashita M, Hirota T, Tanaka S, Masuyama K, Yamada T, et al. Variants in the 17q21 asthma susceptibility locus are associat-ed with allergic rhinitis in the Japanese population. Allergy 2013;68:92-100.
53. Miller M, Tam AB, Cho JY, Doherty TA, Pham A, Khorram N, et al. ORMDL3 is an inducible lung epithelial gene regulating metallo-proteases, chemokines, OAS, and ATF6. Proc Natl Acad Sci U S A 2012;109:16648-53.
54. Ha SG, Ge XN, Bahaie NS, Kang BN, Rao A, Rao SP, et al. ORMDL3 promotes eosinophil trafficking and activation via regulation of in-tegrins and CD48. Nat Commun 2013;4:2479.
55. Miller M, Rosenthal P, Beppu A, Mueller JL, Hoffman HM, Tam AB, et al. ORMDL3 transgenic mice have increased airway remodeling and airway responsiveness characteristic of asthma. J Immunol 2014;192:3475-87.
56. Cali{dotless}şkan M, Bochkov YA, Kreiner-Møller E, Bønnelykke K, Stein MM, Du G, et al. Rhinovirus wheezing illness and genetic risk of childhood-onset asthma. N Engl J Med 2013;368:1398-407.