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Volumn 54, Issue 11, 2009, Pages 624-628

The era of genome-wide association studies: Opportunities and challenges for asthma genetics

Author keywords

Asthma; Atopy; Genetics; Genome wide

Indexed keywords

ASTHMA; CLINICAL STUDY; ENVIRONMENTAL FACTOR; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE PHENOTYPE CORRELATION; HUMAN; HUMAN GENOME; PATHOGENESIS; PHENOTYPE; REVIEW;

EID: 74049162508     PISSN: 14345161     EISSN: None     Source Type: Journal    
DOI: 10.1038/jhg.2009.97     Document Type: Review
Times cited : (17)

References (46)
  • 1
    • 0032995658 scopus 로고    scopus 로고
    • Genetic and environment in asthma: The answer of twin studies
    • Koppelman, G., Los, H. & Postma, D. Genetic and environment in asthma: the answer of twin studies. Eur. Respir. J. 13, 2-4 (1999).
    • (1999) Eur. Respir. J. , vol.13 , pp. 2-4
    • Koppelman, G.1    Los, H.2    Postma, D.3
  • 2
    • 1942494043 scopus 로고    scopus 로고
    • Association studies for asthma and atopic diseases: A comprehensive review of the literature
    • Hoffjan, S., Nicolae, D. & Ober, C. Association studies for asthma and atopic diseases: a comprehensive review of the literature. Respir. Res. 4, 14 (2003).
    • (2003) Respir. Res. , vol.4 , pp. 14
    • Hoffjan, S.1    Nicolae, D.2    Ober, C.3
  • 3
    • 33644774556 scopus 로고    scopus 로고
    • Asthma genetics 2006: The long and winding road to gene discovery
    • Ober, C. & Hoffjan, S. Asthma genetics 2006: the long and winding road to gene discovery. Genes Immun. 7, 95-100 (2006).
    • (2006) Genes Immun. , vol.7 , pp. 95-100
    • Ober, C.1    Hoffjan, S.2
  • 4
    • 40049100646 scopus 로고    scopus 로고
    • Discovering susceptibility genes for asthma and allergy
    • Vercelli, D. Discovering susceptibility genes for asthma and allergy. Nat. Rev. Immunol. 8, 169-182 (2008).
    • (2008) Nat. Rev. Immunol. , vol.8 , pp. 169-182
    • Vercelli, D.1
  • 5
    • 34047142342 scopus 로고    scopus 로고
    • Toward a comprehensive set of asthma susceptibility genes
    • Bosse, Y. & Hudson, T. Toward a comprehensive set of asthma susceptibility genes. Annu. Rev. Med. 58, 171-184 (2007).
    • (2007) Annu. Rev. Med. , vol.58 , pp. 171-184
    • Bosse, Y.1    Hudson, T.2
  • 6
    • 53749088606 scopus 로고    scopus 로고
    • Does the relationship between IgE and the CD14 gene depend on ethnicity?
    • Zhang, G., Goldblatt, J. & LeSouef, P. Does the relationship between IgE and the CD14 gene depend on ethnicity? Allergy 63, 1411-1417 (2008).
    • (2008) Allergy , vol.63 , pp. 1411-1417
    • Zhang, G.1    Goldblatt, J.2    Lesouef, P.3
  • 7
    • 68949209325 scopus 로고    scopus 로고
    • Opposite gene by environment interactions in Karelia for CD14 and CC16 single nucleotide polymorphisms and allergy
    • Zhang, G., Khoo, S., Laatikainen, T., Pekkarinen, P., Vartiainen, E., von Hertzen, L. et al. Opposite gene by environment interactions in Karelia for CD14 and CC16 single nucleotide polymorphisms and allergy. Allergy 64, 1333-1341 (2009).
    • (2009) Allergy , vol.64 , pp. 1333-1341
    • Zhang, G.1    Khoo, S.2    Laatikainen, T.3    Pekkarinen, P.4    Vartiainen, E.5    Von Hertzen, L.6
  • 8
    • 35348983887 scopus 로고    scopus 로고
    • A second generation human haplotype map of over 3.1 million SNPs
    • Frazer, K., Ballinger, D., Cox, D., Hinds, D., Stuve, L., Gibbs, R. et al. A second generation human haplotype map of over 3.1 million SNPs. Nature 449, 851-861 (2007).
    • (2007) Nature , vol.449 , pp. 851-861
    • Frazer, K.1    Ballinger, D.2    Cox, D.3    Hinds, D.4    Stuve, L.5    Gibbs, R.6
  • 9
    • 42349112088 scopus 로고    scopus 로고
    • Genome-wide association studies for complex traits: Consensus, uncertainty and challenges
    • McCarthy, M., Abecasis, G., Cardon, L., Goldstein, D., Little, J., Ioannidis, J. et al. Genome-wide association studies for complex traits: consensus, uncertainty and challenges. Nat. Rev. Genet. 9, 356-369 (2008).
    • (2008) Nat. Rev. Genet. , vol.9 , pp. 356-369
    • McCarthy, M.1    Abecasis, G.2    Cardon, L.3    Goldstein, D.4    Little, J.5    Ioannidis, J.6
  • 10
    • 48749084893 scopus 로고    scopus 로고
    • Genome-wide association studies: A new window into immunemediated diseases
    • Xavier, R. & Rioux, J. Genome-wide association studies: a new window into immunemediated diseases. Nat. Rev. Immunol. 8, 631-643 (2008).
    • (2008) Nat. Rev. Immunol. , vol.8 , pp. 631-643
    • Xavier, R.1    Rioux, J.2
  • 11
    • 34547216747 scopus 로고    scopus 로고
    • Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma
    • Moffatt, M., Kabesch, M., Liang, L., Dixon, A., Strachan, D., Heath, S. et al. Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma. Nature 448, 470-473 (2007).
    • (2007) Nature , vol.448 , pp. 470-473
    • Moffatt, M.1    Kabesch, M.2    Liang, L.3    Dixon, A.4    Strachan, D.5    Heath, S.6
  • 13
    • 0033656830 scopus 로고    scopus 로고
    • Genetics of asthma and allergy
    • Blumenthal, M. Genetics of asthma and allergy. Allergy Asthma Proc. 21, 55-59 (2000).
    • (2000) Allergy Asthma Proc. , vol.21 , pp. 55-59
    • Blumenthal, M.1
  • 14
    • 15944397667 scopus 로고    scopus 로고
    • The role of genetics in the development of asthma and atopy
    • Blumenthal, M. The role of genetics in the development of asthma and atopy. Curr. Opin. Allergy Clin. Immunol. 5, 141-145 (2005).
    • (2005) Curr. Opin. Allergy Clin. Immunol. , vol.5 , pp. 141-145
    • Blumenthal, M.1
  • 15
    • 45549093604 scopus 로고    scopus 로고
    • Metaanalysis of genome-wide linkage studies of asthma and related traits
    • Denham, S., Koppelman, G., Blakey, J., Wjst, M., Ferreira, M., Hall, I. et al. Metaanalysis of genome-wide linkage studies of asthma and related traits. Respir. Res. 9, 38 (2008).
    • (2008) Respir. Res. , vol.9 , pp. 38
    • Denham, S.1    Koppelman, G.2    Blakey, J.3    Wjst, M.4    Ferreira, M.5    Hall, I.6
  • 17
    • 0036799545 scopus 로고    scopus 로고
    • The allelic architecture of human disease genes: Common disease-common variant.or not?
    • Pritchard, J. & Cox, N. The allelic architecture of human disease genes: common disease-common variant.or not? Hum. Mol. Genet. 11, 2417-2423 (2002).
    • (2002) Hum. Mol. Genet. , vol.11 , pp. 2417-2423
    • Pritchard, J.1    Cox, N.2
  • 18
    • 39649123754 scopus 로고    scopus 로고
    • Asthma genetics: From linear to multifactorial approaches
    • Guerra, S. & Martinez, F. Asthma genetics: from linear to multifactorial approaches. Annu. Rev. Med. 59, 327-341 (2008).
    • (2008) Annu. Rev. Med. , vol.59 , pp. 327-341
    • Guerra, S.1    Martinez, F.2
  • 19
    • 56049111877 scopus 로고    scopus 로고
    • Gene-environment interaction in complex diseases: Asthma as an illustrative case
    • Martinez, F. Gene-environment interaction in complex diseases: asthma as an illustrative case. Novartis Found Symp. 293, 184-192 (2008).
    • (2008) Novartis Found Symp. , vol.293 , pp. 184-192
    • Martinez, F.1
  • 20
    • 33846109320 scopus 로고    scopus 로고
    • Gene-environment interactions in asthma: With apologies to William of Ockham
    • Martinez, F. Gene-environment interactions in asthma: with apologies to William of Ockham. Proc. Am. Thorac. Soc. 4, 26-31 (2007).
    • (2007) Proc. Am. Thorac. Soc. , vol.4 , pp. 26-31
    • Martinez, F.1
  • 23
    • 34347335667 scopus 로고    scopus 로고
    • Guilt beyond a reasonable doubt
    • Altshuler, D. & Daly, M. Guilt beyond a reasonable doubt. Nat. Genet. 39, 813-815 (2007).
    • (2007) Nat. Genet. , vol.39 , pp. 813-815
    • Altshuler, D.1    Daly, M.2
  • 24
    • 40149111451 scopus 로고    scopus 로고
    • What can genome-wide association studies tell us about the genetics of common disease?
    • Iles, M. What can genome-wide association studies tell us about the genetics of common disease? PLoS Genet. 4, e33 (2008).
    • (2008) PLoS Genet. , vol.4
    • Iles, M.1
  • 25
    • 55449120805 scopus 로고    scopus 로고
    • Genetic mapping in human disease
    • Altshuler, D., Daly, M. & Lander, E. Genetic mapping in human disease. Science 322, 881-888 (2008).
    • (2008) Science , vol.322 , pp. 881-888
    • Altshuler, D.1    Daly, M.2    Lander, E.3
  • 27
    • 33749013001 scopus 로고    scopus 로고
    • Implications of small effect sizes of individual genetic variants on the design and interpretation of genetic association studies of complex diseases
    • Ioannidis, J., Trikalinos, T. & Khoury, M. Implications of small effect sizes of individual genetic variants on the design and interpretation of genetic association studies of complex diseases. Am. J. Epidemiol. 164, 609-614 (2006).
    • (2006) Am. J. Epidemiol. , vol.164 , pp. 609-614
    • Ioannidis, J.1    Trikalinos, T.2    Khoury, M.3
  • 28
    • 74049138590 scopus 로고    scopus 로고
    • An over-looked clinical relevance of modifiers: Some carriers of so called 'moderate' risk mutations are at high risk
    • Blue Mountains, NSW
    • Southey, M., Byrnes, G. & Hopper, J. An over-looked clinical relevance of modifiers: some carriers of so called 'moderate' risk mutations are at high risk in 7th GeneMappers Conference, Blue Mountains, NSW, (2009).
    • (2009) 7th Gene Mappers Conference
    • Southey, M.1    Byrnes, G.2    Hopper, J.3
  • 29
    • 61349089164 scopus 로고    scopus 로고
    • Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction
    • Gudbjartsson, D., Bjornsdottir, U., Halapi, E., Helgadottir, A., Sulem, P., Jonsdottir, G. et al. Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction. Nat. Genet. 41, 342-347 (2009).
    • (2009) Nat. Genet. , vol.41 , pp. 342-347
    • Gudbjartsson, D.1    Bjornsdottir, U.2    Halapi, E.3    Helgadottir, A.4    Sulem, P.5    Jonsdottir, G.6
  • 30
    • 62449117832 scopus 로고    scopus 로고
    • Asthma and atopy are associated with chromosome 17q21 markers in Chinese children
    • Leung, T., Sy, H., Ng, M., Chan, I., Wong, G., Tang, N. et al. Asthma and atopy are associated with chromosome 17q21 markers in Chinese children. Allergy 64, 621-628 (2009).
    • (2009) Allergy , vol.64 , pp. 621-628
    • Leung, T.1    Sy, H.2    Ng, M.3    Chan, I.4    Wong, G.5    Tang, N.6
  • 31
    • 38949188741 scopus 로고    scopus 로고
    • Replication of an association between 17q21 SNPs and asthma in a French-Canadian familial collection
    • Madore, A., Tremblay, K., Hudson, T. & Laprise, C. Replication of an association between 17q21 SNPs and asthma in a French-Canadian familial collection. Hum. Genet. 123, 93-95 (2008).
    • (2008) Hum. Genet. , vol.123 , pp. 93-95
    • Madore, A.1    Tremblay, K.2    Hudson, T.3    Laprise, C.4
  • 32
    • 62449114842 scopus 로고    scopus 로고
    • Genetic variation in ORM1-like 3 (ORMDL3) and gasdermin-like (GSDML) and childhood asthma
    • Wu, H., Romieu, I., Sienra-Monge, J., Li, H., del Rio-Navarro, B. & London, S. Genetic variation in ORM1-like 3 (ORMDL3) and gasdermin-like (GSDML) and childhood asthma. Allergy 64, 629-635 (2009).
    • (2009) Allergy , vol.64 , pp. 629-635
    • Wu, H.1    Romieu, I.2    Sienra-Monge, J.3    Li, H.4    Del Rio-Navarro, B.5    London, S.6
  • 34
    • 50849120030 scopus 로고    scopus 로고
    • Genome-wide scan on total serum IgE levels identifies FCER1A as novel susceptibility locus
    • Weidinger, S., Gieger, C., Rodriguez, E., Baurecht, H., Mempel, M., Klopp, N. et al. Genome-wide scan on total serum IgE levels identifies FCER1A as novel susceptibility locus. PLoS Genet. 4, e1000166 (2008).
    • (2008) PLoS Genet. , vol.4
    • Weidinger, S.1    Gieger, C.2    Rodriguez, E.3    Baurecht, H.4    Mempel, M.5    Klopp, N.6
  • 35
    • 36749006298 scopus 로고    scopus 로고
    • Toward a major risk factor for atopic eczema: Meta-analysis of filaggrin polymorphism data
    • Baurecht, H., Irvine, A., Novak, N., Illig, T., Buhler, B., Ring, J. et al. Toward a major risk factor for atopic eczema: meta-analysis of filaggrin polymorphism data. J. Allergy Clin. Immunol. 120, 1406-1412 (2007).
    • (2007) J. Allergy Clin. Immunol. , vol.120 , pp. 1406-1412
    • Baurecht, H.1    Irvine, A.2    Novak, N.3    Illig, T.4    Buhler, B.5    Ring, J.6
  • 39
    • 34447129720 scopus 로고    scopus 로고
    • Non-replication and inconsistency in the genome-wide association setting
    • Ioannidis, J. Non-replication and inconsistency in the genome-wide association setting. Hum. Hered. 64, 203-213 (2007).
    • (2007) Hum. Hered. , vol.64 , pp. 203-213
    • Ioannidis, J.1
  • 40
    • 74049147369 scopus 로고    scopus 로고
    • The importance of environment on respiratory genotype/phenotype relationships in the Inuit
    • in press, accepted on 11 Jun 2009
    • Candelaria, P., Backer, V., Khoo, S-K., Bizzintino, J., Hayden, C., Baynam, G. et al. The importance of environment on respiratory genotype/phenotype relationships in the Inuit. Allergy (2009) [in press, accepted on 11 Jun 2009].
    • (2009) Allergy
    • Candelaria, P.1    Backer, V.2    Khoo, S.-K.3    Bizzintino, J.4    Hayden, C.5    Baynam, G.6
  • 42
    • 40949127393 scopus 로고    scopus 로고
    • How to interpret a genome-wide association study
    • Pearson, T. & Manolio, T. How to interpret a genome-wide association study. JAMA 299, 1335-1344 (2008).
    • (2008) JAMA , vol.299 , pp. 1335-1344
    • Pearson, T.1    Manolio, T.2
  • 43
    • 31144469134 scopus 로고    scopus 로고
    • Structural variation in the human genome
    • Feuk, L., Carson, A. & Scherer, S. W. Structural variation in the human genome. Nat Rev Genet. 7, 85-97 (2006).
    • (2006) Nat Rev Genet. , vol.7 , pp. 85-97
    • Feuk, L.1    Carson, A.2    Scherer, S.W.3
  • 44
    • 35948953262 scopus 로고    scopus 로고
    • Power to detect risk alleles using genome-wide tag SNP panels
    • Eberle, M., Ng, P., Kuhn, K., Zhou, L., Peiffer, D., Galver, L. et al. Power to detect risk alleles using genome-wide tag SNP panels. PLoS Genet. 3, 1827-1837 (2007).
    • (2007) PLoS Genet , vol.3 , pp. 1827-1837
    • Eberle, M.1    Ng, P.2    Kuhn, K.3    Zhou, L.4    Peiffer, D.5    Galver, L.6
  • 45
    • 58449107994 scopus 로고    scopus 로고
    • Gene-environment interaction in genomewide association studies
    • Murcray, C., Lewinger, J. & Gauderman, W. Gene-environment interaction in genomewide association studies. Am J Epidemiol. 169, 219-226 (2009).
    • (2009) Am J Epidemiol. , vol.169 , pp. 219-226
    • Murcray, C.1    Lewinger, J.2    Gauderman, W.3
  • 46
    • 57649136554 scopus 로고    scopus 로고
    • Progress and challenges in genome-wide association studies in humans
    • Donnelly, P. Progress and challenges in genome-wide association studies in humans. Nature 456, 728-731 (2008).
    • (2008) Nature , vol.456 , pp. 728-731
    • Donnelly, P.1


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