N-acetylcysteine prevents behavioral and biochemical changes induced by alcohol cessation in rats

Alcohol

Volumn 49, Issue 3, 2015, Pages 259-263

  Schneider, Ricardo ^a   Santos, Carolina Ferreira ^a   Clarimundo, Vanessa ^a   Dalmaz, Carla ^a   Elisabetsky, Elaine ^a   Gomez, Rosane ^a  

^a FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

Author keywords

Addiction; Corticosterone; Ethanol; Leptin; N acetylcysteine (NAC); Open field

Indexed keywords

ACETYLCYSTEINE; ALCOHOL; CORTICOSTERONE; GLUCOSE; LEPTIN; SODIUM CHLORIDE; CENTRAL DEPRESSANT AGENT; SCAVENGER;

ADULT; ALCOHOL ABSTINENCE; ALCOHOL WITHDRAWAL; ALCOHOLISM; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANXIETY DISORDER; ARTICLE; CALORIC INTAKE; CONTROLLED STUDY; CORTICOSTERONE BLOOD LEVEL; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG MECHANISM; EXPERIMENTAL HYPOACTIVITY; MALE; NONHUMAN; OPEN FIELD TEST; RAT; ANIMAL; ANXIETY; CHEMICALLY INDUCED; DRUG EFFECTS; METABOLISM; MOTOR ACTIVITY; PSYCHOLOGY; SUBSTANCE WITHDRAWAL SYNDROME; WISTAR RAT;

ANIMALIA; CANNABIS; NICOTIANA TABACUM; RATTUS; RATTUS NORVEGICUS;

ACETYLCYSTEINE; ANIMALS; ANXIETY; BEHAVIOR, ANIMAL; CENTRAL NERVOUS SYSTEM DEPRESSANTS; CORTICOSTERONE; ETHANOL; FREE RADICAL SCAVENGERS; LEPTIN; MOTOR ACTIVITY; RATS; RATS, WISTAR; SUBSTANCE WITHDRAWAL SYNDROME;

EID: 84929296174     PISSN: 07418329     EISSN: 18736823     Source Type: Journal    
DOI: 10.1016/j.alcohol.2015.01.009     Document Type: Article

References (43)

1. Aguiar-Nemer A.S., Toffolo M.C., da Silva C.J., Laranjeira R., Silva-Fonseca V.A. Leptin influence in craving and relapse of alcoholics and smokers. Journal of Clinical Medical Research 2013, 5:164-167.
2. Ahima R.S., Prabakaran D., Mantzoros C., Qu D., Lowell B., Maratos-Flier E., et al. Role of leptin in the neuroendocrine response to fasting. Nature 1996, 382:250-252.
3. Amen S.L., Piacentine L.B., Ahmad M.E., Li S.J., Mantsch J.R., Risinger R.C., et al. Repeated N-acetyl cysteine reduces cocaine seeking in rodents and craving in cocaine-dependent humans. Neuropsychopharmacology 2011, 36:871-878.
4. Berk M., Malhi G.S., Gray L.J., Dean O.M. The promise of N-acetylcysteine in neuropsychiatry. Trends in Pharmacological Sciences 2013, 34:167-177.
5. Brown R.M., Kupchik Y.M., Kalivas P.W. The story of glutamate in drug addiction and of N-acetylcysteine as a potential pharmacotherapy. JAMA Psychiatry 2013, 70:895-897.
6. Engel J.A., Jerlhag E. Role of appetite-regulating peptides in the pathophysiology of addiction: implications for pharmacotherapy. CNS Drugs 2014, 28:875-886.
7. Esel E., Sofuoglu S., Aslan S.S., Kula M., Yabanoglu I., Turan M.T. Plasma levels of beta-endorphin, adrenocorticotropic hormone and cortisol during early and late alcohol withdrawal. Alcohol and Alcoholism 2001, 36:572-576.
8. Fukushiro D.F., Saito L.P., Mári-Kawamoto E., Aramini T.C., Costa J.M., Josino F.S., et al. Withdrawal from repeated treatment with ethanol induces a protracted decrease in novelty-seeking behavior and enhancement of environmental habituation in mice. Pharmacology, Biochemistry, and Behavior 2012, 101:132-137.
9. Fulton S., Pissios P., Manchon R.P., Stiles L., Frank L., Pothos E.N., et al. Leptin regulation of the mesoaccumbens dopamine pathway. Neuron 2006, 51:811-822.
10. Gass J.T., Olive M.F. Glutamatergic substrates of drug addiction and alcoholism. Biochemical Pharmacology 2008, 75:218-265.
11. Gilpin N.W., Koob G.F. Neurobiology of alcohol dependence: focus on motivational mechanisms. Alcohol Research & Health 2008, 31:185-195.
12. Goldstein R.Z., Volkow N.D. Dysfunction of the prefrontal cortex in addiction: neuroimaging findings and clinical implications. Nature Reviews. Neuroscience 2011, 12:652-669.
13. Gray K.M., Watson N.L., Carpenter M.J., Larowe S.D. N-acetylcysteine (NAC) in young marijuana users: an open-label pilot study. The American Journal on Addictions 2010, 19:187-189.
14. Harvey J. Leptin: a diverse regulator of neuronal function. Journal of Neurochemistry 2007, 100:307-313.
15. Hermann D., Weber-Fahr W., Sartorius A., Hoerst M., Frischknecht U., Tunc-Skarka N., et al. Translational magnetic resonance spectroscopy reveals excessive central glutamate levels during alcohol withdrawal in humans and rats. Biological Psychiatry 2012, 71:1015-1021.
16. Kalivas P.W. The glutamate homeostasis hypothesis of addiction. Nature Reviews. Neuroscience 2008, 10:561-572.
17. Kalivas P.W., Volkow N.D. New medications for drug addiction hiding in glutamatergic neuroplasticity. Molecular Psychiatry 2011, 16:974-986.
18. Kiefer F., Jahn H., Jaschinski M., Holzbach R., Wolf K., Naber D., et al. Leptin: a modulator of alcohol craving?. Biological Psychiatry 2001, 49:782-787.
19. Kiefer F., Jahn H., Kellner M., Naber D., Wiedemann K. Leptin as a possible modulator of craving for alcohol. Archives of General Psychiatry 2001, 58:509-510.
20. Kiefer F., Jahn H., Otte C., Demiralay C., Wolf K., Wiedemann K. Increasing leptin precedes craving and relapse during pharmacological abstinence maintenance treatment of alcoholism. Journal of Psychiatric Research 2005, 39:545-551.
21. Kiefer F., Jahn H., Wolf K., Kämpf P., Knaudt K., Wiedemann K. Free-choice alcohol consumption in mice after application of the appetite regulating peptide leptin. Alcoholism: Clinical and Experimental Research 2001, 25:787-789.
22. Kliethermes C.L. Anxiety-like behaviors following chronic ethanol exposure. Neuroscience and Biobehavioral Reviews 2005, 28:837-850.
23. Knackstedt L.A., LaRowe S., Mardikian P., Malcolm R., Upadhyaya H., Hedden S., et al. The role of cystine-glutamate exchange in nicotine dependence in rats and humans. Biological Psychiatry 2009, 65:841-845.
24. Koob G.F., Le Moal M. Drug addiction, dysregulation of reward, and allostasis. Neuropsychopharmacology 2001, 24:97-129.
25. Kraus T., Reulbach U., Bayerlein K., Mugele B., Hillemacher T., Sperling W., et al. Leptin is associated with craving in females with alcoholism. Addiction Biology 2004, 9:213-219.
26. LaRowe S.D., Kalivas P.W., Nicholas S.J., Randall P.K., Mardikian P.N., Malcolm R.J. Adouble-blind placebo-controlled trial of N-acetylcysteine in the treatment of cocaine dependence. The American Journal on Addictions 2013, 22:443-452.
27. McKeon A., Frye M.A., Delanty N. The alcohol withdrawal syndrome. Journal of Neurology, Neurosurgery, and Psychiatry 2008, 79:854-862.
28. Pähkla R., Harro J., Rägo L. Behavioural effects of pinoline in the rat forced swimming, open field and elevated plus-maze tests. Pharmacological Research 1996, 34:73-78.
29. Popoli M., Yan Z., McEwen B.S., Sanacora G. The stressed synapse: the impact of stress and glucocorticoids on glutamate transmission. Nature Reviews. Neuroscience 2011, 13:22-37.
30. Prut L., Belzung C. The open field as a paradigm to measure the effects of drugs on anxiety-like behaviors: a review. European Journal of Pharmacology 2003, 463:3-33.
31. Ramirez-Niño A.M., D'Souza M.S., Markou A. N-acetylcysteine decreased nicotine self-administration and cue-induced reinstatement of nicotine seeking in rats: comparison with the effects of N-acetylcysteine on food responding and food seeking. Psychopharmacology (Berl) 2013, 225:473-482.
32. Reichel C.M., Moussawi K., Do P.H., Kalivas P.W., See R.E. Chronic N-acetylcysteine during abstinence or extinction after cocaine self-administration produces enduring reductions in drug seeking. The Journal of Pharmacology and Experimental Therapeutics 2011, 337:487-493.
33. Roubos E.W., Dahmen M., Kozicz T., Xu L. Leptin and the hypothalamo-pituitary-adrenal stress axis. General and Comparative Endocrinology 2012, 177:28-36.
34. Sanna E., Mostallino M.C., Busonero F., Talani G., Tranquilli S., Mameli M., et al. Changes in GABA(A) receptor gene expression associated with selective alterations in receptor function and pharmacology after ethanol withdrawal. The Journal of Neuroscience 2003, 23:11711-11724.
35. Schmaal L., Berk L., Hulstijn K.P., Cousijn J., Wiers R.W., van den Brink W. Efficacy of N-acetylcysteine in the treatment of nicotine dependence: a double-blind placebo-controlled pilot study. European Addiction Research 2011, 17:211-216.
36. Schmaal L., Veltman D.J., Nederveen A., van den Brink W., Goudriaan A.E. N-acetylcysteine normalizes glutamate levels in cocaine-dependent patients: a randomized crossover magnetic resonance spectroscopy study. Neuropsychopharmacology 2012, 37:2143-2152.
37. Shanley L.J., Irving A.J., Harvey J. Leptin enhances NMDA receptor function and modulates hippocampal synaptic plasticity. The Journal of Neuroscience 2001, 21:RC186. 1-6.
38. Sharrett-Field L., Butler T.R., Berry J.N., Reynolds A.R., Prendergast M.A. Mifepristone pretreatment reduces ethanol withdrawal severity invivo. Alcoholism: Clinical and Experimental Research 2013, 37:1417-1423.
39. Sinha R. How does stress lead to risk of alcohol relapse?. Alcohol Research 2012, 34:432-440.
40. Slawecki C.J., Roth J. Comparison of the onset of hypoactivity and anxiety-like behavior during alcohol withdrawal in adolescent and adult rats. Alcoholism: Clinical and Experimental Research 2004, 28:598-607.
41. Stephens M.A., Wand G. Stress and the HPA axis: role of glucocorticoids in alcohol dependence. Alcohol Research 2012, 34:468-483.
42. Tsai G.Y., Cui J.Z., Syed H., Xia Z., Ozerdem U., McNeill J.H., et al. Effect of N-acetylcysteine on the early expression of inflammatory markers in the retina and plasma of diabetic rats. Clinical & Experimental Ophthalmology 2009, 37:223-231.
43. Zhou W., Kalivas P.W. N-acetylcysteine reduces extinction responding and induces enduring reductions in cue- and heroin-induced drug-seeking. Biological Psychiatry 2008, 63:338-340.