Behavioural effects of pinoline in the rat forced swimming, open field and elevated plus-maze tests

Pharmacological Research

Volumn 34, Issue 1-2, 1996, Pages 73-78

  Pähkla, Rein ^a   Harro, Jaanus ^a   Rägo, Lembit ^a  

^a UNIVERSITY OF TARTU   (Estonia)

Author keywords

6 methoxytetrahydro carboline; Elevated plus maze; Forced swimming; Open field; Rat

Indexed keywords

6 METHOXYTRYPTOLINE; AMITRIPTYLINE; ANTIDEPRESSANT AGENT; ANXIOLYTIC AGENT; IMIPRAMINE; MONOAMINE OXIDASE A INHIBITOR; PINOLINE; SEROTONIN UPTAKE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; FORCED SWIMMING TEST; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; MAZE TEST; NONHUMAN; OPEN FIELD BEHAVIOR; PRIORITY JOURNAL; RAT; TRANQUILIZING ACTIVITY;

EID: 0030185038     PISSN: 10436618     EISSN: None     Source Type: Journal    
DOI: 10.1006/phrs.1996.0066     Document Type: Article

References (40)

1. 1. Airaksinen MM, Kari I. β-carbolines, psychoactive compounds in the mammalian body. Part I. Occurrence, origin and metabolism. Med Biol 1981; 59: 21-34.
2. 2. Buckholtz NS. Neurobiology of tetrahydro-β-carbolines. Life Sci 1980; 27: 893-903.
3. 3. Langer SZ, Galzin AM, Schoemaker H. Antidepressant binding sites in brain and platelets. Ciba Found Symp 1986; 123: 3-29.
4. 3H]imipramine recognition site. Eur J Pharmacol 1984; 102: 379-80.
5. 5. Kari I, Airaksinen MM, Gynther J, Huhtikangas A. Mass spectrometric identification of 6-methoxy-1,2,3,4-tetrahydro-β-carboline in pineal gland. In: Frigerio A, ed. Recent developments in mass spectrometry in biochemistry, medicine and environmental research 8. Amsterdam: Elsevier Scientific, 1983: 19-24.
6. 6. Fernandez de Arriba A, Lizcano JM, Balsa MD, Unzeta M. Inhibition of monoamine oxidase from bovine retina by β-carbolines. J Pharm Pharmacol 1994; 46: 809-13.
7. 7. Komulainen H, Tuomisto J, Airaksinen MM, Kari I, Peura P, Pollari L. Tetrahydro-β-carbolines and corresponding tryptamines: In vitro inhibition of serotonin, dopamine and noradrenaline uptake in rat brain synaptosomes. Acta Pharmacol Toxicol 1980; 46: 299-307.
8. 3H]imipramine recognition sites in human platelets. J Neurochem 1985; 45: 249-56.
9. 3H]imipramine recognition site. Eur J Pharmacol 1984; 98: 153-4.
10. 10. Marcusson JO, Ross SB. Binding of some antidepressants to the 5-hydroxytryptamine transporter in brain and platelets. Psychopharmacology 1990; 102: 145-55.
11. 11. McIsaac WM, Taylor D, Walker KE, Ho BT. 6-Methoxy-1,2,3,4-tetrahydro-β-carboline - a serotonin elevator. J Neurochem 1972; 19: 1203-6.
12. 12. Airaksinen MM, Ho BT, An R, Taylor D. Major pharmacological effects of 6-methoxytetrahydro-β-carboline, a drug elevating the tissue 5-hydroxytryptamine level. Arzneimittel-Forsch 1978; 28: 42-6.
13. 13. Buckholtz NS. 6-Methoxy-1,2,3,4-tetrahydro-β-carboline produces a retention deficit for one-trial passive avoidance in mice. Behav Biol 1975; 14: 95-101.
14. 14. Porsolt RD, Anton G, Blavet N, Jalfre M. Behavioural despair in rats: a new model sensitive to antidepressant treatments. Eur J Pharmacol 1978; 47: 379-91.
15. 15. Handley SL, Mithani S. Effects of alpha-adrenoceptor agonists and antagonists in a maze-exploration model of 'fear'-motivated behaviour. Naunyn-Schmiede Arch Pharmacol 1984; 327: 1-5.
16. 16. Harro J, Kiivet R-A, Lang A, Vasar E. Rats with anxious or non-anxious type of exploratory behaviour differ in their brain CCK-8 and benzodiazepine receptor characteristics. Behav Brain Res 1990; 39: 63-71.
17. 17. Dawson GR, Tricklebank MD. Use of the elevated plus-maze in the search for novel anxiolytic agents. TIPS 1995; 16: 33-6.
18. 18. Pellow S, Chopin P, File SE, Briley M. Validation of open:closed arm entries in an elevated plus-maze as a measure of anxiety in the rat. J Neurosci Meth 1985; 14: 149-67.
19. 19. Moser PC. An evaluation of the elevated plus-maze test using the novel anxiolytic buspirone. Psychopharmacology 1989; 99: 48-53.
20. 20. Sherif F, Harro J, El-Hwuegi A, Oreland L. Anxiolytic-like effect of the GABA-transaminase inhibitor vigabatrin (gamma-vinyl GABA) on rat exploratory activity. Pharmacol Biochem Behav 1994; 49: 801-5.
21. 21. Dawson GR, Crawford SP, Collinson N, Iversen SD, Tricklebank MD. Evidence that anxiolytic-like effects of chlordiazepoxide on the elevated plus maze are confounded by increases in locomotor activity. Psychopharmacology 1995; 118: 316-23.
22. 3 receptor antagonists, ondansetron and WAY 100289, in the elevated plus-maze test of anxiety of mice. Psychopharmacology 1995; 117: 306-12.
23. 23. Rodgers RJ, Cole JC, Cobain MR, Daly P, Doran PJ, Eells JR, Wallis P. Anxiogenic-like effects of fluprazine and eltoprazine in the mouse elevated plus-maze: profile comparisons with 8-OH-DPAT, CGS 12066B, TFMPP and mCPP. Behav Pharmacol 1992; 3: 621-34.
24. 24. Cole JC, Rodgers RJ. Ethological evaluation of the effects of acute and chronic buspirone treatment in the murine elevated plus-maze test: comparison with haloperidol. Psychopharmacology 1994; 114: 288-96.
25. 25. Fehske KJ, Muller WE. β-carboline inhibition of benzodiazepine receptor binding in vivo. Brain Res 1982; 238: 286-91.
26. 26. Saano V, Airaksinen MM. Binding of β-carbolines and caffeine on benzodiazepine receptors: correlations to convulsions and tremor. Acta Pharmacol Toxicol 1982; 51: 300-8.
27. 27. Airaksinen MM, Mikkonen E. Affinity of β-carbolines on rat brain benzodiazepine and opiate receptors. Med Biol 1980; 58: 341-4.
28. 2 receptors. Psychopharmacology 1987; 93: 502-6.
29. 29. Handley SL, McBlane JW, Critchley MAE, Njung'e K. Multiple serotonin mechanisms in animal model of anxiety: environmental, emotional and cognitive factors. Brain Res 1993; 58: 203-10.
30. 30. Griebel G. 5-Hydroxytryptamine interacting drugs in animal models of anxiety disorders: More than 30 years research. Pharmacol Ther 1995; 65: 319-95.
31. 31. Handley SL, McBlane JW. Serotonin mechanisms in animal models of anxiety. Brazil J Med Biol Res 1993; 26: 1-13.
32. 32. Chopin P, Briley M. Animal models of anxiety: the effect of compounds that modify 5-HT neurotransmission. TIPS 1987; 8: 383-8.
33. 33. Allikmets L, Matto V, Harro J. Comparison of the effects of imipramine, desipramine and citalopram in elevated plus-maze test in rats. Pol J Pharmacol 1995; 47S: 49.
34. 34. Porsolt RD, Bertin A, Blavet N, Deniel M, Jalfre M. Immobility induced by forced swimming in rats: effect of agents which modify central catecholamine and serotonin activity. Eur J Pharmacol 1979; 57: 201-10.
35. 35. Lucki I, Singh A, Kreiss DS. Antidepressant-like behavioural effects of serotonin receptor agonists. Neurosci Biobehav Rev 1994; 18: 85-95.
36. 36. Borsini F. Role of the serotonergic system in the forced swimming test. Neurosci Biobehav Rev 1995; 19: 377-95.
37. 37. Sparks DL, Buckholtz NS. 6-Methoxy-1,2,3,4-tetrahydro-β-carboline: a specific monoamine oxydase-A inhibitor in CF-1 mouse brain. Neurosci Lett 1980; 20: 73-8.
38. 38. Glower V, Liebowitz J, Armande I, Sandler M. β-carbolines as selective monoamine oxidase inhibitors: in vivo implications. J Neural Transmission 1982; 54: 209-18.
39. 3H]pinoline. In: Touitou Y, Arendt J, Pévet P, eds. Melatonin and the pineal gland - from basic science to clinical application. Amsterdam: Elsevier Science, 1993: 83-6.
40. 40. Tobe A, Yoshida Y, Ikoma H, Tonomura S, Kikumoto R. Pharmacological evaluation of 2-(4-methyl-aminobutoxy)diphenylmethane hydrochloride (MCI-2016), a new psychotropic drug with antidepressant activity. Arzneimittel-Forsch 1981; 31: 1278-85.