Hospital management of Clostridium difficile infection: A review of the literature

Journal of Hospital Infection

Volumn 90, Issue 2, 2015, Pages 91-101

  Khanafer, N ^a,b   Voirin, N ^a,b   Barbut, F ^c,d   Kuijper, E ^e   Vanhems, P ^a,b  

^a UNIVERSITÉ DE LYON   (France)

^b EDOUARD HERRIOT HOSPITAL   (France)

^c SORBONNE UNIVERSITÉ   (France)

^d HÔPITAL SAINT ANTOINE   (France)

^e LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Clostridium difficile infection; Effectiveness; Hospital; Intervention study; Management

Indexed keywords

BLEACHING AGENT; CLINDAMYCIN; HYPOCHLORITE; QUATERNARY AMMONIUM DERIVATIVE; SOAP; VANCOMYCIN; WATER; ANTIINFECTIVE AGENT;

ANTIBIOTIC PROPHYLAXIS; BATH; CLEANING; CLOSTRIDIUM DIFFICILE INFECTION; CONTROLLED STUDY; DISINFECTION; HAND WASHING; HEALTH EDUCATION; HOSPITAL MANAGEMENT; HOSPITAL POLICY; HUMAN; INCIDENCE; INFECTION CONTROL; OBSERVATIONAL STUDY; PEPTOCLOSTRIDIUM DIFFICILE; PREVENTION AND CONTROL; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; RISK REDUCTION; SYSTEMATIC REVIEW; CLOSTRIDIUM INFECTIONS; CROSS INFECTION; DRUG EFFECTS; FEMALE; HAND DISINFECTION; MALE; PROCEDURES; PROSPECTIVE STUDY;

ANTI-BACTERIAL AGENTS; CLOSTRIDIUM DIFFICILE; CLOSTRIDIUM INFECTIONS; CROSS INFECTION; DISINFECTION; FEMALE; HAND DISINFECTION; HUMANS; INFECTION CONTROL; MALE; PROSPECTIVE STUDIES;

EID: 84929275951     PISSN: 01956701     EISSN: 15322939     Source Type: Journal    
DOI: 10.1016/j.jhin.2015.02.015     Document Type: Review

References (68)

1. Bartlett J.G. Clinical practice. Antibiotic-associated diarrhea. NEngl J Med 2002, 346:334-339.
2. Wiegand P.N., Nathwani D., Wilcox M.H., Stephens J., Shelbaya A., Haider S. Clinical and economic burden of Clostridium difficile infection in Europe: a systematic review of healthcare-facility-acquired infection. JHosp Infect 2012, 81:1-14.
3. Dubberke E.R., Gerding D.N., Classen D., et al. Strategies to prevent Clostridium difficile infections in acute care hospitals. Infect Control Hosp Epidemiol 2008, 29(Suppl. 1):S81-S92.
4. McDonald L.C., Coignard B., Dubberke E., Song X., Horan T., Kutty P.K. Recommendations for surveillance of Clostridium difficile-associated disease. Infect Control Hosp Epidemiol 2007, 28:140-145. Ad Hoc Clostridium difficile Surveillance Working Group.
5. Dubberke E.R., Butler A.M., Nyazee H.A., et al. The impact of ICD-9-CM code rank order on the estimated prevalence of Clostridium difficile infections. Clin Infect Dis 2007, 53:20-25.
6. Gerding D.N., Muto C.A., Owens R.C. Measures to control and prevent Clostridium difficile infection. Clin Infect Dis 2008, 46(Suppl. 1):S43-S49.
7. Kallen A.J., Thompson A., Ristaino P., et al. Complete restriction of fluoroquinolone use to control an outbreak of Clostridium difficile infection at a community hospital. Infect Control Hosp Epidemiol 2009, 30:264-272.
8. Weiss K., Boisvert A., Chagnon M., et al. Multipronged intervention strategy to control an outbreak of Clostridium difficile infection (CDI) and its impact on the rates of CDI from 2002 to 2007. Infect Control Hosp Epidemiol 2009, 30:156-162.
9. Palmore T.N., Sohn S., Malak S.F., Eagan J., Sepkowitz K.A. Risk factors for acquisition of Clostridium difficile-associated diarrhea among outpatients at a cancer hospital. Infect Control Hosp Epidemiol 2005, 26:680-684.
10. Sohn S., Climo M., Diekema D., et al. Varying rates of Clostridium difficile-associated diarrhea at prevention epicenter hospitals. Infect Control Hosp Epidemiol 2005, 26:676-679.
11. Stone S.P., Cooper B.S., Kibbler C.C., et al. The ORION statement: guidelines for transparent reporting of outbreak reports and intervention studies of nosocomial infection. JAntimicrob Chemother 2007, 59:833-840.
12. Wolkewitz M., Barnett A.G., Palomar Martinez M., Frank U., Schumacher M. Interventions to control nosocomial infections: study designs and statistical issues. JHosp Infect 2014, 86:77-82. IMPLEMENT Study Group.
13. Struelens M.J., Maas A., Nonhoff C., et al. Control of nosocomial transmission of Clostridium difficile based on sporadic case surveillance. Am J Med 1991, 91:138S-144S.
14. Owen L. Improving compliance with the C.difficile root cause analysis tool to reduce incidence. Nurs Times 2009, 105:14-16.
15. Carling P., Fung T., Killion A., Terrin N., Barza M. Favorable impact of a multidisciplinary antibiotic management program conducted during 7 years. Infect Control Hosp Epidemiol 2003, 24:699-706.
16. Gordin F.M., Schultz M.E., Huber R.A., Gill J.A. Reduction in nosocomial transmission of drug-resistant bacteria after introduction of an alcohol-based handrub. Infect Control Hosp Epidemiol 2005, 26:650-653.
17. Teltsch D.Y., Hanley J., Loo V., Goldberg P., Gursahaney A., Buckeridge D.L. Infection acquisition following intensive care unit room privatization. Arch Intern Med 2011, 171:32-38.
18. Rupp M.E., Cavalieri R.J., Lyden E., et al. Effect of hospital-wide chlorhexidine patient bathing on healthcare-associated infections. Infect Control Hosp Epidemiol 2012, 33:1094-1100.
19. Stone S.P., Fuller C., Savage J., et al. Evaluation of the national Cleanyourhands campaign to reduce Staphylococcus aureus bacteraemia and Clostridium difficile infection in hospitals in England and Wales by improved hand hygiene: four year, prospective, ecological, interrupted time series study. BMJ 2012, 344:e3005.
20. Hacek D.M., Ogle A.M., Fisher A., Robicsek A., Peterson L.R. Significant impact of terminal room cleaning with bleach on reducing nosocomial Clostridium difficile. Am J Infect Control 2010, 38:350-353.
21. Daneman N., Stukel T.A., Ma X., Vermeulen M., Guttmann A. Reduction in Clostridium difficile infection rates after mandatory hospital public reporting: findings from a longitudinal cohort study in Canada. PLoS Med 2012, 9:e1001268.
22. Fowler S., Webber A., Cooper B.S., et al. Successful use of feedback to improve antibiotic prescribing and reduce Clostridium difficile infection: a controlled interrupted time series. JAntimicrob Chemother 2007, 59:990-995.
23. Johnson S., Gerding D.N., Olson M.M., et al. Prospective, controlled study of vinyl glove use to interrupt Clostridium difficile nosocomial transmission. Am J Med 1990, 88:137-140.
24. Mayfield J.L., Leet T., Miller J., Mundy L.M. Environmental control to reduce transmission of Clostridium difficile. Clin Infect Dis 2000, 31:995-1000.
25. Talpaert M.J., Gopal Rao G., Cooper B.S., Wade P. Impact of guidelines and enhanced antibiotic stewardship on reducing broad-spectrum antibiotic usage and its effect on incidence of Clostridium difficile infection. JAntimicrob Chemother 2011, 66:2168-2174.
26. Price J., Cheek E., Lippett S., et al. Impact of an intervention to control Clostridium difficile infection on hospital- and community-onset disease; an interrupted time series analysis. Clin Microbiol Infect 2010, 16:1297-1302.
27. Power M., Wigglesworth N., Donaldson E., Chadwick P., Gillibrand S., Goldmann D. Reducing Clostridium difficile infection in acute care by using an improvement collaborative. BMJ 2010, 341:c3359.
28. Abbett S.K., Yokoe D.S., Lipsitz S.R., et al. Proposed checklist of hospital interventions to decrease the incidence of healthcare-associated Clostridium difficile infection. Infect Control Hosp Epidemiol 2009, 30:1062-1069.
29. Manian F.A., Griesnauer S., Bryant A. Implementation of hospital-wide enhanced terminal cleaning of targeted patient rooms and its impact on endemic Clostridium difficile infection rates. Am J Infect Control 2013, 41:537-541.
30. Aldeyab M.A., Kearney M.P., Scott M.G., et al. An evaluation of the impact of antibiotic stewardship on reducing the use of high-risk antibiotics and its effect on the incidence of Clostridium difficile infection in hospital settings. JAntimicrob Chemother 2012, 67:2988-2996.
31. Orenstein R., Aronhalt K.C., McManus J.E., Fedraw L.A. Atargeted strategy to wipe out Clostridium difficile. Infect Control Hosp Epidemiol 2013, 32:1137-1139.
32. Sitzlar B., Deshpande A., Fertelli D., Kundrapu S., Sethi A.K., Donskey C.J. An environmental disinfection odyssey: evaluation of sequential interventions to improve disinfection of Clostridium difficile isolation rooms. Infect Control Hosp Epidemiol 2013, 3:459-465.
33. Boyce J.M., Havill N.L., Otter J.A., et al. Impact of hydrogen peroxide vapor room decontamination on Clostridium difficile environmental contamination and transmission in a healthcare setting. Infect Control Hosp Epidemiol 2008, 29:723-729.
34. Eckstein B.C., Adams D.A., Eckstein E.C., et al. Reduction of Clostridium difficile and vancomycin-resistant Enterococcus contamination of environmental surfaces after an intervention to improve cleaning methods. BMC Infect Dis 2007, 7:61.
35. Cohen S.H., Gerding D.N., Johnson S., et al. Clinical practice guidelines for Clostridium difficile infection in adults: 2010 update by the Society for Healthcare Epidemiology of America (SHEA) and the Infectious Diseases Society of America (IDSA). Infect Control Hosp Epidemiol 2010, 31:431-455.
36. Stone S.P., Cooper B.S., Kibbler C.C., et al. The ORION statement: guidelines for transparent reporting of outbreak reports and intervention studies of nosocomial infection. Lancet Infect Dis 2007, 7:282-288.
37. Fishman N. Antimicrobial stewardship. Am J Infect Control 2006, 34:S55-S63. discussion S64-S73.
38. Dancer S.J., Kirkpatrick P., Corcoran D.S., Christison F., Farmer D., Robertson C. Approaching zero: temporal effects of a restrictive antibiotic policy on hospital-acquired Clostridium difficile, extended-spectrum beta-lactamase-producing coliforms and meticillin-resistant Staphylococcus aureus. Int J Antimicrob Agents 2013, 41:137-142.
39. McNulty C., Logan M., Donald I.P., et al. Successful control of Clostridium difficile infection in an elderly care unit through use of a restrictive antibiotic policy. JAntimicrob Chemother 1997, 40:707-711.
40. Owens R.C., Donskey C.J., Gaynes R.P., Loo V.G., Muto C.A. Antimicrobial-associated risk factors for Clostridium difficile infection. Clin Infect Dis 2008, 46(Suppl. 1):S19-S31.
41. Pépin J., Saheb N., Coulombe M.A., et al. Emergence of fluoroquinolones as the predominant risk factor for Clostridium difficile-associated diarrhea: a cohort study during an epidemic in Quebec. Clin Infect Dis 2005, 41:1254-1260.
42. Thomas C., Stevenson M., Riley T.V. Antibiotics and hospital-acquired Clostridium difficile-associated diarrhoea: a systematic review. JAntimicrob Chemother 2003, 51:1339-1350.
43. Leclair M.A., Allard C., Lesur O., Pépin J. Clostridium difficile infection in the intensive care unit. JIntensive Care Med 2010, 25:23-30.
44. Rupp M.E., Fitzgerald T., Puumala S., et al. Prospective, controlled, cross-over trial of alcohol-based hand gel in critical care units. Infect Control Hosp Epidemiol 2008, 29:8-15.
45. Boyce J.M., Ligi C., Kohan C., Dumigan D., Havill N.L. Lack of association between the increased incidence of Clostridium difficile-associated disease and the increasing use of alcohol-based hand rubs. Infect Control Hosp Epidemiol 2006, 27:479-483.
46. Islam J., Cheek E., Navani V., Rajkumar C., Cohen J., Llewelyn M.J. Influence of cohorting patients with Clostridium difficile infection on risk of symptomatic recurrence. JHosp Infect 2013, 85:17-21.
47. Fawley W.N., Underwood S., Freeman J., et al. Efficacy of hospital cleaning agents and germicides against epidemic Clostridium difficile strains. Infect Control Hosp Epidemiol 2007, 28:920-925.
48. Barbut F., Menuet D., Verachten M., Girou E. Comparison of the efficacy of a hydrogen peroxide dry-mist disinfection system and sodium hypochlorite solution for eradication of Clostridium difficile spores. Infect Control Hosp Epidemiol 2009, 30:507-514.
49. Wilcox M.H., Fawley W.N., Wigglesworth N., Parnell P., Verity P., Freeman J. Comparison of the effect of detergent versus hypochlorite cleaning on environmental contamination and incidence of Clostridium difficile infection. JHosp Infect 2003, 54:109-114.
50. Riggs M.M., Sethi A.K., Zabarsky T.F., Eckstein E.C., Jump R.L., Donskey C.J. Asymptomatic carriers are a potential source for transmission of epidemic and nonepidemic Clostridium difficile strains among long-term care facility residents. Clin Infect Dis 2007, 45:992-998.
51. Akerlund T., Alefjord I., Dohnhammar U., Struwe J., Noren T., Tegmark-Wisell K. Geographical clustering of cases of infection with moxifloxacin-resistant Clostridium difficile PCR-ribotypes 012, 017 and 046 in Sweden, 2008 and 2009. Euro Surveill 2011, 16. Swedish C.difficile Study Group, pii:19813.
52. Hota B. Contamination, disinfection, and cross-colonization: are hospital surfaces reservoirs for nosocomial infection?. Clin Infect Dis 2004, 39:1182-1189.
53. Wilcox M.H., Fawley W.N. Hospital disinfectants and spore formation by Clostridium difficile. Lancet 2000, 356:1324.
54. Wilcox M.H. Respiratory antibiotic use and Clostridium difficile infection: is it the drugs or is it the doctors?. Thorax 2000, 55:633-634.
55. Block C. The effect of Perasafe and sodium dichloroisocyanurate (NaDCC) against spores of Clostridium difficile and Bacillus atrophaeus on stainless steel and polyvinyl chloride surfaces. JHosp Infect 2004, 57:144-148.
56. Guerrero D.M., Carling P.C., Jury L.A., Ponnada S., Nerandzic M.M., Donskey C.J. Beyond the Hawthorne effect: reduction of Clostridium difficile environmental contamination through active intervention to improve cleaning practices. Infect Control Hosp Epidemiol 2013, 34:524-526.
57. Shapey S., Machin K., Levi K., Boswell T.C. Activity of a dry mist hydrogen peroxide system against environmental Clostridium difficile contamination in elderly care wards. JHosp Infect 2008, 70:136-141.
58. Boyce J.M. Environmental contamination makes an important contribution to hospital infection. JHosp Infect 2007, 65(Suppl. 2):50-54.
59. Otter J.A., French G.L., Adams N.M., Watling D., Parks M.J. Hydrogen peroxide vapour decontamination in an overcrowded tertiary care referral centre: some practical answers. JHosp Infect 2006, 62:384-385.
60. Otter J.A., Puchowicz M., Ryan D., et al. Feasibility of routinely using hydrogen peroxide vapor to decontaminate rooms in a busy United States hospital. Infect Control Hosp Epidemiol 2009, 30:574-577.
61. Anderson D.J., Gergen M.F., Smathers E., et al. Decontamination of targeted pathogens from patient rooms using an automated ultraviolet-C-emitting device. Infect Control Hosp Epidemiol 2013, 34:466-471.
62. Omidbakhsh N. Evaluation of sporicidal activities of selected environmental surface disinfectants: carrier tests with the spores of Clostridium difficile and its surrogates. Am J Infect Control 2006, 38:718-722.
63. Doan L., Forrest D.H., Fakis A., Craig J., Claxton L., Khare M. Clinical and cost effectiveness of eight disinfection methods for terminal disinfection of hospital isolation rooms contaminated with Clostridium difficile 027. JHosp Infect 2012, 82:114-121.
64. Brown K.A., Fisman D.N., Daneman N. Hospital Clostridium difficile infection testing rates: is 'don't ask, don't tell' at play?. Infect Control Hosp Epidemiol 2014, 35:911-912.
65. Freeman R., Moore L.S., Garciá Álvarez L., Charlett A., Holmes A. Advances in electronic surveillance for healthcare-associated infections in the 21st Century: a systematic review. JHosp Infect 2013, 84:106-119.
66. Cooper B., Cookson B., Davey P., Stone S. Introducing the ORION statement, a CONSORT equivalent for infection control studies. JHosp Infect 2007, 65(Suppl. 2):85-87.
67. McFarland L.V., Beneda H.W., Clarridge J.E., Raugi G.J. Implications of the changing face of Clostridium difficile disease for health care practitioners. Am J Infect Control 2007, 35:237-253.
68. Eyre D.W., Cule M.L., Wilson D.J., et al. Diverse sources of C.difficile infection identified on whole-genome sequencing. NEngl J Med 2013, 369:1195-1205.