Non-aggregating tau phosphorylation by cyclin-dependent kinase 5 contributes to motor neuron degeneration in spinal muscular atrophy

Journal of Neuroscience

Volumn 35, Issue 15, 2015, Pages 6038-6050

  Miller, Nimrod ^a   Feng, Zhihua ^b   Edens, Brittany M ^a   Yang, Ben ^a   Shi, Han ^a   Sze, Christie C ^a   Hong, Benjamin Taige ^a,c   Su, Susan C ^d   Cantu, Jorge A ^a   Topczewski, Jacek ^a   Crawford, Thomas O ^e   Ko, Chien Ping ^b   Sumner, Charlotte J ^e   Ma, Long ^c   Ma, Yong Chao ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^c CENTRAL SOUTH UNIVERSITY   (China)

^d HARVARD MEDICAL SCHOOL   (United States)

^e JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cdk5; Motor neuron; Neurodegeneration; SMA; Tau

Indexed keywords

CHOLINERGIC RECEPTOR; CYCLIN DEPENDENT KINASE 5; MORPHOLINE; PROTEIN P25; PROTEIN P35; SERINE; TAU PROTEIN; THREONINE; ANTISENSE OLIGODEOXYNUCLEOTIDE; CUTL1 PROTEIN, MOUSE; ENHANCED GREEN FLUORESCENT PROTEIN; GREEN FLUORESCENT PROTEIN; HOMEODOMAIN PROTEIN; NERVE PROTEIN; NUCLEAR PROTEIN; REPRESSOR PROTEIN; SURVIVAL MOTOR NEURON PROTEIN 1;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; AUTORADIOGRAPHY; CELL DEATH; CONTROLLED STUDY; EMBRYO; EXTENSOR DIGITORUM LONGUS MUSCLE; FEMALE; FLEXOR DIGITORUM BREVIS MUSCLE; GENE MUTATION; GENE SILENCING; GLUTAMATERGIC SYNAPSE; HUMAN; HUMAN TISSUE; IMMUNOPRECIPITATION; MALE; MOUSE; MUSCLE DENERVATION; NERVE CELL DEGENERATION; NEUROMUSCULAR JUNCTION DISORDER; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SPINAL MUSCULAR ATROPHY; TUNEL ASSAY; WESTERN BLOTTING; ZEBRA FISH; ANIMAL; CELL CULTURE; COMPLICATION; DEFICIENCY; DISEASE MODEL; GENE EXPRESSION REGULATION; GENETICS; INFANT; METABOLISM; MOTONEURON; NERVE DEGENERATION; NEUROMUSCULAR SYNAPSE; NEWBORN; PATHOLOGY; PHOSPHORYLATION; SKELETAL MUSCLE; SPINAL CORD; TRANSGENIC MOUSE;

ANIMALS; CELLS, CULTURED; CYCLIN-DEPENDENT KINASE 5; DISEASE MODELS, ANIMAL; FEMALE; GENE EXPRESSION REGULATION; GREEN FLUORESCENT PROTEINS; HOMEODOMAIN PROTEINS; HUMANS; IMMUNOPRECIPITATION; INFANT; INFANT, NEWBORN; MALE; MICE; MICE, TRANSGENIC; MOTOR NEURONS; MUSCLE, SKELETAL; MUSCULAR ATROPHY, SPINAL; NERVE DEGENERATION; NERVE TISSUE PROTEINS; NEUROMUSCULAR JUNCTION; NUCLEAR PROTEINS; OLIGODEOXYRIBONUCLEOTIDES, ANTISENSE; PHOSPHORYLATION; REPRESSOR PROTEINS; SPINAL CORD; SURVIVAL OF MOTOR NEURON 1 PROTEIN; TAU PROTEINS; ZEBRAFISH;

EID: 84929256498     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.3716-14.2015     Document Type: Article

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