메뉴 건너뛰기




Volumn 5, Issue , 2015, Pages

Hypermethylated epidermal growth factor receptor (EGFR) promoter is associated with gastric cancer

Author keywords

[No Author keywords available]

Indexed keywords

EGFR PROTEIN, HUMAN; EPIDERMAL GROWTH FACTOR RECEPTOR;

EID: 84929193240     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep10154     Document Type: Article
Times cited : (20)

References (34)
  • 2
    • 33745726677 scopus 로고    scopus 로고
    • Perioperative chemotherapy versus surgery alone for resectable gastroesophageal cancer
    • Cunningham, D. et al. Perioperative chemotherapy versus surgery alone for resectable gastroesophageal cancer. N. Engl. J. Med. 355, 11-20, doi:10.1056/NEJMoa055531 (2006).
    • (2006) N. Engl. J. Med. , vol.355 , pp. 11-20
    • Cunningham, D.1
  • 3
    • 84862181925 scopus 로고    scopus 로고
    • Targeting the EGFR-family for therapy: Biological challenges and clinical perspective
    • Patel, R. & Leung, H. Y. Targeting the EGFR-family for therapy: biological challenges and clinical perspective. Curr. Pharm. Des. 18, 2672-2679 (2012).
    • (2012) Curr. Pharm. Des. , vol.18 , pp. 2672-2679
    • Patel, R.1    Leung, H.Y.2
  • 4
    • 33645761156 scopus 로고    scopus 로고
    • Clinical implications of EGFR expression in the development and progression of solid tumors: Focus on non-small cell lung cancer
    • Ettinger, D. S. Clinical implications of EGFR expression in the development and progression of solid tumors: focus on non-small cell lung cancer. Oncologist 11, 358-373, doi:10.1634/theoncologist.11-4-358 (2006).
    • (2006) Oncologist , vol.11 , pp. 358-373
    • Ettinger, D.S.1
  • 5
    • 84874180366 scopus 로고    scopus 로고
    • EGFR and downstream genetic alterations in KRAS/BRAF and PI3K/AKT pathways in colorectal cancer: Implications for targeted therapy
    • Berg, M. & Soreide, K. EGFR and downstream genetic alterations in KRAS/BRAF and PI3K/AKT pathways in colorectal cancer: implications for targeted therapy. Discov. Med. 14, 207-214 (2012).
    • (2012) Discov. Med. , vol.14 , pp. 207-214
    • Berg, M.1    Soreide, K.2
  • 6
    • 84860803116 scopus 로고    scopus 로고
    • Targeting EGFR in pancreatic cancer treatment
    • Troiani, T. et al. Targeting EGFR in pancreatic cancer treatment. Curr. Drug Targets 13, 802-810 (2012).
    • (2012) Curr. Drug Targets , vol.13 , pp. 802-810
    • Troiani, T.1
  • 7
    • 79961024637 scopus 로고    scopus 로고
    • Targeting the human EGFR family in esophagogastric cancer
    • Okines, A., Cunningham, D. & Chau, I. Targeting the human EGFR family in esophagogastric cancer. Nat. Rev. Clin. Oncol. 8, 492-503, doi:10.1038/nrclinonc.2011.45 (2011).
    • (2011) Nat. Rev. Clin. Oncol. , vol.8 , pp. 492-503
    • Okines, A.1    Cunningham, D.2    Chau, I.3
  • 8
    • 0037795412 scopus 로고    scopus 로고
    • Clinical significance of the epidermal growth factor receptor and HER2 receptor in resectable gastric cancer
    • Garcia, I. et al. Clinical significance of the epidermal growth factor receptor and HER2 receptor in resectable gastric cancer. Ann. Surg. Oncol. 10, 234-241 (2003).
    • (2003) Ann. Surg. Oncol. , vol.10 , pp. 234-241
    • Garcia, I.1
  • 9
    • 84855884072 scopus 로고    scopus 로고
    • Targeting the EGFR signaling pathway in cancer therapy
    • Seshacharyulu, P. et al. Targeting the EGFR signaling pathway in cancer therapy. Expert Opin. Ther. Targets 16, 15-31, doi:10.1 517/14728222.2011.648617 (2012).
    • (2012) Expert Opin. Ther. Targets , vol.16 , pp. 15-31
    • Seshacharyulu, P.1
  • 10
    • 84875129831 scopus 로고    scopus 로고
    • DNA methylation dynamics in health and disease
    • Bergman, Y. & Cedar, H. DNA methylation dynamics in health and disease. Nat. Struct. Mol. Biol. 20, 274-281, doi:10.1038/nsmb.2518 (2013).
    • (2013) Nat. Struct. Mol. Biol. , vol.20 , pp. 274-281
    • Bergman, Y.1    Cedar, H.2
  • 11
    • 42649133793 scopus 로고    scopus 로고
    • EGFR in gastric carcinomas: Prognostic significance of protein overexpression and high gene copy number
    • Kim, M. A. et al. EGFR in gastric carcinomas: prognostic significance of protein overexpression and high gene copy number. Histopathology 52, 738-746, doi:10.1111/j.1365-2559.2008.03021.x (2008).
    • (2008) Histopathology , vol.52 , pp. 738-746
    • Kim, M.A.1
  • 12
    • 0036500831 scopus 로고    scopus 로고
    • Monoclonal antibodies to target epidermal growth factor receptor-positive tumors: A new paradigm for cancer therapy
    • Herbst, R. S. & Shin, D. M. Monoclonal antibodies to target epidermal growth factor receptor-positive tumors: a new paradigm for cancer therapy. Cancer 94, 1593-1611 (2002).
    • (2002) Cancer , vol.94 , pp. 1593-1611
    • Herbst, R.S.1    Shin, D.M.2
  • 13
    • 0345098554 scopus 로고    scopus 로고
    • The epidermal growth factor receptor pathway and its inhibition as anticancer therapy
    • Janmaat, M. L. & Giaccone, G. The epidermal growth factor receptor pathway and its inhibition as anticancer therapy. Drugs Today (Barc) 39 (Suppl C), 61-80 (2003).
    • (2003) Drugs Today (Barc) , vol.39 , pp. 61-80
    • Janmaat, M.L.1    Giaccone, G.2
  • 14
    • 0034235955 scopus 로고    scopus 로고
    • Epidermal growth factor receptor blockade by antibody IMC-C225 inhibits growth of a human pancreatic carcinoma xenograft in nude mice
    • Overholser, J. P., Prewett, M. C., Hooper, A. T., Waksal, H. W. & Hicklin, D. J. Epidermal growth factor receptor blockade by antibody IMC-C225 inhibits growth of a human pancreatic carcinoma xenograft in nude mice. Cancer 89, 74-82 (2000).
    • (2000) Cancer , vol.89 , pp. 74-82
    • Overholser, J.P.1    Prewett, M.C.2    Hooper, A.T.3    Waksal, H.W.4    Hicklin, D.J.5
  • 15
    • 65249179550 scopus 로고    scopus 로고
    • Antibodies specifically targeting a locally misfolded region of tumor associated EGFR
    • Garrett, T. P. et al. Antibodies specifically targeting a locally misfolded region of tumor associated EGFR. Proc. Natl. Acad. Sci. USA 106, 5082-5087, doi:10.1073/pnas.0811559106 (2009).
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , pp. 5082-5087
    • Garrett, T.P.1
  • 16
    • 82455210218 scopus 로고    scopus 로고
    • Drug-induced interstitial lung disease in tyrosine kinase inhibitor therapy for non-small cell lung cancer: A review on current insight
    • Min, J. H. et al. Drug-induced interstitial lung disease in tyrosine kinase inhibitor therapy for non-small cell lung cancer: a review on current insight. Cancer Chemother. Pharmacol. 68, 1099-1109, doi:10.1007/s00280-011-1737-2 (2011).
    • (2011) Cancer Chemother. Pharmacol. , vol.68 , pp. 1099-1109
    • Min, J.H.1
  • 17
    • 0034954124 scopus 로고    scopus 로고
    • The type III epidermal growth factor receptor mutation. Biological significance and potential target for anti-cancer therapy
    • Pedersen, M. W., Meltorn, M., Damstrup, L. & Poulsen, H. S. The type III epidermal growth factor receptor mutation. Biological significance and potential target for anti-cancer therapy. Ann. Oncol. 12, 745-760 (2001).
    • (2001) Ann. Oncol. , vol.12 , pp. 745-760
    • Pedersen, M.W.1    Meltorn, M.2    Damstrup, L.3    Poulsen, H.S.4
  • 18
    • 2342471392 scopus 로고    scopus 로고
    • Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
    • Lynch, T. J. et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N. Engl. J. Med. 350, 2129-2139, doi:10.1056/NEJMoa040938 (2004).
    • (2004) N. Engl. J. Med. , vol.350 , pp. 2129-2139
    • Lynch, T.J.1
  • 19
    • 0026521394 scopus 로고
    • Amplified and rearranged epidermal growth factor receptor genes in human glioblastomas reveal deletions of sequences encoding portions of the N- and/or C-terminal tails
    • Ekstrand, A. J., Sugawa, N., James, C. D. & Collins, V. P. Amplified and rearranged epidermal growth factor receptor genes in human glioblastomas reveal deletions of sequences encoding portions of the N- and/or C-terminal tails. Proc. Natl. Acad. Sci. USA 89, 4309-4313 (1992).
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 4309-4313
    • Ekstrand, A.J.1    Sugawa, N.2    James, C.D.3    Collins, V.P.4
  • 20
    • 0029146954 scopus 로고
    • EGFR gene amplification-rearrangement in human glioblastomas
    • Schwechheimer, K., Huang, S. & Cavenee, W. K. EGFR gene amplification-rearrangement in human glioblastomas. Int. J. Cancer 62, 145-148 (1995).
    • (1995) Int. J. Cancer , vol.62 , pp. 145-148
    • Schwechheimer, K.1    Huang, S.2    Cavenee, W.K.3
  • 21
    • 0037372003 scopus 로고    scopus 로고
    • Epigenetic regulation of gene expression: How the genome integrates intrinsic and environmental signals
    • Jaenisch, R. & Bird, A. Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals. Nat. Genet. 33 (Suppl), 245-254, doi:10.1038/ng1089 (2003).
    • (2003) Nat. Genet. , vol.33 , pp. 245-254
    • Jaenisch, R.1    Bird, A.2
  • 22
    • 34250630933 scopus 로고    scopus 로고
    • Epidermal growth factor receptor (EGFR) expression is associated with a worse prognosis in gastric cancer patients undergoing curative surgery
    • Galizia, G. et al. Epidermal growth factor receptor (EGFR) expression is associated with a worse prognosis in gastric cancer patients undergoing curative surgery. World J. Surg. 31, 1458-1468, doi:10.1007/s00268-007-9016-4 (2007).
    • (2007) World J. Surg. , vol.31 , pp. 1458-1468
    • Galizia, G.1
  • 23
    • 38049177080 scopus 로고    scopus 로고
    • Expression of vascular endothelial growth factor (VEGF) and epidermal growth factor receptor (EGFR) is an independent prognostic indicator of worse outcome in gastric cancer patients
    • Lieto, E. et al. Expression of vascular endothelial growth factor (VEGF) and epidermal growth factor receptor (EGFR) is an independent prognostic indicator of worse outcome in gastric cancer patients. Ann. Surg. Oncol. 15, 69-79, doi:10.1245/s10434-007-9596-0 (2008).
    • (2008) Ann. Surg. Oncol. , vol.15 , pp. 69-79
    • Lieto, E.1
  • 24
    • 0032033804 scopus 로고    scopus 로고
    • Expression of metastasis-related genes in surgical specimens of human gastric cancer can predict disease recurrence
    • Anzai, H. et al. Expression of metastasis-related genes in surgical specimens of human gastric cancer can predict disease recurrence. Eur. J. Cancer 34, 558-565 (1998).
    • (1998) Eur. J. Cancer , vol.34 , pp. 558-565
    • Anzai, H.1
  • 25
    • 0029811249 scopus 로고    scopus 로고
    • Increased estrogen receptor and epidermal growth factor receptor gene product co-expression in surgically resected gastric adenocarcinomas
    • Koullias, G. J. et al. Increased estrogen receptor and epidermal growth factor receptor gene product co-expression in surgically resected gastric adenocarcinomas. J. Surg. Oncol. 63, 166-171, doi:10.1002/(SICI)1096-9098(199611)63:3<166::AIDJSO6>3.0.CO;2-B (1996).
    • (1996) J. Surg. Oncol. , vol.63 , pp. 166-171
    • Koullias, G.J.1
  • 26
    • 79957599577 scopus 로고    scopus 로고
    • Epidermal growth factor receptor (EGFR) gene promoter methylation and cetuximab treatment in colorectal cancer patients
    • Scartozzi, M. et al. Epidermal growth factor receptor (EGFR) gene promoter methylation and cetuximab treatment in colorectal cancer patients. Br. J. Cancer 104, 1786-1790, doi:10.1038/bjc.2011.161 (2011).
    • (2011) Br. J. Cancer , vol.104 , pp. 1786-1790
    • Scartozzi, M.1
  • 27
    • 84857789620 scopus 로고    scopus 로고
    • Concurrent hypermethylation of DNMT1, MGMT and EGFR genes in progression of gliomas
    • Gomori, E., Pal, J., Kovacs, B. & Doczi, T. Concurrent hypermethylation of DNMT1, MGMT and EGFR genes in progression of gliomas. Diagn Pathol. 7, 8, doi:10.1186/1746-1596-7-8 (2012).
    • (2012) Diagn Pathol. , vol.7 , pp. 8
    • Gomori, E.1    Pal, J.2    Kovacs, B.3    Doczi, T.4
  • 28
    • 84876959600 scopus 로고    scopus 로고
    • Methylation of the TERT promoter and risk stratification of childhood brain tumours: An integrative genomic and molecular study
    • Castelo-Branco, P. et al. Methylation of the TERT promoter and risk stratification of childhood brain tumours: an integrative genomic and molecular study. Lancet Oncol. 14, 534-542, doi:10.1016/S1470-2045(13)70110-4 (2013).
    • (2013) Lancet Oncol. , vol.14 , pp. 534-542
    • Castelo-Branco, P.1
  • 29
    • 0035117177 scopus 로고    scopus 로고
    • Wilms' tumor suppressor gene (WT1) is expressed in primary breast tumors despite tumor-specific promoter methylation
    • Loeb, D. M. et al. Wilms' tumor suppressor gene (WT1) is expressed in primary breast tumors despite tumor-specific promoter methylation. Cancer Res. 61, 921-925 (2001).
    • (2001) Cancer Res. , vol.61 , pp. 921-925
    • Loeb, D.M.1
  • 30
    • 33845324531 scopus 로고    scopus 로고
    • DNA methylation paradigm shift: 15-lipoxygenase-1 upregulation in prostatic intraepithelial neoplasia and prostate cancer by atypical promoter hypermethylation
    • Kelavkar, U. P. et al. DNA methylation paradigm shift: 15-lipoxygenase-1 upregulation in prostatic intraepithelial neoplasia and prostate cancer by atypical promoter hypermethylation. Prostaglandins Other Lipid Mediat 82, 185-197, doi:10.1016/j. prostaglandins.2006.05.015 (2007).
    • (2007) Prostaglandins Other Lipid Mediat , vol.82 , pp. 185-197
    • Kelavkar, U.P.1
  • 31
    • 55949131420 scopus 로고    scopus 로고
    • Genomic imprinting mechanisms in mammals
    • Ideraabdullah, F. Y., Vigneau, S. & Bartolomei, M. S. Genomic imprinting mechanisms in mammals. Mutat. Res. 647, 77-85, doi:10.1016/j.mrfmmm.2008.08.008 (2008).
    • (2008) Mutat. Res. , vol.647 , pp. 77-85
    • Ideraabdullah, F.Y.1    Vigneau, S.2    Bartolomei, M.S.3
  • 32
    • 0034713375 scopus 로고    scopus 로고
    • Methylation of a CTCF-dependent boundary controls imprinted expression of the igf2 gene
    • Bell, A. C. & Felsenfeld, G. Methylation of a CTCF-dependent boundary controls imprinted expression of the Igf2 gene. Nature 405, 482-485, doi:10.1038/35013100 (2000).
    • (2000) Nature , vol.405 , pp. 482-485
    • Bell, A.C.1    Felsenfeld, G.2
  • 33
    • 0034713275 scopus 로고    scopus 로고
    • CTCF mediates methylation-sensitive enhancer-blocking activity at the H19/Igf2 locus
    • Hark, A. T. et al. CTCF mediates methylation-sensitive enhancer-blocking activity at the H19/Igf2 locus. Nature 405, 486-489, doi:10.1038/35013106 (2000).
    • (2000) Nature , vol.405 , pp. 486-489
    • Hark, A.T.1
  • 34
    • 0033529654 scopus 로고    scopus 로고
    • The protein CTCF is required for the enhancer blocking activity of vertebrate insulators
    • Bell, A. C., West, A. G. & Felsenfeld, G. The protein CTCF is required for the enhancer blocking activity of vertebrate insulators. Cell 98, 387-396 (1999).
    • (1999) Cell , vol.98 , pp. 387-396
    • Bell, A.C.1    West, A.G.2    Felsenfeld, G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.