-
1
-
-
14944385553
-
Global cancer statistics, 2002
-
Parkin, D. M., Bray, F., Ferlay, J. & Pisani, P. Global cancer statistics, 2002. CA Cancer J. Clin. 55, 74-108 (2005).
-
(2005)
CA Cancer J. Clin.
, vol.55
, pp. 74-108
-
-
Parkin, D.M.1
Bray, F.2
Ferlay, J.3
Pisani, P.4
-
2
-
-
33745726677
-
Perioperative chemotherapy versus surgery alone for resectable gastroesophageal cancer
-
Cunningham, D. et al. Perioperative chemotherapy versus surgery alone for resectable gastroesophageal cancer. N. Engl. J. Med. 355, 11-20, doi:10.1056/NEJMoa055531 (2006).
-
(2006)
N. Engl. J. Med.
, vol.355
, pp. 11-20
-
-
Cunningham, D.1
-
3
-
-
84862181925
-
Targeting the EGFR-family for therapy: Biological challenges and clinical perspective
-
Patel, R. & Leung, H. Y. Targeting the EGFR-family for therapy: biological challenges and clinical perspective. Curr. Pharm. Des. 18, 2672-2679 (2012).
-
(2012)
Curr. Pharm. Des.
, vol.18
, pp. 2672-2679
-
-
Patel, R.1
Leung, H.Y.2
-
4
-
-
33645761156
-
Clinical implications of EGFR expression in the development and progression of solid tumors: Focus on non-small cell lung cancer
-
Ettinger, D. S. Clinical implications of EGFR expression in the development and progression of solid tumors: focus on non-small cell lung cancer. Oncologist 11, 358-373, doi:10.1634/theoncologist.11-4-358 (2006).
-
(2006)
Oncologist
, vol.11
, pp. 358-373
-
-
Ettinger, D.S.1
-
5
-
-
84874180366
-
EGFR and downstream genetic alterations in KRAS/BRAF and PI3K/AKT pathways in colorectal cancer: Implications for targeted therapy
-
Berg, M. & Soreide, K. EGFR and downstream genetic alterations in KRAS/BRAF and PI3K/AKT pathways in colorectal cancer: implications for targeted therapy. Discov. Med. 14, 207-214 (2012).
-
(2012)
Discov. Med.
, vol.14
, pp. 207-214
-
-
Berg, M.1
Soreide, K.2
-
6
-
-
84860803116
-
Targeting EGFR in pancreatic cancer treatment
-
Troiani, T. et al. Targeting EGFR in pancreatic cancer treatment. Curr. Drug Targets 13, 802-810 (2012).
-
(2012)
Curr. Drug Targets
, vol.13
, pp. 802-810
-
-
Troiani, T.1
-
7
-
-
79961024637
-
Targeting the human EGFR family in esophagogastric cancer
-
Okines, A., Cunningham, D. & Chau, I. Targeting the human EGFR family in esophagogastric cancer. Nat. Rev. Clin. Oncol. 8, 492-503, doi:10.1038/nrclinonc.2011.45 (2011).
-
(2011)
Nat. Rev. Clin. Oncol.
, vol.8
, pp. 492-503
-
-
Okines, A.1
Cunningham, D.2
Chau, I.3
-
8
-
-
0037795412
-
Clinical significance of the epidermal growth factor receptor and HER2 receptor in resectable gastric cancer
-
Garcia, I. et al. Clinical significance of the epidermal growth factor receptor and HER2 receptor in resectable gastric cancer. Ann. Surg. Oncol. 10, 234-241 (2003).
-
(2003)
Ann. Surg. Oncol.
, vol.10
, pp. 234-241
-
-
Garcia, I.1
-
9
-
-
84855884072
-
Targeting the EGFR signaling pathway in cancer therapy
-
Seshacharyulu, P. et al. Targeting the EGFR signaling pathway in cancer therapy. Expert Opin. Ther. Targets 16, 15-31, doi:10.1 517/14728222.2011.648617 (2012).
-
(2012)
Expert Opin. Ther. Targets
, vol.16
, pp. 15-31
-
-
Seshacharyulu, P.1
-
10
-
-
84875129831
-
DNA methylation dynamics in health and disease
-
Bergman, Y. & Cedar, H. DNA methylation dynamics in health and disease. Nat. Struct. Mol. Biol. 20, 274-281, doi:10.1038/nsmb.2518 (2013).
-
(2013)
Nat. Struct. Mol. Biol.
, vol.20
, pp. 274-281
-
-
Bergman, Y.1
Cedar, H.2
-
11
-
-
42649133793
-
EGFR in gastric carcinomas: Prognostic significance of protein overexpression and high gene copy number
-
Kim, M. A. et al. EGFR in gastric carcinomas: prognostic significance of protein overexpression and high gene copy number. Histopathology 52, 738-746, doi:10.1111/j.1365-2559.2008.03021.x (2008).
-
(2008)
Histopathology
, vol.52
, pp. 738-746
-
-
Kim, M.A.1
-
12
-
-
0036500831
-
Monoclonal antibodies to target epidermal growth factor receptor-positive tumors: A new paradigm for cancer therapy
-
Herbst, R. S. & Shin, D. M. Monoclonal antibodies to target epidermal growth factor receptor-positive tumors: a new paradigm for cancer therapy. Cancer 94, 1593-1611 (2002).
-
(2002)
Cancer
, vol.94
, pp. 1593-1611
-
-
Herbst, R.S.1
Shin, D.M.2
-
13
-
-
0345098554
-
The epidermal growth factor receptor pathway and its inhibition as anticancer therapy
-
Janmaat, M. L. & Giaccone, G. The epidermal growth factor receptor pathway and its inhibition as anticancer therapy. Drugs Today (Barc) 39 (Suppl C), 61-80 (2003).
-
(2003)
Drugs Today (Barc)
, vol.39
, pp. 61-80
-
-
Janmaat, M.L.1
Giaccone, G.2
-
14
-
-
0034235955
-
Epidermal growth factor receptor blockade by antibody IMC-C225 inhibits growth of a human pancreatic carcinoma xenograft in nude mice
-
Overholser, J. P., Prewett, M. C., Hooper, A. T., Waksal, H. W. & Hicklin, D. J. Epidermal growth factor receptor blockade by antibody IMC-C225 inhibits growth of a human pancreatic carcinoma xenograft in nude mice. Cancer 89, 74-82 (2000).
-
(2000)
Cancer
, vol.89
, pp. 74-82
-
-
Overholser, J.P.1
Prewett, M.C.2
Hooper, A.T.3
Waksal, H.W.4
Hicklin, D.J.5
-
15
-
-
65249179550
-
Antibodies specifically targeting a locally misfolded region of tumor associated EGFR
-
Garrett, T. P. et al. Antibodies specifically targeting a locally misfolded region of tumor associated EGFR. Proc. Natl. Acad. Sci. USA 106, 5082-5087, doi:10.1073/pnas.0811559106 (2009).
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 5082-5087
-
-
Garrett, T.P.1
-
16
-
-
82455210218
-
Drug-induced interstitial lung disease in tyrosine kinase inhibitor therapy for non-small cell lung cancer: A review on current insight
-
Min, J. H. et al. Drug-induced interstitial lung disease in tyrosine kinase inhibitor therapy for non-small cell lung cancer: a review on current insight. Cancer Chemother. Pharmacol. 68, 1099-1109, doi:10.1007/s00280-011-1737-2 (2011).
-
(2011)
Cancer Chemother. Pharmacol.
, vol.68
, pp. 1099-1109
-
-
Min, J.H.1
-
17
-
-
0034954124
-
The type III epidermal growth factor receptor mutation. Biological significance and potential target for anti-cancer therapy
-
Pedersen, M. W., Meltorn, M., Damstrup, L. & Poulsen, H. S. The type III epidermal growth factor receptor mutation. Biological significance and potential target for anti-cancer therapy. Ann. Oncol. 12, 745-760 (2001).
-
(2001)
Ann. Oncol.
, vol.12
, pp. 745-760
-
-
Pedersen, M.W.1
Meltorn, M.2
Damstrup, L.3
Poulsen, H.S.4
-
18
-
-
2342471392
-
Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
-
Lynch, T. J. et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N. Engl. J. Med. 350, 2129-2139, doi:10.1056/NEJMoa040938 (2004).
-
(2004)
N. Engl. J. Med.
, vol.350
, pp. 2129-2139
-
-
Lynch, T.J.1
-
19
-
-
0026521394
-
Amplified and rearranged epidermal growth factor receptor genes in human glioblastomas reveal deletions of sequences encoding portions of the N- and/or C-terminal tails
-
Ekstrand, A. J., Sugawa, N., James, C. D. & Collins, V. P. Amplified and rearranged epidermal growth factor receptor genes in human glioblastomas reveal deletions of sequences encoding portions of the N- and/or C-terminal tails. Proc. Natl. Acad. Sci. USA 89, 4309-4313 (1992).
-
(1992)
Proc. Natl. Acad. Sci. USA
, vol.89
, pp. 4309-4313
-
-
Ekstrand, A.J.1
Sugawa, N.2
James, C.D.3
Collins, V.P.4
-
20
-
-
0029146954
-
EGFR gene amplification-rearrangement in human glioblastomas
-
Schwechheimer, K., Huang, S. & Cavenee, W. K. EGFR gene amplification-rearrangement in human glioblastomas. Int. J. Cancer 62, 145-148 (1995).
-
(1995)
Int. J. Cancer
, vol.62
, pp. 145-148
-
-
Schwechheimer, K.1
Huang, S.2
Cavenee, W.K.3
-
21
-
-
0037372003
-
Epigenetic regulation of gene expression: How the genome integrates intrinsic and environmental signals
-
Jaenisch, R. & Bird, A. Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals. Nat. Genet. 33 (Suppl), 245-254, doi:10.1038/ng1089 (2003).
-
(2003)
Nat. Genet.
, vol.33
, pp. 245-254
-
-
Jaenisch, R.1
Bird, A.2
-
22
-
-
34250630933
-
Epidermal growth factor receptor (EGFR) expression is associated with a worse prognosis in gastric cancer patients undergoing curative surgery
-
Galizia, G. et al. Epidermal growth factor receptor (EGFR) expression is associated with a worse prognosis in gastric cancer patients undergoing curative surgery. World J. Surg. 31, 1458-1468, doi:10.1007/s00268-007-9016-4 (2007).
-
(2007)
World J. Surg.
, vol.31
, pp. 1458-1468
-
-
Galizia, G.1
-
23
-
-
38049177080
-
Expression of vascular endothelial growth factor (VEGF) and epidermal growth factor receptor (EGFR) is an independent prognostic indicator of worse outcome in gastric cancer patients
-
Lieto, E. et al. Expression of vascular endothelial growth factor (VEGF) and epidermal growth factor receptor (EGFR) is an independent prognostic indicator of worse outcome in gastric cancer patients. Ann. Surg. Oncol. 15, 69-79, doi:10.1245/s10434-007-9596-0 (2008).
-
(2008)
Ann. Surg. Oncol.
, vol.15
, pp. 69-79
-
-
Lieto, E.1
-
24
-
-
0032033804
-
Expression of metastasis-related genes in surgical specimens of human gastric cancer can predict disease recurrence
-
Anzai, H. et al. Expression of metastasis-related genes in surgical specimens of human gastric cancer can predict disease recurrence. Eur. J. Cancer 34, 558-565 (1998).
-
(1998)
Eur. J. Cancer
, vol.34
, pp. 558-565
-
-
Anzai, H.1
-
25
-
-
0029811249
-
Increased estrogen receptor and epidermal growth factor receptor gene product co-expression in surgically resected gastric adenocarcinomas
-
Koullias, G. J. et al. Increased estrogen receptor and epidermal growth factor receptor gene product co-expression in surgically resected gastric adenocarcinomas. J. Surg. Oncol. 63, 166-171, doi:10.1002/(SICI)1096-9098(199611)63:3<166::AIDJSO6>3.0.CO;2-B (1996).
-
(1996)
J. Surg. Oncol.
, vol.63
, pp. 166-171
-
-
Koullias, G.J.1
-
26
-
-
79957599577
-
Epidermal growth factor receptor (EGFR) gene promoter methylation and cetuximab treatment in colorectal cancer patients
-
Scartozzi, M. et al. Epidermal growth factor receptor (EGFR) gene promoter methylation and cetuximab treatment in colorectal cancer patients. Br. J. Cancer 104, 1786-1790, doi:10.1038/bjc.2011.161 (2011).
-
(2011)
Br. J. Cancer
, vol.104
, pp. 1786-1790
-
-
Scartozzi, M.1
-
27
-
-
84857789620
-
Concurrent hypermethylation of DNMT1, MGMT and EGFR genes in progression of gliomas
-
Gomori, E., Pal, J., Kovacs, B. & Doczi, T. Concurrent hypermethylation of DNMT1, MGMT and EGFR genes in progression of gliomas. Diagn Pathol. 7, 8, doi:10.1186/1746-1596-7-8 (2012).
-
(2012)
Diagn Pathol.
, vol.7
, pp. 8
-
-
Gomori, E.1
Pal, J.2
Kovacs, B.3
Doczi, T.4
-
28
-
-
84876959600
-
Methylation of the TERT promoter and risk stratification of childhood brain tumours: An integrative genomic and molecular study
-
Castelo-Branco, P. et al. Methylation of the TERT promoter and risk stratification of childhood brain tumours: an integrative genomic and molecular study. Lancet Oncol. 14, 534-542, doi:10.1016/S1470-2045(13)70110-4 (2013).
-
(2013)
Lancet Oncol.
, vol.14
, pp. 534-542
-
-
Castelo-Branco, P.1
-
29
-
-
0035117177
-
Wilms' tumor suppressor gene (WT1) is expressed in primary breast tumors despite tumor-specific promoter methylation
-
Loeb, D. M. et al. Wilms' tumor suppressor gene (WT1) is expressed in primary breast tumors despite tumor-specific promoter methylation. Cancer Res. 61, 921-925 (2001).
-
(2001)
Cancer Res.
, vol.61
, pp. 921-925
-
-
Loeb, D.M.1
-
30
-
-
33845324531
-
DNA methylation paradigm shift: 15-lipoxygenase-1 upregulation in prostatic intraepithelial neoplasia and prostate cancer by atypical promoter hypermethylation
-
Kelavkar, U. P. et al. DNA methylation paradigm shift: 15-lipoxygenase-1 upregulation in prostatic intraepithelial neoplasia and prostate cancer by atypical promoter hypermethylation. Prostaglandins Other Lipid Mediat 82, 185-197, doi:10.1016/j. prostaglandins.2006.05.015 (2007).
-
(2007)
Prostaglandins Other Lipid Mediat
, vol.82
, pp. 185-197
-
-
Kelavkar, U.P.1
-
31
-
-
55949131420
-
Genomic imprinting mechanisms in mammals
-
Ideraabdullah, F. Y., Vigneau, S. & Bartolomei, M. S. Genomic imprinting mechanisms in mammals. Mutat. Res. 647, 77-85, doi:10.1016/j.mrfmmm.2008.08.008 (2008).
-
(2008)
Mutat. Res.
, vol.647
, pp. 77-85
-
-
Ideraabdullah, F.Y.1
Vigneau, S.2
Bartolomei, M.S.3
-
32
-
-
0034713375
-
Methylation of a CTCF-dependent boundary controls imprinted expression of the igf2 gene
-
Bell, A. C. & Felsenfeld, G. Methylation of a CTCF-dependent boundary controls imprinted expression of the Igf2 gene. Nature 405, 482-485, doi:10.1038/35013100 (2000).
-
(2000)
Nature
, vol.405
, pp. 482-485
-
-
Bell, A.C.1
Felsenfeld, G.2
-
33
-
-
0034713275
-
CTCF mediates methylation-sensitive enhancer-blocking activity at the H19/Igf2 locus
-
Hark, A. T. et al. CTCF mediates methylation-sensitive enhancer-blocking activity at the H19/Igf2 locus. Nature 405, 486-489, doi:10.1038/35013106 (2000).
-
(2000)
Nature
, vol.405
, pp. 486-489
-
-
Hark, A.T.1
-
34
-
-
0033529654
-
The protein CTCF is required for the enhancer blocking activity of vertebrate insulators
-
Bell, A. C., West, A. G. & Felsenfeld, G. The protein CTCF is required for the enhancer blocking activity of vertebrate insulators. Cell 98, 387-396 (1999).
-
(1999)
Cell
, vol.98
, pp. 387-396
-
-
Bell, A.C.1
West, A.G.2
Felsenfeld, G.3
|