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Volumn 45, Issue 5, 2015, Pages 412-452

Ozone exposure and systemic biomarkers: Evaluation of evidence for adverse cardiovascular health impacts

Author keywords

Air pollution; Biomarkers; Causal framework; Epidemiology; Inflammation; Mode of action; Ozone; Risk assessment; Weight of evidence

Indexed keywords

BIOLOGICAL MARKER; C REACTIVE PROTEIN; HOMOCYSTEINE; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 1; INTERLEUKIN 10; INTERLEUKIN 6; INTERLEUKIN 8; OZONE; TUMOR NECROSIS FACTOR ALPHA; VASCULAR CELL ADHESION MOLECULE 1; AIR POLLUTANT;

EID: 84929172237     PISSN: 10408444     EISSN: 15476898     Source Type: Journal    
DOI: 10.3109/10408444.2015.1031371     Document Type: Review
Times cited : (80)

References (122)
  • 3
    • 84886483041 scopus 로고    scopus 로고
    • Short-term exposure to ozone does not impair vascular function or aff ect heart rate variability in healthy young men
    • Barath S, Langrish JP, Lundback M, Bosson JA, Goudie C, Newby DE, et al. (2013). Short-term exposure to ozone does not impair vascular function or aff ect heart rate variability in healthy young men. Toxicol Sci, 135, 292-9.
    • (2013) Toxicol Sci , vol.135 , pp. 292-299
    • Barath, S.1    Langrish, J.P.2    Lundback, M.3    Bosson, J.A.4    Goudie, C.5    Newby, D.E.6
  • 4
    • 20544458330 scopus 로고    scopus 로고
    • A meta-analysis of timeseries studies of ozone and mortality with comparison to the National Morbidity, Mortality, and Air Pollution Study
    • Bell ML, Dominici F, Samet JM. (2005). A meta-analysis of timeseries studies of ozone and mortality with comparison to the National Morbidity, Mortality, and Air Pollution Study. Epidemiology, 15, 436-45.
    • (2005) Epidemiology , vol.15 , pp. 436-445
    • Bell, M.L.1    Dominici, F.2    Samet, J.M.3
  • 6
    • 33644525912 scopus 로고    scopus 로고
    • Biological determinants of and reference values for plasma interleukin-8, monocyte chemoattractant protein-1, epidermal growth factor, and vascular endothelial growth factor: Results from the STANISLAS cohort
    • Berrahmoune H, Lamont JV, Herbeth B, Fitzgerald PS, Visvikis-Siest S. (2006). Biological determinants of and reference values for plasma interleukin-8, monocyte chemoattractant protein-1, epidermal growth factor, and vascular endothelial growth factor: results from the STANISLAS cohort. Clin Chem, 52, 504-10.
    • (2006) Clin Chem , vol.52 , pp. 504-510
    • Berrahmoune, H.1    Lamont, J.V.2    Herbeth, B.3    Fitzgerald, P.S.4    Visvikis-Siest, S.5
  • 7
    • 84876015737 scopus 로고    scopus 로고
    • Serum malondialdehyde level: Surrogate stress marker in the Sikkimese diabetics
    • Bhutia Y, Ghosh A, Sherpa ML, Pal R, Mohanta PK. (2011). Serum malondialdehyde level: surrogate stress marker in the Sikkimese diabetics. J Nat Sci Biol Med, 2, 107-12.
    • (2011) J Nat Sci Biol Med , vol.2 , pp. 107-112
    • Bhutia, Y.1    Ghosh, A.2    Sherpa, M.L.3    Pal, R.4    Mohanta, P.K.5
  • 8
    • 84857055272 scopus 로고    scopus 로고
    • Air pollution and markers of coagulation, infl ammation, and endothelial function: Associations and epigene-environment interactions in an elderly cohort
    • Bind MA, Baccarelli A, Zanobetti A, Tarantini L, Suh H, Vokonas P, Schwartz J. (2012). Air pollution and markers of coagulation, infl ammation, and endothelial function: associations and epigene-environment interactions in an elderly cohort. Epidemiology, 23, 332-40.
    • (2012) Epidemiology , vol.23 , pp. 332-340
    • Bind, M.A.1    Baccarelli, A.2    Zanobetti, A.3    Tarantini, L.4    Suh, H.5    Vokonas, P.6    Schwartz, J.7
  • 9
    • 0014150920 scopus 로고
    • Neutrophil-to-lymphocyte ratio as indicator of ozone exposure
    • Bobb GA, Fairchild EJ. (1967). Neutrophil-to-lymphocyte ratio as indicator of ozone exposure. Toxicol Appl Pharmacol, 11, 558-64.
    • (1967) Toxicol Appl Pharmacol , vol.11 , pp. 558-564
    • Bobb, G.A.1    Fairchild, E.J.2
  • 10
    • 0031770795 scopus 로고    scopus 로고
    • Acute eff ects of inhaled urban particles and ozone: Lung morphology, macrophage activity, and plasma endothelin-1
    • Bouthillier L, Vincent R, Goegan P, Adamson IY, Bjarnason S, Stewart M, et al. (1998). Acute eff ects of inhaled urban particles and ozone: lung morphology, macrophage activity, and plasma endothelin-1. Am J Pathol, 153, 1873-84.
    • (1998) Am J Pathol , vol.153 , pp. 1873-1884
    • Bouthillier, L.1    Vincent, R.2    Goegan, P.3    Adamson, I.Y.4    Bjarnason, S.5    Stewart, M.6
  • 11
    • 70349263586 scopus 로고    scopus 로고
    • Insights into the mechanisms and mediators of the eff ects of air pollution exposure on blood pressure and vascular function in healthy humans
    • Brook RD, Urch B, Dvonch JT, Bard RL, Speck M, Keeler G, et al. (2009). Insights into the mechanisms and mediators of the eff ects of air pollution exposure on blood pressure and vascular function in healthy humans. Hypertension, 54, 659-67.
    • (2009) Hypertension , vol.54 , pp. 659-667
    • Brook, R.D.1    Urch, B.2    Dvonch, J.T.3    Bard, R.L.4    Speck, M.5    Keeler, G.6
  • 12
    • 79960038616 scopus 로고    scopus 로고
    • Ambient air pollution and lipoprotein-associated phospholipase A2 in survivors of myocardial infarction
    • Bruske I, Hampel R, Baumgartner Z, R kerl R, Greven S, Koenig W, et al. (2011). Ambient air pollution and lipoprotein-associated phospholipase A2 in survivors of myocardial infarction. Environ Health Perspect, 119, 921-6.
    • (2011) Environ Health Perspect , vol.119 , pp. 921-926
    • Bruske, I.1    Hampel, R.2    Baumgartner, Z.3    Rkerl, R.4    Greven, S.5    Koenig, W.6
  • 14
    • 38749090972 scopus 로고    scopus 로고
    • Effects of chronic and acute ozone exposure on lipid peroxidation and antioxidant capacity in healthy young adults
    • Chen C, Arjomandi M, Balmes J, Tager I, Holland N. (2007). Eff ects of chronic and acute ozone exposure on lipid peroxidation and antioxidant capacity in healthy young adults. Environ Health Perspect, 115, 1732-7.
    • (2007) Environ Health Perspect , vol.115 , pp. 1732-1737
    • Chen, C.1    Arjomandi, M.2    Balmes, J.3    Tager, I.4    Holland, N.5
  • 15
    • 77954445446 scopus 로고    scopus 로고
    • Effect of ozone on response to ovalbumin & its modulation by vitamins C & e in sensitized guinea pigs
    • Chhabra SK, Yasir A, Chaudhry K, Shah B. (2010). Eff ect of ozone on response to ovalbumin & its modulation by vitamins C & E in sensitized guinea pigs. Indian J Med Res, 132, 87-93.
    • (2010) Indian J Med Res , vol.132 , pp. 87-93
    • Chhabra, S.K.1    Yasir, A.2    Chaudhry, K.3    Shah, B.4
  • 17
    • 34547941468 scopus 로고    scopus 로고
    • The eff ect of urban air pollution on infl ammation, oxidative stress, coagulation, and autonomic dysfunction in young adults
    • Chuang KJ, Chan CC, Su TC, Lee CT, Tang CS. (2007). The eff ect of urban air pollution on infl ammation, oxidative stress, coagulation, and autonomic dysfunction in young adults. Am J Respir Crit Care Med, 176, 370-6.
    • (2007) Am J Respir Crit Care Med , vol.176 , pp. 370-376
    • Chuang, K.J.1    Chan, C.C.2    Su, T.C.3    Lee, C.T.4    Tang, C.S.5
  • 18
    • 77949483486 scopus 로고    scopus 로고
    • Eff ect of air pollution on blood pressure, blood lipids, and blood sugar: A population-based approach
    • Chuang KJ, Yan YH, Cheng TJ. (2010). Eff ect of air pollution on blood pressure, blood lipids, and blood sugar: a population-based approach. J Occup Environ Med, 52, 258-62.
    • (2010) J Occup Environ Med , vol.52 , pp. 258-262
    • Chuang, K.J.1    Yan, Y.H.2    Cheng, T.J.3
  • 19
    • 84902174660 scopus 로고    scopus 로고
    • Interleukin 1, interleukin 6, interleukin 10, and tumor necrosis factor a in active and quiescent systemic lupus erythematosus
    • Cigni A, Pileri PV, Faedda R, Gallo P, Sini A, Satta AE, et al. (2014). Interleukin 1, interleukin 6, interleukin 10, and tumor necrosis factor a in active and quiescent systemic lupus erythematosus. J Invest Med, 62, 825-9. doi:10.231/JIM.0000000000000085.
    • (2014) J Invest Med , vol.62 , pp. 825-829
    • Cigni, A.1    Pileri, P.V.2    Faedda, R.3    Gallo, P.4    Sini, A.5    Satta, A.E.6
  • 20
    • 67651202238 scopus 로고    scopus 로고
    • Promotion of cardiovascular disease by exposure to the air pollutant ozone
    • Cole MP, Freeman BA. (2009). Promotion of cardiovascular disease by exposure to the air pollutant ozone. Am J Physiol Lung Cell Mol Physiol, 297, L205-8.
    • (2009) Am J Physiol Lung Cell Mol Physiol , vol.297 , pp. L205-L208
    • Cole, M.P.1    Freeman, B.A.2
  • 21
    • 78649979299 scopus 로고    scopus 로고
    • Morpho-pathological and physiological changes of the brain and liver after ozone exposure
    • Cretu DI, Sovrea A, Ignat RM, Filip A, Bidian C, Cretu A. (2010). Morpho-pathological and physiological changes of the brain and liver after ozone exposure. Rom J Morphol Embryol, 51, 701-6.
    • (2010) Rom J Morphol Embryol , vol.51 , pp. 701-706
    • Cretu, D.I.1    Sovrea, A.2    Ignat, R.M.3    Filip, A.4    Bidian, C.5    Cretu, A.6
  • 22
    • 51749093324 scopus 로고    scopus 로고
    • Consensus panel recommendation for incorporating lipoprotein-associated phospholipase A2 testing into cardiovascular disease risk assessment guidelines
    • Davidson MH, Corson MA, Alberts MJ, Anderson JL, Gorelick PB, Jones PH, et al. (2011). Consensus panel recommendation for incorporating lipoprotein-associated phospholipase A2 testing into cardiovascular disease risk assessment guidelines. Am J Cardiol, ( 101 Suppl), 51F-7F. doi:10.1016/j.amjcard.2008.04.019
    • (2011) Am J Cardiol , vol.101 , pp. 51F-7F
    • Davidson, M.H.1    Corson, M.A.2    Alberts, M.J.3    Anderson, J.L.4    Gorelick, P.B.5    Jones, P.H.6
  • 23
    • 77958507033 scopus 로고    scopus 로고
    • Associations of primary and secondary organic aerosols with airway and systemic infl ammation in an elderly panel cohort
    • Delfi no RJ, Staimer N, Tjoa T, Arhami M, Polidori A, Gillen DL, et al. (2010). Associations of primary and secondary organic aerosols with airway and systemic infl ammation in an elderly panel cohort. Epidemiology, 21, 892-902.
    • (2010) Epidemiology , vol.21 , pp. 892-902
    • Delfino, R.J.1    Staimer, N.2    Tjoa, T.3    Arhami, M.4    Polidori, A.5    Gillen, D.L.6
  • 25
    • 0025174705 scopus 로고
    • Structure and function of thrombomodulin: A natural anticoagulant
    • Dittman WA, Majerus PW. (1990). Structure and function of thrombomodulin: a natural anticoagulant. Blood, 75, 329-36.
    • (1990) Blood , vol.75 , pp. 329-336
    • Dittman, W.A.1    Majerus, P.W.2
  • 26
    • 84859627495 scopus 로고    scopus 로고
    • Eff ects of exercise on systemic infl ammatory, coagulatory, and cardiac autonomic parameters in an inhalational exposure study
    • Donde A, Wong H, Frelinger J, Power K, Balmes JR, Arjomandi M. (2012). Eff ects of exercise on systemic infl ammatory, coagulatory, and cardiac autonomic parameters in an inhalational exposure study. J Occup Environ Med, 54, 466-70.
    • (2012) J Occup Environ Med , vol.54 , pp. 466-470
    • Donde, A.1    Wong, H.2    Frelinger, J.3    Power, K.4    Balmes, J.R.5    Arjomandi, M.6
  • 29
    • 0035874179 scopus 로고    scopus 로고
    • A new murine oxidative stress model associated with senescence
    • Feng R, He W, Ochi H. (2001). A new murine oxidative stress model associated with senescence. Mech Ageing Dev, 122, 547-59.
    • (2001) Mech Ageing Dev , vol.122 , pp. 547-559
    • Feng, R.1    He, W.2    Ochi, H.3
  • 30
    • 84879912527 scopus 로고    scopus 로고
    • Classical and novel biomarkers for cardiovascular risk prediction in the United States
    • Folsom AR. (2013). Classical and novel biomarkers for cardiovascular risk prediction in the United States. J Epidemiol, 23, 158-62. doi:10.2188/jea.JE20120157
    • (2013) J Epidemiol , vol.23 , pp. 158-162
    • Folsom, A.R.1
  • 31
    • 45249120307 scopus 로고    scopus 로고
    • The impact of secondary particles on the association between ambient ozone and mortality
    • Franklin M, Schwartz J. (2008). The impact of secondary particles on the association between ambient ozone and mortality. Environ Health Perspect, 116, 453-8.
    • (2008) Environ Health Perspect , vol.116 , pp. 453-458
    • Franklin, M.1    Schwartz, J.2
  • 32
    • 0023353650 scopus 로고
    • Changes in delayed hypersensitivity reaction in mice exposed to O 3
    • Fujimaki H, Shiraishi F, Ashikawa T, Murakami M. (1987). Changes in delayed hypersensitivity reaction in mice exposed to O 3. Environ Res, 43, 186-90.
    • (1987) Environ Res , vol.43 , pp. 186-190
    • Fujimaki, H.1    Shiraishi, F.2    Ashikawa, T.3    Murakami, M.4
  • 33
    • 84862907755 scopus 로고    scopus 로고
    • Biomarkers and cardiovascular risk assessment for primary prevention: An update
    • Gilstrap LG, Wang TJ. (2012). Biomarkers and cardiovascular risk assessment for primary prevention: an update. Clin Chem, 58, 72-82.
    • (2012) Clin Chem , vol.58 , pp. 72-82
    • Gilstrap, L.G.1    Wang, T.J.2
  • 35
    • 84888628894 scopus 로고    scopus 로고
    • Evaluation of the causal framework used for setting National Ambient Air Quality Standards
    • Goodman JE, Prueitt RL, Sax SN, Bailey LA, Rhomberg LR. (2013). Evaluation of the causal framework used for setting National Ambient Air Quality Standards. Crit Rev Toxicol, 43, 829-49. doi:10.3109/10 408444.2013.837864.
    • (2013) Crit Rev Toxicol , vol.43 , pp. 829-849
    • Goodman, J.E.1    Prueitt, R.L.2    Sax, S.N.3    Bailey, L.A.4    Rhomberg, L.R.5
  • 36
    • 84925233358 scopus 로고    scopus 로고
    • Weight-of-evidence evaluation of short-term ozone exposure and cardiovascular eff ects
    • Goodman JE, Prueitt RL, Sax SN, Lynch HN, Zu K, Lemay JC, et al. (2014). Weight-of-evidence evaluation of short-term ozone exposure and cardiovascular eff ects. Crit Rev Toxicol 44 725-90. doi:10.3109/10408444.2014.937854.
    • (2014) Crit Rev Toxicol , vol.44 , pp. 725-790
    • Goodman, J.E.1    Prueitt, R.L.2    Sax, S.N.3    Lynch, H.N.4    Zu, K.5    Lemay, J.C.6
  • 37
    • 84927633970 scopus 로고    scopus 로고
    • Are the elements of the proposed ozone National Ambient Air Quality Standards based on the best available science
    • In press
    • Goodman JE, Sax SN, Lange S, Rhomberg LR. (2015). Are the elements of the proposed ozone National Ambient Air Quality Standards based on the best available science Reg Toxicol Pharmacol. In press.
    • (2015) Reg Toxicol Pharmacol
    • Goodman, J.E.1    Sax, S.N.2    Lange, S.3    Rhomberg, L.R.4
  • 38
    • 84878097423 scopus 로고    scopus 로고
    • Biomarkers of dose and eff ect of inhaled ozone in resting versus exercising human subjects: Comparison with resting rats
    • Hatch GE, McKee J, Brown J, McDonnell W, Seal E, Soukup J, et al. (2013). Biomarkers of dose and eff ect of inhaled ozone in resting versus exercising human subjects: comparison with resting rats. Biomark Insights, 8, 53-67.
    • (2013) Biomark Insights , vol.8 , pp. 53-67
    • Hatch, G.E.1    McKee, J.2    Brown, J.3    McDonnell, W.4    Seal, E.5    Soukup, J.6
  • 39
    • 0028037656 scopus 로고
    • Ozone dose and eff ect in humans and rats. A comparison using oxygen,-18 labeling and bronchoalveolar lavage
    • Hatch GE, Slade R, Harris LP, McDonnell WF, Devlin RB, Koren HS, et al. (1994). Ozone dose and eff ect in humans and rats. A comparison using oxygen,-18 labeling and bronchoalveolar lavage. Am J Respir Crit Care Med, 150, 676-83.
    • (1994) Am J Respir Crit Care Med , vol.150 , pp. 676-683
    • Hatch, G.E.1    Slade, R.2    Harris, L.P.3    McDonnell, W.F.4    Devlin, R.B.5    Koren, H.S.6
  • 40
    • 84929217042 scopus 로고    scopus 로고
    • Cat. 5366, 5367, 5368, 5369. Available at Accessed on 9 December 2014
    • Helena Laboratories. (2012). Helena platelet aggregation reagents. Cat. No. 5366, 5367, 5368, 5369. Available at: http://www.helena.com/Procedures/Pro063Rev7.pdf. Accessed on 9 December 2014.
    • (2012) Helena Platelet Aggregation Reagents
    • Helena, L.1
  • 41
    • 31844443695 scopus 로고
    • The environment and disease: Association or causation
    • Hill AB. (1965). The environment and disease: association or causation Proc R Soc Med, 58, 295-300.
    • (1965) Proc R Soc Med , vol.58 , pp. 295-300
    • Hill, A.B.1
  • 42
    • 84991041599 scopus 로고    scopus 로고
    • Institute of Medicine (IOM) Committee on Evaluation of the Presumptive Disability Decision-Making Process for Veterans, Board on Military and Veterans Health. National Academies Press [Online] Available at Accessed on 9 October 2009
    • Institute of Medicine (IOM).(2008). Improving the Presumptive Disability Decision-Making Process for Veterans. Committee on Evaluation of the Presumptive Disability Decision-Making Process for Veterans, Board on Military and Veterans Health. National Academies Press [Online]. 781p. Available at: http://books.nap.edu/openbook. phprecord-id-11908. Accessed on 9 October 2009.
    • (2008) Improving the Presumptive Disability Decision-Making Process for Veterans
  • 43
    • 57749092004 scopus 로고    scopus 로고
    • The pathology of atherosclerosis: Plaque development and plaque responses to medical treatment
    • Insull W. (2009). The pathology of atherosclerosis: Plaque development and plaque responses to medical treatment. Am J Med, 122(Suppl 1), S3-S14.
    • (2009) Am J Med , vol.122 , pp. S3-S14
    • Insull, W.1
  • 44
    • 11244262844 scopus 로고    scopus 로고
    • The level of some acute phase proteins, total protein, gamma-globulins and activity of lysozyme in blood plasma of rats supplemented with vitamin e and exposed to ozone
    • Jakubowski K, Jedlinska-Krakowska M, Siwicki AK. (2004). The level of some acute phase proteins, total protein, gamma-globulins and activity of lysozyme in blood plasma of rats supplemented with vitamin E and exposed to ozone. Pol J Vet Sci, 7, 283-7.
    • (2004) Pol J Vet Sci , vol.7 , pp. 283-287
    • Jakubowski, K.1    Jedlinska-Krakowska, M.2    Siwicki, A.K.3
  • 46
    • 84878127644 scopus 로고    scopus 로고
    • Biomarkers of oxidative stress study V: Ozone exposure of rats and its eff ect on lipids, proteins, and DNA in plasma and urine
    • Kadiiska MB, Basu S, Brot N, Cooper C, Saari Csallany A, Davies MJ, et al. (2013). Biomarkers of oxidative stress study V: ozone exposure of rats and its eff ect on lipids, proteins, and DNA in plasma and urine. Free Radic Biol Med, 61, 408-15. doi:10.1016/j. freeradbiomed.2013.04.023.
    • (2013) Free Radic Biol Med , vol.61 , pp. 408-415
    • Kadiiska, M.B.1    Basu, S.2    Brot, N.3    Cooper, C.4    Saari Csallany, A.5    Davies, M.J.6
  • 47
    • 80053601061 scopus 로고    scopus 로고
    • Biomarkers of oxidative stress study IV: Ozone exposure of rats and its eff ect on antioxidants in plasma and bronchoalveolar lavage fl uid
    • Kadiiska MB, Hatch GE, Nyska A, Jones DP, Hensley K, Stocker R, et al. (2011). Biomarkers of oxidative stress study IV: ozone exposure of rats and its eff ect on antioxidants in plasma and bronchoalveolar lavage fl uid. Free Radic Biol. Med, 51, 1636-42. doi:10.1016/j. freeradbiomed.2011.07.013.
    • (2011) Free Radic Biol. Med , vol.51 , pp. 1636-1642
    • Kadiiska, M.B.1    Hatch, G.E.2    Nyska, A.3    Jones, D.P.4    Hensley, K.5    Stocker, R.6
  • 48
    • 0141925659 scopus 로고    scopus 로고
    • Fibrinogen: Biochemistry, epidemiology and determinants
    • Kamath S, Lip GYH. (2003). Fibrinogen: biochemistry, epidemiology and determinants. QJM, 96, 711-29.
    • (2003) QJM , vol.96 , pp. 711-729
    • Kamath, S.1    Lip, G.Y.H.2
  • 50
    • 85041813459 scopus 로고    scopus 로고
    • Improving bioscience research reporting: The ARRIVE guidelines for reporting animal research
    • Kilkenny C, Browne WJ, Cuthill IC, Emerson M, Altman DG. (2010). Improving bioscience research reporting: the ARRIVE guidelines for reporting animal research. PLoS Biol, 8, e1000412.
    • (2010) PLoS Biol , vol.8 , pp. e1000412
    • Kilkenny, C.1    Browne, W.J.2    Cuthill, I.C.3    Emerson, M.4    Altman, D.G.5
  • 54
    • 84864434153 scopus 로고    scopus 로고
    • A review on metaanalysis of biomarkers: Promises and pitfalls
    • Lewington S, Bragg F, Clarke R. (2012). A review on metaanalysis of biomarkers: promises and pitfalls. Clin Chem, 58, 1192-204.
    • (2012) Clin Chem , vol.58 , pp. 1192-1204
    • Lewington, S.1    Bragg, F.2    Clarke, R.3
  • 56
    • 79956319051 scopus 로고    scopus 로고
    • Progress and challenges in translating the biology of atherosclerosis
    • Libby P, Ridker PM, Hansson GK. (2011). Progress and challenges in translating the biology of atherosclerosis. Nature, 473, 317-25.
    • (2011) Nature , vol.473 , pp. 317-325
    • Libby, P.1    Ridker, P.M.2    Hansson, G.K.3
  • 57
    • 0011972869 scopus 로고    scopus 로고
    • Prevention and treatment of atherosclerosis
    • New York: McGraw-Hill
    • Libby P. (2001). Prevention and treatment of atherosclerosis. In: Braunwald, E, Fauci, AS, Kasper, DL, Hauser, SL, Longo, DL, Jameson, JL, eds. Harrison ' ' s Principles of Internal Medicine, 15th edition. New York: McGraw-Hill, pp. 1382-6.
    • (2001) Harrison S Principles of Internal Medicine, 15th Edition , pp. 1382-1386
    • Libby, P.1
  • 58
    • 80053408119 scopus 로고    scopus 로고
    • Long-term exposure to air pollution sand cardiorespiratory disease in the California teachers study cohort
    • Lipsett MJ, Ostro BD, Reynolds P, Goldberg D, Hertz A, Jerrett M, et al. (2011). Long-term exposure to air pollution sand cardiorespiratory disease in the California teachers study cohort. Am J Respir Crit Care Med, 184, 828-35.
    • (2011) Am J Respir Crit Care Med , vol.184 , pp. 828-835
    • Lipsett, M.J.1    Ostro, B.D.2    Reynolds, P.3    Goldberg, D.4    Hertz, A.5    Jerrett, M.6
  • 59
    • 0030459727 scopus 로고    scopus 로고
    • Hydroxylation of salicylate in lungs of Fischer 344 rats: Eff ects of aging and ozone exposure
    • Liu L, Kumarathasan P, Guenette J, Vincent R. (1996). Hydroxylation of salicylate in lungs of Fischer 344 rats: eff ects of aging and ozone exposure. Am J Physiol, 271(6 pt. 1), L995-1003.
    • (1996) Am J Physiol , vol.271 , Issue.6 , pp. L995-1003
    • Liu, L.1    Kumarathasan, P.2    Guenette, J.3    Vincent, R.4
  • 61
    • 0030712096 scopus 로고    scopus 로고
    • In vivo salicylate hydroxylation: A potential biomarker for assessing acute ozone exposure and eff ects in humans
    • Liu L, Leech JA, Urch RB, Silverman FS. (1997). In vivo salicylate hydroxylation: a potential biomarker for assessing acute ozone exposure and eff ects in humans. Am J Respir Crit Care Med, 156, 1405-12.
    • (1997) Am J Respir Crit Care Med , vol.156 , pp. 1405-1412
    • Liu, L.1    Leech, J.A.2    Urch, R.B.3    Silverman, F.S.4
  • 62
    • 76349121984 scopus 로고    scopus 로고
    • Defi ning and setting national goals for cardiovascular health promotion and disease reduction: The American Heart Association ' ' s strategic impact goal through 2020 and beyond
    • Lloyd-Jones DM, Hong Y, Labarthe D, Mozaff arian D, Appel LJ, Van Horn L, et al. (2010). Defi ning and setting national goals for cardiovascular health promotion and disease reduction: the American Heart Association ' ' s strategic impact goal through 2020 and beyond. Circulation, 121, 586-613.
    • (2010) Circulation , vol.121 , pp. 586-613
    • Lloyd-Jones, D.M.1    Hong, Y.2    Labarthe, D.3    Mozaffarian, D.4    Appel, L.J.5    Van Horn, L.6
  • 65
    • 0002157973 scopus 로고    scopus 로고
    • Determinants of gas and vapor uptake in the respiratory tract
    • Medinsky MA. (1996). Determinants of gas and vapor uptake in the respiratory tract. CIIT Activities, 16, 1-6.
    • (1996) CIIT Activities , vol.16 , pp. 1-6
    • Medinsky, M.A.1
  • 66
    • 0029609045 scopus 로고
    • Uptake and fate of ozone in the respiratory tract
    • Miller FJ. (1995). Uptake and fate of ozone in the respiratory tract. Toxicol Lett, 82-83, 277-85.
    • (1995) Toxicol Lett , vol.82-83 , pp. 277-285
    • Miller, F.J.1
  • 68
    • 84873821419 scopus 로고    scopus 로고
    • Metabolic biomarkers for predicting cardiovascular disease
    • Montgomery JE, Brown JR. (2013). Metabolic biomarkers for predicting cardiovascular disease. Vasc Health Risk Manag, 9, 37-45.
    • (2013) Vasc Health Risk Manag , vol.9 , pp. 37-45
    • Montgomery, J.E.1    Brown, J.R.2
  • 69
    • 80052360839 scopus 로고    scopus 로고
    • Adult patients with congenital adrenal hyperplasia have elevated blood pressure but otherwise a normal cardiovascular risk profi le
    • Mooij CF, Kroese JM, Sweep FC, Hermus AR, Tack CJ. (2011). Adult patients with congenital adrenal hyperplasia have elevated blood pressure but otherwise a normal cardiovascular risk profi le. PLoS ONE, 6, e24204. doi:10.1371/journal.pone.0024204.
    • (2011) PLoS ONE , vol.6 , pp. e24204
    • Mooij, C.F.1    Kroese, J.M.2    Sweep, F.C.3    Hermus, A.R.4    Tack, C.J.5
  • 70
    • 84886797808 scopus 로고    scopus 로고
    • Macrophages in atherosclerosis: A dynamic balance
    • Moore KJ, Sheedy FJ, Fisher EA. (2013). Macrophages in atherosclerosis: a dynamic balance. Nat Rev Immunol, 13, 709-21. doi:10.1038/nri3520.
    • (2013) Nat Rev Immunol , vol.13 , pp. 709-721
    • Moore, K.J.1    Sheedy, F.J.2    Fisher, E.A.3
  • 71
    • 0023772696 scopus 로고
    • Ozone inhalation in rats: Eff ects on alkaline phosphatase and lactic dehydrogenase isoenzymes in lavage and plasma
    • Nachtman JP, Moon HL, Miles RC. (1988). Ozone inhalation in rats: eff ects on alkaline phosphatase and lactic dehydrogenase isoenzymes in lavage and plasma. Bull Environ Contam Toxicol, 41, 502-7
    • (1988) Bull Environ Contam Toxicol , vol.41 , pp. 502-507
    • Nachtman, J.P.1    Moon, H.L.2    Miles, R.C.3
  • 72
    • 84925239984 scopus 로고    scopus 로고
    • National Library of Medicine (NLM) Available at Accessed on 12 May 2014
    • National Library of Medicine (NLM). (2014). HazMap for ozone (CAS No. 10028-15-6). Available at: http://hazmap.nlm.nih.gov/categorydetails id-68 & table-copytblagents. Accessed on 12 May 2014.
    • (2014) HazMap for Ozone (CAS No. 10028-15-6)
  • 74
    • 84863600341 scopus 로고    scopus 로고
    • Reliability of serum biomarkers of infl ammation from repeated measures in healthy individuals
    • Navarro SL, Brasky TM, Schwarz Y, Song X, Wang CY, Kristal AR, et al. (2012). Reliability of serum biomarkers of infl ammation from repeated measures in healthy individuals. Cancer Epidemiol Biomarkers Prev, 21, 1167-770. doi:10.1158/1055-9965.EPI-12-0110.
    • (2012) Cancer Epidemiol Biomarkers Prev , vol.21 , pp. 1167-1770
    • Navarro, S.L.1    Brasky, T.M.2    Schwarz, Y.3    Song, X.4    Wang, C.Y.5    Kristal, A.R.6
  • 75
    • 29344461578 scopus 로고    scopus 로고
    • Organisation for Economic Co-operation and Development (OECD) Environment Directorate, Chemicals Group and Management Committee. EN, V/MC/CHEM(98), 17. OECD Series on Principles of Good Laboratory Practice and Compliance Monitoring January 21
    • Organisation for Economic Co-operation and Development (OECD).(1998). OECD Principles on Good Laboratory Practice (Revised). Environment Directorate, Chemicals Group and Management Committee. EN, V/MC/CHEM(98), 17. OECD Series on Principles of Good Laboratory Practice and Compliance Monitoring 1. 41p. January 21.
    • (1998) OECD Principles on Good Laboratory Practice (Revised) , vol.1
  • 77
    • 0037469232 scopus 로고    scopus 로고
    • Markers of infl ammation and cardiovascular disease: Application to clinical and public health practice: A statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association
    • Pearson TA, Mensah GA, Alexander RW, Anderson JL, Cannon RO III, Criqui M, et al. (2003). Markers of infl ammation and cardiovascular disease: application to clinical and public health practice: a statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association. Circulation, 107, 499-511. doi:10.1161/01.CIR.0000052939.59093.45.
    • (2003) Circulation , vol.107 , pp. 499-511
    • Pearson, T.A.1    Mensah, G.A.2    Alexander, R.W.3    Anderson, J.L.4    Cannon, R.O.5    Criqui, M.6
  • 80
    • 77649237310 scopus 로고    scopus 로고
    • Enhanced death signaling in ozone-exposed ischemic-reperfused hearts
    • Perepu RS, Garcia C, Dostal D, Sethi R. (2010). Enhanced death signaling in ozone-exposed ischemic-reperfused hearts. Mol Cell Biochem, 336, 55-64.
    • (2010) Mol Cell Biochem , vol.336 , pp. 55-64
    • Perepu, R.S.1    Garcia, C.2    Dostal, D.3    Sethi, R.4
  • 81
    • 84927135122 scopus 로고    scopus 로고
    • Providing perspective for interpreting cardiovascular mortality risks associated with ozone exposures
    • Petito Boyce C, Goodman JE, Sax SN, Loftus CT. (2015). Providing perspective for interpreting cardiovascular mortality risks associated with ozone exposures. Reg Tox Pharmacol, doi: 10.1016/j.yrtph.2015.03.009
    • (2015) Reg Tox Pharmacol
    • Petito Boyce, C.1    Goodman, J.E.2    Sax, S.N.3    Loftus, C.T.4
  • 82
    • 79951562375 scopus 로고    scopus 로고
    • The relationship of air pollution and surrogate markers of endothelial dysfunction in a population-based sample of children
    • Poursafa P, Kelishadi R, Lahijanzadeh A, Modaresi M, Javanmard SH, et al. (2011). The relationship of air pollution and surrogate markers of endothelial dysfunction in a population-based sample of children. BMC Public Health, 11, 115.
    • (2011) BMC Public Health , vol.11 , pp. 115
    • Poursafa, P.1    Kelishadi, R.2    Lahijanzadeh, A.3    Modaresi, M.4    Javanmard, S.H.5
  • 83
    • 84925241844 scopus 로고    scopus 로고
    • Weight-of-evidence evaluation of long-term ozone exposure and cardiovascular eff ects
    • Prueitt RL, Lynch HN, Zu K, Sax SN, Venditti FJ, Goodman JE. (2014). Weight-of-evidence evaluation of long-term ozone exposure and cardiovascular eff ects. Crit Rev Toxicol, 44, 791-822. doi:10.3109/10408444.2014.937855.
    • (2014) Crit Rev Toxicol , vol.44 , pp. 791-822
    • Prueitt, R.L.1    Lynch, H.N.2    Zu, K.3    Sax, S.N.4    Venditti, F.J.5    Goodman, J.E.6
  • 84
    • 79960076984 scopus 로고    scopus 로고
    • Urinary 8-hydroxy-2 '-deoxyguanosine as a biomarker of oxidative DNA damage induced by ambient pollution in the Normative Aging Study
    • Ren C, Fang S, Wright RO, Suh H, Schwartz J. (2011). Urinary 8-hydroxy-2 '-deoxyguanosine as a biomarker of oxidative DNA damage induced by ambient pollution in the Normative Aging Study. Occup Environ Med, 68, 562-9.
    • (2011) Occup Environ Med , vol.68 , pp. 562-569
    • Ren, C.1    Fang, S.2    Wright, R.O.3    Suh, H.4    Schwartz, J.5
  • 85
    • 77955906183 scopus 로고    scopus 로고
    • Hypothesis-based weight of evidence: A tool for evaluating and communicating uncertainties and inconsistencies in the large body of evidence in proposing a carcinogenic mode of action-Naphthalene as an example
    • Rhomberg LR, Bailey LA, Goodman JE. (2010). Hypothesis-based weight of evidence: a tool for evaluating and communicating uncertainties and inconsistencies in the large body of evidence in proposing a carcinogenic mode of action-Naphthalene as an example. Crit Rev Toxicol, 40, 671-96.
    • (2010) Crit Rev Toxicol , vol.40 , pp. 671-696
    • Rhomberg, L.R.1    Bailey, L.A.2    Goodman, J.E.3
  • 87
    • 84861059277 scopus 로고    scopus 로고
    • Association between changes in air pollution levels during the Beijing Olympics and biomarkers of infl ammation and thrombosis in healthy young adults
    • Rich DQ, Kipen HM, Huang W, Wang G, Wang Y, Zhu P, et al. (2012). Association between changes in air pollution levels during the Beijing Olympics and biomarkers of infl ammation and thrombosis in healthy young adults. JAMA, 307, 2068-78.
    • (2012) JAMA , vol.307 , pp. 2068-2078
    • Rich, D.Q.1    Kipen, H.M.2    Huang, W.3    Wang, G.4    Wang, Y.5    Zhu, P.6
  • 88
    • 0037078969 scopus 로고    scopus 로고
    • Comparison of C-reactive protein and low-density lipoprotein cholesterol levels in the prediction of fi rst cardiovascular events
    • Ridker PM, Rifai N, Rose L, Buring JE, Cook NR. (2002). Comparison of C-reactive protein and low-density lipoprotein cholesterol levels in the prediction of fi rst cardiovascular events. N Engl J Med, 347, 1557-65.
    • (2002) N Engl J Med , vol.347 , pp. 1557-1565
    • Ridker, P.M.1    Rifai, N.2    Rose, L.3    Buring, J.E.4    Cook, N.R.5
  • 89
    • 0034681920 scopus 로고    scopus 로고
    • Plasma concentration of interleukin-6 and the risk of future myocardial infarction among apparently healthy men
    • Ridker PM, Rifai N, Stampfer MJ, Hennekens CH. (2000). Plasma concentration of interleukin-6 and the risk of future myocardial infarction among apparently healthy men. Circulation, 101, 1767-72. doi: 10.1161/01.CIR.101.15.1767.
    • (2000) Circulation , vol.101 , pp. 1767-1772
    • Ridker, P.M.1    Rifai, N.2    Stampfer, M.J.3    Hennekens, C.H.4
  • 91
    • 0037443406 scopus 로고    scopus 로고
    • Von Willebrand disease type 1: A diagnosis in search of a disease
    • Sadler JE. (2003). Von Willebrand disease type 1: a diagnosis in search of a disease. Blood, 101, 2089-93.
    • (2003) Blood , vol.101 , pp. 2089-2093
    • Sadler, J.E.1
  • 93
    • 70349920745 scopus 로고    scopus 로고
    • Markers of infl ammation and risk of coronary heart disease
    • Sarwar N, Thompson AJ, Di Angelantonio E. (2009). Markers of infl ammation and risk of coronary heart disease. Dis Markers, 26, 217-25.
    • (2009) Dis Markers , vol.26 , pp. 217-225
    • Sarwar, N.1    Thompson, A.J.2    Di Angelantonio, E.3
  • 94
    • 0034958179 scopus 로고    scopus 로고
    • Air pollution and blood markers of cardiovascular risk
    • Schwartz J. (2001). Air pollution and blood markers of cardiovascular risk. Environ Health Perspect, ( 109 Suppl 3), 405-9.
    • (2001) Environ Health Perspect , vol.109 , pp. 405-409
    • Schwartz, J.1
  • 95
    • 84865649402 scopus 로고    scopus 로고
    • Diff erential expression of caveolin-1 and caveolin-3: Potential marker for cardiac toxicity subsequent to chronic ozone inhalation
    • Sethi R, Manchanda S, Perepu RS, Kumar A, Garcia C, Kennedy RH, et al. (2012). Diff erential expression of caveolin-1 and caveolin-3: potential marker for cardiac toxicity subsequent to chronic ozone inhalation. Mol Cell Biochem, 369, 9-15.
    • (2012) Mol Cell Biochem , vol.369 , pp. 9-15
    • Sethi, R.1    Manchanda, S.2    Perepu, R.S.3    Kumar, A.4    Garcia, C.5    Kennedy, R.H.6
  • 96
    • 79961102786 scopus 로고    scopus 로고
    • Publication bias in epidemiological studies
    • Siddiqi N. (2011). Publication bias in epidemiological studies. Cent Eur J Public Health, 19, 118-20.
    • (2011) Cent Eur J Public Health , vol.19 , pp. 118-120
    • Siddiqi, N.1
  • 97
    • 0027999047 scopus 로고
    • Levels of soluble VCAM1, soluble ICAM-1, and soluble E-selectin during disease exacerbations in patients with systemic lupus erythematosus (SLE), a long term prospective study
    • Spronk PE, Bootsma H, Huitema MG, Limburg PC, Kallenberg CGM. (1994). Levels of soluble VCAM1, soluble ICAM-1, and soluble E-selectin during disease exacerbations in patients with systemic lupus erythematosus (SLE), a long term prospective study. Clin Exp Immunol, 97, 439-44.
    • (1994) Clin Exp Immunol , vol.97 , pp. 439-444
    • Spronk, P.E.1    Bootsma, H.2    Huitema, M.G.3    Limburg, P.C.4    Kallenberg, C.G.M.5
  • 100
    • 84877586533 scopus 로고    scopus 로고
    • Components of ambient air pollution aff ect thrombin generation in healthy humans: The RAPTES project
    • Strak M, Hoek G, Steenhof M, Kilinc E, Godri KJ, Gosens I, et al. (2013). Components of ambient air pollution aff ect thrombin generation in healthy humans: the RAPTES project. Occup Environ Med, 70, 332-40.
    • (2013) Occup Environ Med , vol.70 , pp. 332-340
    • Strak, M.1    Hoek, G.2    Steenhof, M.3    Kilinc, E.4    Godri, K.J.5    Gosens, I.6
  • 101
    • 84882418517 scopus 로고    scopus 로고
    • Ambient fi ne particulate matter and ozone exposures induce infl ammation in epicardial and perirenal adipose tissues in rats fed a high fructose diet
    • Sun L, Liu C, Xu X, Ying Z, Maiseyeu A, Wang A, et al. (2013). Ambient fi ne particulate matter and ozone exposures induce infl ammation in epicardial and perirenal adipose tissues in rats fed a high fructose diet. Part Fibre Toxicol, 10, 43.
    • (2013) Part Fibre Toxicol , vol.10 , pp. 43
    • Sun, L.1    Liu, C.2    Xu, X.3    Ying, Z.4    Maiseyeu, A.5    Wang, A.6
  • 102
    • 0016574489 scopus 로고
    • Eff ect of ozone exposure on lecithin: Cholesterol acyltransferase activity in rat serum
    • Takatori T. (1975). Eff ect of ozone exposure on lecithin: cholesterol acyltransferase activity in rat serum. Hokkaido Igaku Zasshi, 50, 567-70.
    • (1975) Hokkaido Igaku Zasshi , vol.50 , pp. 567-570
    • Takatori, T.1
  • 103
    • 0029049462 scopus 로고
    • Epidemiology faces its limits
    • Taubes G. (1995). Epidemiology faces its limits. Science, 269, 164-9.
    • (1995) Science , vol.269 , pp. 164-169
    • Taubes, G.1
  • 104
    • 77149147091 scopus 로고    scopus 로고
    • Baseline repeated measures from controlled human exposure studies: Associations between ambient air pollution exposure and the systemic infl ammatory biomarkers IL-6 and fi brinogen
    • Thompson AM, Zanobetti A, Silverman F, Schwartz J, Coull B, Urch B, et al. (2010). Baseline repeated measures from controlled human exposure studies: associations between ambient air pollution exposure and the systemic infl ammatory biomarkers IL-6 and fi brinogen. Environ Health Perspect, 118, 120-4.
    • (2010) Environ Health Perspect , vol.118 , pp. 120-124
    • Thompson, A.M.1    Zanobetti, A.2    Silverman, F.3    Schwartz, J.4    Coull, B.5    Urch, B.6
  • 105
    • 33744932408 scopus 로고    scopus 로고
    • Pulmonary expression of preproET-1 and preproET-3 mRNAs is altered reciprocally in rats after inhalation of air pollutants
    • Thomson E, Kumarathasan P, Vincent R. (2006). Pulmonary expression of preproET-1 and preproET-3 mRNAs is altered reciprocally in rats after inhalation of air pollutants. Exp Biol Med, 231, 979-84.
    • (2006) Exp Biol Med , vol.231 , pp. 979-984
    • Thomson, E.1    Kumarathasan, P.2    Vincent, R.3
  • 106
    • 77149129854 scopus 로고    scopus 로고
    • Concentrated ambient fi ne particles and not ozone induce a systemic interleukin-6 response in humans
    • Urch B, Speck M, Corey P, Wasserstein D, Manno M, Lukic KZ, et al. (2010). Concentrated ambient fi ne particles and not ozone induce a systemic interleukin-6 response in humans. Inhal Toxicol, 22, 210-18
    • (2010) Inhal Toxicol , vol.22 , pp. 210-218
    • Urch, B.1    Speck, M.2    Corey, P.3    Wasserstein, D.4    Manno, M.5    Lukic, K.Z.6
  • 108
    • 77949416105 scopus 로고    scopus 로고
    • USEPA Offi ce of Research and Development, National Center for Environmental Assessment (NCEA)-RTP Division. EPA/600/R-08/139F December. Available at Accessed on 3 February 2010
    • USEPA. (2009). Integrated Science Assessment for Particulate Matter (Final). Offi ce of Research and Development, National Center for Environmental Assessment (NCEA)-RTP Division. EPA/600/R-08/139F. 2228p. December. Available at: http://www.epa.gov/ncea/pdfs/partmatt/Dec2009/PM-ISA-full.pdf. Accessed on 3 February 2010
    • (2009) Integrated Science Assessment for Particulate Matter (Final)
  • 111
    • 0028287274 scopus 로고
    • Ozone increases atrial natriuretic peptides in heart, lung and circulation of aged vs. Adult animals
    • Vesely DL, Giordano AT, Raska-Emery P, Montgomery MR. (1994a). Ozone increases atrial natriuretic peptides in heart, lung and circulation of aged vs. adult animals. Gerontology, 40, 227-36.
    • (1994) Gerontology , vol.40 , pp. 227-236
    • Vesely, D.L.1    Giordano, A.T.2    Raska-Emery, P.3    Montgomery, M.R.4
  • 112
    • 0028410549 scopus 로고
    • Ozone increases amino-and carboxy-terminal atrial natriuretic factor prohormone peptides in lung, heart, and circulation
    • Vesely DL, Giordano AT, Raska-Emery P, Montgomery MR. (1994b). Ozone increases amino-and carboxy-terminal atrial natriuretic factor prohormone peptides in lung, heart, and circulation. J Biochem Toxicol, 9, 107-12.
    • (1994) J Biochem Toxicol , vol.9 , pp. 107-112
    • Vesely, D.L.1    Giordano, A.T.2    Raska-Emery, P.3    Montgomery, M.R.4
  • 113
    • 0028271165 scopus 로고
    • Increase in atrial natriuretic factor in the lungs, heart, and circulatory system owing to ozone
    • Vesely DL, Giordano AT, Raska-Emery P, Montgomery MR. (1994c). Increase in atrial natriuretic factor in the lungs, heart, and circulatory system owing to ozone. Chest, 105, 1551-4.
    • (1994) Chest , vol.105 , pp. 1551-1554
    • Vesely, D.L.1    Giordano, A.T.2    Raska-Emery, P.3    Montgomery, M.R.4
  • 114
    • 2442453249 scopus 로고    scopus 로고
    • A review of surface ozone background levels and trends
    • Vingarzan R. (2004). A review of surface ozone background levels and trends. Atmos Environ, 38, 3431-42.
    • (2004) Atmos Environ , vol.38 , pp. 3431-3442
    • Vingarzan, R.1
  • 115
    • 13544275663 scopus 로고    scopus 로고
    • Rationale for using apolipoprotein B and apolipoprotein A-Ias indicators of cardiac risk and as targets for lipid-lowering therapy (Letter)
    • Walldius G, Jungner I. (2005). Rationale for using apolipoprotein B and apolipoprotein A-Ias indicators of cardiac risk and as targets for lipid-lowering therapy (Letter). Eur Heart J, 26, 210-12. doi:10.1093/eurheartj/ehi077.
    • (2005) Eur Heart J , vol.26 , pp. 210-212
    • Walldius, G.1    Jungner, I.2
  • 116
    • 84872178562 scopus 로고    scopus 로고
    • Eff ects of ozone and fi ne particulate matter (PM(2.5)) on rat system infl ammation and cardiac function
    • Wang G, Jiang R, Zhao Z, Song W. (2013). Eff ects of ozone and fi ne particulate matter (PM(2.5)) on rat system infl ammation and cardiac function. Toxicol Lett, 217, 23-33.
    • (2013) Toxicol Lett , vol.217 , pp. 23-33
    • Wang, G.1    Jiang, R.2    Zhao, Z.3    Song, W.4
  • 117
    • 84871365528 scopus 로고    scopus 로고
    • World Health Organization (WHO) Special Programme for Research and Training in Tropical Diseases (TDR). Report to United Nations Children ' s Fund (UNICEF, ); United Nations Development Programme (UNDP); World Bank
    • World Health Organization (WHO). (2009). Handbook: good Laboratory Practice (GLP): quality Practices for Regulated Non-Clinical Research and Development (Second Edition). Special Programme for Research and Training in Tropical Diseases (TDR). Report to United Nations Children ' s Fund (UNICEF, ); United Nations Development Programme (UNDP); World Bank. 328p.
    • (2009) Handbook: Good Laboratory Practice (GLP): Quality Practices for Regulated Non-Clinical Research and Development (Second Edition)
  • 118
    • 65849453194 scopus 로고    scopus 로고
    • Infl ammatory biomarkers in coronary artery disease
    • Zakynthinos E, Pappa N. (2009). Infl ammatory biomarkers in coronary artery disease. J Cardiology, 53, 317-33. doi:10.1016/j. jjcc.2008.12.007.
    • (2009) J Cardiology , vol.53 , pp. 317-333
    • Zakynthinos, E.1    Pappa, N.2
  • 120
    • 80053913305 scopus 로고    scopus 로고
    • Improved estimate of the policy-relevant background ozone in the United States using the GEOS-Chem global model with 2/3 horizontal resolution over North America
    • Zhang L, Jacob DJ, Downey NV, Wood DA, Blewitt D, Carouge CC, et al. (2011). Improved estimate of the policy-relevant background ozone in the United States using the GEOS-Chem global model with 2/3 horizontal resolution over North America. Atmos Environ, 45, 6769-76.
    • (2011) Atmos Environ , vol.45 , pp. 6769-6776
    • Zhang, L.1    Jacob, D.J.2    Downey, N.V.3    Wood, D.A.4    Blewitt, D.5    Carouge, C.C.6
  • 121
    • 84902252358 scopus 로고    scopus 로고
    • Association between serum homocysteine and arterial stiffness in elderly: A community-based study
    • Zhang S, Bai YY, Luo LM, Xiao WK, Wu HM, Ye P. (2014). Association between serum homocysteine and arterial stiffness in elderly: a community-based study. J Geriatr Cardiol, 11, 32-8. doi:10.3969/j. issn.1671-5411.2014.01.007.
    • (2014) J Geriatr Cardiol , vol.11 , pp. 32-38
    • Zhang, S.1    Bai, Y.Y.2    Luo, L.M.3    Xiao, W.K.4    Wu, H.M.5    Ye, P.6
  • 122
    • 77955924626 scopus 로고    scopus 로고
    • Conceptual and methodological issues relevant to cytokine and infl ammatory marker measurements in clinical research
    • Zhou X, Fragala MS, McElhaney JE, Kuchel GA. (2010). Conceptual and methodological issues relevant to cytokine and infl ammatory marker measurements in clinical research. Curr Opin Clin Nutr Metab Care, 13, 541-7.
    • (2010) Curr Opin Clin Nutr Metab Care , vol.13 , pp. 541-547
    • Zhou, X.1    Fragala, M.S.2    McElhaney, J.E.3    Kuchel, G.A.4


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