Hydroxylation of salicylate in lungs of Fischer 344 rats: Effects of aging and ozone exposure

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 271, Issue 6 15-6, 1996, Pages

  Liu, Ling ^a   Kumarathasan, Prem ^a   Guénette, Josée ^a   Vincent, Renaud ^a,b  

^a HEALTH CANADA   (Canada)

^b Environmental Health Centre Ottawa   (Canada)

Author keywords

biomarkers; hydroxyl radical; oxidative stress

Indexed keywords

BENZOIC ACID DERIVATIVE; OZONE; SALICYLIC ACID;

AGED; AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BREATHING; CONTROLLED STUDY; DRUG METABOLISM; MALE; NONHUMAN; OXIDATIVE STRESS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RAT;

EID: 0030459727     PISSN: 10400605     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajplung.1996.271.6.l995     Document Type: Article

References (34)

1. Evans, M. J., L. J. Cabral-Anderson, and G. Freeman. Effects of nitrogen dioxide on the lungs of aging rats. II. Cell proliferation. Exp. Mol. Pathol. 27: 366-376, 1977.
2. Evans, M. J., W. Mayr, R. F. Bils, and C. G. Loosli. Effects of ozone on cell renewal in pulmonary alveoli of aging mice. Arch. Environ. Health 22: 450-453, 1971.
3. 2-dependent hydroxyl radical production during ischemia-reperfusion lung injury. Am. J. Physiol. 265 (Lung Cell. Mol. Physiol. 9): L279-L285, 1993.
4. Flamm, D. L. Analysis of ozone at low concentrations with boric acid buffered KI. Environ. Sci. Technol. 11: 978-983, 1977
5. Freeman, B. A., and J. D. Crapo. Hyperoxia increases oxygen radical production in rat lungs and lung mitochondria. J. Biol. Chem. 256: 10986-10992, 1981.
6. Grootveld, M., and B. Halliwell. Aromatic hydroxylation as a potential measure of hydroxyl-radical formation in vivo. Biochem. J. 237: 499-504, 1986.
7. Hatch, G. E., R. Slade, L. P. Harris, W. F. McDonald, R. B. Devlin, H. S. Koren, D. L. Costa, and J. McKee. Ozone dose and effect in humans and rats: a comparison using oxygen-18 labeling and bronchoalveolar lavage. Am. Rev. Respir. Cell Mol. Biol. 150: 676-683, 1994.
8. Hatch, G. E., M. J. Wiester, J. H. Overton, and M. Aissa. Respiratory tract dosimetry of [18]O-labeled ozone in rats: implications for a rat-human extrapolation of ozone dose. In: Atmospheric Ozone Research and Its Policy Implications, edited by T. Schneider, S. D. Lee, G. J. R. Wolters, and L. D. Grant. Amsterdam: Elsevier, 1989, p. 553-560.
9. Ingelman-Sundberg, M., H. Kaur, Y. Terelius, J. O. Persson, and B. Halliwell. Hydroxylation of salicylate by microsomal fractions and cytochrome P-450. Lack of production of 2,3-dihydroxybenzoate unless hydroxyl radical formation is permitted. Biochem. J. 276: 753-757, 1991.
10. Koren, H. S., R. B. Devlin, D. E. Graham, R. Mann, M. P. McGee, D. H. Horstman, W. J. Kozumbo, S. Becker, D. E. House, and W. F. McDonnell. Ozone-induced inflammation in the lower airways of human subjects. Am. Rev. Respir. Dis. 139: 407-415, 1989.
11. Kyle, M. E., and J. J. Kocsis. The effect of age on salicylate-induced nephrotoxicity in male rats. Toxicol. Appl. Pharmacol. 81: 337-347, 1985.
12. Kyle, M. E., and J. J. Kocsis. Metabolism of salicylate by isolated kidney and liver mitochondria. Chem. Biol. Interactions 59: 325-335, 1986.
13. Lippmann, M. Health effects of tropospheric ozone: implications for recent research findings to ambient air quality standards. J. Expo. Anal. Environ. Epidemiol. 3: 103-129, 1993.
14. McMahon, T. F., J. J. Diliberto, and L. S. Birnbaum. Effects of age and dose on disposition and metabolism of salicylic acid in male Fischer 344 rats. Drug Metab. Dispos. 18: 494-503, 1990.
15. McMahon, T. F., J. O. Peggins, M. M. Centra, and M. Weiner. Age-related changes in biotransformation of azoxymethane and methylazoxymethanol in vitro. Xenobiotica 20: 501-513, 1990.
16. McMahon, T. F., S. A. Stefanski, R. E. Wilson, P. C. Blair, A. M. Clark, and L. S. Birnbaum. Comparative acute nephrotoxicity of salicylic acid, 2,3-dihydroxybenzoic acid, and 2,5-dihydroxybenzoic acid in young and middle aged Fischer 344 rats. Toxicology 66: 297-311, 1991.
17. Montgomery, M. R., P. Raska-Emery, and J. U. Balis. Age related differences in pulmonary response to ozone. Biochim. Biophys. Acta 890: 271-274, 1987.
18. Mustafa, M. G. Biochemical basis of ozone toxicity. Free Radical Biol. Med. 9. 245-265, 1990.
19. Overton, J. H., R. C. Graham, and F. J. Miller. A model of the regional uptake of gaseous pollutants in the lung. II. The sensitivity of ozone uptake in laboratory animal lungs to anatomical and ventillatory parameters. Toxicol. Appl. Pharmacol. 88: 418-432, 1987.
20. Pendino, K. J., T. M. Meidhof, D. E. Heck, J. D. Laskin, and D. L. Laskin. Inhibition of macrophages with gadolinium chloride abrogates ozone-induced pulmonary injury and inflammatory mediator production. Am. J. Respir. Cell Mol. Biol. 13: 125-132, 1995.
21. Pinkerton, K. E., P. Gehr, and J. D. Crapo. Architectural and cellular composition of the air-blood barrier. In: Comprehensive Treatise on Pulmonary Toxicology. Comparative Biology of the Normal Lung. Boca Raton, FL: CRC, 1991, vol. 1, chapt. 11, p. 121-128.
22. Pinkerton, K. E., R. Vincent, C. G. Plopper, and S. L. Young. Normal development, growth, and aging of the lung. In: Pathobiology of the Aging Rat, edited by U. Mohr, D. L. Dungworth, and C. C. Capen. Washington, DC: ILSI, 1992, vol. 1, p. 97-109.
23. Plopper, C. G., X. Duan, A. R. Buckpitt, and K. E. Pinkerton. Dose-dependent tolerance to ozone. IV. Site-specific elevation in antioxidant enzymes in the lungs of rats exposed for 90 days or 20 months. Toxicol. Appl. Pharmacol. 127: 124-131, 1994.
24. Pryor, W. A. How far does ozone penetrate into the pulmonary air/tissue boundary before it reacts? Free Radical Biol. Med. 12: 83-88, 1992.
25. Pryor, W. A., B. Das, and D. F. Church. The ozonation of unsaturated fatty acids: aldehydes and hydrogen peroxide as products and possible mediators of ozone toxicity. Chem. Res. Toxicol. 4: 341-348, 1991.
26. Pryor, W. A., D. G. Prier, and D. F. Church. Radical production from the interaction of ozone and PUFA as demonstrated by electron spin resonance spin-trapping techniques. Environ. Res. 24: 42-52, 1981.
27. Richter, C., J. W. Park, and B. N. Ames. Normal oxidative damage to mitochondrial and nuclear DNA is extensive. Proc. Natl. Acad. Sci. USA 85: 6465-6467, 1988.
28. Shapira, R. M., A. J. Ghio, R. M. Effros, J. Morrisey, U. A. Almagro, C. A. Dawson, and A. D. Hacker. Hydroxyl radical production and lung injury in the rat following silica or titanium dioxide instillation in vivo. Am. J. Respir. Cell Mol. Biol. 12: 220-226, 1995.
29. Tokumitsu, Y., S. Lee, and M. Ui. In vitro effects of nonsteroidal anti-inflammatory drugs on oxidative phosphorylation in rats. Biochem. Pharmacol. 26: 2101-2110, 1978.
30. Tosaki, A., D. Bagchi, T. Pali, G. A. Cordis, and D. K. Das. Comparisons of ESR and HPLC methods for the detection of OH· radicals in ischemic/reperfused hearts. A relationship between the genesis of free radicals and reperfusion arrhythmias. Biochem. Pharmacol 45: 961-969, 1993.
31. Varma, D. R., and T. L. Yue. Influence of age, sex, pregnancy and protein-calorie malnutrition on the pharmacokinetics of salicylate in rats. Br. J. Pharmacol. 82: 241-248, 1984.
32. Vincent, R., and I. Y. R. Adamson. Cellular kinetics in the lungs of aging Fischer 344 rats following acute exposure to ozone. Am. J. Pathol. 146: 1008-1016, 1995.
33. Vincent, R., E. G. Janzen, G. Chen, P. Kumarathasan, D. L. Haire, J. Guénette, J. Z. Chen, and T. M. Bray. Spin trapping study in the lungs and liver of F344 rats after exposure to ozone. Free Radical Res. 25: 475-488, 1996.
34. Vincent, R., D. Vu, G. Hatch, R. Poon, K. Dreher, J. Guénette, S. Bjarnason, M. Potvin, J. Norwood, and E. McMullen. Sensitivity of lungs of aging Fisher 344 rats to ozone: assessment by bronchoalveolar lavage. Am. J. Physiol. 271 (Lung Cell. Mol. Physiol. 15): L555-L565, 1996.