Short-term exposure to ozone does not impair vascular function or: Affect heart rate variability in healthy young men

Toxicological Sciences

Volumn 135, Issue 2, 2013, Pages 292-299

  Barath, Stefan ^a   Langrish, Jeremy P ^b   Lundbäck, Magnus ^a   Bosson, Jenny A ^a   Goudie, Colin ^b   Newby, David E ^b   Sandström, Thomas ^a   Mills, Nicholas L ^b   Blomberg, Anders ^a  

^a UMEÅ UNIVERSITY   (Sweden)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

Air pollution; Blood flow; Endothelium; Fibrinolysis; Oxidative stress; Ozone

Indexed keywords

ACETYLCHOLINE; NITROPRUSSIDE SODIUM; OZONE; VASODILATOR AGENT;

ADULT; AIR; AIR POLLUTANT; ARTICLE; AUTONOMIC NERVOUS SYSTEM FUNCTION; BLOOD PRESSURE; CARDIOVASCULAR FUNCTION; CONTROLLED STUDY; EXPOSURE; FIBRINOLYSIS; FOREARM BLOOD FLOW; HEART INNERVATION; HEART RATE VARIABILITY; HEART RHYTHM; HEMODYNAMIC MONITORING; HUMAN; HUMAN EXPERIMENT; LONG TERM EXPOSURE; MALE; NORMAL HUMAN; VASODILATATION; VASOMOTOR REFLEX; VEIN OCCLUSION PLETHYSMOGRAPHY;

AIR POLLUTION; BLOOD FLOW; ENDOTHELIUM; FIBRINOLYSIS; OXIDATIVE STRESS; OZONE.;

ADULT; AIR POLLUTANTS; BLOOD VESSELS; ENVIRONMENTAL EXPOSURE; FIBRINOLYSIS; HEALTHY VOLUNTEERS; HEART RATE; HUMANS; MALE; OZONE; YOUNG ADULT;

EID: 84886483041     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kft157     Document Type: Article

References (45)

1. Behndig, A. F., Blomberg, A., Helleday, R., Duggan, S. T., Kelly, F. J., and Mudway, I. S. (2009). Antioxidant responses to acute ozone challenge in the healthy human airway. Inhal. Toxicol. 21, 933-942.
2. Bell, M. L., Kim, J. Y., and Dominici, F. (2007). Potential confounding of particulate matter on the short-term association between ozone and mortality in multisite time-series studies. Environ. Health Perspect. 115, 1591-1595.
3. Bell, M. L., McDermott, A., Zeger, S. L., Samet, J. M., and Dominici, F. (2004). Ozone and short-term mortality in 95 US urban communities, 1987-2000. JAMA 292, 2372-2378.
4. Bhaskaran, K., Hajat, S., Haines, A., Herrett, E., Wilkinson, P., and Smeeth, L. (2009). Effects of air pollution on the incidence of myocardial infarction. Heart 95, 1746-1759.
5. Blomberg, A., Mudway, I. S., Nordenhäll, C., Hedenström, H., Kelly, F. J., Frew, A. J., Holgate, S. T., and Sandström, T. (1999). Ozone-induced lung function decrements do not correlate with early airway inflammatory or antioxidant responses. Eur. Respir. J. 13, 1418-1428.
6. Bosson, J., Barath, S., Pourazar, J., Behndig, A. F., Sandström, T., Blomberg, A., and Adelroth, E. (2008). Diesel exhaust exposure enhances the ozoneinduced airway inflammation in healthy humans. Eur. Respir. J. 31, 1234-1240.
7. Brook, R. D., Brook, J. R., Urch, B., Vincent, R., Rajagopalan, S., and Silverman, F. (2002). Inhalation of fine particulate air pollution and ozone causes acute arterial vasoconstriction in healthy adults. Circulation 105, 1534-1536.
8. Brook, R. D., Rajagopalan, S., Pope, C. A., 3rd, Brook, J. R., Bhatnagar, A., Diez-Roux, A. V., Holguin, F., Hong, Y., Luepker, R. V., Mittleman, M. A., et al.; American Heart Association Council on Epidemiology and Prevention, Council on the Kidney in Cardiovascular Disease, and Council on Nutrition, Physical Activity and Metabolism. (2010). Particulate matter air pollution and cardiovascular disease: An update to the scientific statement from the American Heart Association. Circulation 121, 2331-2378.
9. Brook, R. D., Urch, B., Dvonch, J. T., Bard, R. L., Speck, M., Keeler, G., Morishita, M., Marsik, F. J., Kamal, A. S., Kaciroti, N., et al. (2009). Insights into the mechanisms and mediators of the effects of air pollution exposure on blood pressure and vascular function in healthy humans. Hypertension 54, 659-667.
10. Brunekreef, B., and Holgate, S. T. (2002). Air pollution and health. Lancet 360, 1233-1242.
11. Chuang, K. J., Chan, C. C., Su, T. C., Lee, C. T., and Tang, C. S. (2007). The effect of urban air pollution on inflammation, oxidative stress, coagulation, and autonomic dysfunction in young adults. Am. J. Respir. Crit. Care Med. 176, 370-376.
12. Cosselman, K. E., Krishnan, R. M., Oron, A. P., Jansen, K., Peretz, A., Sullivan, J. H., Larson, T. V., and Kaufman, J. D. (2012). Blood pressure response to controlled diesel exhaust exposure in human subjects. Hypertension 59, 943-948.
13. de Almeida, S. P., Casimiro, E., and Calheiros, J. (2011). Short-term association between exposure to ozone and mortality in Oporto, Portugal. Environ. Res. 111, 406-410.
14. Devlin, R. B., Duncan, K. E., Jardim, M., Schmitt, M. T., Rappold, A. G., and Diaz-Sanchez, D. (2012). Controlled exposure of healthy young volunteers to ozone causes cardiovascular effects. Circulation 126, 104-111.
15. Di Filippo, C., Luongo, M., Marfella, R., Ferraraccio, F., Lettieri, B., Capuano, A., Rossi, F., and D'Amico, M. (2010). Oxygen/ozone protects the heart from acute myocardial infarction through local increase of eNOS activity and endothelial progenitor cells recruitment. Naunyn Schmiedebergs Arch. Pharmacol. 382, 287-291.
16. Di Filippo, C., Marfella, R., Capodanno, P., Ferraraccio, F., Coppola, L., Luongo, M., Mascolo, L., Luongo, C., Capuano, A., Rossi, F., et al. (2008). Acute oxygen-ozone administration to rats protects the heart from ischemia reperfusion infarct. Inflamm. Res. 57, 445-449.
17. Ensor, K. B., Raun, L. H., and Persse, D. (2013). A case-crossover analysis of out-of-hospital cardiac arrest and air pollution. Circulation 127, 1192-1199.
18. Frampton, M. W., Pryor, W. A., Cueto, R., Cox, C., Morrow, P. E., and Utell, M. J. (1999). Ozone exposure increases aldehydes in epithelial lining fluid in human lung. Am. J. Respir. Crit. Care Med. 159(4 Pt 1), 1134-1137.
19. Gryparis, A., Forsberg, B., Katsouyanni, K., Analitis, A., Touloumi, G., Schwartz, J., Samoli, E., Medina, S., Anderson, H. R., Niciu, E. M., et al. (2004). Acute effects of ozone on mortality from the "air pollution and health: A European approach" project. Am. J. Respir. Crit. Care Med. 170, 1080-1087.
20. Halonen, J. I., Lanki, T., Tiittanen, P., Niemi, J. V., Loh, M., and Pekkanen, J. (2010). Ozone and cause-specific cardiorespiratory morbidity and mortality. J. Epidemiol. Community Health 64, 814-820.
21. Hoffmann, B., Luttmann-Gibson, H., Cohen, A., Zanobetti, A., de Souza, C., Foley, C., Suh, H. H., Coull, B. A., Schwartz, J., Mittleman, M., et al. (2012). Opposing effects of particle pollution, ozone, and ambient temperature on arterial blood pressure. Environ. Health Perspect. 120, 241-246.
22. Ito, K., De Leon, S. F., and Lippmann, M. (2005). Associations between ozone and daily mortality: Analysis and meta-analysis. Epidemiology 16, 446-457.
23. Jerrett, M., Burnett, R. T., Pope, C. A., 3rd, Ito, K., Thurston, G., Krewski, D., Shi, Y., Calle, E., and Thun, M. (2009). Long-term ozone exposure and mortality. N. Engl. J. Med. 360, 1085-1095.
24. Katsouyanni, K., Pantazopoulou, A., Touloumi, G., Tselepidaki, I., Moustris, K., Asimakopoulos, D., Poulopoulou, G., and Trichopoulos, D. (1993). Evidence for interaction between air pollution and high temperature in the causation of excess mortality. Arch. Environ. Health 48, 235-242.
25. Lai, C. J., and Kou, Y. R. (1998). Stimulation of vagal pulmonary C fibers by inhaled wood smoke in rats. J. Appl. Physiol. 84, 30-36.
26. Langrish, J. P., Mills, N. L., Donaldson, K., and Newby, D. E. (2010). Response to Peter Joseph. Heart 96, 472-473.
27. Lee, L. Y., and Pisarri, T. E. (2001). Afferent properties and reflex functions of bronchopulmonary C-fibers. Respir. Physiol. 125, 47-65.
28. Levy, J. I., Chemerynski, S. M., and Sarnat, J. A. (2005). Ozone exposure and mortality: An empiric bayes metaregression analysis. Epidemiology 16, 458-468.
29. Lucking, A. J., Lundbäck, M., Barath, S. L., Mills, N. L., Sidhu, M. K., Langrish, J. P., Boon, N. A., Pourazar, J., Badimon, J. J., Gerlofs-Nijland, M. E., et al. (2011). Particle traps prevent adverse vascular and prothrombotic effects of diesel engine exhaust inhalation in men. Circulation 123, 1721-1728.
30. Lucking, A. J., Lundback, M., Mills, N. L., Faratian, D., Barath, S. L., Pourazar, J., Cassee, F. R., Donaldson, K., Boon, N. A., Badimon, J. J., et al. (2008). Diesel exhaust inhalation increases thrombus formation in man. Eur. Heart J. 29, 3043-3051.
31. Miller, K. A., Siscovick, D. S., Sheppard, L., Shepherd, K., Sullivan, J. H., Anderson, G. L., and Kaufman, J. D. (2007). Long-term exposure to air pollution and incidence of cardiovascular events in women. N. Engl. J. Med. 356, 447-458.
32. Mills, N. L., Miller, M. R., Lucking, A. J., Beveridge, J., Flint, L., Boere, A. J., Fokkens, P. H., Boon, N. A., Sandstrom, T., Blomberg, A., et al. (2011). Combustion-derived nanoparticulate induces the adverse vascular effects of diesel exhaust inhalation. Eur. Heart J. 32, 2660-2671.
33. Mills, N. L., Törnqvist, H., Gonzalez, M. C., Vink, E., Robinson, S. D., Söderberg, S., Boon, N. A., Donaldson, K., Sandström, T., Blomberg, A., et al. (2007). Ischemic and thrombotic effects of dilute diesel-exhaust inhalation in men with coronary heart disease. N. Engl. J. Med. 357, 1075-1082.
34. Mills, N. L., Törnqvist, H., Robinson, S. D., Gonzalez, M., Darnley, K., MacNee, W., Boon, N. A., Donaldson, K., Blomberg, A., Sandstrom, T., et al. (2005). Diesel exhaust inhalation causes vascular dysfunction and impaired endogenous fibrinolysis. Circulation 112, 3930-3936.
35. Mudway, I. S., and Kelly, F. J. (2000). Ozone and the lung: A sensitive issue. Mol. Aspects Med. 21, 1-48.
36. Peters, A., von Klot, S., Heier, M., Trentinaglia, I., Hörmann, A., Wichmann, H. E., and Löwel, H.; Cooperative Health Research in the Region of Augsburg Study Group. (2004). Exposure to traffic and the onset of myocardial infarction. N. Engl. J. Med. 351, 1721-1730.
37. Ren, C., Williams, G. M., Morawska, L., Mengersen, K., and Tong, S. (2008). Ozone modifies associations between temperature and cardiovascular mortality: Analysis of the NMMAPS data. Occup. Environ. Med. 65, 255-260.
38. Ruidavets, J. B., Cournot, M., Cassadou, S., Giroux, M., Meybeck, M., and Ferrières, J. (2005). Ozone air pollution is associated with acute myocardial infarction. Circulation 111, 563-569.
39. Smith, K. R., Jerrett, M., Anderson, H. R., Burnett, R. T., Stone, V., Derwent, R., Atkinson, R. W., Cohen, A., Shonkoff, S. B., Krewski, D., et al. (2009). Public health benefits of strategies to reduce greenhouse-gas emissions: Health implications of short-lived greenhouse pollutants. Lancet 374, 2091-2103.
40. Stafoggia, M., Forastiere, F., Faustini, A., Biggeri, A., Bisanti, L., Cadum, E., Cernigliaro, A., Mallone, S., Pandolfi, P., Serinelli, M., et al.; Epi Air Group. (2010). Susceptibility factors to ozone-related mortality: A population-based case-crossover analysis. Am. J. Respir. Crit. Care Med. 182, 376-384.
41. Stenfors, N., Pourazar, J., Blomberg, A., Krishna, M. T., Mudway, I., Helleday, R., Kelly, F. J., Frew, A. J., and Sandström, T. (2002). Effect of ozone on bronchial mucosal inflammation in asthmatic and healthy subjects. Respir. Med. 96, 352-358.
42. Taylor-Clark, T. E., and Undem, B. J. (2010). Ozone activates airway nerves via the selective stimulation of TRPA1 ion channels. J. Physiol. (Lond.) 588(Pt 3), 423-433.
43. Törnqvist, H., Mills, N. L., Gonzalez, M., Miller, M. R., Robinson, S. D., Megson, I. L., Macnee, W., Donaldson, K., Söderberg, S., Newby, D. E., et al. (2007). Persistent endothelial dysfunction in humans after diesel exhaust inhalation. Am. J. Respir. Crit. Care Med. 176, 395-400.
44. Tsuji, H., Larson, M. G., Venditti, F. J., Jr, Manders, E. S., Evans, J. C., Feldman, C. L., and Levy, D. (1996). Impact of reduced heart rate variability on risk for cardiac events. The Framingham Heart Study. Circulation 94, 2850-2855.
45. Urch, B., Silverman, F., Corey, P., Brook, J. R., Lukic, K. Z., Rajagopalan, S., and Brook, R. D. (2005). Acute blood pressure responses in healthy adults during controlled air pollution exposures. Environ. Health Perspect. 113, 1052-1055.