Epigenetics in the perioperative period

British Journal of Pharmacology

Volumn 172, Issue 11, 2015, Pages 2748-2755

  Lirk, P ^a   Fiegl, H ^b   Weber, N C ^a   Hollmann, M W ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b INNSBRUCK MEDICAL UNIVERSITY   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

BUPRENORPHINE; DNA METHYLTRANSFERASE 1; LIDOCAINE; MU OPIATE RECEPTOR; OPIATE; PROCAINE; REMIFENTANIL; LOCAL ANESTHETIC AGENT; NARCOTIC ANALGESIC AGENT;

ALCOHOLISM; ANESTHESIA; ANTIINFLAMMATORY ACTIVITY; ANTINOCICEPTION; CANCER SURVIVAL; DEMETHYLATION; DIABETES MELLITUS; DISEASE FREE SURVIVAL; DNA METHYLATION; ENZYME INHIBITION; EPIGENETICS; GENE; GENETIC PREDISPOSITION; GENETIC SUSCEPTIBILITY; GENOTYPE; HAPLOTYPE; HERITABILITY; HUMAN; HYPERALGESIA; INFLAMMATION; KCNS1 GENE; METASTASIS INHIBITION; NONHUMAN; OUTCOME ASSESSMENT; PAIN; PAIN INTENSITY; PAIN THRESHOLD; PERIOPERATIVE INFLAMMATION; PERIOPERATIVE PERIOD; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; SINGLE NUCLEOTIDE POLYMORPHISM; SURGICAL STRESS; TUMOR RECURRENCE; WOUND HEALING; ANESTHETIC RECOVERY; DRUG EFFECTS; GENETIC EPIGENESIS; GENETICS; PAIN, POSTOPERATIVE; PHYSIOLOGICAL STRESS;

ANALGESICS, OPIOID; ANESTHESIA RECOVERY PERIOD; ANESTHETICS, LOCAL; DNA METHYLATION; EPIGENESIS, GENETIC; HUMANS; HYPERALGESIA; INFLAMMATION; PAIN, POSTOPERATIVE; PERIOPERATIVE PERIOD; STRESS, PHYSIOLOGICAL; WOUND HEALING;

EID: 84929170557     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/bph.12865     Document Type: Review

References (74)

1. Alexander SPH, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Spedding M, et al. (2013a). The Concise Guide to PHARMACOLOGY 2013/14: G Protein-Coupled Receptors. Br J Pharmacol 170: 1459-1581.
2. Alexander SPH, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Spedding M, et al. (2013b). The Concise Guide to PHARMACOLOGY 2013/14: Enzymes. Br J Pharmacol 170: 1797-1867.
3. Alexander SPH, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Catterall WA, et al. (2013c). The Concise Guide to PHARMACOLOGY 2013/14: Ion Channels. Br J Pharmacol 170: 1607-1651.
4. Bain CR, Shaw AD, (2012). Genetics and epigenetics in perioperative medicine. Curr Opin Crit Care 18: 548-554.
5. Bais M, McLean J, Sebastiani P, Young M, Wigner N, Smith T, et al. (2009). Transcriptional analysis of fracture healing and the induction of embryonic stem cell-related genes. PLoS ONE 4: e5393.
6. Barnes PJ, (2013). New anti-inflammatory targets for chronic obstructive pulmonary disease. Nat Rev Drug Discov 12: 543-559.
7. Bekhit MH, (2010). Opioid-induced hyperalgesia and tolerance. Am J Ther 17: 498-510.
8. Belkina AC, Nikolajczyk BS, Denis GV, (2013). BET protein function is required for inflammation: Brd2 genetic disruption and BET inhibitor JQ1 impair mouse macrophage inflammatory responses. J Immunol 190: 3670-3678.
9. Bell JT, Loomis AK, Butcher LM, Gao F, Zhang B, Hyde CL, et al. (2014). Differential methylation of the TRPA1 promoter in pain sensitivity. Nat Commun 5: 2978.
10. Buchheit T, Van de Ven T, Shaw A, (2012). Epigenetics and the transition from acute to chronic pain. Pain Med 13: 1474-1490.
11. Castellano S, Kuck D, Sala M, Novellino E, Lyko F, Sbardella G, (2008). Constrained analogues of procaine as novel small molecule inhibitors of DNA methyltransferase-1. J Med Chem 51: 2321-2325.
12. Chiou LC, Fan SH, Chuang KC, Liao YY, Lee SZ, (2004). Pharmacological characterization of nociceptin/orphanin FQ receptors, a novel opioid receptor family, in the midbrain periaqueductal gray. Ann N Y Acad Sci 1025: 398-403.
13. Coffey JC, Wang JH, Smith MJ, Bouchier-Hayes D, Cotter TG, Redmond HP, (2003). Excisional surgery for cancer cure: therapy at a cost. Lancet Oncol 4: 760-768.
14. Correll DJ, Vlassakov KV, Kissin I, (2014). No evidence of real progress in treatment of acute pain, 1993-2012: scientometric analysis. J Pain Res 7: 199-210.
15. Costigan M, Belfer I, Griffin RS, Dai F, Barrett LB, Coppola G, et al. (2010). Multiple chronic pain states are associated with a common amino acid-changing allele in KCNS1. Brain 133: 2519-2527.
16. Cutroneo KR, Chiu JF, (2000). Comparison and evaluation of gene therapy and epigenetic approaches for wound healing. Wound Repair Regen 8: 494-502.
17. Deegan CA, Murray D, Doran P, Ecimovic P, Moriarty DC, Buggy DJ, (2009). Effect of anaesthetic technique on oestrogen receptor-negative breast cancer cell function in vitro. Br J Anaesth 103: 685-690.
18. Denk F, McMahon SB, Tracey I, (2014). Pain vulnerability: a neurobiological perspective. Nat Neurosci 17: 192-200.
19. Doehring A, Geisslinger G, Lotsch J, (2011). Epigenetics in pain and analgesia: an imminent research field. Eur J Pain 15: 11-16.
20. Doehring A, Oertel BG, Sittl R, Lotsch J, (2013). Chronic opioid use is associated with increased DNA methylation correlating with increased clinical pain. Pain 154: 15-23.
21. Dong H, Zhang Y, Xi H, (2012). The effects of epidural anaesthesia and analgesia on natural killer cell cytotoxicity and cytokine response in patients with epithelial ovarian cancer undergoing radical resection. J Int Med Res 40: 1822-1829.
22. Exadaktylos AK, Buggy DJ, Moriarty DC, Mascha E, Sessler DI, (2006). Can anesthetic technique for primary breast cancer surgery affect recurrence or metastasis? Anesthesiology 105: 660-664.
23. Finnerty CC, Mabvuure NT, Ali A, Kozar RA, Herndon DN, (2013). The surgically induced stress response. JPEN J Parenter Enteral Nutr 37: 21S-29S.
24. Fukuda T, Kakiuchi Y, Miyabe M, Kihara S, Kohda Y, Toyooka H, (2003). Free lidocaine concentrations during continuous epidural anesthesia in geriatric patients. Reg Anesth Pain Med 28: 215-220.
25. van Gulik L, Ahlers SJ, van de Garde EM, Bruins P, van Boven WJ, Tibboel D, et al. (2012). Remifentanil during cardiac surgery is associated with chronic thoracic pain 1 yr after sternotomy. Br J Anaesth 109: 616-622.
26. Heijmans BT, Tobi EW, Stein AD, Putter H, Blauw GJ, Susser ES, et al. (2008). Persistent epigenetic differences associated with prenatal exposure to famine in humans. Proc Natl Acad Sci U S A 105: 17046-17049.
27. Herroeder S, Pecher S, Schonherr ME, Kaulitz G, Hahnenkamp K, Friess H, et al. (2007). Systemic lidocaine shortens length of hospital stay after colorectal surgery: a double-blinded, randomized, placebo-controlled trial. Ann Surg 246: 192-200.
28. Hollmann MW, Durieux ME, (2000). Local anesthetics and the inflammatory response: a new therapeutic indication? Anesthesiology 93: 858-875.
29. Hollmann MW, Wieczorek KS, Smart M, Durieux ME, (2001). Epidural anesthesia prevents hypercoagulation in patients undergoing major orthopedic surgery. Reg Anesth Pain Med 26: 215-222.
30. Hwang CK, Song KY, Kim CS, Choi HS, Guo XH, Law PY, et al. (2007). Evidence of endogenous mu opioid receptor regulation by epigenetic control of the promoters. Mol Cell Biol 27: 4720-4736.
31. Imai S, Ikegami D, Yamashita A, Shimizu T, Narita M, Niikura K, et al. (2013). Epigenetic transcriptional activation of monocyte chemotactic protein 3 contributes to long-lasting neuropathic pain. Brain 136: 828-843.
32. Julius D, (2013). TRP channels and pain. Annu Rev Cell Dev Biol 29: 355-384.
33. Kalkman CJ, Visser K, Moen J, Bonsel GJ, Grobbee DE, Moons KG, (2003). Preoperative prediction of severe postoperative pain. Pain 105: 415-423.
34. Kehlet H, Jensen TS, Woolf CJ, (2006). Persistent postsurgical pain: risk factors and prevention. Lancet 367: 1618-1625.
35. Kern U, Busch V, Rockland M, Kohl M, Birklein F, (2009). Prevalence and risk factors of phantom limb pain and phantom limb sensations in Germany. A nationwide field survey. Schmerz 23: 479-488.
36. Koppert W, Weigand M, Neumann F, Sittl R, Schuettler J, Schmelz M, et al. (2004). Perioperative intravenous lidocaine has preventive effects on postoperative pain and morphine consumption after major abdominal surgery. Anesth Analg 98: 1050-1055.
37. Kruidenier L, Chung CW, Cheng Z, Liddle J, Che K, Joberty G, et al. (2012). A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response. Nature 488: 404-408.
38. Laulin JP, Maurette P, Corcuff JB, Rivat C, Chauvin M, Simonnet G, (2002). The role of ketamine in preventing fentanyl-induced hyperalgesia and subsequent acute morphine tolerance. Anesth Analg 94: 1263-1269.
39. Liang DY, Li X, Clark JD, (2013). Epigenetic regulation of opioid-induced hyperalgesia, dependence, and tolerance in mice. J Pain 14: 36-47.
40. Lirk P, Hollmann M, (2013). Outcome after regional anesthesia: weighing risks and benefits. Minerva Anestesiol 80: 610-618.
41. Lirk P, Berger R, Hollmann MW, Fiegl H, (2012). Lidocaine time- and dose-dependently demethylates deoxyribonucleic acid in breast cancer cell lines in vitro. Br J Anaesth 109: 200-207.
42. Lirk P, Hollmann M, Fleischer M, Hauck-Weber NC, Fiegl H, (2014). Lignocaine and ropivacaine, but not bupivacaine, demethylate deoxyribonucleic acid in breast cancer cells in vitro. Br J Anaesth 113 (Suppl. 1): i32-i38.
43. Mann J, Mann DA, (2013). Epigenetic regulation of wound healing and fibrosis. Curr Opin Rheumatol 25: 101-107.
44. Martin DS, Khosravi M, Grocott MP, Mythen MG, (2010). Concepts in hypoxia reborn. Crit Care 14: 315.
45. Martin F, Cherif K, Gentili ME, Enel D, Abe E, Alvarez JC, et al. (2008). Lack of impact of intravenous lidocaine on analgesia, functional recovery, and nociceptive pain threshold after total hip arthroplasty. Anesthesiology 109: 118-123.
46. McCarthy GC, Megalla SA, Habib AS, (2010). Impact of intravenous lidocaine infusion on postoperative analgesia and recovery from surgery: a systematic review of randomized controlled trials. Drugs 70: 1149-1163.
47. Naguib M, Bie B, Ting AH, (2012). Fundamental concepts of epigenetics for consideration in anesthesiology. Curr Opin Anaesthesiol 25: 434-443.
48. Nan X, Ng HH, Johnson CA, Laherty CD, Turner BM, Eisenman RN, et al. (1998). Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex. Nature 393: 386-389.
49. Naso-Kaspar CK, Herndon GW, Wyman JF, Felo JA, Lavins ES, Gilson TP, (2013). 'Lingering' opiate deaths? Concentration of opiates in medulla and femoral blood. J Anal Toxicol 37: 507-511.
50. Navada SC, Steinmann J, Lubbert M, Silverman LR, (2014). Clinical development of demethylating agents in hematology. J Clin Invest 124: 40-46.
51. Norbury TA, MacGregor AJ, Urwin J, Spector TD, McMahon SB, (2007). Heritability of responses to painful stimuli in women: a classical twin study. Brain 130: 3041-3049.
52. Nyman T, Mulder M, Iliadou A, Svartengren M, Wiktorin C, (2011). High heritability for concurrent low back and neck-shoulder pain: a study of twins. Spine (Phila Pa 1976) 36: E1469-E1476.
53. Pasternak GW, (2004). Multiple opiate receptors: deja vu all over again. Neuropharmacology 47 (Suppl. 1): 312-323.
54. Pasternak GW, Pan YX, (2013). Mu opioids and their receptors: evolution of a concept. Pharmacol Rev 65: 1257-1317.
55. Pawson AJ, Sharman JL, Benson HE, Faccenda E, Alexander SP, Buneman OP, et al.; NC-IUPHAR (2014). The IUPHAR/BPS Guide to PHARMACOLOGY: an expert-driven knowledge base of drug targets and their ligands. Nucl Acids Res 42 (Database Issue): D1098-D1106.
56. Pergolizzi J, Aloisi AM, Dahan A, Filitz J, Langford R, Likar R, et al. (2010). Current knowledge of buprenorphine and its unique pharmacological profile. Pain Pract 10: 428-450.
57. Portela A, Esteller M, (2010). Epigenetic modifications and human disease. Nat Biotechnol 28: 1057-1068.
58. Rafehi H, El-Osta A, Karagiannis TC, (2011). Genetic and epigenetic events in diabetic wound healing. Int Wound J 8: 12-21.
59. Reiber GE, McFarland LV, Hubbard S, Maynard C, Blough DK, Gambel JM, et al. (2010). Servicemembers and veterans with major traumatic limb loss from Vietnam war and OIF/OEF conflicts: survey methods, participants, and summary findings. J Rehabil Res Dev 47: 275-297.
60. Richardson C, Glenn S, Nurmikko T, Horgan M, (2006). Incidence of phantom phenomena including phantom limb pain 6 months after major lower limb amputation in patients with peripheral vascular disease. Clin J Pain 22: 353-358.
61. Sampson HW, Chaput CD, Brannen J, Probe RA, Guleria RS, Pan J, et al. (2011). Alcohol induced epigenetic perturbations during the inflammatory stage of fracture healing. Exp Biol Med (Maywood) 236: 1389-1401.
62. Schlagenhauff B, Ellwanger U, Breuninger H, Stroebel W, Rassner G, Garbe C, (2000). Prognostic impact of the type of anaesthesia used during the excision of primary cutaneous melanoma. Melanoma Res 10: 165-169.
63. Scott LJ, Perry CM, (2000). Tramadol: a review of its use in perioperative pain. Drugs 60: 139-176.
64. Sharma A, Jamal MM, (2013). Opioid induced bowel disease: a twenty-first century physicians' dilemma. Considering pathophysiology and treatment strategies. Curr Gastroenterol Rep 15: 334.
65. Shaw T, Martin P, (2009). Epigenetic reprogramming during wound healing: loss of polycomb-mediated silencing may enable upregulation of repair genes. EMBO Rep 10: 881-886.
66. Snyder GL, Greenberg S, (2010). Effect of anaesthetic technique and other perioperative factors on cancer recurrence. Br J Anaesth 105: 106-115.
67. Sun Y, Li T, Wang N, Yun Y, Gan TJ, (2012). Perioperative systemic lidocaine for postoperative analgesia and recovery after abdominal surgery: a meta-analysis of randomized controlled trials. Dis Colon Rectum 55: 1183-1194.
68. Tajerian M, Alvarado S, Millecamps M, Vachon P, Crosby C, Bushnell MC, et al. (2013). Peripheral nerve injury is associated with chronic, reversible changes in global DNA methylation in the mouse prefrontal cortex. PLoS ONE 8: e55259.
69. Teschendorff AE, Menon U, Gentry-Maharaj A, Ramus SJ, Weisenberger DJ, Shen H, et al. (2010). Age-dependent DNA methylation of genes that are suppressed in stem cells is a hallmark of cancer. Genome Res 20: 440-446.
70. Votta-Velis EG, Piegeler T, Minshall RD, Aguirre J, Beck-Schimmer B, Schwartz DE, et al. (2013). Regional anaesthesia and cancer metastases: the implication of local anaesthetics. Acta Anaesthesiol Scand 57: 1211-1229.
71. van den Wijngaard RM, Stanisor OI, van Diest SA, Welting O, Wouters MM, Cailotto C, et al. (2013). Susceptibility to stress induced visceral hypersensitivity in maternally separated rats is transferred across generations. Neurogastroenterol Motil 25: e780-e790.
72. Zeybel M, Hardy T, Wong YK, Mathers JC, Fox CR, Gackowska A, et al. (2012). Multigenerational epigenetic adaptation of the hepatic wound-healing response. Nat Med 18: 1369-1377.
73. Zhang Z, Cai YQ, Zou F, Bie B, Pan ZZ, (2011). Epigenetic suppression of GAD65 expression mediates persistent pain. Nat Med 17: 1448-1455.
74. Zheng C, Yu Z, Zhou Y, Tao L, Pang Y, Chen T, et al. (2012). Live cell imaging analysis of the epigenetic regulation of the human endothelial cell migration at single-cell resolution. Lab Chip 12: 3063-3072.