Drug distribution to human tissues: Prediction and examination of the basic assumption in in vivo pharmacokinetics-pharmacodynamics (PK/PD) research

Journal of Pharmaceutical Sciences

Volumn 104, Issue 6, 2015, Pages 2110-2118

  Poulin, Patrick ^a  

^a NONE   (Canada)

Author keywords

ADME; clinical pharmacokinetics; disposition; distribution; partition coefficients; PBPK modeling; pharmacokinetics; PKPD

Indexed keywords

4,4' ISOPROPYLIDENEDIPHENOL; ANILINE; BARBITAL; BASE; CAFFEINE; CHLORDIAZEPOXIDE; CIMETIDINE; DESIPRAMINE; DRUG; FLEROXACIN; HEXOBARBITAL; METHOHEXITAL; MORPHINE; NITROFURANTOIN; OXYPHENBUTAZONE; PHENAZONE; PHENOBARBITAL; PHENYLBUTAZONE; PHENYTOIN; PROMETHAZINE; QUININE; SALICYLIC ACID; SULFADIMETHOXINE; SULFAGUANIDINE; SULFAMETOXYDIAZINE; THIAMYLAL; THIOPENTAL;

ARTICLE; CLINICAL TRIAL (TOPIC); CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; DRUG TISSUE LEVEL; HUMAN; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; PH; PREDICTION; BIOLOGICAL MODEL; COMPUTER SIMULATION; METABOLISM; TISSUE DISTRIBUTION;

COMPUTER SIMULATION; HUMANS; MODELS, BIOLOGICAL; PHARMACEUTICAL PREPARATIONS; TISSUE DISTRIBUTION;

EID: 84929165416     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.24427     Document Type: Article

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