Protein binding and the metabolism of thiamylal enantiomers in vitro

Anesthesia and Analgesia

Volumn 91, Issue 3, 2000, Pages 736-740

  Sueyasu, Masanori ^a   Fujito, Kimihito ^a   Shuto, Hideki ^a   Mizokoshi, Takako ^a   Kataoka, Yasufumi ^a   Oishi, Ryozo ^a  

^a KYUSHU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450; OCTANOIC ACID; OLEIC ACID; THIAMYLAL; WARFARIN;

ARTICLE; BINDING AFFINITY; CHIRALITY; DRUG METABOLISM; ENANTIOMER; LIVER MICROSOME; PLASMA PROTEIN BINDING; PRIORITY JOURNAL; PROTEIN BINDING;

EID: 0033863375     PISSN: 00032999     EISSN: None     Source Type: Journal    
DOI: 10.1213/00000539-200009000-00045     Document Type: Article

References (25)

1. Anesthetic potency and acute toxicity of optically active disubstituted barbituric acids
2. Pharmacokinetics of thiamylal enantiomers in humans
3. Application of Akaike's information criterion (AIC) in the evaluation of linear pharmaco-kinetic equation
4. Evaluation of triacetylole-andomycin, α-naphthoflavone and diethyldithiocarbamate as selective chemical probes for inhibition of human cytochromes P450
5. Purification and characterization of human liver microsomal cytochrome P-450 2A6
6. Tolbutamide hydroxylation by human liver microsomes: Kinetic characterisation and relationship to other cytochrome P-450 dependent xenobiotic oxidations
7. Evaluation of omeprazole and lansoprazole as inhibitors of cytochrome P450 isoforms
8. In vitro inhibition studies of two isozymes of human liver cytochrome P-450: Mephenytoin p-hydroxylase and sparteine monooxygenase
9. Role of human cytochrome P-450 2E1 in the oxidation of many low molecular weight cancer suspects
10. Effects of imidazole derivatives on cytochromes P450 from human hepatocytes in primary culture
11. Improved method of determining thiamylal enantiomers in human serum by high-performance liquid chromatography
12. Binding sites of fluorescent probes on human serum albumin
13. Structural requirements for drug binding to site II on human serum albumin
14. Effects of fatty acids on two specific drug binding sites on human serum albumin
15. The binding of L-tryptophan to serum albumins in the presence of non-esterified fatty acids
16. Determination of optically active thiopental, thiamylal, and their metabolites in human urine
17. Cytochrome P450 inhibitors: Evaluation of specificities in the in vitro metabolism of therapeutic agents by human liver microsomes
18. Differential selectivity of cytochrome P450 inhibitors against probe substrates in human and rat liver microsomes
19. Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: Studies with liver microsomes of 30 Japanese and 30 Caucasians
20. Relationship between CYP2C9 and 2C19 genotypes and tolbutamide methyl hydroxyllation and S-mephenytoin 4'-hydroxylation activities in livers of Japanese and Caucasian populations
21. Cytochrome P4502C9: An enzyme of major importance in human drug metabolism
22. Site-directed mutation studies of human liver cytochrome P-450 isoenzymes in the CYP2C subfamily
23. The role of the CYP2C9-Leu359 allelic variant in the tolbutamide polymorphism
24. Genetic analysis of the human cytochrome P450 CYP2C9 locus
25. Genetic analysis of CYP2C9 polymorphism in a Japanese population