Hepatocyte composition-based model as a mechanistic tool for predicting the cell suspension: Aqueous phase partition coefficient of drugs in in vitro metabolic studies

Journal of Pharmaceutical Sciences

Volumn 102, Issue 8, 2013, Pages 2806-2818

  Poulin, Patrick ^a   Haddad, Sami ^b  

^a Université de Montréal ^*

^b UNIVERSITÉ DE MONTRÉAL   (Canada)

Author keywords

Computational ADME; Distribution; Hepatocytes; in vitro in vivo extrapolation; IVIVE; Liver; Metabolic clearance; Metabolism; PBPK modeling; Pharmacokinetics; Unbound fraction

Indexed keywords

ALBENDAZOLE; BOSENTAN; BUMETANIDE; CERIVASTATIN; DIAZEPAM; DICLOFENAC; DIFLUNISAL; ETHENZAMIDE; ETODOLAC; FENOPROFEN; FUROSEMIDE; GEMFIBROZIL; GLIBENCLAMIDE; GLIPIZIDE; IBUPROFEN; INDAPAMIDE; INDOMETACIN; ISRADIPINE; METYRAPONE; MONTELUKAST; OMEPRAZOLE; OXAPROZIN; PARACETAMOL; PHENYTOIN; TENOXICAM; TOLBUTAMIDE; TOLCAPONE; TROGLITAZONE; UNINDEXED DRUG; WARFARIN;

ACCURACY; ANIMAL CELL; AQUEOUS SOLUTION; ARTICLE; CELL COMPOSITION; CELL SUSPENSION; COMPARATIVE STUDY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CULTURE MEDIUM; DRUG BINDING; DRUG CLEARANCE; DRUG METABOLISM; ERYTHROCYTE; HUMAN; HUMAN CELL; IN VITRO STUDY; LIPID COMPOSITION; LIVER CELL; MICROSOME; MOLECULAR MODEL; NONHUMAN; PARTITION COEFFICIENT; PHYSICAL CHEMISTRY; PREDICTION; RAT; SPECIES DIFFERENCE; TISSUE DISTRIBUTION;

EID: 84881024229     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.23602     Document Type: Article

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