Immediate and long-term consequences of vascular toxicity during zebrafish development

Reproductive Toxicology

Volumn 48, Issue , 2014, Pages 51-61

  Tal, T L ^a   McCollum, C W ^b   Harris, P S ^a   Olin, J ^a   Kleinstreuer, N ^c,f   Wood, C E ^a   Hans, C ^d   Shah, S ^e   Merchant, F A ^d,e   Bondesson, M ^b   Knudsen, T B ^c   Padilla, S ^a   Hemmer, M J ^a  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^b University of Houston   (United States)

^c U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^d University of Houston   (United States)

^e UNIVERSITY OF HOUSTON   (United States)

^f INTEGRATED LABORATORY SYSTEMS   (United States)

Author keywords

Adverse outcome pathway; EGFR; Intersegmental vessel; VEGFR2

Indexed keywords

4 (3 CHLOROANILINO) 6,7 DIMETHOXYQUINAZOLINE; EPIDERMAL GROWTH FACTOR RECEPTOR; VASCULOTROPIN RECEPTOR 2; VATALANIB; ANGIOGENESIS INHIBITOR; PHTHALAZINE DERIVATIVE; PROTEIN KINASE INHIBITOR; PYRIDINE DERIVATIVE; QUINAZOLINE DERIVATIVE; TYRPHOSTIN;

ADVERSE OUTCOME; ANGIOGENESIS; ANIMAL TISSUE; ARTICLE; BIOASSAY; BODY HEIGHT; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DEVELOPMENTAL TOXICITY; EMBRYO; EMBRYO DEVELOPMENT; EMBRYOTOXICITY; JUVENILE ANIMAL; MORPHOGENESIS; NEOVASCULARIZATION (PATHOLOGY); NONHUMAN; PROTEIN TARGETING; SIGNAL TRANSDUCTION; TOXICITY TESTING; TRANSGENIC FISH; ZEBRA FISH; ANIMAL; ANIMAL EMBRYO; ANTAGONISTS AND INHIBITORS; BLOOD VESSEL; DRUG EFFECTS; EMBRYOLOGY; PHYSIOLOGY; TRANSGENIC ANIMAL;

DANIO RERIO;

ANGIOGENESIS INHIBITORS; ANIMALS; ANIMALS, GENETICALLY MODIFIED; BLOOD VESSELS; EMBRYO, NONMAMMALIAN; EMBRYONIC DEVELOPMENT; PHTHALAZINES; PROTEIN KINASE INHIBITORS; PYRIDINES; QUINAZOLINES; RECEPTOR, EPIDERMAL GROWTH FACTOR; TYRPHOSTINS; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2; ZEBRAFISH;

EID: 84929137706     PISSN: 08906238     EISSN: 18731708     Source Type: Journal    
DOI: 10.1016/j.reprotox.2014.05.014     Document Type: Article

References (54)

1. Chung A.S., Ferrara N. Developmental and pathological angiogenesis. Annu Rev Cell Dev Biol 2011, 27:563-584.
2. Ellertsdottir E., Lenard A., Blum Y., Krudewig A., Herwig L., Affolter M., et al. Vascular morphogenesis in the zebrafish embryo. Dev Biol 2010, 341:56-65.
3. Herbert S.P., Stainier D.Y. Molecular control of endothelial cell behaviour during blood vessel morphogenesis. Nat Rev Mol Cell Biol 2011, 12:551-564.
4. Bonventre J.A., White L.A., Cooper K.R. Methyl tert butyl ether targets developing vasculature in zebrafish (Danio Rerio) embryos. Aquat Toxicol 2011, 105:29-40.
5. Yeh C.H., Liao Y.F., Chang C.Y., Tsai J.N., Wang Y.H., Cheng C.C., et al. Caffeine treatment disturbs the angiogenesis of zebrafish embryos. Drug Chem Toxicol 2012, 35:361-365.
6. Lin C., Wu M., Dong J. Quercetin-4'-o-beta-d-glucopyranoside (Qodg) inhibits angiogenesis by suppressing Vegfr2-mediated Signaling in zebrafish and endothelial cells. PLOS ONE 2012, 7:e31708.
7. Kleinstreuer N.C., Judson R.S., Reif D.M., Sipes N.S., Singh A.V., Chandler K.J., et al. Environmental impact on vascular development predicted by high-throughput screening. Environ Health Perspect 2011, 119:1596-1603.
8. Knudsen T.B., Kleinstreuer N.C. Disruption of embryonic vascular development in predictive toxicology. Birth Defects Res C: Embryo Today 2011, 93:312-323.
9. Chandler K.J., Barrier M., Jeffay S., Nichols H.P., Kleinstreuer N.C., Singh A.V., et al. Evaluation of 309 environmental chemicals using a mouse embryonic stem cell adherent cell differentiation and cytotoxicity assay. PLoS ONE 2011, 6:e18540.
10. Allard P., Kleinstreuer N.C., Knudsen T.B., Colaiacovo M.P. A C. elegans screening platform for the rapid assessment of chemical disruption of germline function. Environ Health Perspect 2013, 121:717-724.
11. Padilla S., Corum D., Padnos B., Hunter D.L., Beam A., Houck K.A., et al. Zebrafish developmental screening of the ToxCast™ Phase I chemical library. Reprod Toxicol 2012, 33:174-187.
12. Grandel H., Brand M. Zebrafish limb development is triggered by a retinoic acid signal during gastrulation. Dev Dyn 2011, 240:1116-1126.
13. Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., et al. The Zebrafish reference genome sequence and its relationship to the human genome. Nature 2013, 496:498-503.
14. Kikuta H., Fredman D., Rinkwitz S., Lenhard B., Becker T.S. Retroviral enhancer detection insertions in Zebrafish combined with comparative genomics reveal genomic regulatory blocks - a fundamental feature of vertebrate genomes. Genome Biol 2007, 8(Suppl. 1):S4.
15. Kikuta H., Laplante M., Navratilova P., Komisarczuk A.Z., Engstrom P.G., Fredman D., et al. Genomic regulatory blocks encompass multiple neighboring genes and maintain conserved synteny in vertebrates. Genome Res 2007, 17:545-555.
16. Postlethwait J.H., Woods I.G., Ngo-Hazelett P., Yan Y.L., Kelly P.D., Chu F., et al. Zebrafish comparative genomics and the origins of vertebrate chromosomes. Genome Res 2000, 10:1890-1902.
17. Navratilova P., Fredman D., Hawkins T.A., Turner K., Lenhard B., Becker T.S. Systematic human/zebrafish comparative identification of Cis-regulatory activity around vertebrate developmental transcription factor genes. Dev Biol 2009, 327:526-540.
18. Gunnarsson L., Jauhiainen A., Kristiansson E., Nerman O., Larsson D.G. Evolutionary conservation of human drug targets in organisms used for environmental risk assessments. Environ Sci Technol 2008, 42:5807-5813.
19. Jin S.W., Beis D., Mitchell T., Chen J.N., Stainier D.Y. Cellular and molecular analyses of vascular tube and lumen formation in zebrafish. Development 2005, 132:5199-5209.
20. Tran T.C., Sneed B., Haider J., Blavo D., White A., Aiyejorun T., et al. Automated quantitative screening assay for antiangiogenic compounds using transgenic zebrafish. Cancer Res 2007, 67:11386-11392.
21. Yozzo K.L., Isales G.M., Raftery T.D., Volz D.C. High-content screening assay for identification of chemicals impacting cardiovascular function in zebrafish embryos. Environ Sci Technol 2013, 47:11302-11310.
22. Yano T., Abe G., Yokoyama H., Kawakami K., Tamura K. Mechanism of pectoral fin outgrowth in zebrafish development. Development 2012, 139:2916-2925.
23. Hans C., Shete A., Shah S.K., McCollum C.W., Bondesson M.B., Merchant F.A. 3D imaging for quantitative assessment of toxicity on vascular development in zebrafish. Conf Proc IEEE Eng Med Biol Soc 2011, 5969-5972.
24. McCollum C.W., Hans C., Shah S., Merchant F.A., Gustafsson J.A., Bondesson M. Embryonic exposure to sodium arsenite perturbs vascular development in zebrafish. Aquat Toxicol 2014, 152C:152-163.
25. Chan J., Bayliss P.E., Wood J.M., Roberts T.M. Dissection of angiogenic signaling in zebrafish using a chemical genetic approach. Cancer Cell 2002, 1:257-267.
26. Goishi K., Lee P., Davidson A.J., Nishi E., Zon L.I., Klagsbrun M. Inhibition of zebrafish epidermal growth factor receptor activity results in cardiovascular defects. Mech Dev 2003, 120:811-822.
27. Westerfield M. The Zebrafish Book. 2007, University of Oregon Press, Eugene, OR. 5th ed.
28. Peravali R., Gehrig J., Giselbrecht S., Lutjohann D.S., Hadzhiev Y., Muller F., et al. Automated feature detection and imaging for high-resolution screening of zebrafish embryos. Biotechniques 2011, 50:319-324.
29. Grush J., Noakes D.L., Moccia R.D. The efficacy of clove oil as an anesthetic for the zebrafish, Danio Rerio (Hamilton). Zebrafish 2004, 1:46-53.
30. Hans C., McCollum C., Bondesson M., Gustafsson J., Shah S.K., Merchant F. Automated analysis of zebrafish images for screening toxicants. Conf Proc IEEE Eng Med Biol Soc 2013, 2013:3004-3007. 10.1109/EMBC.2013.6610172.
31. Li C., Tam P. An iterative algorithm for minimum cross entropy thresholding. Pattern Recognit Lett 1998, 19:771-776.
32. Jahrling N., Becker K., Dodt H.U. 3D-reconstruction of blood vessels by ultramicroscopy. Organogenesis 2009, 5:227-230.
33. Cumming G., Fidler F., Vaux D.L. Error bars in experimental biology. J Cell Biol 2007, 177:7-11.
34. Wood J.M., Bold G., Buchdunger E., Cozens R., Ferrari S., Frei J., et al. Ptk787/Zk 222584, a novel and potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, impairs vascular endothelial growth factor-induced responses and tumor growth after oral administration. Cancer Res 2000, 60:2178-2189.
35. Bradbury S.P., Russom C.L., Ankley G.T., Schultz T.W., Walker J.D. Overview of data and conceptual approaches for derivation of quantitative structure-activity relationships for ecotoxicological effects of organic chemicals. Environ Toxicol Chem 2003, 22:1789-1798.
36. Schmieder P.K., Tapper M.A., Denny J.S., Kolanczyk R.C., Sheedy B.R., Henry T.R., et al. Use of trout liver slices to enhance mechanistic interpretation of estrogen receptor binding for cost-effective prioritization of chemicals within large inventories. Environ Sci Technol 2004, 38:6333-6342.
37. Ankley G.T., Bennett R.S., Erickson R.J., Hoff D.J., Hornung M.W., Johnson R.D., et al. Adverse outcome pathways: a conceptual framework to support ecotoxicology research and risk assessment. Environ Toxicol Chem 2010, 29:730-741.
38. Shalaby F., Rossant J., Yamaguchi T.P., Gertsenstein M., Wu X.F., Breitman M.L., et al. Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice. Nature 1995, 376:62-66.
39. Olsson A.K., Dimberg A., Kreuger J., Claesson-Welsh L. VEGF receptor signalling - in control of vascular function. Nat Rev Mol Cell Biol 2006, 7:359-371.
40. Fong G.H., Rossant J., Gertsenstein M., Breitman M.L. Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium. Nature 1995, 376:66-70.
41. Jacob E., Drexel M., Schwerte T., Pelster B. Influence of hypoxia and of hypoxemia on the development of cardiac activity in zebrafish larvae. Am J Physiol Regul Integr Comp Physiol 2002, 283:R911-R917.
42. Rombough P.J. Partitioning of oxygen uptake between the gills and skin in fish larvae: a novel method for estimating cutaneous oxygen uptake. J Exp Biol 1998, 201:1763-1769.
43. Miettinen P.J., Berger J.E., Meneses J., Phung Y., Pedersen R.A., Werb Z., et al. Epithelial immaturity and multiorgan failure in mice lacking epidermal growth factor receptor. Nature 1995, 376:337-341.
44. Sibilia M., Wagner E.F. Strain-dependent epithelial defects in mice lacking the egf receptor. Science 1995, 269:234-238.
45. Threadgill D.W., Dlugosz A.A., Hansen L.A., Tennenbaum T., Lichti U., Yee D., et al. Targeted disruption of mouse EGF receptor: effect of genetic background on mutant phenotype. Science 1995, 269:230-234.
46. Grandel H., Draper B.W., Schulte-Merker S. Dackel acts in the ectoderm of the zebrafish pectoral fin bud to maintain AER signaling. Development 2000, 127:4169-4178.
47. Grandel H., Schulte-Merker S. The development of the paired fins in the zebrafish (Danio Rerio). Mech Dev 1998, 79:99-120.
48. Wang S.H., Simcox A., Campbell G. Dual role for drosophila epidermal growth factor receptor signaling in early wing disc development. Genes Dev 2000, 14:2271-2276.
49. Omi M., Fisher M., Maihle N.J., Dealy C.N. Studies on epidermal growth factor receptor signaling in vertebrate limb patterning. Dev Dyn 2005, 233:288-300.
50. Lenz W. A short history of thalidomide embryopathy. Teratology 1988, 38:203-215.
51. Smithells R.W. The thalidomide legacy. Proc R Soc Med 1965, 58:491-492.
52. Smithells R.W., Newman C.G. Recognition of thalidomide defects. J Med Genet 1992, 29:716-723.
53. Therapontos C., Erskine L., Gardner E.R., Figg W.D., Vargesson N. Thalidomide induces limb defects by preventing angiogenic outgrowth during early limb formation. Proc Natl Acad Sci USA 2009, 106:8573-8578.
54. Ito T., Ando H., Suzuki T., Ogura T., Hotta K., Imamura Y., et al. Identification of a primary target of thalidomide teratogenicity. Science 2010, 327:1345-1350.