Biotransformed soybean extract induces cell death of estrogen-dependent breast cancer cells by modulation of apoptotic proteins

Nutrition and Cancer

Volumn 67, Issue 4, 2015, Pages 612-619

  Stocco, Bianca ^a   Toledo, Karina A ^b   Fumagalli, Helen F ^a   Bianchini, Francine J ^a   Fortes, Vanessa S ^a   Fonseca, Maria José V ^a   Toloi, Maria Regina T ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; DAIDZEIN; DAIDZIN; ESTROGEN; GENISTEIN; GENISTIN; ISOFLAVONE; ISOFLAVONE DERIVATIVE; PROTEIN; PROTEIN BAD; PROTEIN BAX; PROTEIN BCL XL; SOYBEAN EXTRACT; BCL2 PROTEIN, HUMAN; CASP3 PROTEIN, HUMAN; PHYTOESTROGEN; PLANT EXTRACT; PROTEIN BCL 2;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; ASPERGILLUS AWAMORI; BREAST CANCER; CANCER CELL; CELL MEMBRANE PERMEABILITY; CELL VIABILITY; CONTROLLED STUDY; DNA DEGRADATION; DRUG MECHANISM; DRUG TRANSFORMATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; MCF 7 CELL LINE; MEMBRANE PERMEABILITY; ASPERGILLUS; BIOTRANSFORMATION; CELL DEATH; CELL SURVIVAL; CHEMISTRY; DRUG EFFECTS; GENETICS; METABOLISM; MICROBIOLOGY; SOYBEAN; TUMOR CELL LINE;

FUNGI; GLYCINE MAX;

APOPTOSIS; ASPERGILLUS; BIOTRANSFORMATION; CASPASE 3; CELL DEATH; CELL LINE, TUMOR; CELL SURVIVAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; GENISTEIN; HUMANS; ISOFLAVONES; MCF-7 CELLS; PHYTOESTROGENS; PLANT EXTRACTS; PROTO-ONCOGENE PROTEINS C-BCL-2; SOYBEANS;

EID: 84929129252     PISSN: 01635581     EISSN: 15327914     Source Type: Journal    
DOI: 10.1080/01635581.2015.1015744     Document Type: Article

References (29)

1. Renoir JM: Estradiol receptors in breast cancer cells: Associated co-factors as targets for new therapeutic approaches. Steroids 77, 1249-1261, 2012.
2. Glazier MG and Bowman MA: A review of the evidence for the use of phytoestrogens as a replacement for traditional estrogen replacement therapy. Arch Intern Med 161, 1161-1172, 2001.
3. Larner JM, MacLusky NJ, and Hochberg RB: The naturally occurring C-17 fatty acid esters of estradiol are long-acting estrogens. J Steroid Biochem 22, 407-413, 1985.
4. Murkies AL, Wilcox G, and Davis SR: Clinical review 92: Phytoestrogens. J Clin Endocrinol Metab 83, 297-303, 1998.
5. Imhof M, Gocan A, Reithmayr F, Lipovac M, Schimitzek C, et al.: Effects of a red clover extract (MF11RCE) on endometrium and sex hormones in postmenopausal women. Maturitas 55, 76-81, 2006.
6. Leclercq G and Jacquot Y: Interactions of isoflavones and other plant derived estrogens with estrogen receptors for prevention and treatment of breast cancer-considerations concerning related efficacy and safety. J Steroid Biochem Mol Biol 139, 237-244, 2014.
7. Izumi T, Piskula MK, Osawa S, Obata A, Tobe K, et al.: Soy isoflavone aglycones are absorbed faster and in higher amounts than their glucosides in humans. J Nutr 130, 1695-1699, 2000.
8. Dong JY and Qin LQ: Soy isoflavones consumption and risk of breast cancer incidence or recurrence: A meta-analysis of prospective studies. Breast Cancer Res Treat 125, 315-323, 2011.
9. Rahal OM and Simmen RC: PTEN and p53 cross-regulation induced by soy isoflavone genistein promotes mammary epithelial cell cycle arrest and lobuloalveolar differentiation. Carcinogenesis 31, 1491-1500, 2010.
10. Ullah MF, Ahmad A, Zubair H, Khan HY, Wang Z, et al.: Soy isoflavone genistein induces cell death in breast cancer cells through mobilization of endogenous copper ions and generation of reactive oxygen species. Mol Nutr Food Res 55, 553-559, 2011.
11. Marazza JA, Garro MS, and De Giori GS: Aglycone production by Lactobacillus rhamnosus CRL981 during soymilk fermentation. Food Microbiol 26, 333-339, 2009.
12. Georgetti SR, Vicentini FT, Yokoyama CY, Borin MF, Spadaro AC, et al.: Enhanced in vitro and in vivo antioxidant activity and mobilization of free phenolic compounds of soybean flour fermented with different beta-glucosidase-producing fungi. J Appl Microbiol 106, 459-466, 2009.
13. Tsou MJ, Kao FJ, Lu HC, Kao HC, and Chiang WD: Purification and identification of lipolysis-stimulating peptides derived from enzymatic hydrolysis of soy protein. Food Chem 138, 1454-1460, 2013.
14. Song T, Barua K, Buseman G, and Murphy PA: Soy isoflavone analysis: quality control and a new internal standard. Am J Clin Nutr 68, 1474S-1479S, 1998.
15. Lee IH and Chou CC: Distribution profiles of isoflavone isomers in black bean kojis prepared with various filamentous fungi. J Agric Food Chem 54, 1309-1314, 2006.
16. Gallo D, Giacomelli S, Cantelmo F, Zannoni GF, Ferrandina G, et al.: Chemoprevention of DMBA-induced mammary cancer in rats by dietary soy. Breast Cancer Res Treat 69, 153-164, 2001.
17. Whitsett TG, Jr. and Lamartiniere CA: Genistein and resveratrol: mammary cancer chemoprevention and mechanisms of action in the rat. Expert Rev Anticancer Ther 6, 1699-1706, 2006.
18. Jin S, Zhang QY, Kang XM, Wang JX, and Zhao WH: Daidzein induces MCF-7 breast cancer cell apoptosis via the mitochondrial pathway. Ann Oncol 21, 263-268, 2010.
19. Pugazhendhi D,Watson KA, Mills S, Botting N, Pope GS, et al.: Effect of sulphation on the oestrogen agonist activity of the phytoestrogens genistein and daidzein in MCF-7 human breast cancer cells. J Endocrinol 197, 503-515, 2008.
20. Peterson G and Barnes S: Genistein and biochanin A inhibit the growth of human prostate cancer cells but not epidermal growth factor receptor tyrosine autophosphorylation. Prostate 22, 335-345, 1993.
21. Taylor RC, Cullen SP, and Martin SJ: Apoptosis: Controlled demolition at the cellular level. Nat Rev Mol Cell Biol 9, 231-241, 2008.
22. Aziz MH, Kumar R, and Ahmad N: Cancer chemoprevention by resveratrol: In vitro and in vivo studies and the underlying mechanisms (review). Int J Oncol 23, 17-28, 2003.
23. Aziz MH, Nihal M, Fu VX, Jarrard DF, and Ahmad N: Resveratrolcaused apoptosis of human prostate carcinoma LNCaP cells is mediated via modulation of phosphatidylinositol 3'-kinase/Akt pathway and Bcl-2 family proteins. Mol Cancer Ther 5, 1335-1341, 2006.
24. Stocco B, Toledo K, Salvador M, Paulo M, Koyama N, et al.: Dosedependent effect of resveratrol on bladder cancer cells: Chemoprevention and oxidative stress. Maturitas 72, 72-78, 2012.
25. Kim HY, Choi TW, Kim HJ, Kim SM, Park KR, et al.: A methylene chloride fraction of Saururus chinensis induces apoptosis through the activation of caspase-3 in prostate and breast cancer cells. Phytomedicine 18, 567-574, 2011.
26. Lin YJ, Hou YC, Lin CH, Hsu YA, Sheu JJ, et al.: Puerariae radix isoflavones and their metabolites inhibit growth and induce apoptosis in breast cancer cells. Biochem Biophys Res Commun 378, 683-688, 2009.
27. Janicke RU, Sprengart ML, Wati MR, and Porter AG: Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosis. J Biol Chem 273, 9357-9360, 1998.
28. Cui Q, Yu JH, Wu JN, Tashiro S, Onodera S, et al.: P53-mediated cell cycle arrest and apoptosis through a caspase-3-independent, but caspase-9-dependent pathway in oridonin-treated MCF-7 human breast cancer cells. Acta Pharmacol Sin 28, 1057-1066, 2007.
29. Kushner PJ, Agard DA, Greene GL, Scanlan TS, Shiau AK, et al.: Estrogen receptor pathways to AP-1. J Steroid Biochem Mol Biol 74, 311-317, 2000.