Polydatin restores endothelium-dependent relaxation in rat aorta rings impaired by high glucose a novel insight into the PPARβ-no signaling pathway

PLoS ONE

Volumn 10, Issue 5, 2015, Pages

  Wu, Yang ^a   Xue, Lai ^a   Du, Weimin ^a   Huang, Bo ^a   Tang, Cuiping ^a   Liu, Changqing ^b   Qiu, Hongmei ^a   Jiang, Qingsong ^a  

^a CHONGQING MEDICAL UNIVERSITY   (China)

^b Pharmaceutical College Fujiang Medical University   (China)

Author keywords

[No Author keywords available]

Indexed keywords

3 [(4 ANILINO 2 METHOXYPHENYL)SULFAMOYL] 2 THENOIC ACID METHYL ESTER; ACETYLCHOLINE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GLUCOSE; INDUCIBLE NITRIC OXIDE SYNTHASE; MELOXICAM; N(G) NITROARGININE METHYL ESTER; NATURAL PRODUCT; NITRIC OXIDE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; POLYDATIN; UNCLASSIFIED DRUG; GLUCOSIDE; NOS2 PROTEIN, RAT; NOS3 PROTEIN, RAT; PICEID; PLANT MEDICINAL PRODUCT; STILBENE DERIVATIVE; VASODILATOR AGENT;

ANIMAL TISSUE; AORTA; ARTICLE; CARDIOVASCULAR DISEASE; CELL DAMAGE; CONTROLLED STUDY; DRUG MECHANISM; ENDOTHELIUM CELL; ENDOTHELIUM DEPENDENT RELAXATION; ENZYME ACTIVITY; FEMALE; MALE; NONHUMAN; POLYGONUM CUSPIDATUM; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; THORACIC AORTA; VASODILATATION; ANIMAL; BIOSYNTHESIS; CYTOLOGY; DRUG EFFECTS; ENDOTHELIUM; ENZYME ACTIVATION; HYPERGLYCEMIA; METABOLISM; PATHOLOGY; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

POLYGONUM CUSPIDATUM; RATTUS;

ANIMALS; AORTA, THORACIC; ENDOTHELIAL CELLS; ENDOTHELIUM; ENZYME ACTIVATION; FALLOPIA JAPONICA; FEMALE; GLUCOSE; GLUCOSIDES; HYPERGLYCEMIA; MALE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; NITRIC OXIDE SYNTHASE TYPE III; PLANT PREPARATIONS; PPAR-BETA; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; STILBENES; VASODILATION; VASODILATOR AGENTS;

EID: 84929120260     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0126249     Document Type: Article

References (22)

1. Giugliano D, Ceriello A, Espositom K. Glucose metabolism and hyperglycemia. Am J Clin Nutr. 2008; 87:217-222. PMID: 18175761
2. Gray SP, Jandeleit-Dahm K. The pathobiology of diabetic vascular complications-cardiovascular and kidney disease. J Mol Med (Berl). 2014; 92:441-452. doi: 10.1007/s00109-014-1146-1 PMID: 24687627
3. Du QH, Peng C, Zhang H. Polydatin: a review of pharmacology and pharmacokinetics. Pharm Biol. 2013; 51:1347-54. doi: 10.3109/13880209.2013.792849 PMID: 23862567
4. Kerem Z, Bilkis I, Flaishman MA, Sivan L. Antioxidant activity and inhibition of alpha-glucosidase by trans-resveratrol, piceid, and a novel trans-stilbene from the roots of Israeli Rumex bucephalophorus L. J Agric Food Chem. 2006; 54:1243-1247. PMID: 16478243
5. Miao Q, Wang S, Miao S, Wang J, Xie Y, Yang Q. Cardioprotective effect of polydatin against ischemia/reperfusion injury: roles of protein kinase C and mito K(ATP) activation. Phytomedicine. 2011; 19:8-12. doi: 10.1016/j.phymed.2011.06.023 PMID: 21795031
6. Indraccolo U, Barbieri F. Effect of palmitoylethanolamide-polydatin combination on chronic pelvic pain associated with endometriosis: preliminary observations. Eur J Obstet Gynecol Reprod Biol. 2010; 150:76-79. doi: 10.1016/j.ejogrb.2010.01.008 PMID: 20176435
7. Wang X, Song R, Bian HN, Brunk UT, Zhao M, Zhao KS. Polydatin, a natural polyphenol, protects arterial smooth muscle cells against mitochondrial dysfunction and lysosomal destabilization following hemorrhagic shock. Am J Physiol Regul Integr Comp Physiol. 2012; 302:805-814. doi: 10.1152/ ajpregu.00350.2011 PMID: 22277937
8. Xie X, Peng J, Huang K, Huang J, Shen X, Liu P, et al. Polydatin ameliorates experimental diabetes-induced fibronectin through inhibiting the activation of NF-κB signaling pathway in rat glomerular mesangial cells. Mol Cell Endocrinol. 2012; 362:183-193. doi: 10.1016/j.mce.2012.06.008 PMID: 22732364
9. Gao JP, Chen CX, Gu WL, Wu Q, Wang Y, Lü J. Effects of polydatin on attenuating ventricular remodeling in isoproterenol-induced mouse and pressure-overload rat models. Fitoterapia. 2010; 81:953-960. doi: 10.1016/j.fitote.2010.06.023 PMID: 20603198
10. Markus MA, Morris BJ. Resveratrol in prevention and treatment of common clinical conditions of aging. Clin Interv Aging, 2008; 3:331-339. PMID: 18686754
11. Nicholson SK, Tucker GA, Brameld JM. Effects of dietary polyphenols on gene expression in human vascular endothelial cells. Proc Nutr Soc. 2008; 67:42-47. doi: 10.1017/S0029665108006009 PMID: 18234130
12. Neels JG, Grimaldi PA. Physiological functions of peroxisome proliferator-activated receptor β. Physiol Rev. 2014; 94:795-858. doi: 10.1152/physrev.00027.2013 PMID: 24987006
13. Verma S, Szmitko PE. The vascular biology of peroxisome proliferator-activated receptors: Modulation of atherosclerosis. Can J Cardiol. 2006; 22:12-17.
14. Tian XY, Wong WT, Wang NP. PPARβ Activation Protects Endothelial Function in Diabetic Mice. Diabetes. 2012; 61:3285-3293. doi: 10.2337/db12-0117 PMID: 22933110
15. Qian LB, Wang HP, Chen Y, Chen FX, Ma YY, Bruce IC, et al. Luteolin reduces high glucose-mediated mpairment of endothelium-dependent relaxation in rat aorta by reducing oxidative stress. Pharmacol Res. 2010; 61:281-287. doi: 10.1016/j.phrs.2009.10.004 PMID: 19892019
16. Zhou C, Pridgen B, King N, Xu J, Breslow JL. Hyperglycemic Ins2AkitaLdlr-/- mice show severely elevated lipid levels and increased atherosclerosis: a model of type 1 diabetic macrovascular disease. Journal of Lipid Research. 2011; 52:1483-1493. doi: 10.1194/jlr.M014092 PMID: 21606463
17. Campos C. Chronic hyperglycemia and glucose toxicity: pathology and clinical sequelae. Postgrad Med. 2012; 124:90-97. doi: 10.3810/pgm.2012.11.2615 PMID: 23322142
18. Wallerath T, Deckert G, Ternes T. Resveratrol, a polyphenolic phytoalexin present in red wine, enhances expression and activity of endothelial nitric oxide synthase. Circulation. 2002; 106:1652-1658. PMID: 12270858
19. Räthel TR, Samtleben R, Vollmar AM. Activation of endothelial nitric oxide synthase by red wine polyphenols: impact of grape cultivars, growing area and the vinification process. Hypertens. 2007; 25:541-549. PMID: 17278969
20. Appeldoorn MM, Venema DP, Peters TH. Some phenolic compounds increase the nitric oxide level in endothelial cells in vitro. Agric Food Chem. 2009; 57:7693-7699. doi: 10.1021/jf901381x PMID: 19722703
21. Takahashi S, Uchiyama T, Toda K. Differential effect of resveratrol on nitric oxide production in endothelial f-2 cells. Biol Pharm Bull. 2009; 32:1840-1843. PMID: 19881294
22. Quintela AM1, Jiménez R, Gómez-Guzmán M, Zarzuelo MJ, Galindo P, Sánchez M, et al. Activation of peroxisome proliferator-activated receptor-b/-d (PPARb/d) prevents endothelial dysfunction in type 1 diabetic rats. Free Radical Biology and Medicine.2012; 53:730-741. doi: 10.1016/j.freeradbiomed.2012.05.045 PMID: 22683600