Behavioral characterization of a mouse model overexpressing DSCR1/RCAN1

PLoS ONE

Volumn 6, Issue 2, 2011, Pages

  Dierssen, Mara ^a   Arqué, Gloria ^a   McDonald, Jerome ^a   Andreu, Nuria ^a   Martínez Cué, Carmen ^b   Flórez, Jesús ^b,c   Fillat, Cristina ^a  

^a Barcelona Biomedical Research Park   (Spain)

^b UNIVERSITY OF CANTABRIA   (Spain)

^c Fundación Síndrome de Down de Cantabria   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

CALCINEURIN INHIBITOR; DOWN SYNDROME CANDIDATE REGION 1 PROTEIN; UNCLASSIFIED DRUG; DSCR1 PROTEIN, MOUSE; MUSCLE PROTEIN; SIGNAL PEPTIDE;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN REGION; COGNITION; CONTROLLED STUDY; DEPTH PERCEPTION; FEMALE; GENE DISRUPTION; GENE FUNCTION; GENE LOCATION; GENE OVEREXPRESSION; LEARNING DISORDER; MEMORY CONSOLIDATION; MOUSE; NONHUMAN; PASSIVE AVOIDANCE; TASK PERFORMANCE; ANIMAL; AVOIDANCE BEHAVIOR; C57BL MOUSE; DISEASE MODEL; GENETICS; MAZE TEST; MEMORY; PATHOPHYSIOLOGY; PHYSIOLOGY; PSYCHOLOGICAL ASPECT; SWIMMING; TRANSGENIC MOUSE; UPREGULATION;

ANIMALIA; MUS; MUS MUSCULUS;

ANIMALS; AVOIDANCE LEARNING; BEHAVIOR, ANIMAL; DISEASE MODELS, ANIMAL; FEMALE; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LEARNING DISORDERS; MAZE LEARNING; MEMORY; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MUSCLE PROTEINS; PHYSICAL CONDITIONING, ANIMAL; SWIMMING; UP-REGULATION;

EID: 79952173561     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0017010     Document Type: Article

References (24)

1. Casas C, Martinez S, Pritchard MA, Fuentes JJ, Nadal M, et al. (2001) Dscr1, a novel endogenous inhibitor of calcineurin signaling, is expressed in the primitive ventricle of the heart and during neurogenesis. Mech Dev 101: 289-292.
2. Guimera J, Pucharcos C, Domenech A, Casas C, Solans A, et al. (1997) Cosmid contig and transcriptional map of three regions of human chromosome 21q22: identification of 37 novel transcripts by direct selection. Genomics 45: 59-67.
3. Baek KH, Zaslavsky A, Lynch RC, Britt C, Okada Y, et al. (2009) Down's syndrome suppression of tumour growth and the role of the calcineurin inhibitor DSCR1. Nature 459: 1126-1130.
4. Fuentes JJ, Genesca L, Kingsbury TJ, Cunningham KW, Perez-Riba M, et al. (2000) DSCR1, overexpressed in Down syndrome, is an inhibitor of calcineurin-mediated signaling pathways. Hum Mol Genet 9: 1681-1690.
5. Porta S, Marti E, de la Luna S, Arbones ML, (2007) Differential expression of members of the RCAN family of calcineurin regulators suggests selective functions for these proteins in the brain. Eur J Neurosci 26: 1213-1226.
6. Park J, Oh Y, Chung KC, (2009) Two key genes closely implicated with the neuropathological characteristics in Down syndrome: DYRK1A and RCAN1. BMB Rep 42: 6-15.
7. Mitchell AN, Jayakumar L, Koleilat I, Qian J, Sheehan C, et al. (2007) Brain expression of the calcineurin inhibitor RCAN1 (Adapt78). Arch Biochem Biophys 467: 185-192.
8. Keating DJ, Dubach D, Zanin MP, Yu Y, Martin K, et al. (2008) DSCR1/RCAN1 regulates vesicle exocytosis and fusion pore kinetics: implications for Down syndrome and Alzheimer's disease. Hum Mol Genet 17: 1020-1030.
9. Ermak G, Hench KJ, Chang KT, Sachdev S, Davies KJ, (2009) Regulator of calcineurin (RCAN1-1L) is deficient in Huntington disease and protective against mutant huntingtin toxicity in vitro. J Biol Chem 284: 11845-11853.
10. Sun X, Wu Y, Chen B, Zhang Z, Zhou W, et al. Regulator of calcineurin 1 (RCAN1) facilitates neuronal apoptosis through caspase 3 activation. J Biol Chem.
11. Tam GW, van de Lagemaat LN, Redon R, Strathdee KE, Croning MD, et al. (2010) Confirmed rare copy number variants implicate novel genes in schizophrenia. Biochem Soc Trans 38: 445-451.
12. Chang KT, Shi YJ, Min KT, (2003) The Drosophila homolog of Down's syndrome critical region 1 gene regulates learning: implications for mental retardation. Proc Natl Acad Sci U S A 100: 15794-15799.
13. Hoeffer CA, Dey A, Sachan N, Wong H, Patterson RJ, et al. (2007) The Down syndrome critical region protein RCAN1 regulates long-term potentiation and memory via inhibition of phosphatase signaling. J Neurosci 27: 13161-13172.
14. Dierssen M, Fotaki V, Martinez de Lagran M, Gratacos M, Arbones M, et al. (2002) Neurobehavioral development of two mouse lines commonly used in transgenic studies. Pharmacol Biochem Behav 73: 19-25.
15. Martinez de Lagran M, Altafaj X, Gallego X, Marti E, Estivill X, et al. (2004) Motor phenotypic alterations in TgDyrk1a transgenic mice implicate DYRK1A in Down syndrome motor dysfunction. Neurobiol Dis 15: 132-142.
16. Escorihuela RM, Fernandez-Teruel A, Vallina IF, Baamonde C, Lumbreras MA, et al. (1995) A behavioral assessment of Ts65Dn mice: a putative Down syndrome model. Neurosci Lett 199: 143-146.
17. Arque G, Fotaki V, Fernandez D, Martinez de Lagran M, Arbones ML, et al. (2008) Impaired spatial learning strategies and novel object recognition in mice haploinsufficient for the dual specificity tyrosine-regulated kinase-1A (Dyrk1A). PLoS One 3: e2575.
18. Sasahara M, Fries JW, Raines EW, Gown AM, Westrum LE, et al. (1991) PDGF B-chain in neurons of the central nervous system, posterior pituitary, and in a transgenic model. Cell 64: 217-227.
19. Resnick N, Collins T, Atkinson W, Bonthron DT, Dewey CF Jr, et al. (1993) Platelet-derived growth factor B chain promoter contains a cis-acting fluid shear-stress-responsive element. Proc Natl Acad Sci U S A 90: 4591-4595.
20. Mansuy IM, Mayford M, Jacob B, Kandel ER, Bach ME, (1998) Restricted and regulated overexpression reveals calcineurin as a key component in the transition from short-term to long-term memory. Cell 92: 39-49.
21. Ikegami S, Inokuchi K, (2000) Antisense DNA against calcineurin facilitates memory in contextual fear conditioning by lowering the threshold for hippocampal long-term potentiation induction. Neuroscience 98: 637-646.
22. Malleret G, Haditsch U, Genoux D, Jones MW, Bliss TV, et al. (2001) Inducible and reversible enhancement of learning, memory, and long-term potentiation by genetic inhibition of calcineurin. Cell 104: 675-686.
23. Escorihuela RM, Vallina IF, Martinez-Cue C, Baamonde C, Dierssen M, et al. (1998) Impaired short- and long-term memory in Ts65Dn mice, a model for Down syndrome. Neurosci Lett 247: 171-174.
24. Dierssen M, Marmol F, Vivas NM, Clos MV, Badia A, (1992) Post-train administration of 9-amino-1,2,3,4-tetrahydroacridine enhances passive avoidance retention and decreases beta-adrenoceptor-linked cyclic AMP formation in middle-aged rats. Brain Res 586: 117-120.