Alpha-melanocyte stimulating hormone: An emerging anti-inflammatory antimicrobial peptide

BioMed Research International

Volumn 2014, Issue , 2014, Pages

  Singh, Madhuri ^a   Mukhopadhyay, Kasturi ^a  

^a JAWAHARLAL NEHRU UNIVERSITY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA DEFENSIN; ALPHA INTERMEDIN; BETA DEFENSIN; CATHELICIDIN ANTIMICROBIAL PEPTIDE LL 37; POLYPEPTIDE ANTIBIOTIC AGENT; ANTIFUNGAL AGENT; ANTIINFLAMMATORY AGENT; ANTIMICROBIAL CATIONIC PEPTIDE; NEUROPEPTIDE;

ADAPTIVE IMMUNITY; ANTIMICROBIAL ACTIVITY; DRUG MECHANISM; HOST RESISTANCE; HUMAN; IMMUNOMODULATION; INFLAMMATION; INNATE IMMUNITY; LEUKOCYTE; MACROPHAGE; NEUTROPHIL; NONHUMAN; PHAGOCYTOSIS; REVIEW; CANDIDA ALBICANS; CHEMISTRY; DRUG EFFECTS; PATHOLOGY; STAPHYLOCOCCUS AUREUS; STRUCTURE ACTIVITY RELATION;

ALPHA-MSH; ANTI-INFLAMMATORY AGENTS; ANTIFUNGAL AGENTS; ANTIMICROBIAL CATIONIC PEPTIDES; CANDIDA ALBICANS; HUMANS; INFLAMMATION; NEUROPEPTIDES; STAPHYLOCOCCUS AUREUS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84929057220     PISSN: 23146133     EISSN: 23146141     Source Type: Journal    
DOI: 10.1155/2014/874610     Document Type: Review

References (72)

1. A. Catania, C. Lonati, A. Sordi, A. Carlin, P. Leonardi, and S. Gatti, "The melanocortin system in control of inflammation, " TheScientificWorldJOURNAL, vol. 10, pp. 1840-1853, 2010.
2. A. Bertolini, R. Tacchi, and A. V. Vergoni, "Brain effects of melanocortins, " Pharmacological Research, vol. 59, no. 1, pp. 13-47, 2009.
3. R. M. Dores, "Adrenocorticotropic hormone, melanocyte-stimulating hormone, and themelanocortin receptors: revisiting the work of robert schwyzer: a thirty-year retrospective, " Annals of the New York Academy of Sciences, vol. 1163, pp. 93-100, 2009.
4. A. Catania, Ed. , Melanocortins:MultipleActions and Therapeutic Potential, Landes Biosciences and Springer Science + Business Media, New York, NY, USA, 2010.
5. D. Li and A. W. Taylor, "Diminishment of α-MSH antiinflammatory activity in MC1r siRNA-transfected RAW264. 7 macrophages, " Journal of Leukocyte Biology, vol. 84, no. 1, pp. 191-198, 2008.
6. K. Fosgerau, K. Raun, C. Nilsson, K. Dahl, and B. S. Wulff, "Novel a-MSH analogue causes weight loss in obese rats and minipigs and improves insulin sensitivity, " Journal of Endocrinology, vol. 220, no. 2, pp. 97-107, 2014.
7. F. Capsoni, A. M. Ongari, E. Reali, and A. Catania, "Melanocortin peptides inhibit urate crystal-induced activation of phagocytic cells, " Arthritis Research & Therapy, vol. 11, no. 5, article R151, 2009.
8. M. Zasloff, "Antimicrobial peptides ofmulticellular organisms, " Nature, vol. 415, no. 6870, pp. 389-395, 2002.
9. M. Zasloff, "Inducing endogenous antimicrobial peptides to battle infections, " Proceedings of the National Academy of Sciences of the United States of America, vol. 103, no. 24, pp. 8913-8914, 2006.
10. S. A. Baltzer and M. H. Brown, "Antimicrobial peptides-promising alternatives to conventional antibiotics, " Journal of Molecular Microbiology and Biotechnology, vol. 20, no. 4, pp. 228-235, 2011.
11. T. Brzoska, T. A. Luger, C. Maaser, C. Abels, and M. Böhm, "α-Melanocyte-stimulating hormone and related tripeptides: biochemistry, antiinflammatory and protective effects in vitro and in vivo, and future perspectives for the treatment of immunemediated inflammatory diseases, " Endocrine Reviews, vol. 29, no. 5, pp. 581-602, 2008.
12. A. Catania, G. Colombo, C. Rossi et al. , "Antimicrobial properties of α-MSH and related synthetic melanocortins, " TheScientificWorldJournal, vol. 6, pp. 1241-1246, 2006.
13. S. Gatti, A. Carlin, A. Sordi et al. , "Inhibitory effects of the peptide (CKPV)2 on endotoxin-induced host reactions, " Journal of Surgical Research, vol. 131, pp. 209-214, 2006.
14. M. Cutuli, S. Cristiani, J. M. Lipton, and A. Catania, "Antimicrobial effects of -MSH peptides, " Journal of Leukocyte Biology, vol. 67, pp. 233-239, 2000.
15. M. Charnley, A. J. G. Moir, C. W. I. Douglas, and J. W. Haycock, "Anti-microbial action of melanocortin peptides and identification of a novel X-Pro-d/l-Val sequence in Gram-positive and Gram-negative bacteria, " Peptides, vol. 29, no. 6, pp. 1004-1009, 2008.
16. Madhuri, T. Shireen, S. K. Venugopal et al. , "In vitro antimicrobial activity of alpha-melanocyte stimulating hormone against major human pathogen Staphylococcus aureus, " Peptides, vol. 30, no. 9, pp. 1627-1635, 2009.
17. A. Catania, P. Grieco, A. Randazzo et al. , "Three-dimensional structure of the alpha-MSH-derived candidacidal peptide [Ac-CKPV ]2, " Journal of Peptide Research, vol. 66, no. 1, pp. 19-26, 2005.
18. M. Singh and K. Mukhopadhyay, "C-terminal amino acids of alpha-melanocyte-stimulating hormone are requisite for its antibacterial activity against Staphylococcus aureus, " Antimicrobial Agents and Chemotherapy, vol. 55, no. 5, pp. 1920-1929, 2011.
19. H. X. Ji, Y. L. Zou, J. J. Duan et al. , "The synthetic melanocortin (CKPV)2 exerts anti-fungal and anti-inflammatory effects against Candida albicans vaginitis via inducing macrophage M2 polarization, " PLoS ONE, vol. 8, no. 2, Article ID e56004, 2013.
20. K. A. Brogden, G. K. Johnson, S. D. Vincent, T. Abbasi, and S. Vali, "Oral inflammation , a role for antimicrobial peptide modulation of cytokine and chemokine responses, " Expert Review of Anti-Infective Therapy, vol. 11, pp. 1097-1113, 2013.
21. A. L. Hilchie, K. Wuerth, and R. E. Hancock, "Immune modulation by multifaceted cationic host defense (antimicrobial) peptides, " Nature Chemical Biology, vol. 9, no. 12, pp. 761-768, 2013.
22. R. I. Lehrer and W. Lu, "α-Defensins in human innate immunity, " Immunological Reviews, vol. 245, pp. 84-112, 2012.
23. M. Wilmes, B. P. Cammue, H. G. Sahl, and K. Thevissen, "Antibiotic activities of host defense peptides: more to it than lipid bilayer perturbation, " Natural Product Reports, vol. 28, pp. 1350-1358, 2011.
24. C. L. Bevins and N. H. Salzman, "Paneth cells, antimicrobialpeptides and maintenance of intestinal homeostasis, " Nature Reviews Microbiology, vol. 9, pp. 356-368, 2011.
25. D. Vandamme, B. Landuyt, W. Luyten, and L. Schoofs, "A comprehensive summary of LL-37, the factotum human cathelicidin peptide, " Cellular Immunology, vol. 280, no. 1, pp. 22-35, 2012.
26. A. Sol, O. Ginesin, S. Chaushu et al. , "LL-37 Opsonizes and inhibits biofilm formation of Aggregatibacter actinomcetemcomitans at subbactericidal concentrations, " Infection and Immunity, vol. 81, no. 10, pp. 3577-3585, 2013.
27. A. Linde, B. Wachter, O. P. Höner et al. , "Natural history of innate host defense peptides, " Probiotics and Antimicrobial Proteins, vol. 1, no. 2, pp. 97-112, 2009.
28. G. Wang, Ed. , Antimicrobial Peptides, Discovery Design and Novel Therapeutic Strategies, CAB International, Oxfordshire, UK.
29. A. Catania, S. Gatti, G. Colombo, and J. M. Lipton, "Targeting melanocortin receptors as a novel strategy to control inflammation, " Pharmacological Reviews, vol. 56, no. 1, pp. 1-29, 2004.
30. Y. Yang, "Structure, function and regulation of the melanocortin receptors, " European Journal of Pharmacology, vol. 660, no. 1, pp. 125-130, 2011.
31. V. J. Hruby, M. Cai, J. Cain, J. Nyberg, and D. Trivedi, "Design of novel melanocortin receptor ligands: multiple receptors, complex pharmacology, the challenge, " European Journal of Pharmacology, vol. 660, no. 1, pp. 88-93, 2011.
32. R. M. Dores, R. L. Londraville, J. Prokop, P. Davis, N. Dewey, and L. N. J. Mol Endocrinol, "Molecular evolution of GPCRS: melanocortin/melanocortin receptors, " Journal of Molecular Endocrinology, vol. 52, no. 3, pp. T29-T42, 2014.
33. M. Auriemma, T. Brzoska, L. Klenner et al. , "α-MSH-stimulated tolerogenic dendritic cells induce functional regulatory T cells and ameliorate ongoing skin inflammation, " Journal of Investigative Dermatology, vol. 132, no. 7, pp. 1814-1824, 2012.
34. H. Jenssen and R. E. W. Hancock, "Therapeutic potential of HDPs as immunomodulatory agents, " in Antimicrobial Peptides, A. Giuliani and A. C. Rinaldi, Eds. , vol. 20 of Methods in Molecular Biology, pp. 329-347, Springer Science+Business Media LLC, 2010.
35. Y. N. Yount and M. R. Yeaman, "Emerging themes and therapeutic prospects for anti-infective peptides, " Annual Review of Pharmacology and Toxicology, vol. 52, pp. 337-360, 2012.
36. H. W. Huang, "Peptide-lipid interactions and mechanisms of antimicrobial peptides, " Novartis Foundation Symposium, vol. 225, pp. 188-206, 1999.
37. K. Matsuzaki, "Why and how are peptide-lipid interactions utilized for self-defense? Magainins and tachyplesins as archetypes, " Biochimica et Biophysica Acta-Biomembranes, vol. 1462, no. 1-2, pp. 1-10, 1999.
38. Y. Shai, "Mechanism of the binding, insertion and destabilization of phospholipid bilayer membranes by α-helical antimicrobial and cell non-selective membrane-lytic peptides, " Biochimica et Biophysica Acta: Biomembranes, vol. 1462, no. 1-2, pp. 55-70, 1999.
39. R. M. Epand and H. J. Vogel, "Diversity of antimicrobial peptides and their mechanisms of action, " Biochimica et Biophysica Acta, vol. 1462, pp. 11-28, 1999.
40. S. Yenugu, K. G. Hamil, Y. Radhakrishnan, F. S. French, and S. H. Hall, "Theandrogen-regulated epididymal sperm-binding protein, human β-defensin 118 (DEFB118) (formerly ESC42), is an antimicrobial β-defensin, " Endocrinology, vol. 145, no. 7, pp. 3165-3173, 2004.
41. I. Wiedemann, E. Breukink, C. Van Kraaij et al. , "Specific binding of nisin to the peptidoglycan precursor lipid II combines pore formation and inhibition of cell wall biosynthesis for potent antibiotic activity, "The Journal of Biological Chemistry, vol. 276, no. 3, pp. 1772-1779, 2001.
42. N. K. Brogden, L. Mehalick, C. L. Fischer, P. W. Wertz, and K. A. Brogden, "The emerging role of peptides and lipids as antimicrobial epidermal barriers and modulators of local inflammation, " Skin Pharmacology and Physiology, vol. 25, no. 4, pp. 167-181, 2012.
43. K. L. Brown, G. F. Poon, D. Birkenhead et al. , "Host defense peptide ll-37 selectively reduces proinflammatory macrophage responses, "The Journal of Immunology, vol. 186, pp. 5497-5505, 2011.
44. D. Drider and S. Rebuffat, Eds. , Prokaryotic Antimicrobial Peptides from Genes to Applications, Springer, New York, NY, USA, 2011.
45. I. A. El Karim, G. J. Linden, D. F. Orr, and F. T. Lundy, "Antimicrobial activity of neuropeptides against a range of microorganisms from skin, oral, respiratory and gastrointestinal tract sites, " Journal of Neuroimmunology, vol. 200, no. 1, pp. 11-16, 2008.
46. K. A. Brogden, J. M. Guthmiller, M. Salzet, and M. Zasloff, "The nervous system and innate immunity: the neuropeptide connection, " Nature Immunology, vol. 6, no. 6, pp. 558-564, 2005.
47. S. Leone, G. Noera, and A. Bertolini, "Melanocortins as innovative drugs for ischemic diseases and neurodegenerative disorders: established data and perspectives, " CurrentMedicinal Chemistry, vol. 20, no. 6, pp. 735-750, 2013.
48. L. A. Devi, Ed. , The G-Protein-Coupled Receptors Handbook, Humana Express, Totowa, NJ, USA, 2005.
49. R. P. Hill, S. MacNeil, and J. W. Haycock, "Melanocyte stimulating hormone peptides inhibit TNF-α signaling in human dermal fibroblast cells, " Peptides, vol. 27, no. 2, pp. 421-430, 2006.
50. P. Grieco, C. Rossi, G. Colombo et al. , "Novel α-melanocyte stimulating hormone peptide analogues with high candidacidal activity, " Journal ofMedicinal Chemistry, vol. 46, no. 5, pp. 850-855, 2003.
51. T. A. Luger and T. Brzoska, "α-MSHrelated peptides: a newclass of anti-inflammatory and immunomodulating drugs, " Annals of the Rheumatic Diseases, vol. 66, supplement 3, pp. iii52-iii55, 2007.
52. K. Ma and J. McLaurin, "α-melanocyte stimulating hormone prevents GABAergic neronal loss and improves cognitive functions in Alzheimers disease, " The Journal of Neuroscience, vol. 34, no. 20, pp. 6736-6745, 2014.
53. A. Costa, P. Bini, M. Hamze-Sinno et al. , "Galanin and α-MSH autoantibodies in cerebrospinal fluid of patients with Alzheimers disease, " Journal of Neuroimmunology, vol. 240-241, pp. 114-120, 2011.
54. D. Giuliani, A. Bitto, M. Galntucci, D. Zaffe, A. Otani, and N. Irrera, "Melanocortins protect against progression of Alzheimers disease in tripletransgenic mice by targeting multiple pathophysiological pathways, " Neurobiology of Aging, vol. 35, no. 3, pp. 537-547, 2014.
55. A. Catania and J. M. Lipton, "α-Melanocyte stimulating hormone in the modulation of host reactions, " Endocrine Reviews, vol. 14, no. 5, pp. 564-576, 1993.
56. T. Brzoska, M. Böhm, A. Lugering, K. Loser, and T. A. Luger, "Terminal signal anti-inflammatory effects of alphamelanocyte-stimulating hormone related peptides beyondthe pharmacophore, " Advances in Experimental Medicine and Biology, vol. 681, pp. 107-116, 2010.
57. E. Schaible, A. Steinstraer, A. Jahn-Eimermacher et al. , "Single administration of tripeptide α-MSH(11-13) attenuates brain damage by reduced inflammation and apoptosis after experimental traumatic brain injury in mice, " PLoS ONE, vol. 8, no. 8, Article ID e71056, 2013.
58. R. Delgado, A. Carlin, L. Airaghi et al. , "Melanocortin peptides inhibit production of proinflammatory cytokines and nitric oxide by activated microglia, " Journal of Leukocyte Biology, vol. 63, no. 6, pp. 740-745, 1998.
59. A. Catania, "Neuroprotective actions of melanocortins: a therapeutic opportunity, " Trends in Neurosciences, vol. 31, no. 7, pp. 353-360, 2008.
60. R. D. Cone, "Studies on the physiological functions of the melanocortin system, " Endocrine Reviews, vol. 27, pp. 736-749, 2006.
61. S. K. Manna and B. B. Aggarwal, "α-melanocyte-stimulating hormone inhibits the nuclear transcription factor NF-B activation induced by various inflammatory agents, " Journal of Immunology, vol. 161, no. 6, pp. 2873-2880, 1998.
62. M. E. Hiltz and J. M. Lipton, "Antiinflammatory activity of a COOH-terminal fragment of the neuropeptide α-MSH, " FASEB Journal, vol. 3, no. 11, pp. 2282-2284, 1989.
63. J. M. Lipton, A. Catania, and T. Ichiyama, "Marshaling the anti-inflammatory influence of the neuroimmunomodulator α-MSH, " News in Physiological Sciences, vol. 15, no. 4, pp. 192-195, 2000.
64. P. C. Eves and J. W. Haycock, "Melanocortin signalling mechanisms, " Advances in Experimental Medicine and Biology, vol. 681, pp. 19-28, 2010.
65. M. Nonaka, X. Chen, J. E. S. Pierce et al. , "Prolonged activation of NF-B following traumatic brain injury in rats, " Journal of Neurotrauma, vol. 16, no. 11, pp. 1023-1034, 1999.
66. S. Gatti, C. Lonati, F. Acerbi et al. , "Protective action of NDPMSH in experimental subarachnoid hemorrhage, " Experimental Neurology, vol. 234, no. 1, pp. 230-238, 2012.
67. F. Capsoni, A. Ongari, G. Colombo, F. Turcatti, and A. Catania, "The synthetic melanocortin (CKPV)2 exerts broad antiinflammatory effects in human neutrophils, " Peptides, vol. 28, no. 10, pp. 2016-2022, 2007.
68. M. Singh, R. Gadepalli, B. Dhawan, and K. Mukhopadhyay, "Combination of alpha-melanocyte stimulating hormone with conventional antibiotics against methicillin resistant Staphylococcus aureus, " PLoS ONE, vol. 8, Article IDe73815, 2013.
69. M. F. Masman, A. M. Rodŕguez, L. Svetaz et al. , "Synthesis and conformational analysis of His-Phe-Arg-Trp-NH2 and analogueswith antifungal properties, " Bioorganic andMedicinal Chemistry, vol. 14, no. 22, pp. 7604-7614, 2006.
70. T. Shireen, M. Singh, B. Dhawan, and K. Mukhopadhyay, "Characterization of cell membrane parameters of clinical isolates of Staphylococcus aureus with varied susceptibility to alpha-melanocyte stimulating hormone, " Peptides, vol. 37, no. 2, pp. 334-339, 2012.
71. P. Grieco, A. Carotenuto, L. Auriemma, A. Limatola, S. diMaro, and F. Merlino, "Novel α-MSH peptide analogues with broad spectrum antimicrobial activity, " PLoS ONE, vol. 8, Article ID e61614, 2013.
72. A. Cederlund, G. H. Gudmundsson, and B. Agerberth, "Antimicrobial peptides important in innate immunity, " FEBS Journal, vol. 278, no. 20, pp. 3942-3951, 2011.