The Synthetic Melanocortin (CKPV)2 Exerts Anti-Fungal and Anti-Inflammatory Effects against Candida albicans Vaginitis via Inducing Macrophage M2 Polarization

PLoS ONE

Volumn 8, Issue 2, 2013, Pages

  Ji, Hai Xia ^a   Zou, Yu Lian ^a   Duan, Jing Jing ^a   Jia, Zhi Rong ^a   Li, Xian Jing ^a   Wang, Zhuo ^a   Li, Li ^b   Li, Yong Wen ^b   Liu, Gen Yan ^c   Tong, Ming Qing ^c   Li, Xiao Yi ^e   Zhang, Guo Hui ^e   Dai, Xiang Rong ^e   He, Ling ^a   Li, Zhi Yu ^a   Cao, Cong ^d   Yang, Yong ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b GUILIN MEDICAL UNIVERSITY   (China)

^c THE FIRST AFFILIATED HOSPITAL OF NANJING MEDICAL UNIVERSITY   (China)

^d SOOCHOW UNIVERSITY   (China)

^e Hefei Zhaoke Pharmaceutical ^*  (China)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTYLLYSYLPROLYLVALYLAMINE; ALPHA INTERMEDIN; CD163 ANTIGEN; CD68 ANTIGEN; CYCLIC AMP; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6; MELANOCORTIN; MELANOCORTIN 1 RECEPTOR; MICONAZOLE; PLACEBO; SMALL INTERFERING RNA; SYNTHETIC PEPTIDE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ANTIFUNGAL ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CANDIDA ALBICANS; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DRUG TARGETING; EXPERIMENTAL RAT; FEMALE; IN VITRO STUDY; INFLAMMATORY INFILTRATE; MACROPHAGE ACTIVATION; MACROPHAGE MIGRATION INHIBITION; NONHUMAN; POLARIZATION; RAT; SURVIVAL RATE; VAGINA CANDIDIASIS;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTIFUNGAL AGENTS; CANDIDA ALBICANS; CANDIDIASIS, VULVOVAGINAL; CELLS, CULTURED; CERCOPITHECUS AETHIOPS; COS CELLS; CYTOKINES; FEMALE; HUMANS; MACROPHAGES; MELANOCORTINS; MICE; PHAGOCYTOSIS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, MELANOCORTIN, TYPE 1; VAGINA;

EID: 84874014300     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0056004     Document Type: Article

References (50)

1. Singh V, Sinha I, Sadhale PP, (2005) Global analysis of altered gene expression during morphogenesis of Candida albicans in vitro. Biochem Biophys Res Commun 334: 1149-1158.
2. Fidel PL, (2002) The protective immune response against vaginal candidiasis: lessons learned from clinical studies and animal models. Int Rev Immunol 21: 515-548.
3. Kim J, Sudbery P, (2011) Candida albicans, a major human fungal pathogen. J Microbiol 49: 171-177.
4. Sobel JD, (1985) Epidemiology and pathogenesis of recurrent vulvovaginal candidiasis. Am J Obstet Gynecol 152: 924-935.
5. Chen JY, Tian H, Beigi RH, (2009) Treatment considerations for bacterial vaginosis and the risk of recurrence. J Womens Health (Larchmt) 18: 1997-2004.
6. Sobel JD, Faro S, Force RW, Foxman B, Ledger WJ, et al. (1998) Vulvovaginal candidiasis: epidemiologic, diagnostic, and therapeutic considerations. Am J Obstet Gynecol 178: 203-211.
7. Fong IW, (1996) Clinical and cost considerations in the pharmacotherapy of vulvovaginal candidiasis. Pharmacoeconomics 9: 497-505.
8. Cutuli M, Cristiani S, Lipton JM, Catania A, (2000) Antimicrobial effects of alpha-MSH peptides. J Leukoc Biol 67: 233-239.
9. Madhuri, Shireen T, Venugopal SK, Ghosh D, Gadepalli R, et al. (2009) In vitro antimicrobial activity of alpha-melanocyte stimulating hormone against major human pathogen Staphylococcus aureus. Peptides 30: 1627-1635.
10. Catania A, Colombo G, Rossi C, Carlin A, Sordi A, et al. (2006) Antimicrobial properties of alpha-MSH and related synthetic melanocortins. ScientificWorldJournal 6: 1241-1246.
11. Cragnolini AB, Caruso C, Lasaga M, Scimonelli TN, (2006) Alpha-MSH and gamma-MSH modulate early release of hypothalamic PGE2 and NO induced by IL-1beta differently. Neurosci Lett 409: 168-172.
12. Hill RP, MacNeil S, Haycock JW, (2006) Melanocyte stimulating hormone peptides inhibit TNF-alpha signaling in human dermal fibroblast cells. Peptides 27: 421-430.
13. Raap U, Brzoska T, Sohl S, Path G, Emmel J, et al. (2003) Alpha-melanocyte-stimulating hormone inhibits allergic airway inflammation. J Immunol 171: 353-359.
14. Getting SJ, (2002) Melanocortin peptides and their receptors: new targets for anti-inflammatory therapy. Trends Pharmacol Sci 23: 447-449.
15. Li D, Taylor AW, (2008) Diminishment of alpha-MSH anti-inflammatory activity in MC1r siRNA-transfected RAW264.7 macrophages. J Leukoc Biol 84: 191-198.
16. Getting SJ, Schioth HB, Perretti M, (2003) Dissection of the anti-inflammatory effect of the core and C-terminal (KPV) alpha-melanocyte-stimulating hormone peptides. J Pharmacol Exp Ther 306: 631-637.
17. Prabhu NV, Perkyns JS, Pettitt BM, (1999) Modeling of alpha-MSH conformations with implicit solvent. J Pept Res 54: 394-407.
18. Catania A, Grieco P, Randazzo A, Novellino E, Gatti S, et al. (2005) Three-dimensional structure of the alpha-MSH-derived candidacidal peptide [Ac-CKPV]2. J Pept Res 66: 19-26.
19. Gatti S, Carlin A, Sordi A, Leonardi P, Colombo G, et al. (2006) Inhibitory effects of the peptide (CKPV)2 on endotoxin-induced host reactions. J Surg Res 131: 209-214.
20. Capsoni F, Ongari A, Colombo G, Turcatti F, Catania A, (2007) The synthetic melanocortin (CKPV)2 exerts broad anti-inflammatory effects in human neutrophils. Peptides 28: 2016-2022.
21. Capsoni F, Ongari AM, Reali E, Catania A, (2009) Melanocortin peptides inhibit urate crystal-induced activation of phagocytic cells. Arthritis Res Ther 11: R151.
22. Mosser DM, Edwards JP, (2008) Exploring the full spectrum of macrophage activation. Nat Rev Immunol 8: 958-969.
23. Schleicher U, Bogdan C, (2009) Generation, culture and flow-cytometric characterization of primary mouse macrophages. Methods Mol Biol 531: 203-224.
24. Stringaro A, Crateri P, Adriani D, Arancia G, Cassone A, et al. (1998) Expression of the complement-binding protein (MP60) of Candida albicans in experimental vaginitis. Mycopathologia 144: 147-152.
25. Carrara MA, Donatti L, Damke E, Svidizinski TI, Consolaro ME, et al. (2010) A new model of vaginal infection by Candida albicans in rats. Mycopathologia 170: 331-338.
26. Fidel PL Jr, Lynch ME, Sobel JD, (1993) Candida-specific cell-mediated immunity is demonstrable in mice with experimental vaginal candidiasis. Infect Immun 61: 1990-1995.
27. Pander J, Heusinkveld M, van der Straaten T, Jordanova ES, Baak-Pablo R, et al. (2011) Activation of tumor-promoting type 2 macrophages by EGFR-targeting antibody cetuximab. Clin Cancer Res 17: 5668-5673.
28. Liu X, Yu H, Yang L, Li C, Li L (2012) 15-Deoxy-Delta(12,14)-prostaglandin J(2) attenuates the biological activities of monocyte/macrophage cell lines. Eur J Cell Biol.
29. McGillis JP, Sudduth-Klinger J, Harrowe G, Mitsuhashi M, Payan DG, (1989) Transient expression of the angiotensin II receptor: a rapid and functional analysis of a calcium-mobilizing seven-transmembrane domain receptor in COS-7 cells. Biochem Biophys Res Commun 165: 935-941.
30. Bonetto S, Carlavan I, Baty D, (2005) Isolation and characterization of antagonist and agonist peptides to the human melanocortin 1 receptor. Peptides 26: 2302-2313.
31. Seong I, Min HJ, Lee JH, Yeo CY, Kang DM, et al. (2012) Sox10 controls migration of B16F10 melanoma cells through multiple regulatory target genes. PLoS One 7: e31477.
32. Newton RA, Smit SE, Barnes CC, Pedley J, Parsons PG, et al. (2005) Activation of the cAMP pathway by variant human MC1R alleles expressed in HEK and in melanoma cells. Peptides 26: 1818-1824.
33. Lam CW, Perretti M, Getting SJ, (2006) Melanocortin receptor signaling in RAW264.7 macrophage cell line. Peptides 27: 404-412.
34. Shiau MY, Chiou HL, Lee YL, Kuo TM, Chang YH, (2001) Establishment of a consistent L929 bioassay system for TNF-alpha quantitation to evaluate the effect of lipopolysaccharide, phytomitogens and cytodifferentiation agents on cytotoxicity of TNF-alpha secreted by adherent human mononuclear cells. Mediators Inflamm 10: 199-208.
35. Humphreys DT, Wilson MR, (1999) Modes of L929 cell death induced by TNF-alpha and other cytotoxic agents. Cytokine 11: 773-782.
36. Motran CC, Diaz FL, Gruppi A, Slavin D, Chatton B, et al. (2002) Human pregnancy-specific glycoprotein 1a (PSG1a) induces alternative activation in human and mouse monocytes and suppresses the accessory cell-dependent T cell proliferation. J Leukoc Biol 72: 512-521.
37. Tansini A, de Medeiros BM, (2009) Susceptibility to Yersinia pseudotuberculosis infection is linked to the pattern of macrophage activation. Scand J Immunol 69: 310-318.
38. Medrek C, Ponten F, Jirstrom K, Leandersson K, (2012) The presence of tumor associated macrophages in tumor stroma as a prognostic marker for breast cancer patients. BMC Cancer 12: 306.
39. Ydens E, Cauwels A, Asselbergh B, Goethals S, Peeraer L, et al. (2012) Acute injury in the peripheral nervous system triggers an alternative macrophage response. J Neuroinflammation 9: 176.
40. Martinez FO, Sica A, Mantovani A, Locati M, (2008) Macrophage activation and polarization. Front Biosci 13: 453-461.
41. Fidel PL Jr, Sobel JD, (1996) Immunopathogenesis of recurrent vulvovaginal candidiasis. Clin Microbiol Rev 9: 335-348.
42. Quayle AJ, (2002) The innate and early immune response to pathogen challenge in the female genital tract and the pivotal role of epithelial cells. J Reprod Immunol 57: 61-79.
43. Badylak SF, Valentin JE, Ravindra AK, McCabe GP, Stewart-Akers AM, (2008) Macrophage phenotype as a determinant of biologic scaffold remodeling. Tissue Eng Part A 14: 1835-1842.
44. Schenk M, Mueller C, (2007) Adaptations of intestinal macrophages to an antigen-rich environment. Semin Immunol 19: 84-93.
45. Mantovani A, Sica A, Sozzani S, Allavena P, Vecchi A, et al. (2004) The chemokine system in diverse forms of macrophage activation and polarization. Trends Immunol 25: 677-686.
46. Szardenings M, Muceniece R, Mutule I, Mutulis F, Wikberg JE, (2000) New highly specific agonistic peptides for human melanocortin MC(1) receptor. Peptides 21: 239-243.
47. Moon EY, Pyo S, (2007) Lipopolysaccharide stimulates Epac1-mediated Rap1/NF-kappaB pathway in Raw 264.7 murine macrophages. Immunol Lett 110: 121-125.
48. Ballinger MN, Welliver T, Straight S, Peters-Golden M, Swanson JA, (2010) Transient increase in cyclic AMP localized to macrophage phagosomes. PLoS One 5: e13962.
49. Yoon SW, Goh SH, Chun JS, Cho EW, Lee MK, et al. (2003) alpha-Melanocyte-stimulating hormone inhibits lipopolysaccharide-induced tumor necrosis factor-alpha production in leukocytes by modulating protein kinase A, p38 kinase, and nuclear factor kappa B signaling pathways. J Biol Chem 278: 32914-32920.
50. Maaser C, Kannengiesser K, Specht C, Lugering A, Brzoska T, et al. (2006) Crucial role of the melanocortin receptor MC1R in experimental colitis. Gut 55: 1415-1422.