Cortistatin inhibits NLRP3 inflammasome activation of cardiac fibroblasts during sepsis

Journal of Cardiac Failure

Volumn 21, Issue 5, 2015, Pages 426-433

  Zhang, Bo ^a   Liu, Yue ^a   Sui, Yu Bin ^b   Cai, Huai Qiu ^c   Liu, Wen Xiu ^a   Zhu, Minling ^a   Yin, Xin Hua ^a  

^a THE FIRST AFFILIATED HOSPITAL OF HARBIN MEDICAL UNIVERSITY   (China)

^b China Meitan General Hospital   (China)

^c HARBIN MEDICAL UNIVERSITY   (China)

Author keywords

Cortistatin sepsis; fibroblasts; IL 1 cardiac; NLRP3 inflammasome

Indexed keywords

CORTISTATIN; CRYOPYRIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INFLAMMASOME; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; LIPOPOLYSACCHARIDE; CARRIER PROTEIN; CORTISTATIN 14; CYCLOPEPTIDE; NEUROPEPTIDE; NOD-LIKE RECEPTOR 3, RAT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DRUG MECHANISM; HEART FIBROBLAST; HEART MUSCLE INJURY; HEART PROTECTION; IMMUNOMODULATION; IN VITRO STUDY; IN VIVO STUDY; LIGATION; MALE; NONHUMAN; PRIORITY JOURNAL; PUNCTURE; RAT; SEPSIS; SIGNAL TRANSDUCTION; ANIMAL; ANTAGONISTS AND INHIBITORS; CARDIAC MUSCLE CELL; CELL CULTURE; DRUG EFFECTS; FIBROBLAST; METABOLISM; SPRAGUE DAWLEY RAT;

ANIMALS; CARRIER PROTEINS; CELLS, CULTURED; FIBROBLASTS; INFLAMMASOMES; MALE; MYOCYTES, CARDIAC; NEUROPEPTIDES; PEPTIDES, CYCLIC; RATS; RATS, SPRAGUE-DAWLEY; SEPSIS;

EID: 84929028889     PISSN: 10719164     EISSN: 15328414     Source Type: Journal    
DOI: 10.1016/j.cardfail.2015.01.002     Document Type: Article

References (42)

1. D.C. Angus, W.T. Linde-Zwirble, J. Lidicker, G. Clermont, J. Carcillo, and M.R. Pinsky Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care Crit Care Med 29 2001 1303 1310
2. S.D. Wright, R.A. Ramos, P.S. Tobias, R.J. Ulevitch, and J.C. Mathison CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein Science 249 1990 1431 1433
3. Z. Jiang, P. Georgel, X. Du, L. Shamel, S. Sovath, and S. Mudd CD14 is required for MyD88-independent LPS signaling Nat Immunol 6 2005 565 570
4. C.A. Dinarello Immunological and inflammatory functions of the interleukin-1 family Annu Rev Immunol 27 2009 519 550
5. E. Latz The inflammasomes: mechanisms of activation and function Curr Opin Immunol 22 2010 28 33
6. S.A. Lakhani, and C.W. Bogue Toll-like receptor signaling in sepsis Curr Opin Pediatr 15 2003 278 282
7. R.J. Fahy, M.C. Exline, M.A. Gavrilin, N.Y. Bhatt, B.Y. Besecker, and A. Sarkar Inflammasome mRNA expression in human monocytes during early septic shock Am J Respir Crit Care Med 177 2008 983 988
8. M. Saleh, J.C. Mathison, M.K. Wolinski, S.J. Bensinger, P. Fitzgerald, and N. Droin Enhanced bacterial clearance and sepsis resistance in caspase-12-deficient mice Nature 440 2006 1064 1068
9. R. Kakkar, and R.T. Lee Intramyocardial fibroblast myocyte communication Circ Res 106 2010 47 57
10. N.G. Frangogiannis, C.W. Smith, and M.L. Entman The inflammatory response in myocardial infarction Cardiovasc Res 53 2002 31 47
11. ∅. Sandanger, T. Ranheim, L.E. Vinge, M. Bliksøen, K. Alfsnes, and A.V. Finsen The NLRP3 inflammasome is up-regulated in cardiac fibroblasts and mediates myocardial ischaemia-reperfusion injury Cardiovasc Res 99 2013 164 174
12. V.A. Dalm, P.M. van Hagen, P.M. van Koetsveld, S. Achilefu, A.B. Houtsmuller, and D.H. Pols Expression of somatostatin, cortistatin, and somatostatin receptors in human monocytes, macrophages, and dendritic cells Am J Physiol Endocrinol Metab 285 2003 E344 E353
13. V.A. Dalm, P.M. van Hagen, P.M. van Koetsveld, A.W. Langerak, A.J. van der Lely, and S.W. Lamberts Cortistatin rather than somatostatin as a potential endogenous ligand for somatostatin receptors in the human immune system J Clin Endocrinol Metab 88 2003 270 276
14. S. Krantic Peptides as regulators of the immune system: emphasis on somatostatin Peptides 21 2000 1941 1964
15. E. Gonzalez-Rey, A. Chorny, G. Robledo, and M. Delgado Cortistatin, a new antiinflammatory peptide with therapeutic effect on lethal endotoxemia J Exp Med 203 2006 563 571
16. C. Tang, and M. Liu Initial externalization followed by internalization of β-adrenergic receptors in rat heart during sepsis Am J Physiol 270 1996 R254.e63
17. B. Geng, L. Chang, C. Pan, Y. Qi, J. Zhao, and Y. Pang Endogenous hydrogen sulfide regulation of myocardial injury induced by isoproterenol Biochem Biophys Res Commun 318 2004 756e63
18. S.Y. Han, H.X. Li, X. Ma, K. Zhang, Z.Z. Ma, and P.F. Tu Protective effects of purified safflower extract on myocardial ischemia in vivo and in vitro Phytomedicine 16 2009 694 702
19. C. Rattarasarn Hypoglycemia in sepsis: risk factors and clinical characteristics J Med Assoc Thai 80 1997 760 766
20. W. Zhang, X. Xu, R. Kao, T. Mele, P. Kvietys, and C.M. Martin Cardiac fibroblasts contribute to myocardial dysfunction in mice with sepsis: the role of NLRP3 inflammasome activation PLoS One 9 2014 e107639
21. D. Annane, E. Bellissant, and J.M. Cavaillon Septic shock Lancet 365 2005 63 78
22. M.M. Levy, M.P. Fink, J.C. Marshall, E. Abraham, D. Angus, and D. Cook 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference Crit Care Med 31 2003 1250 1256
23. D.T. Fearon, and R.M. Locksley The instructive role of innate immunity in the acquired immune response Science 272 1996 50 53
24. A. Kumar, V. Thota, L. Dee, J. Olson, E. Uretz, and J.E. Parrillo Tumor necrosis factor alpha and interleukin 1beta are responsible for in vitro myocardial cell depression induced by human septic shock serum J Exp Med 183 1996 949 958
25. D.G. Hesse, K.J. Tracey, Y. Fong, K.R. Manogue, M.A. Palladino, and A. Cerami Cytokine appearance in human endotoxemia and primate bacteremia Surg Gynecol Obstet 166 1988 147 153
26. C.J. Fisher Jr., G.J. Slotman, S.M. Opal, J.P. Pribble, R.C. Bone, and G. Emmanuel Initial evaluation of human recombinant interleukin-1 receptor antagonist in the treatment of sepsis syndrome: a randomized, open-label, placebo-controlled multicenter trial Crit Care Med 22 1994 12 21
27. A. Savva, and T. Roger Targeting Toll-like receptors: promising therapeutic strategies for the management of sepsis-associated pathology and infectious diseases Front Immunol 4 2013 387
28. K. Mao, S. Chen, M. Chen, Y. Ma, Y. Wang, and B. Huang Nitric oxide suppresses NLRP3 inflammasome activation and protects against LPS-induced septic shock Cell Res 23 2013 201 212
29. K. Schroder, and J. Tschopp The inflammasomes Cell 140 2010 821 832
30. F.L. van de Veerdonk, M.G. Netea, C.A. Dinarello, and L.A. Joosten Inflammasome activation and IL-1β and IL-18 processing during infection Trends Immunol 32 2011 110 116
31. G.Y. Chen, and G. Nunez Sterile inflammation:sensing and reacting to damage Nat Rev Immunol 10 2010 826 837
32. F. Martinon, A. Mayor, and J. Tschopp The inflammasomes: guardians of the body Annu Rev Immunol 27 2009 229 265
33. H.B. Yu, and B.B. Finlay The caspase-1 inflammasome: a pilot of innate immune responses Cell Host Microbe 4 2008 198 208
34. A. Sarkar, M. Duncan, J. Hart, E. Hertlein, D.C. Guttridge, and M.D. Wewers ASC directs NF-κB activation by regulating receptor interacting protein-2 (RIP2) caspase-1 interactions J Immunol 176 2006 4979 4986
35. A.M. Scott, and M. Saleh The inflammatory caspases: guardians against infections and sepsis Cell Death Differ 14 2007 23 31
36. P. Li, H. Allen, S. Banerjee, S. Franklin, L. Herzog, and C. Johnston Mice deficient in IL-1beta converting enzyme are defective in production of mature IL-1beta and resistant to endotoxic shock Cell 80 1995 401 411
37. A. Sarkar, M.W. Hall, M. Exline, J. Hart, N. Knatz, and N. Gatson Caspase-1 regulates E. coli sepsis and splenic B cell apoptosis independently of IL-1β and IL-18 Am J Respir Crit Care Med 174 2006 1003 1010
38. M. Lara-Tejero, F.S. Sutterwala, Y. Ogura, E.P. Grant, J. Bertin, and A.J. Coyle Role of the caspase-1 inflammasome in Salmonella typhimurium pathogenesis J Exp Med 203 2006 1407 1412
39. H.D. Brightbill, D.H. Libraty, S.R. Krutzik, R.B. Yang, J.T. Belisle, and J.R. Bleharski Host defense mechanisms triggered by microbial lipoproteins through Toll-like receptors Science 285 1999 732 736
40. F.Y. Liew, D. Xu, E.K. Brint, and L.A. O'Neill Negative regulation of Tolllike receptor - mediated immune responses Nat Rev Immunol 5 2005 446 458
41. K.E. Porter, and N.A. Turner Cardiac fifroblasts: at the heart of myocardial remodeling Pharmacol Ther 123 2009 255 278
42. A.V. Shinde, and N.G. Frangogiannis Fibroblasts in myocardial infarction: a role in inflammation and repair J Mol Cell Cardiol 70 2014 74 82