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Volumn 7, Issue 3, 2015, Pages 231-242

The role of interferon-λ locus polymorphisms in Hepatitis C and other infectious diseases

Author keywords

Autoimmunity; Cytokines; Epithelium; Hepatitis C virus; Host defence; IL28B; Immune response; Interferon ; Polymorphism; Single nucleotide polymorphism; Virology

Indexed keywords

ANTIVIRUS AGENT; INTERFERON; LAMBDA INTERFERON; UNCLASSIFIED DRUG; CYTOKINE RECEPTOR; IFNLR1 PROTEIN, HUMAN;

EID: 84929028887     PISSN: 1662811X     EISSN: 16628128     Source Type: Journal    
DOI: 10.1159/000369902     Document Type: Review
Times cited : (32)

References (105)
  • 1
    • 0034110026 scopus 로고    scopus 로고
    • Chronic viral hepatitis and the human genome
    • Thio CL, Thomas DL, Carrington M: Chronic viral hepatitis and the human genome. Hepatology 2000; 31: 819-827.
    • (2000) Hepatology , vol.31 , pp. 819-827
    • Thio, C.L.1    Thomas, D.L.2    Carrington, M.3
  • 2
    • 55149102403 scopus 로고    scopus 로고
    • Inborn errors of interferon (IFN)-mediated immunity in humans: Insights into the respective roles of IFNalpha/ beta, IFN-gamma, and IFN-lambda in host defense
    • Zhang SY, Boisson-Dupuis S, Chapgier A, Yang K, Bustamante J, Puel A, Picard C, Abel L, Jouanguy E, Casanova JL: Inborn errors of interferon (IFN)-mediated immunity in humans: insights into the respective roles of IFNalpha/ beta, IFN-gamma, and IFN-lambda in host defense. Immunol Rev 2008; 226: 29-40.
    • (2008) Immunol Rev , vol.226 , pp. 29-40
    • Zhang, S.Y.1    Boisson-Dupuis, S.2    Chapgier, A.3    Yang, K.4    Bustamante, J.5    Puel, A.6    Picard, C.7    Abel, L.8    Jouanguy, E.9    Casanova, J.L.10
  • 3
    • 84857190262 scopus 로고    scopus 로고
    • Human genetic susceptibility to infectious disease
    • Chapman SJ, Hill AV: Human genetic susceptibility to infectious disease. Nat Rev Genet 2012; 13: 175-188.
    • (2012) Nat Rev Genet , vol.13 , pp. 175-188
    • Chapman, S.J.1    Hill, A.V.2
  • 7
    • 0036467492 scopus 로고    scopus 로고
    • The interferon-alpha/ beta system in antiviral responses: A multimodal machinery of gene regulation by the IRF family of transcription factors
    • Taniguchi T, Takaoka A: The interferon-alpha/ beta system in antiviral responses: A multimodal machinery of gene regulation by the IRF family of transcription factors. Curr Opin Immunol 2002; 14: 111-116.
    • (2002) Curr Opin Immunol , vol.14 , pp. 111-116
    • Taniguchi, T.1    Takaoka, A.2
  • 11
    • 34447273319 scopus 로고    scopus 로고
    • Type III interferon (IFN) induces a type i IFN-like response in a restricted subset of cells through signaling pathways involving both the Jak-STAT pathway and the mitogen-activated protein kinases
    • Zhou Z, Hamming OJ, Ank N, Paludan SR, Nielsen AL, Hartmann R: Type III interferon (IFN) induces a type I IFN-like response in a restricted subset of cells through signaling pathways involving both the Jak-STAT pathway and the mitogen-activated protein kinases. J Virol 2007; 81: 7749-7758.
    • (2007) J Virol , vol.81 , pp. 7749-7758
    • Zhou, Z.1    Hamming, O.J.2    Ank, N.3    Paludan, S.R.4    Nielsen, A.L.5    Hartmann, R.6
  • 13
    • 78650149393 scopus 로고    scopus 로고
    • Comparative analysis of the lambda-interferons IL-28A and IL-IL-29 regarding their transcriptome and their antiviral properties against hepatitis C virus
    • Diegelmann J, Beigel F, Zitzmann K, Kaul A, Goke B, Auernhammer CJ, Bartenschlager R, Diepolder HM, Brand S: Comparative analysis of the lambda-interferons IL-28A and IL-29 regarding their transcriptome and their antiviral properties against hepatitis C virus. PLoS One 2010; 5:e15200.
    • (2010) PLoS One , vol.5 , pp. e15200
    • Diegelmann, J.1    Beigel, F.2    Zitzmann, K.3    Kaul, A.4    Goke, B.5    Auernhammer, C.J.6    Bartenschlager, R.7    Diepolder, H.M.8    Brand, S.9
  • 14
    • 33845605155 scopus 로고    scopus 로고
    • Interferons alpha and lambda inhibit hepatitis C virus replication with distinct signal transduction and gene regulation kinetics
    • Marcello T, Grakoui A, Barba-Spaeth G, Machlin ES, Kotenko SV, MacDonald MR, Rice CM: Interferons alpha and lambda inhibit hepatitis C virus replication with distinct signal transduction and gene regulation kinetics. Gastroenterology 2006; 131: 1887-1898.
    • (2006) Gastroenterology , vol.131 , pp. 1887-1898
    • Marcello, T.1    Grakoui, A.2    Barba-Spaeth, G.3    Machlin, E.S.4    Kotenko, S.V.5    Macdonald, M.R.6    Rice, C.M.7
  • 16
    • 79952130188 scopus 로고    scopus 로고
    • IL-29 and IFNalpha differ in their ability to modulate IL-12 production by TLR-activated human macrophages and exhibit differential regulation of the IFNgamma receptor expression
    • Liu BS, Janssen HL, Boonstra A: IL-29 and IFNalpha differ in their ability to modulate IL-12 production by TLR-activated human macrophages and exhibit differential regulation of the IFNgamma receptor expression. Blood 2011; 117: 2385-2395.
    • (2011) Blood , vol.117 , pp. 2385-2395
    • Liu, B.S.1    Janssen, H.L.2    Boonstra, A.3
  • 17
    • 84896713226 scopus 로고    scopus 로고
    • Transcriptional regulation of IFNlambda genes in hepatitis C virus-infected hepatocytes via IRF-3IRF-7NF-B complex
    • Lee HC, Narayanan S, Park SJ, Seong SY, Hahn YS: Transcriptional regulation of IFNlambda genes in hepatitis C virus-infected hepatocytes via IRF-3IRF-7NF-B complex. J Biol Chem 2014; 289: 5310-5319.
    • (2014) J Biol Chem , vol.289 , pp. 5310-5319
    • Lee, H.C.1    Narayanan, S.2    Park, S.J.3    Seong, S.Y.4    Hahn, Y.S.5
  • 18
    • 82755186757 scopus 로고    scopus 로고
    • Regulation of IFN-lambda1 promoter activity (IFN-lambda1/ IL-29) in human airway epithelial cells
    • Siegel R, Eskdale J, Gallagher G: Regulation of IFN-lambda1 promoter activity (IFN-lambda1/ IL-29) in human airway epithelial cells. J Immunol 2011; 187: 5636-5644.
    • (2011) J Immunol , vol.187 , pp. 5636-5644
    • Siegel, R.1    Eskdale, J.2    Gallagher, G.3
  • 19
    • 84888204679 scopus 로고    scopus 로고
    • Regulation of interferon lambda-1 (IFNL1/ IFN-lambda1/IL-29) expression in human colon epithelial cells
    • Swider A, Siegel R, Eskdale J, Gallagher G: Regulation of interferon lambda-1 (IFNL1/ IFN-lambda1/IL-29) expression in human colon epithelial cells. Cytokine 2014; 65: 17-23.
    • (2014) Cytokine , vol.65 , pp. 17-23
    • Swider, A.1    Siegel, R.2    Eskdale, J.3    Gallagher, G.4
  • 21
    • 14744276042 scopus 로고    scopus 로고
    • Lambda interferon inhibits hepatitis B and C virus replication
    • Robek MD, Boyd BS, Chisari FV: Lambda interferon inhibits hepatitis B and C virus replication. J Virol 2005; 79: 3851-3854.
    • (2005) J Virol , vol.79 , pp. 3851-3854
    • Robek, M.D.1    Boyd, B.S.2    Chisari, F.V.3
  • 22
    • 33646185492 scopus 로고    scopus 로고
    • Lambda interferon (IFN-lambda), a type III IFN, is induced by viruses and IFNs and displays potent antiviral activity against select virus infections in vivo
    • Ank N, West H, Bartholdy C, Eriksson K, Thomsen AR, Paludan SR: Lambda interferon (IFN-lambda), a type III IFN, is induced by viruses and IFNs and displays potent antiviral activity against select virus infections in vivo. J Virol 2006; 80: 4501-4509.
    • (2006) J Virol , vol.80 , pp. 4501-4509
    • Ank, N.1    West, H.2    Bartholdy, C.3    Eriksson, K.4    Thomsen, A.R.5    Paludan, S.R.6
  • 24
    • 84862019026 scopus 로고    scopus 로고
    • HHV-6B induces IFN-lambda1 responses in cord plasmacytoid dendritic cells through TLR9
    • Nordstrom I, Eriksson K: HHV-6B induces IFN-lambda1 responses in cord plasmacytoid dendritic cells through TLR9. PLoS One 2012; 7: e38683.
    • (2012) PLoS One , vol.7 , pp. e38683
    • Nordstrom, I.1    Eriksson, K.2
  • 25
    • 64049087021 scopus 로고    scopus 로고
    • Lambda interferon inhibits human immunodeficiency virus type 1 infection of macrophages
    • Hou W, Wang X, Ye L, Zhou L, Yang ZQ, Riedel E, Ho WZ: Lambda interferon inhibits human immunodeficiency virus type 1 infection of macrophages. J Virol 2009; 83: 3834-3842.
    • (2009) J Virol , vol.83 , pp. 3834-3842
    • Hou, W.1    Wang, X.2    Ye, L.3    Zhou, L.4    Yang, Z.Q.5    Riedel, E.6    Ho, W.Z.7
  • 26
    • 80052181676 scopus 로고    scopus 로고
    • Type-III interferon, not type-I, is the predominant interferon induced by respiratory viruses in nasal epithelial cells
    • Okabayashi T, Kojima T, Masaki T, Yokota S, Imaizumi T, Tsutsumi H, Himi T, Fujii N, Sawada N: Type-III interferon, not type-I, is the predominant interferon induced by respiratory viruses in nasal epithelial cells. Virus Res 2011; 160: 360-366.
    • (2011) Virus Res , vol.160 , pp. 360-366
    • Okabayashi, T.1    Kojima, T.2    Masaki, T.3    Yokota, S.4    Imaizumi, T.5    Tsutsumi, H.6    Himi, T.7    Fujii, N.8    Sawada, N.9
  • 29
    • 53049101323 scopus 로고    scopus 로고
    • Interferon-lambda contributes to innate immunity of mice against influenza a virus but not against hepatotropic viruses
    • Mordstein M, Kochs G, Dumoutier L, Renauld JC, Paludan SR, Klucher K, Staeheli P: Interferon-lambda contributes to innate immunity of mice against influenza a virus but not against hepatotropic viruses. PLoS Pathog 2008; 4:e1000151.
    • (2008) PLoS Pathog , vol.4 , pp. e1000151
    • Mordstein, M.1    Kochs, G.2    Dumoutier, L.3    Renauld, J.C.4    Paludan, S.R.5    Klucher, K.6    Staeheli, P.7
  • 33
    • 42949160129 scopus 로고    scopus 로고
    • IFN-lambda (IFN-lambda) is expressed in a tissue-dependent fashion and primarily acts on epithelial cells in vivo
    • Sommereyns C, Paul S, Staeheli P, Michiels T: IFN-lambda (IFN-lambda) is expressed in a tissue-dependent fashion and primarily acts on epithelial cells in vivo. PLoS Pathog 2008; 4: e1000017.
    • (2008) PLoS Pathog , vol.4 , pp. e1000017
    • Sommereyns, C.1    Paul, S.2    Staeheli, P.3    Michiels, T.4
  • 35
    • 84893832436 scopus 로고    scopus 로고
    • Interferon lambda genetic polymorphisms and viral infection: The tip of the iceberg
    • Russell CD, Griffiths SJ, Haas J: Interferon lambda genetic polymorphisms and viral infection: the tip of the iceberg? DNA Cell Biol 2014; 33: 60-63.
    • (2014) DNA Cell Biol , vol.33 , pp. 60-63
    • Russell, C.D.1    Griffiths, S.J.2    Haas, J.3
  • 36
    • 77957342033 scopus 로고    scopus 로고
    • Interferon-lambda in immunocompetent individuals with a history of recurrent herpes labialis
    • Pica F, Volpi A, Gaziano R, Garaci E: Interferon-lambda in immunocompetent individuals with a history of recurrent herpes labialis. Antivir Ther 2010; 15: 737-743.
    • (2010) Antivir Ther , vol.15 , pp. 737-743
    • Pica, F.V.1
  • 37
    • 77957961248 scopus 로고    scopus 로고
    • The anticancer face of interferon alpha (IFN-alpha): From biology to clinical results, with a focus on melanoma
    • Pasquali S, Mocellin S: The anticancer face of interferon alpha (IFN-alpha): from biology to clinical results, with a focus on melanoma. Curr Med Chem 2010; 17: 3327-3336.
    • (2010) Curr Med Chem , vol.17 , pp. 3327-3336
    • Pasquali, S.1    Mocellin, S.2
  • 38
    • 3242672021 scopus 로고    scopus 로고
    • Role of the interleukin (IL)-28 receptor tyrosine residues for antiviral and antiproliferative activity of IL-29/interferon-lambda 1: Similarities with type i interferon signaling
    • Dumoutier L, Tounsi A, Michiels T, Sommereyns C, Kotenko SV, Renauld JC: Role of the interleukin (IL)-28 receptor tyrosine residues for antiviral and antiproliferative activity of IL-29/interferon-lambda 1: similarities with type I interferon signaling. J Biol Chem 2004; 279: 32269-32274.
    • (2004) J Biol Chem , vol.279 , pp. 32269-32274
    • Dumoutier, L.1    Tounsi, A.2    Michiels, T.3    Sommereyns, C.4    Kotenko, S.V.5    Renauld, J.C.6
  • 39
    • 84893733987 scopus 로고    scopus 로고
    • Epigenetic reprogramming of the type III interferon response potentiates antiviral activity and suppresses tumor growth
    • Ding S, Khoury-Hanold W, Iwasaki A, Robek MD: Epigenetic reprogramming of the type III interferon response potentiates antiviral activity and suppresses tumor growth. PLoS Biol 2014; 12:e1001758.
    • (2014) PLoS Biol , vol.12 , pp. e1001758
    • Ding, S.1    Khoury-Hanold, W.2    Iwasaki, A.3    Robek, M.D.4
  • 50
    • 84891870231 scopus 로고    scopus 로고
    • IFNL4 ss469415590 variant is a better predictor than rs12979860 of pegylated interferon-alpha/ribavirin therapy failure in hepatitis C virus/HIV-1 coinfected patients
    • Franco S, Aparicio E, Parera M, Clotet B, Tural C, Martinez MA: IFNL4 ss469415590 variant is a better predictor than rs12979860 of pegylated interferon-alpha/ribavirin therapy failure in hepatitis C virus/HIV-1 coinfected patients. AIDS 2014; 28: 133-136.
    • (2014) AIDS , vol.28 , pp. 133-136
    • Franco, S.1    Aparicio, E.2    Parera, M.3    Clotet, B.4    Tural, C.5    Martinez, M.A.6
  • 51
    • 80053563904 scopus 로고    scopus 로고
    • Genetic variation in IL28RA is associated with the outcomes of HCV infection in a high-risk Chinese population
    • Cui Q, Zhang YX, Su J, Chen X, Ding K, Lei N, Liu Y, Li J, Zhang Y, Yu RB: Genetic variation in IL28RA is associated with the outcomes of HCV infection in a high-risk Chinese population. Infect Genet Evol 2011; 11: 1682-1689.
    • (2011) Infect Genet Evol , vol.11 , pp. 1682-1689
    • Cui, Q.1    Zhang, Y.X.2    Su, J.3    Chen, X.4    Ding, K.5    Lei, N.6    Liu, Y.7    Li, J.8    Zhang, Y.9    Yu, R.B.10
  • 53
    • 84887538459 scopus 로고    scopus 로고
    • Evaluation of the relationship between IL28B, IL10RB and IL28RA single-nucleotide polymorphisms and susceptibility to hepatitis C virus in Chinese Han population
    • Jin G, Kang H, Chen X, Dai D: Evaluation of the relationship between IL28B, IL10RB and IL28RA single-nucleotide polymorphisms and susceptibility to hepatitis C virus in Chinese Han population. Infect Genet Evol 2014; 21: 8-14.
    • (2014) Infect Genet Evol , vol.21 , pp. 8-14
    • Jin, G.1    Kang, H.2    Chen, X.3    Dai, D.4
  • 54
    • 84909579830 scopus 로고    scopus 로고
    • Interleukin 28B genetic polymorphism and hepatitis B virus infection
    • Takahashi T: Interleukin 28B genetic polymorphism and hepatitis B virus infection. World J Gastroenterol 2014; 20: 12026-12030.
    • (2014) World J Gastroenterol , vol.20 , pp. 12026-12030
    • Takahashi, T.1
  • 55
    • 84878294955 scopus 로고    scopus 로고
    • HLA-DP and IL28B polymorphisms: Influence of host genome on hepatitis B surface antigen seroclearance in chronic hepatitis B
    • Seto WK, Wong DK, Kopaniszen M, Proitsi P, Sham PC, Hung IF, Fung J, Lai CL, Yuen MF: HLA-DP and IL28B polymorphisms: Influence of host genome on hepatitis B surface antigen seroclearance in chronic hepatitis B. Clin Infect Dis 2013; 56: 1695-1703.
    • (2013) Clin Infect Dis , vol.56 , pp. 1695-1703
    • Seto, W.K.1    Wong, D.K.2    Kopaniszen, M.3    Proitsi, P.4    Sham, P.C.5    Hung, I.F.6    Fung, J.7    Lai, C.L.8    Yuen, M.F.9
  • 57
  • 59
    • 84894562959 scopus 로고    scopus 로고
    • Systematic review with meta-analysis: Do interferon lambda 3 polymorphisms predict the outcome of interferon-therapy in hepatitis B infection
    • Galmozzi E, Vigano M, Lampertico P: Systematic review with meta-analysis: Do interferon lambda 3 polymorphisms predict the outcome of interferon-therapy in hepatitis B infection? Aliment Pharmacol Ther 2014; 39: 569-578.
    • (2014) Aliment Pharmacol Ther , vol.39 , pp. 569-578
    • Galmozzi, E.1    Vigano, M.2    Lampertico, P.3
  • 61
    • 77956547987 scopus 로고    scopus 로고
    • The recent breakthroughs in the understanding of host genomics in hepatitis C
    • Rauch A, Rohrbach J, Bochud PY: The recent breakthroughs in the understanding of host genomics in hepatitis C. Eur J Clin Invest 2010; 40: 950-959.
    • (2010) Eur J Clin Invest , vol.40 , pp. 950-959
    • Rauch, A.1    Rohrbach, J.2    Bochud, P.Y.3
  • 70
    • 80055029005 scopus 로고    scopus 로고
    • Genetic variation of the IL-28B promoter affecting gene expression
    • Sugiyama M, Tanaka Y, Wakita T, Nakanishi M, Mizokami M: Genetic variation of the IL-28B promoter affecting gene expression. PLoS One 2011; 6:e26620.
    • (2011) PLoS One , vol.6 , pp. e26620
    • Sugiyama, M.1    Tanaka, Y.2    Wakita, T.3    Nakanishi, M.4    Mizokami, M.5
  • 74
    • 84862330427 scopus 로고    scopus 로고
    • Update on the management and treatment of hepatitis C virus infection: Recommendations from the Department of Veterans Affairs Hepatitis C Resource Center Program and the National Hepatitis C Program Office
    • quiz 690
    • Yee HS, Chang MF, Pocha C, Lim J, Ross D, Morgan TR, Monto A: Update on the management and treatment of hepatitis C virus infection: recommendations from the Department of Veterans Affairs Hepatitis C Resource Center Program and the National Hepatitis C Program Office. Am J Gastroenterol 2012; 107: 669-689, quiz 690.
    • (2012) Am J Gastroenterol , vol.107 , pp. 669-689
    • Yee, H.S.1    Chang, M.F.2    Pocha, C.3    Lim, J.4    Ross, D.5    Morgan, T.R.6    Monto, A.7
  • 85
    • 84893783668 scopus 로고    scopus 로고
    • Suppression of interferon lambda signaling by SOCS-results in their excessive production during influenza virus infection
    • Wei H, Wang S, Chen Q, Chen Y, Chi X, Zhang L, Huang S, Gao GF, Chen JL: Suppression of interferon lambda signaling by SOCS-1results in their excessive production during influenza virus infection results in their excessive production during influenza virus infection. PLoS Pathog 2014; 10: e1003845.
    • (2014) PLoS Pathog , vol.10 , pp. e1003845
    • Wei, H.1    Wang, S.2    Chen, Q.3    Chen, Y.4    Chi, X.5    Zhang, L.6    Huang, S.7    Gao, G.F.8    Chen, J.L.9
  • 86
    • 84876785606 scopus 로고    scopus 로고
    • Interferon-lambdas: Special immunomodulatory agents and potential therapeutic targets
    • Zheng YW, Li H, Yu JP, Zhao H, Wang SE, Ren XB: Interferon-lambdas: special immunomodulatory agents and potential therapeutic targets. J Innate Immun 2013; 5: 209-218.
    • (2013) J Innate Immun , vol.5 , pp. 209-218
    • Zheng, Y.W.1    Li, H.2    Yu, J.P.3    Zhao, H.4    Wang, S.E.5    Ren, X.B.6
  • 92
    • 78651095500 scopus 로고    scopus 로고
    • Cd14+ cell-derived IL-29 modulates proinflammatory cytokine production in patients with allergic airway inflammation
    • He S, Li T, Chen H, Ma W, Yao Q, Yang H, Wang H, Wang F, Zhao C, Yang P: Cd14+ cell-derived IL-29 modulates proinflammatory cytokine production in patients with allergic airway inflammation. Allergy 2011; 66: 238-246.
    • (2011) Allergy , vol.66 , pp. 238-246
    • He, S.1    Li, T.2    Chen, H.3    Ma, W.4    Yao, Q.5    Yang, H.6    Wang, H.7    Wang, F.8    Zhao, C.9    Yang, P.10
  • 93
    • 83155180585 scopus 로고    scopus 로고
    • Profiling the expression of interleukin (IL)-28 and IL-28 receptor alpha in systemic lupus erythematosus patients
    • Lin SC, Kuo CC, Tsao JT, Lin LJ: Profiling the expression of interleukin (IL)-28 and IL-28 receptor alpha in systemic lupus erythematosus patients. Eur J Clin Invest 2012; 42: 61-69.
    • (2012) Eur J Clin Invest , vol.42 , pp. 61-69
    • Lin, S.C.1    Kuo, C.C.2    Tsao, J.T.3    Lin, L.J.4
  • 94
    • 79959272970 scopus 로고    scopus 로고
    • Interferon-lambda1 induces peripheral blood mononuclear cell-derived chemokines secretion in patients with systemic lupus erythematosus: Its correlation with disease activity
    • Wu Q, Yang Q, Lourenco E, Sun H, Zhang Y: Interferon-lambda1 induces peripheral blood mononuclear cell-derived chemokines secretion in patients with systemic lupus erythematosus: its correlation with disease activity. Arthritis Res Ther 2011; 13:R88.
    • (2011) Arthritis Res Ther , vol.13 , pp. R88
    • Wu, Q.1    Yang, Q.2    Lourenco, E.3    Sun, H.4    Zhang, Y.5
  • 96
    • 84888013695 scopus 로고    scopus 로고
    • The cryptic interplay between systemic lupus erythematosus and infections
    • Rigante D, Mazzoni MB, Esposito S: The cryptic interplay between systemic lupus erythematosus and infections. Autoimmun Rev 2014; 13: 96-102.
    • (2014) Autoimmun Rev , vol.13 , pp. 96-102
    • Rigante, D.1    Mazzoni, M.B.2    Esposito, S.3
  • 102
    • 84898670631 scopus 로고    scopus 로고
    • Comparative analysis of rs12979860 SNP of the IFNL3 gene in children with hepatitis C and ethnic matched controls using 1000 Genomes Project data
    • Indolfi G, Mangone G, Bartolini E, Nebbia G, Calvo PL, Moriondo M, Tovo PA, de Martino M, Azzari C, Resti M: Comparative analysis of rs12979860 SNP of the IFNL3 gene in children with hepatitis C and ethnic matched controls using 1000 Genomes Project data. PLoS One 2014; 9:e85899.
    • (2014) PLoS One , vol.9 , pp. e85899
    • Indolfi, G.1    Mangone, G.2    Bartolini, E.3    Nebbia, G.4    Calvo, P.L.5    Moriondo, M.6    Tovo, P.A.7    De Martino, M.8    Azzari, C.9    Resti, M.10
  • 103
    • 80053055939 scopus 로고    scopus 로고
    • IL28B polymorphisms associated with therapy response in Chilean chronic hepatitis C patients
    • Venegas M, Villanueva RA, Gonzalez K, Brahm J: IL28B polymorphisms associated with therapy response in Chilean chronic hepatitis C patients. World J Gastroenterol 2011; 17: 3636-3639.
    • (2011) World J Gastroenterol , vol.17 , pp. 3636-3639
    • Venegas, M.1    Villanueva, R.A.2    Gonzalez, K.3    Brahm, J.4


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