Regulation of IFN-λ1 promoter activity (IFN-λ1/IL-29) in human airway epithelial cells

Journal of Immunology

Volumn 187, Issue 11, 2011, Pages 5636-5644

  Siegel, Rachael ^a   Eskdale, Joyce ^a   Gallagher, Grant ^a  

^a HUMIGEN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

B LYMPHOCYTE INDUCED MATURATION PROTEIN 1; HETERODIMER; HOMODIMER; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERFERON REGULATORY FACTOR 1; INTERLEUKIN 29; POLYINOSINIC POLYCYTIDYLIC ACID; REPRESSOR PROTEIN; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR RELA; UNCLASSIFIED DRUG; ZEB1 PROTEIN;

ARTICLE; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DIMERIZATION; DNA FOOTPRINTING; EPITHELIUM CELL; GENE; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROMOTER REGION; RESPIRATORY EPITHELIUM; TYPE III INTERFERON 1 GENE;

CHROMATIN IMMUNOPRECIPITATION; DNA FOOTPRINTING; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITHELIAL CELLS; GENE EXPRESSION; GENE EXPRESSION REGULATION; HUMANS; INTERLEUKINS; POLYMERASE CHAIN REACTION; PROMOTER REGIONS, GENETIC; RESPIRATORY MUCOSA; RNA, SMALL INTERFERING; TRANSFECTION;

EID: 82755186757     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1003988     Document Type: Article

References (48)

1. Kotenko, S. V., G. Gallagher, V. V. Baurin, A. Lewis-Antes, M. Shen, N. K. Shah, J. A. Langer, F. Sheikh, H. Dickensheets, and R. P. Donnelly. 2003. IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex. Nat. Immunol. 4: 69-77. (Pubitemid 36109115)
2. Sheppard, P., W. Kindsvogel, W. Xu, K. Henderson, S. Schlutsmeyer, T. E. Whitmore, R. Kuestner, U. Garrigues, C. Birks, J. Roraback, et al. 2003. IL-28, IL-29 and their class II cytokine receptor IL-28R. Nat. Immunol. 4: 63-68. (Pubitemid 36104710)
3. Zou, J., C. Tafalla, J. Truckle, and C. J. Secombes. 2007. Identification of a second group of type I IFNs in fish sheds light on IFN evolution in vertebrates. J. Immunol. 179: 3859-3871.
4. Lasfar, A., A. Lewis-Antes, S. V. Smirnov, S. Anantha, W. Abushahba, B. Tian, K. Reuhl, H. Dickensheets, F. Sheikh, R. P. Donnelly, et al. 2006. Characterization of the mouse IFN-lambda ligand-receptor system: IFN-lambdas exhibit antitumor activity against B16 melanoma. Cancer Res. 66: 4468-4477.
5. Onoguchi, K., M. Yoneyama, A. Takemura, S. Akira, T. Taniguchi, H. Namiki, and T. Fujita. 2007. Viral infections activate types I and III interferon genes through a common mechanism. J. Biol. Chem. 282: 7576-7581. (Pubitemid 47093699)
6. Osterlund, P. I., T. E. Pietilä, V. Veckman, S. V. Kotenko, and I. Julkunen. 2007. IFN regulatory factor family members differentially regulate the expression of type III IFN (IFN-lambda) genes. J. Immunol. 179: 3434-3442.
7. Thomson, S. J., F. G. Goh, H. Banks, T. Krausgruber, S. V. Kotenko, B. M. Foxwell, and I. A. Udalova. 2009. The role of transposable elements in the regulation of IFN-lambda1 gene expression. Proc. Natl. Acad. Sci. USA 106: 11564-11569.
8. Khaitov, M. R., V. Laza-Stanca, M. R. Edwards, R. P. Walton, G. Rohde, M. Contoli, A. Papi, L. A. Stanciu, S. V. Kotenko, and S. L. Johnston. 2009. Respiratory virus induction of alpha-, beta- and lambda-interferons in bronchial epithelial cells and peripheral blood mononuclear cells. Allergy 64: 375-386.
9. Megjugorac, N. J., G. E. Gallagher, and G. Gallagher. 2009. Modulation of human plasmacytoid DC function by IFN-lambda1 (IL-29). J. Leukoc. Biol. 86: 1359-1363.
10. Sommereyns, C., S. Paul, P. Staeheli, and T. Michiels. 2008. IFN-lambda (IFN-lambda) is expressed in a tissue-dependent fashion and primarily acts on epithelial cells in vivo. PLoS Pathog. 4: e1000017.
11. Dai, J., N. J. Megjugorac, G. E. Gallagher, R. Y. Yu, and G. Gallagher. 2009. IFN-lambda1 (IL-29) inhibits GATA3 expression and suppresses Th2 responses in human naive and memory T cells. Blood 113: 5829-5838.
12. Megjugorac, N. J., G. E. Gallagher, and G. Gallagher. 2010. IL-4 enhances IFN-lambda1 (IL-29) production by plasmacytoid DCs via monocyte secretion of IL-1Ra. Blood 115: 4185-4190.
13. Dumoutier, L., D. Lejeune, S. Hor, H. Fickenscher, and J. C. Renauld. 2003. Cloning of a new type II cytokine receptor activating signal transducer and activator of transcription (STAT)1, STAT2 and STAT3. Biochem. J. 370: 391-396. (Pubitemid 36315126)
14. Dumoutier, L., A. Tounsi, T. Michiels, C. Sommereyns, S. V. Kotenko, and J. C. Renauld. 2004. Role of the interleukin (IL)-28 receptor tyrosine residues for antiviral and antiproliferative activity of IL-29/interferon-lambda 1: similarities with type I interferon signaling. J. Biol. Chem. 279: 32269-32274. (Pubitemid 39014676)
15. Zhou, Z., O. J. Hamming, N. Ank, S. R. Paludan, A. L. Nielsen, and R. Hartmann. 2007. Type III interferon (IFN) induces a type I IFN-like response in a restricted subset of cells through signaling pathways involving both the Jak-STAT pathway and the mitogen-activated protein kinases. J. Virol. 81: 7749-7758. (Pubitemid 47047861)
16. Li, M., X. Liu, Y. Zhou, and S. B. Su. 2009. Interferon-lambdas: the modulators of antivirus, antitumor, and immune responses. J. Leukoc. Biol. 86: 23-32.
17. Dellgren, C., H. H. Gad, O. J. Hamming, J. Melchjorsen, and R. Hartmann. 2009. Human interferon-lambda3 is a potent member of the type III interferon family. Genes Immun. 10: 125-131.
18. Meager, A., K. Visvalingam, P. Dilger, D. Bryan, and M. Wadhwa. 2005. Biological activity of interleukins-28 and -29: comparison with type I interferons. Cytokine 31: 109-118. (Pubitemid 40910226)
19. Jordan, W. J., J. Eskdale, M. Boniotto, M. Rodia, D. Kellner, and G. Gallagher. 2007. Modulation of the human cytokine response by interferon lambda-1 (IFNlambda1/IL-29). Genes Immun. 8: 13-20. (Pubitemid 46164287)
20. Pekarek, V., S. Srinivas, J. Eskdale, and G. Gallagher. 2007. Interferon lambda-1 (IFN-lambda1/IL-29) induces ELR(-) CXC chemokine mRNA in human peripheral blood mononuclear cells, in an IFN-gamma-independent manner. Genes Immun. 8: 177-180. (Pubitemid 46390918)
21. Jordan, W. J., J. Eskdale, S. Srinivas, V. Pekarek, D. Kelner, M. Rodia, and G. Gallagher. 2007. Human interferon lambda-1 (IFN-lambda1/IL-29) modulates the Th1/Th2 response. Genes Immun. 8: 254-261. (Pubitemid 46679436)
22. Srinivas, S., J. Dai, J. Eskdale, G. E. Gallagher, N. J. Megjugorac, and G. Gallagher. 2008. Interferon-lambda1 (interleukin-29) preferentially down-regulates interleukin-13 over other T helper type 2 cytokine responses in vitro. Immunology 125: 492-502.
23. Gallagher, G., N. J. Megjugorac, R. Y. Yu, J. Eskdale, G. E. Gallagher, R. Siegel, and E. Tollar. 2010. The lambda interferons: guardians of the immune-epithelial interface and the T-helper 2 response. J. Interferon Cytokine Res. 30: 603-615.
24. Contoli, M., S. D. Message, V. Laza-Stanca, M. R. Edwards, P. A. Wark, N. W. Bartlett, T. Kebadze, P. Mallia, L. A. Stanciu, H. L. Parker, et al. 2006. Role of deficient type III interferon-lambda production in asthma exacerbations. Nat. Med. 12: 1023-1026. (Pubitemid 44353382)
25. Bullens, D. M., A. Decraene, E. Dilissen, I. Meyts, K. De Boeck, L. J. Dupont, and J. L. Ceuppens. 2008. Type III IFN-lambda mRNA expression in sputum of adult and school-aged asthmatics. Clin. Exp. Allergy 38: 1459-1467.
26. Hammad, H., and B. N. Lambrecht. 2008. Dendritic cells and epithelial cells: linking innate and adaptive immunity in asthma. Nat. Rev. Immunol. 8: 193-204. (Pubitemid 351323293)
27. Early, S. B., P. Huyett, K. Brown-Steinke, L. Borish, and J. W. Steinke. 2009. Functional analysis of -351 interleukin-9 promoter polymorphism reveals an activator controlled by NF-kappaB. Genes Immun. 10: 341-349.
28. Morris, D. L., R. R. Graham, L. P. Erwig, P. M. Gaffney, K. L. Moser, T. W. Behrens, T. J. Vyse, and D. S. Graham. 2009. Variation in the upstream region of P-Selectin (SELP) is a risk factor for SLE. Genes Immun. 10: 404-413.
29. Schoof, N., F. von Bonin, I. R. König, R. Mössner, U. Krüger, K. Reich, C. Berking, M. Volkenandt, A. Ziegler, L. Böckmann, et al. 2009. Distal and proximal interleukin (IL)-10 promoter polymorphisms associated with risk of cutaneous melanoma development: a case-control study. Genes Immun. 10: 586-590.
30. Schmitt, C., B. Ghazi, F. Bellier, and A. Bensussan. 2009. Identification and analysis of the human CD160 promoter: implication of a potential AML-1 binding site in promoter activation. Genes Immun. 10: 616-623.
31. Pfaffl, M. W. 2001. A new mathematical model for relative quantification in realtime RT-PCR. Nucleic Acids Res. 29: e45.
32. Fujita, T., G. P. Nolan, S. Ghosh, and D. Baltimore. 1992. Independent modes of transcriptional activation by the p50 and p65 subunits of NF-kappa B. Genes Dev. 6: 775-787.
33. Zhong, H., M. J. May, E. Jimi, and S. Ghosh. 2002. The phosphorylation status of nuclear NF-kappa B determines its association with CBP/p300 or HDAC-1. Mol. Cell 9: 625-636. (Pubitemid 34273792)
34. Vandewalle, C., F. Van Roy, and G. Berx. 2009. The role of the ZEB family of transcription factors in development and disease. Cell. Mol. Life Sci. 66: 773-787.
35. Kuo, T. C., and K. L. Calame. 2004. B lymphocyte-induced maturation protein (Blimp)-1, IFN regulatory factor (IRF)-1, and IRF-2 can bind to the same regulatory sites. J. Immunol. 173: 5556-5563. (Pubitemid 39392142)
36. Keller, A. D., and T. Maniatis. 1991. Identification and characterization of a novel repressor of beta-interferon gene expression. Genes Dev. 5: 868-879. (Pubitemid 21906003)
37. Ren, B., K. J. Chee, T. H. Kim, and T. Maniatis. 1999. PRDI-BF1/Blimp-1 repression is mediated by corepressors of the Groucho family of proteins. Genes Dev. 13: 125-137. (Pubitemid 29045121)
38. Corne, J. M., C. Marshall, S. Smith, J. Schreiber, G. Sanderson, S. T. Holgate, and S. L. Johnston. 2002. Frequency, severity, and duration of rhinovirus infections in asthmatic and non-asthmatic individuals: a longitudinal cohort study. Lancet 359: 831-834. (Pubitemid 34233753)
39. Hansbro, N. G., J. C. Horvat, P. A. Wark, and P. M. Hansbro. 2008. Understanding the mechanisms of viral induced asthma: new therapeutic directions. Pharmacol. Ther. 117: 313-353.
40. Peinado, H., D. Olmeda, and A. Cano. 2007. Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype? Nat. Rev. Cancer 7: 415-428. (Pubitemid 46809165)
41. Sanjabi, S., A. Hoffmann, H. C. Liou, D. Baltimore, and S. T. Smale. 2000. Selective requirement for c-Rel during IL-12 P40 gene induction in macrophages. Proc. Natl. Acad. Sci. USA 97: 12705-12710.
42. Rao, B. M., A. T. Girvin, T. Ciardelli, D. A. Lauffenburger, and K. D. Wittrup. 2003. Interleukin-2 mutants with enhanced alpha-receptor subunit binding affinity. Protein Eng. 16: 1081-1087. (Pubitemid 38281759)
43. Banerjee, D., H. C. Liou, and R. Sen. 2005. c-Rel-dependent priming of naive T cells by inflammatory cytokines. Immunity 23: 445-458. (Pubitemid 41443445)
44. Carmody, R. J., Q. Ruan, H. C. Liou, and Y. H. Chen. 2007. Essential roles of c-Rel in TLR-induced IL-23 p19 gene expression in dendritic cells. J. Immunol. 178: 186-191. (Pubitemid 46033600)
45. Liu, J., X. Guan, and X. Ma. 2007. Regulation of IL-27 p28 gene expression in macrophages through MyD88- and interferon-gamma-mediated pathways. J. Exp. Med. 204: 141-152. (Pubitemid 46148764)
46. Grundström, S., P. Anderson, P. Scheipers, and A. Sundstedt. 2004. Bcl-3 and NFkappaB p50-p50 homodimers act as transcriptional repressors in tolerant CD4+ T cells. J. Biol. Chem. 279: 8460-8468. (Pubitemid 38294739)
47. Kang, S. M., A. C. Tran, M. Grilli, and M. J. Lenardo. 1992. NF-kappa B subunit regulation in nontransformed CD4+ T lymphocytes. Science 256: 1452-1456.
48. Cimmino, L., G. A. Martins, J. Liao, E. Magnusdottir, G. Grunig, R. K. Perez, and K. L. Calame. 2008. Blimp-1 attenuates Th1 differentiation by repression of ifng, tbx21, and bcl6 gene expression. J. Immunol. 181: 2338-2347.