The IFNL3/4 Δg variant increases susceptibility to cytomegalovirus retinitis among HIV-infected patients

AIDS

Volumn 28, Issue 13, 2014, Pages 1885-1889

  Bibert, Stéphanie ^a   Wojtowicz, Agnieszka ^a   Taffé, Patrick ^b   Manuel, Oriol ^a   Bernasconi, Enos ^c   Furrer, Hansjakob ^d   Günthard, Huldrych F ^e   Hoffmann, Matthias ^f   Kaiser, Laurent ^g,h   Osthoff, Michael ⁱ   Cavassini, Matthias ^a   Bochud, Pierre Yves ^a  

^a LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

^b UNIVERSITY OF LAUSANNE   (Switzerland)

^c REGIONAL HOSPITAL OF LUGANO   (Switzerland)

^d UNIVERSITY OF BERN   (Switzerland)

^e UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^f CANTONAL HOSPITAL ST GALLEN   (Switzerland)

^g UNIVERSITY OF GENEVA   (Switzerland)

^h GENEVA UNIVERSITY HOSPITALS   (Switzerland)

ⁱ UNIVERSITY HOSPITAL BASEL   (Switzerland)

Author keywords

AIDS; Cytomegalovirus retinitis; HIV; IFNL3; Immunogenetics; Polymorphism

Indexed keywords

ANTIRETROVIRUS AGENT; INTERFERON LAMBDA 3; INTERFERON LAMBDA 4; INTERLEUKIN 28B; UNCLASSIFIED DRUG; IFNL4 PROTEIN, HUMAN; IL28B PROTEIN, HUMAN; INTERLEUKIN DERIVATIVE;

ALLELE; ARTICLE; CAUCASIAN; CD4 LYMPHOCYTE COUNT; CYTOMEGALOVIRUS RETINITIS; DISEASE ASSOCIATION; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INCIDENCE; INFECTION RISK; INFECTION SENSITIVITY; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; RETROSPECTIVE STUDY; ADULT; CLINICAL TRIAL; COMPLICATION; DISEASE PREDISPOSITION; FEMALE; GENETIC ASSOCIATION; GENETICS; IMMUNOLOGY; MALE; MIDDLE AGED; MULTICENTER STUDY; SWITZERLAND;

ADULT; CYTOMEGALOVIRUS RETINITIS; DISEASE SUSCEPTIBILITY; FEMALE; GENETIC ASSOCIATION STUDIES; HIV INFECTIONS; HUMANS; INTERLEUKINS; LONGITUDINAL STUDIES; MALE; MIDDLE AGED; RETROSPECTIVE STUDIES; SWITZERLAND;

EID: 84906557493     PISSN: 02699370     EISSN: 14735571     Source Type: Journal    
DOI: 10.1097/QAD.0000000000000379     Document Type: Article

References (19)

1. Heiden D, Ford N, Wilson D, Rodriguez WR, Margolis T, Janssens B, et al. Cytomegalovirus retinitis: the neglected disease of the AIDS pandemic. PLoS Med 2007; 4:e334.
2. Jabs DA. Ocular manifestations of HIV infection. Trans Am Ophthalmol Soc 1995; 93:623-683.
3. Jabs DA, Van Natta ML, Holbrook JT, Kempen JH, Meinert CL, Davis MD, et al. Longitudinal study of the ocular complications of AIDS: 1. Ocular diagnoses at enrollment. Ophthalmology 2007; 114:780-786.
4. Jacobson MA, Stanley H, Holtzer C, Margolis TP, Cunningham ET. Natural history and outcome of new AIDS-related cytomegalovirus retinitis diagnosed in the era of highly active antiretroviral therapy. Clin Infect Dis 2000; 30:231-233.
5. Sezgin E, Jabs DA, Hendrickson SL, Van Natta M, Zdanov A, Lewis RA, et al. Effect of host genetics on the development of cytomegalovirus retinitis in patients with AIDS. J Infect Dis 2010; 202:606-613.
6. Sezgin E, van Natta ML, Ahuja A, Lyon A, Srivastava S, Troyer JL, et al. Association of host genetic risk factors with the course of cytomegalovirus retinitis in patients infected with human immunodeficiency virus. Am J Ophthalmol 2011; 151:999-1006e1004.
7. Deghaide NH, Rodrigues Mde L, Castelli EC, Mendes-Junior CT, Figueiredo JF, Donadi EA. Tumor necrosis factor region polymorphisms are associated with AIDS and with cytomegalovirus retinitis. AIDS 2009; 23:1641-1647.
8. Prokunina-Olsson L, Muchmore B, Tang W, Pfeiffer RM, Park H, Dickensheets H, et al. A variant upstream of IFNL3 (IL28B) creating a new interferon gene IFNL4 is associated with impaired clearance of hepatitis C virus. Nat Genet 2013; 45:164-171.
9. Bibert S, Roger T, Calandra T, Bochud M, Cerny A, Semmo N, et al. IL28B expression depends on a novel TT/-G polymorphism which improves HCV clearance prediction. J Exp Med 2013; 210:1109-1116.
10. Ank N, West H, Bartholdy C, Eriksson K, Thomsen AR, Paludan SR. Lambda interferon (IFN-lambda), a type III IFN, is induced by viruses and IFNs and displays potent antiviral activity against select virus infections in vivo. J Virol 2006; 80:4501-4509.
11. Ank N, Iversen MB, Bartholdy C, Staeheli P, Hartmann R, Jensen UB, et al. An important role for type III interferon (IFNlambda/ IL-28) in TLR-induced antiviral activity. J Immunol 2008; 180:2474-2485.
12. Schneider K, Meyer-Koenig U, Hufert FT. Human cytomegalovirus impairs the function of plasmacytoid dendritic cells in lymphoid organs. PLoS One 2008; 3:e3482.
13. Taffe P, May M, Swiss HIVCS. A joint back calculation model for the imputation of the date of HIV infection in a prevalent cohort. Stat Med 2008; 27:4835-4853.
14. Manuel O, Wojtowicz A, Bibert S, Kralidis G, Egli A, Mueller N, et al. IL28B Polymorphisms influence cytomegalovirus viremia in solid organ transplant recipients. American Transplant Congress, Seattle May 18-22, 2013.
15. Brand S, Beigel F, Olszak T, Zitzmann K, Eichhorst ST, Otte JM, et al. IL-28A and IL-29 mediate antiproliferative and antiviral signals in intestinal epithelial cells and murine CMV infection increases colonic IL-28A expression. Am J Physiol Gastrointest Liver Physiol 2005; 289:G960-968.
16. Takase H, Futagami Y, Yoshida T, Kamoi K, Sugita S, Imai Y, et al. Cytokine profile in aqueous humor and sera of patients with infectious or noninfectious uveitis. Invest Ophthalmol Vis Sci 2006; 47:1557-1561.
17. Iyer JV, Connolly J, Agrawal R, Yeo TK, Lee B, Au B, et al. Cytokine analysis of aqueous humor in HIV patients with cytomegalovirus retinitis. Cytokine 2013; 64:541-547.
18. Bigger JE, Thomas CA 3rd, Atherton SS. NK cell modulation of murine cytomegalovirus retinitis. J Immunol 1998; 160:5826-5831.
19. Hamming OJ, Terczynska-Dyla E, Vieyres G, Dijkman R, Jorgensen SE, Akhtar H, et al. Interferon lambda 4 signals via the IFNlambda receptor to regulate antiviral activity against HCV and coronaviruses. EMBO J 2013; 32:3055-3065.