HHV-6B induces IFN-lambda1 responses in cord plasmacytoid dendritic cells through TLR9

PLoS ONE

Volumn 7, Issue 6, 2012, Pages

  Nordström, Inger ^a   Eriksson, Kristina ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; CD3 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 13; INTERLEUKIN 28A; INTERLEUKIN 29; INTERLEUKIN 5; NEUTRALIZING ANTIBODY; TOLL LIKE RECEPTOR 9; IL29 PROTEIN, HUMAN; INTERLEUKIN DERIVATIVE; TLR9 PROTEIN, HUMAN;

ARTICLE; CD4+ T LYMPHOCYTE; CELL ACTIVATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; FLUORESCENCE ACTIVATED CELL SORTING; HUMAN; HUMAN HERPESVIRUS 6; INTERFERON PRODUCTION; MIXED LYMPHOCYTE REACTION; MOUSE; NONHUMAN; PLASMACYTOID DENDRITIC CELL; POLARIZATION; PROMOTER REGION; PROTEIN EXPRESSION; TH1 CELL; TH2 CELL; ANALYSIS OF VARIANCE; CELL POLARITY; CYTOLOGY; DENDRITIC CELL; FETUS BLOOD; FLOW CYTOMETRY; GENETICS; IMMUNOLOGY;

ANALYSIS OF VARIANCE; CELL POLARITY; DENDRITIC CELLS; FETAL BLOOD; FLOW CYTOMETRY; HERPESVIRUS 6, HUMAN; HUMANS; INTERLEUKINS; TH1 CELLS; TOLL-LIKE RECEPTOR 9;

EID: 84862019026     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0038683     Document Type: Article

References (29)

1. Kotenko SV, Gallagher G, Baurin VV, Lewis-Antes A, Shen M, et al. (2003) IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex. Nat Immunol 4: 69-77.
2. Sheppard P, Kindsvogel W, Xu W, Henderson K, Schlutsmeyer S, et al. (2003) IL-28, IL-29 and their class II cytokine receptor IL-28R. Nat Immunol 4: 63-68.
3. Sommereyns C, Paul S, Staeheli P, Michiels T, (2008) IFN-lambda (IFN-lambda) is expressed in a tissue-dependent fashion and primarily acts on epithelial cells in vivo. PLoS Pathog 4: e1000017.
4. Dumoutier L, Tounsi A, Michiels T, Sommereyns C, Kotenko SV, et al. (2004) Role of the interleukin (IL)-28 receptor tyrosine residues for antiviral and antiproliferative activity of IL-29/interferon-lambda 1: similarities with type I interferon signaling. J Biol Chem 279: 32269-32274.
5. Ank N, West H, Bartholdy C, Eriksson K, Thomsen AR, et al. (2006) Lambda interferon (IFN-lambda), a type III IFN, is induced by viruses and IFNs and displays potent antiviral activity against select virus infections in vivo. J Virol 80: 4501-4509.
6. Mordstein M, Kochs G, Dumoutier L, Renauld JC, Paludan SR, et al. (2008) Interferon-lambda contributes to innate immunity of mice against influenza A virus but not against hepatotropic viruses. PLoS Pathog 4: e1000151.
7. Nguyen KB, Watford WT, Salomon R, Hofmann SR, Pien GC, et al. (2002) Critical role for STAT4 activation by type 1 interferons in the interferon-gamma response to viral infection. Science 297: 2063-2066.
8. Pien GC, Nguyen KB, Malmgaard L, Satoskar AR, Biron CA, (2002) A unique mechanism for innate cytokine promotion of T cell responses to viral infections. J Immunol 169: 5827-5837.
9. Farkas L, Kvale EO, Johansen FE, Jahnsen FL, Lund-Johansen F, (2004) Plasmacytoid dendritic cells activate allergen-specific TH2 memory cells: modulation by CpG oligodeoxynucleotides. J Allergy Clin Immunol 114: 436-443.
10. Xu X, Sun YL, Hoey T, (1996) Cooperative DNA binding and sequence-selective recognition conferred by the STAT amino-terminal domain. Science 273: 794-797.
11. Jordan WJ, Eskdale J, Srinivas S, Pekarek V, Kelner D, et al. (2007) Human interferon lambda-1 (IFN-lambda1/IL-29) modulates the Th1/Th2 response. Genes Immun 8: 254-261.
12. Srinivas S, Dai J, Eskdale J, Gallagher GE, Megjugorac NJ, et al. (2008) Interferon-lambda1 (interleukin-29) preferentially down-regulates interleukin-13 over other T helper type 2 cytokine responses in vitro. Immunology 125: 492-502.
13. Dai J, Megjugorac NJ, Gallagher GE, Yu RY, Gallagher G, (2009) IFN-lambda1 (IL-29) inhibits GATA3 expression and suppresses Th2 responses in human naive and memory T cells. Blood 113: 5829-5838.
14. Kotenko SV, (2011) IFN-lambdas. Curr Opin Immunol 23: 583-590.
15. Nordström I, Rudin A, Adlerberth I, Wold A, Saalman R, et al. (2010) Infection of infants with human herpesvirus type 6 may be associated with reduced allergic sensitization and Th2 development. Clin Exp Allergy 40: 882-890.
16. Svensson A, Almqvist N, Nordström I, George-Chandy A, Eriksson K, (2010) Exposure to Human Herpes Virus type 6 protects against allergic asthma in mice. Journal of Allergy & Therapy 1: 101.
17. Osterlund PI, Pietila TE, Veckman V, Kotenko SV, Julkunen I, (2007) IFN regulatory factor family members differentially regulate the expression of type III IFN (IFN-lambda) genes. J Immunol 179: 3434-3442.
18. Izaguirre A, Barnes BJ, Amrute S, Yeow WS, Megjugorac N, et al. (2003) Comparative analysis of IRF and IFN-alpha expression in human plasmacytoid and monocyte-derived dendritic cells. J Leukoc Biol 74: 1125-1138.
19. Yu HR, Huang HC, Kuo HC, Sheen JM, Ou CY, et al. (2011) IFN-alpha production by human mononuclear cells infected with varicella-zoster virus through TLR9-dependent and-independent pathways. Cell Mol Immunol 8: 181-188.
20. Lund J, Sato A, Akira S, Medzhitov R, Iwasaki A, (2003) Toll-like receptor 9-mediated recognition of Herpes simplex virus-2 by plasmacytoid dendritic cells. J Exp Med 198: 513-520.
21. Fiola S, Gosselin D, Takada K, Gosselin J, (2010) TLR9 contributes to the recognition of EBV by primary monocytes and plasmacytoid dendritic cells. J Immunol 185: 3620-3631.
22. Svensson A, Nordström I, Rudin A, Bergström T, Eriksson K, (2011) Enveloped virus but not bacteria block IL-13 responses in human cord blood T-cells in vitro. Scand J Immunol in press.
23. Lin SC, Kuo CC, Tsao JT, Lin LJ, (2012) Profiling the expression of interleukin (IL)-28 and IL-28 receptor alpha in systemic lupus erythematosus patients. Eur J Clin Invest 42: 61-69.
24. Arasteh J, Ebtekar M, Pourpak Z, Pourfatollah AA, Hassan ZM, et al. (2010) The effect of IL-28A on human cord blood CD4+ T cells. Immunopharmacol Immunotoxicol 32: 339-347.
25. Liu BS, Janssen HL, Boonstra A, (2011) IL-29 and IFNalpha differ in their ability to modulate IL-12 production by TLR-activated human macrophages and exhibit differential regulation of the IFNgamma receptor expression. Blood 117: 2385-2395.
26. Megjugorac NJ, Gallagher GE, Gallagher G, (2009) Modulation of human plasmacytoid DC function by IFN-lambda1 (IL-29). J Leukoc Biol 86: 1359-1363.
27. Jordan WJ, Eskdale J, Boniotto M, Rodia M, Kellner D, et al. (2007) Modulation of the human cytokine response by interferon lambda-1 (IFN-lambda1/IL-29). Genes Immun 8: 13-20.
28. Koltsida O, Hausding M, Stavropoulos A, Koch S, Tzelepis G, et al. (2011) IL-28A (IFN-lambda2) modulates lung DC function to promote Th1 immune skewing and suppress allergic airway disease. EMBO Mol Med 3: 348-361.
29. Peter M, Bode K, Lipford GB, Eberle F, Heeg K, et al. (2008) Characterization of suppressive oligodeoxynucleotides that inhibit Toll-like receptor-9-mediated activation of innate immunity. Immunology 123: 118-128.