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Angewandte Chemie - International Edition

Volumn 54, Issue 20, 2015, Pages 5874-5878

Intracellular delivery of peptidyl ligands by reversible cyclization: Discovery of a PDZ domain inhibitor that rescues CFTR activity

(6) Qian, Ziqing a Xu, Xiaohua a Amacher, Jeanine F b Madden, Dean R b Cormet Boyaka, Estelle a Pei, Dehua a

a OHIO STATE UNIVERSITY (United States)

b DARTMOUTH MEDICAL SCHOOL (United States)

Author keywords

cell penetrating peptides; cyclic peptides; cystic fibrosis; PDZ domains; protein protein interactions

Indexed keywords

CELL DEATH; CELLS; COVALENT BONDS; CYCLIZATION; CYTOLOGY; LIGANDS; PROTEINS;

CELL-PENETRATING PEPTIDE; CYCLIC PEPTIDES; CYSTIC FIBROSIS; PDZ DOMAINS; PROTEIN-PROTEIN INTERACTIONS;

PEPTIDES;

CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; LIGAND; PEPTIDE;

CHEMISTRY; CONFORMATION; CYCLIZATION; DRUG DELIVERY SYSTEM; DRUG DEVELOPMENT; DRUG EFFECTS; HELA CELL LINE; HUMAN; METABOLISM; PDZ DOMAIN;

CYCLIZATION; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; DRUG DELIVERY SYSTEMS; DRUG DISCOVERY; HELA CELLS; HUMANS; LIGANDS; MOLECULAR CONFORMATION; PDZ DOMAINS; PEPTIDES;

EID: 84929018299 PISSN: 14337851 EISSN: 15213773 Source Type: Journal
DOI: 10.1002/anie.201411594 Document Type: Article

Times cited : (62)

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