메뉴 건너뛰기




Volumn 125, Issue 5, 2015, Pages 1944-1954

12/15-lipoxygenase-mediated enzymatic lipid oxidation regulates DC maturation and function

Author keywords

[No Author keywords available]

Indexed keywords

ARACHIDONATE 12 LIPOXYGENASE; ARACHIDONATE 15 LIPOXYGENASE; GLUTAMATE CYSTEINE LIGASE; HEME OXYGENASE 1; INTERLEUKIN 12; INTERLEUKIN 23; INTERLEUKIN 23P19; OXIDIZED LOW DENSITY LIPOPROTEIN; TRANSCRIPTION FACTOR NRF2; ALOX15 PROTEIN, MOUSE; FATTY ACID; NFE2L2 PROTEIN, MOUSE; PHOSPHOLIPID;

EID: 84929000116     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI78490     Document Type: Article
Times cited : (81)

References (44)
  • 1
    • 84875528275 scopus 로고    scopus 로고
    • The dendritic cell lineage:Ontogeny and function of dendritic cells and their subsets in the steady state and the inflamed setting
    • Merad M, Sathe P, Helft J, Miller J, Mortha A. The dendritic cell lineage:ontogeny and function of dendritic cells and their subsets in the steady state and the inflamed setting. Annu Rev Immunol. 2013;31:563-604.
    • (2013) Annu Rev Immunol , vol.31 , pp. 563-604
    • Merad, M.1    Sathe, P.2    Helft, J.3    Miller, J.4    Mortha, A.5
  • 2
  • 3
    • 77957021373 scopus 로고    scopus 로고
    • Molecular enzymology of lipoxygenases
    • Ivanov I, et al. Molecular enzymology of lipoxygenases. Arch Biochem Biophys. 2010;503(2):161-174.
    • (2010) Arch Biochem Biophys , vol.503 , Issue.2 , pp. 161-174
    • Ivanov, I.1
  • 4
    • 28444468096 scopus 로고    scopus 로고
    • The role of lipoxygenase-isoforms in atherogenesis
    • Kühn H, Römisch I, Belkner J. The role of lipoxygenase-isoforms in atherogenesis. Mol Nutr Food Res. 2005;49(11):1014-1029.
    • (2005) Mol Nutr Food Res , vol.49 , Issue.11 , pp. 1014-1029
    • Kühn, H.1    Römisch, I.2    Belkner, J.3
  • 5
    • 0032752579 scopus 로고    scopus 로고
    • Disruption of the 12/15-lipoxygenase gene diminishes atherosclerosis in apo E-deficient mice
    • Cyrus T, et al. Disruption of the 12/15-lipoxygenase gene diminishes atherosclerosis in apo E-deficient mice. J Clin Invest. 1999;103(11):1597-1604.
    • (1999) J Clin Invest , vol.103 , Issue.11 , pp. 1597-1604
    • Cyrus, T.1
  • 6
    • 33744550207 scopus 로고    scopus 로고
    • Inflammation and immune regulation by 12/15-lipoxygenases
    • Kühn H, O'Donnell VB. Inflammation and immune regulation by 12/15-lipoxygenases. Prog Lipid Res. 2006;45(4):334-356.
    • (2006) Prog Lipid Res , vol.45 , Issue.4 , pp. 334-356
    • Kühn, H.1    O'Donnell, V.B.2
  • 7
    • 42649089790 scopus 로고    scopus 로고
    • Resolving inflammation:Dual anti-inflammatory and pro-resolution lipid mediators
    • Serhan CN, Chiang N, Van Dyke TE. Resolving inflammation:dual anti-inflammatory and pro-resolution lipid mediators. Nat Rev Immunol. 2008;8(5):349-361.
    • (2008) Nat Rev Immunol , vol.8 , Issue.5 , pp. 349-361
    • Serhan, C.N.1    Chiang, N.2    Van Dyke, T.E.3
  • 8
    • 10744224448 scopus 로고    scopus 로고
    • Reduced inflammation and tissue damage in transgenic rabbits overexpressing 15-lipoxygenase and endogenous anti-inflammatory lipid mediators
    • Serhan CN, et al. Reduced inflammation and tissue damage in transgenic rabbits overexpressing 15-lipoxygenase and endogenous anti-inflammatory lipid mediators. J Immunol. 2003;171(12):6856-6865.
    • (2003) J Immunol , vol.171 , Issue.12 , pp. 6856-6865
    • Serhan, C.N.1
  • 9
    • 70349251362 scopus 로고    scopus 로고
    • 12/15-lipoxygenase counteracts inflammation tissue damage in arthritis
    • Krönke G, et al. 12/15-lipoxygenase counteracts inflammation tissue damage in arthritis. J Immunol. 2009;183(5):3383-3389.
    • (2009) J Immunol , vol.183 , Issue.5 , pp. 3383-3389
    • Krönke, G.1
  • 10
    • 84861440668 scopus 로고    scopus 로고
    • 12/15-lipoxygenase orchestrates the clearance of apoptotic cells maintains immunologic tolerance
    • Uderhardt S, et al. 12/15-lipoxygenase orchestrates the clearance of apoptotic cells maintains immunologic tolerance. Immunity. 2012;36(5):834-846.
    • (2012) Immunity , vol.36 , Issue.5 , pp. 834-846
    • Uderhardt, S.1
  • 11
    • 84868156748 scopus 로고    scopus 로고
    • 12/15-lipoxygenase during the regulation of inflammation, immunity, self-tolerance
    • Uderhardt S, Krönke G. 12/15-lipoxygenase during the regulation of inflammation, immunity, self-tolerance. J Mol Med (Berl). 2012;90(11):1247-1256.
    • (2012) J Mol Med (Berl) , vol.90 , Issue.11 , pp. 1247-1256
    • Uderhardt, S.1    Krönke, G.2
  • 12
    • 0035942212 scopus 로고    scopus 로고
    • IL-4 determines eicosanoid formation in dendritic cells by down-regulation of 5-lipoxygenase up-regulation of 15-lipoxygenase 1 expression
    • Spanbroek R, et al. IL-4 determines eicosanoid formation in dendritic cells by down-regulation of 5-lipoxygenase up-regulation of 15-lipoxygenase 1 expression. Proc Natl Acad Sci U S A. 2001;98(9):5152-5157.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , Issue.9 , pp. 5152-5157
    • Spanbroek, R.1
  • 13
    • 33847128883 scopus 로고    scopus 로고
    • Dyslipidemia inhibits toll-like receptor-induced activation of CD8alpha-negative dendritic cells protective Th1 type immunity
    • Shamshiev AT, Ampenberger F, Ernst B, Rohrer L, Marsland BJ, Kopf M. Dyslipidemia inhibits toll-like receptor-induced activation of CD8alpha-negative dendritic cells protective Th1 type immunity. J Exp Med. 2007;204(2):441-452.
    • (2007) J Exp Med , vol.204 , Issue.2 , pp. 441-452
    • Shamshiev, A.T.1    Ampenberger, F.2    Ernst, B.3    Rohrer, L.4    Marsland, B.J.5    Kopf, M.6
  • 14
    • 69249139081 scopus 로고    scopus 로고
    • Phosphatidylethanolamine-esterified eicosanoids in the mouse:Tissue localization and inflammation-dependent formation in Th-2 disease
    • Morgan AH, et al. Phosphatidylethanolamine-esterified eicosanoids in the mouse:tissue localization and inflammation-dependent formation in Th-2 disease. J Biol Chem. 2009;284(32):21185-21191.
    • (2009) J Biol Chem , vol.284 , Issue.32 , pp. 21185-21191
    • Morgan, A.H.1
  • 15
    • 77957260181 scopus 로고    scopus 로고
    • Identification of a novel macrophage phenotype that develops in response to atherogenic phospholipids via Nrf2
    • Kadl A, et al. Identification of a novel macrophage phenotype that develops in response to atherogenic phospholipids via Nrf2. Circ Res. 2010;107(6):737-746.
    • (2010) Circ Res , vol.107 , Issue.6 , pp. 737-746
    • Kadl, A.1
  • 16
    • 84864124859 scopus 로고    scopus 로고
    • IL-12 family cytokines: Immunological playmakers
    • Vignali DA, Kuchroo VK. IL-12 family cytokines: immunological playmakers. Nat Immunol. 2012;13(8):722-728.
    • (2012) Nat Immunol , vol.13 , Issue.8 , pp. 722-728
    • Vignali, D.A.1    Kuchroo, V.K.2
  • 17
    • 84862736185 scopus 로고    scopus 로고
    • Mechanisms regulating regional localization of inflammation during CNS autoimmunity
    • Pierson E, Simmons SB, Castelli L, Goverman JM. Mechanisms regulating regional localization of inflammation during CNS autoimmunity. Immunol Rev. 2012;248(1):205-215.
    • (2012) Immunol Rev , vol.248 , Issue.1 , pp. 205-215
    • Pierson, E.1    Simmons, S.B.2    Castelli, L.3    Goverman, J.M.4
  • 18
    • 0033837450 scopus 로고    scopus 로고
    • Structural basis for the positional specificity of lipoxygenases
    • Kuhn H. Structural basis for the positional specificity of lipoxygenases. Prostaglandins Other Lipid Mediat. 2000;62(3):255-270.
    • (2000) Prostaglandins Other Lipid Mediat , vol.62 , Issue.3 , pp. 255-270
    • Kuhn, H.1
  • 19
    • 21244448322 scopus 로고    scopus 로고
    • Oxidized phospholipids negatively regulate dendritic cell maturation induced by TLRs and CD40
    • Blüml S, et al. Oxidized phospholipids negatively regulate dendritic cell maturation induced by TLRs and CD40. J Immunol. 2005;175(1):501-508.
    • (2005) J Immunol , vol.175 , Issue.1 , pp. 501-508
    • Blüml, S.1
  • 20
    • 76249088380 scopus 로고    scopus 로고
    • Epigenetic regulation of dendritic cell differentiation and function by oxidized phospholipids
    • Blüml S, et al. Epigenetic regulation of dendritic cell differentiation and function by oxidized phospholipids. Blood. 2009;114(27):5481-5489.
    • (2009) Blood , vol.114 , Issue.27 , pp. 5481-5489
    • Blüml, S.1
  • 21
    • 75749091474 scopus 로고    scopus 로고
    • Apolipoprotein E-deficient mice are resistant to the development of collagen-induced arthritis
    • Asquith DL, Miller AM, Hueber AJ, Liew FY, Sattar N, McInnes IB. Apolipoprotein E-deficient mice are resistant to the development of collagen-induced arthritis. Arthritis Rheum. 2010;62(2):472-477.
    • (2010) Arthritis Rheum , vol.62 , Issue.2 , pp. 472-477
    • Asquith, D.L.1    Miller, A.M.2    Hueber, A.J.3    Liew, F.Y.4    Sattar, N.5    McInnes, I.B.6
  • 22
    • 5644273775 scopus 로고    scopus 로고
    • Dyslipidemia associated with atherosclerotic disease systemically alters dendritic cell mobilization
    • Angeli V, et al. Dyslipidemia associated with atherosclerotic disease systemically alters dendritic cell mobilization. Immunity. 2004;21(4):561-574.
    • (2004) Immunity , vol.21 , Issue.4 , pp. 561-574
    • Angeli, V.1
  • 23
    • 0035826892 scopus 로고    scopus 로고
    • Absence of 12/15-lipoxygenase expression decreases lipid peroxidation atherogenesis in apolipoprotein e-deficient mice
    • Cyrus T, et al. Absence of 12/15-lipoxygenase expression decreases lipid peroxidation atherogenesis in apolipoprotein e-deficient mice. Circulation. 2001;103(18):2277-2282.
    • (2001) Circulation , vol.103 , Issue.18 , pp. 2277-2282
    • Cyrus, T.1
  • 25
    • 84881220250 scopus 로고    scopus 로고
    • Nuclear factor-erythroid 2 (NF-E2) p45-related factor-2 (Nrf2) modulates dendritic cell immune function through regulation of p38 MAPK-cAMP-responsive element binding protein/activating transcription factor 1 signaling
    • Al-Huseini LM, et al. Nuclear factor-erythroid 2 (NF-E2) p45-related factor-2 (Nrf2) modulates dendritic cell immune function through regulation of p38 MAPK-cAMP-responsive element binding protein/activating transcription factor 1 signaling. J Biol Chem. 2013;288(31):22281-22288.
    • (2013) J Biol Chem , vol.288 , Issue.31 , pp. 22281-22288
    • Al-Huseini, L.M.1
  • 26
    • 84858992660 scopus 로고    scopus 로고
    • Loss of transcription factor nuclear factor-erythroid 2 (NF-E2) p45-related factor-2 (Nrf2) leads to dysregulation of immune functions, redox homeostasis, intracellular signaling in dendritic cells
    • Aw Yeang HX, et al. Loss of transcription factor nuclear factor-erythroid 2 (NF-E2) p45-related factor-2 (Nrf2) leads to dysregulation of immune functions, redox homeostasis, intracellular signaling in dendritic cells. J Biol Chem. 2012;287(13):10556-10564.
    • (2012) J Biol Chem , vol.287 , Issue.13 , pp. 10556-10564
    • Aw Yeang, H.X.1
  • 27
    • 77956624172 scopus 로고    scopus 로고
    • Nuclear erythroid 2 p45-related factor 2 inhibits the maturation of murine dendritic cells by ragweed extract
    • Rangasamy T, et al. Nuclear erythroid 2 p45-related factor 2 inhibits the maturation of murine dendritic cells by ragweed extract. Am J Respir Cell Mol Biol. 2010;43(3):276-285.
    • (2010) Am J Respir Cell Mol Biol , vol.43 , Issue.3 , pp. 276-285
    • Rangasamy, T.1
  • 28
    • 58149288682 scopus 로고    scopus 로고
    • Disruption of the transcription factor Nrf2 promotes pro-oxidative dendritic cells that stimulate Th2-like immunoresponsiveness upon activation by ambient particulate matter
    • Williams MA, et al. Disruption of the transcription factor Nrf2 promotes pro-oxidative dendritic cells that stimulate Th2-like immunoresponsiveness upon activation by ambient particulate matter. J Immunol. 2008;181(7):4545-4559.
    • (2008) J Immunol , vol.181 , Issue.7 , pp. 4545-4559
    • Williams, M.A.1
  • 29
    • 29644436198 scopus 로고    scopus 로고
    • Cellular and molecular mechanisms of the selective regulation of IL-12 production by 12/15-lipoxygenase
    • Middleton MK, Rubinstein T, Puré E. Cellular and molecular mechanisms of the selective regulation of IL-12 production by 12/15-lipoxygenase. J Immunol. 2006;176(1):265-274.
    • (2006) J Immunol , vol.176 , Issue.1 , pp. 265-274
    • Middleton, M.K.1    Rubinstein, T.2    Puré, E.3
  • 30
    • 0037144594 scopus 로고    scopus 로고
    • Selective interleukin-12 synthesis defect in 12/15-lipoxygenase-deficient macrophages associated with reduced atherosclerosis in a mouse model of familial hypercholesterolemia
    • Zhao L, et al. Selective interleukin-12 synthesis defect in 12/15-lipoxygenase-deficient macrophages associated with reduced atherosclerosis in a mouse model of familial hypercholesterolemia. J Biol Chem. 2002;277(38):35350-35356.
    • (2002) J Biol Chem , vol.277 , Issue.38 , pp. 35350-35356
    • Zhao, L.1
  • 31
    • 9444244401 scopus 로고    scopus 로고
    • Prostaglandin E2 induces IL-23 production in bone marrow-derived dendritic cells
    • Sheibanie AF, Tadmori I, Jing H, Vassiliou E, Ganea D. Prostaglandin E2 induces IL-23 production in bone marrow-derived dendritic cells. FASEB J. 2004;18(11):1318-1320.
    • (2004) FASEB J , vol.18 , Issue.11 , pp. 1318-1320
    • Sheibanie, A.F.1    Tadmori, I.2    Jing, H.3    Vassiliou, E.4    Ganea, D.5
  • 32
    • 4344661069 scopus 로고    scopus 로고
    • Experimental allergic encephalomyelitis is exacerbated in mice deficient for 12/15-lipoxygenase or 5-lipoxygenase
    • Emerson MR, LeVine SM. Experimental allergic encephalomyelitis is exacerbated in mice deficient for 12/15-lipoxygenase or 5-lipoxygenase. Brain Res. 2004;1021(1):140-145.
    • (2004) Brain Res , vol.1021 , Issue.1 , pp. 140-145
    • Emerson, M.R.1    LeVine, S.M.2
  • 33
    • 77951557888 scopus 로고    scopus 로고
    • The absence of the pro-antioxidant transcription factor Nrf2 exacerbates experimental autoimmune encephalomyelitis
    • Johnson DA, Amirahmadi S, Ward C, Fabry Z, Johnson JA. The absence of the pro-antioxidant transcription factor Nrf2 exacerbates experimental autoimmune encephalomyelitis. Toxicol Sci. 2010;114(2):237-246.
    • (2010) Toxicol Sci , vol.114 , Issue.2 , pp. 237-246
    • Johnson, D.A.1    Amirahmadi, S.2    Ward, C.3    Fabry, Z.4    Johnson, J.A.5
  • 34
    • 84859759069 scopus 로고    scopus 로고
    • Triterpenoid modulation of IL-17 and Nrf-2 expression ameliorates neuroinflammation promotes remyelination in autoimmune encephalomyelitis
    • Pareek TK, et al. Triterpenoid modulation of IL-17 and Nrf-2 expression ameliorates neuroinflammation promotes remyelination in autoimmune encephalomyelitis. Sci Rep. 2011;1:201.
    • (2011) Sci Rep , vol.1 , pp. 201
    • Pareek, T.K.1
  • 35
    • 84884339141 scopus 로고    scopus 로고
    • Clinical efficacy of BG-12 (dimethyl fumarate) in patients with relapsing-remitting multiple sclerosis:Subgroup analyses of the DEFINE study
    • Bar-Or A, et al. Clinical efficacy of BG-12 (dimethyl fumarate) in patients with relapsing-remitting multiple sclerosis:subgroup analyses of the DEFINE study. J Neurol. 2013;260(9):2297-2305.
    • (2013) J Neurol , vol.260 , Issue.9 , pp. 2297-2305
    • Bar-Or, A.1
  • 36
    • 84866423965 scopus 로고    scopus 로고
    • Placebo-controlled phase 3 study of oral BG-12 for relapsing multiple sclerosis
    • Gold R, et al. Placebo-controlled phase 3 study of oral BG-12 for relapsing multiple sclerosis. N Engl J Med. 2012;367(12):1098-1107.
    • (2012) N Engl J Med , vol.367 , Issue.12 , pp. 1098-1107
    • Gold, R.1
  • 38
    • 0031577292 scopus 로고    scopus 로고
    • An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements
    • Itoh K, et al. An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements. Biochem Biophys Res Commun. 1997;236(2):313-322.
    • (1997) Biochem Biophys Res Commun , vol.236 , Issue.2 , pp. 313-322
    • Itoh, K.1
  • 39
    • 0027940262 scopus 로고
    • Mechanisms of tolerance induction in major histocompatibility complex class II-restricted T cells specific for a blood-borne self-antigen
    • Zal T, Volkmann A, Stockinger B. Mechanisms of tolerance induction in major histocompatibility complex class II-restricted T cells specific for a blood-borne self-antigen. J Exp Med. 1994;180(6):2089-2099.
    • (1994) J Exp Med , vol.180 , Issue.6 , pp. 2089-2099
    • Zal, T.1    Volkmann, A.2    Stockinger, B.3
  • 40
    • 0033012030 scopus 로고    scopus 로고
    • An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow
    • Lutz MB, et al. An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow. J Immunol Methods. 1999;223(1):77-92.
    • (1999) J Immunol Methods , vol.223 , Issue.1 , pp. 77-92
    • Lutz, M.B.1
  • 41
    • 84884125559 scopus 로고    scopus 로고
    • Leukoreduction system chambers are an efficient, valid, and economic source of functional monocyte-derived dendritic cells and lymphocytes
    • Pfeiffer IA, et al. Leukoreduction system chambers are an efficient, valid, and economic source of functional monocyte-derived dendritic cells and lymphocytes. Immunobiology. 2013;218(11):1392-1401.
    • (2013) Immunobiology , vol.218 , Issue.11 , pp. 1392-1401
    • Pfeiffer, I.A.1
  • 42
    • 61549140074 scopus 로고    scopus 로고
    • Multi-hit inhibition of circulating and cell-associated components of the toll-like receptor 4 pathway by oxidized phospholipids
    • von Schlieffen E, et al. Multi-hit inhibition of circulating and cell-associated components of the toll-like receptor 4 pathway by oxidized phospholipids. Arterioscler Thromb Vasc Biol. 2009;29(3):356-362.
    • (2009) Arterioscler Thromb Vasc Biol , vol.29 , Issue.3 , pp. 356-362
    • Von Schlieffen, E.1
  • 43
    • 17944387960 scopus 로고    scopus 로고
    • Structural identification by mass spectrometry of oxidized phospholipids in minimally oxidized low density lipoprotein that induce monocyte/endothelial interactions and evidence for their presence in vivo
    • Watson AD, et al. Structural identification by mass spectrometry of oxidized phospholipids in minimally oxidized low density lipoprotein that induce monocyte/endothelial interactions and evidence for their presence in vivo. J Biol Chem. 1997;272(21):13597-13607.
    • (1997) J Biol Chem , vol.272 , Issue.21 , pp. 13597-13607
    • Watson, A.D.1
  • 44
    • 0345803942 scopus 로고    scopus 로고
    • Oxidized phospholipids induce expression of human heme oxygenase-1 involving activation of cAMP-responsive element-binding protein
    • Krönke G, et al. Oxidized phospholipids induce expression of human heme oxygenase-1 involving activation of cAMP-responsive element-binding protein. J Biol Chem. 2003;278(51):51006-51014.
    • (2003) J Biol Chem , vol.278 , Issue.51 , pp. 51006-51014
    • Krönke, G.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.