CCN1 induces hepatic ductular reaction through integrin αvβ5-mediated activation of NF-κB

Journal of Clinical Investigation

Volumn 125, Issue 5, 2015, Pages 1886-1900

  Kim, Ki Hyun ^a   Chen, Chih Chiun ^a   Alpini, Gianfranco ^b,c,d   Lau, Lester F ^a  

^a UNIVERSITY OF ILLINOIS   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c SCOTT AND WHITE MEMORIAL HOSPITAL   (United States)

^d TEXAS A AND M HEALTH SCIENCE CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ALPHA SMOOTH MUSCLE ACTIN; ALPHAVBETA5 INTEGRIN; ASPARTATE AMINOTRANSFERASE; BILE ACID; CYCLINE; CYSTEINE RICH PROTEIN 61; CYTOKERATIN 19; GAMMA SECRETASE; HEPATOCYTE NUCLEAR FACTOR 1BETA; HEPATOCYTE NUCLEAR FACTOR 6; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; JAGGED1; NOTCH RECEPTOR; TRANSCRIPTION FACTOR HES 1; TRANSCRIPTION FACTOR RELA; VITRONECTIN RECEPTOR; CALCIUM BINDING PROTEIN; CYR61 PROTEIN, HUMAN; CYR61 PROTEIN, MOUSE; HYBRID PROTEIN; LIGATIN; MEMBRANE PROTEIN; SERRATE PROTEINS; SIGNAL PEPTIDE;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BILE ACID SYNTHESIS; BILE DUCT LIGATION; BILE DUCT REGENERATION; BINDING SITE; CELL COUNT; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; DNA SYNTHESIS; FIBROBLAST; HEPATIC DUCT; HEPATIC PROGENITOR CELL; IMMUNOHISTOCHEMISTRY; INTRAHEPATIC BILE DUCT; INTRAHEPATIC CHOLESTASIS; LIVER CELL; LIVER FIBROSIS; LIVER HISTOLOGY; LIVER NECROSIS; MORTALITY; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; REGENERATION; SIGNAL TRANSDUCTION; STELLATE CELL; TRANSCRIPTION INITIATION; UPREGULATION; ANIMAL; BILE DUCT; BIOSYNTHESIS; C57BL MOUSE; CELL CULTURE; CELL DIVISION; GENE EXPRESSION REGULATION; GENE TARGETING; GENETICS; HUMAN; LIVER; METABOLISM; OBSTRUCTIVE JAUNDICE; PATHOLOGY; PHYSIOLOGY; RNA INTERFERENCE;

ANIMALS; BILE DUCTS; CALCIUM-BINDING PROTEINS; CELL DIVISION; CELLS, CULTURED; CHOLESTASIS, EXTRAHEPATIC; CYSTEINE-RICH PROTEIN 61; GENE EXPRESSION REGULATION; GENE KNOCK-IN TECHNIQUES; HEPATIC STELLATE CELLS; HEPATOCYTES; HUMANS; INTEGRIN ALPHAVBETA3; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LIVER; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; NF-KAPPA B; RECEPTORS, NOTCH; RECEPTORS, VITRONECTIN; RECOMBINANT FUSION PROTEINS; REGENERATION; RNA INTERFERENCE;

EID: 84928989197     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI79327     Document Type: Article

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