Targeting DDX3 with a small molecule inhibitor for lung cancer therapy

EMBO Molecular Medicine

Volumn 7, Issue 5, 2015, Pages 648-669

  Bol, Guus M ^a,b   Vesuna, Farhad ^a   Xie, Min ^a   Zeng, Jing ^a   Aziz, Khaled ^a   Gandhi, Nishant ^a   Levine, Anne ^a   Irving, Ashley ^a   Korz, Dorian ^a   Tantravedi, Saritha ^a   Heerma van Voss, Marise R ^a,b   Gabrielson, Kathleen ^a   Bordt, Evan A ^c   Polster, Brian M ^c   Cope, Leslie ^a   van der Groep, Petra ^b   Kondaskar, Atul ^d   Rudek, Michelle A ^a   Hosmane, Ramachandra S ^d   van der Wall, Elsken ^b   van Diest, Paul J ^a,b   Tran, Phuoc T ^a   Raman, Venu ^a,b   more..

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^c UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF MARYLAND BALTIMORE COUNTY   (United States)

Author keywords

DDX3; DNA repair; Lung cancer; Radiation sensitizing agent; Small molecule inhibitor

Indexed keywords

ANTINEOPLASTIC AGENT; BETA CATENIN; CARBOPLATIN; DIIMIDAZO[4,5 D:4',5' F] [1,3]DIAZEPINE; ENZYME INHIBITOR; RNA HELICASE; SHORT HAIRPIN RNA; UNCLASSIFIED DRUG; AZEPINE DERIVATIVE; DDX3X PROTEIN, HUMAN; DEAD BOX PROTEIN; IMIDAZOLE DERIVATIVE; RADIOSENSITIZING AGENT; RK-33 COMPOUND;

ADULT; AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER THERAPY; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CONTROLLED STUDY; DNA END JOINING REPAIR; DNA REPAIR; DRUG BINDING; DRUG TARGETING; FEMALE; HUMAN; HUMAN CELL; LOSS OF FUNCTION MUTATION; LUNG CANCER; MAJOR CLINICAL STUDY; MALE; MAMMAL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; RADIATION INDUCED NEOPLASM; RADIOSENSITIZATION; TUMOR REGRESSION; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL CYCLE; CELL CYCLE CHECKPOINT; CELL LINE; DRUG EFFECTS; ISOLATION AND PURIFICATION; LUNG NEOPLASMS; NUDE MOUSE; TRANSGENIC MOUSE;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; AZEPINES; CELL CYCLE; CELL CYCLE CHECKPOINTS; CELL LINE; DEAD-BOX RNA HELICASES; HUMANS; IMIDAZOLES; LUNG NEOPLASMS; MICE, NUDE; MICE, TRANSGENIC; RADIATION-SENSITIZING AGENTS;

EID: 84928987020     PISSN: 17574676     EISSN: 17574684     Source Type: Journal    
DOI: 10.15252/emmm.201404368     Document Type: Article

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