Novel, broad spectrum anticancer agents containing the tricyclic 5:7:5-fused diimidazodiazepine ring system

ACS Medicinal Chemistry Letters

Volumn 2, Issue 3, 2011, Pages 252-256

  Kondaskar, Atul ^a   Kondaskar, Shilpi ^a   Kumar, Raj ^a   Fishbein, James C ^a   Muvarak, Nidal ^b   Lapidus, Rena G ^b   Sadowska, Mariola ^b   Edelman, Martin J ^b   Bol, Guus M ^c   Vesuna, Farhad ^c   Raman, Venu ^c   Hosmane, Ramachandra S ^a  

^a UNIVERSITY OF MARYLAND BALTIMORE COUNTY   (United States)

^b UNIVERSITY OF MARYLAND   (United States)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

5:7:5 fused tricycles; and ovarian cancers; breast; broad spectrum anticancer activity; diimidazo 4,5 d:4 ,5 f 1,3 diazepine ring system; effects on G1 and S phases of the cell cycle; in vitro screening; lung; preliminary mechanistic studies; prostate; Synthesis

Indexed keywords

ANTINEOPLASTIC AGENT; DIAZEPINE DERIVATIVE; DIIMIDAZO[4,5 D:4',5' F][1,3]DIAZEPINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CELL STRAIN MCF 7; DRUG SYNTHESIS; FLOW CYTOMETRY; HUMAN; IC 50; LUNG CANCER; MOUSE; NONHUMAN; OVARY CANCER; PRIORITY JOURNAL; PROSTATE CANCER; STRUCTURE ACTIVITY RELATION;

MUS;

EID: 79952649904     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/ml100281b     Document Type: Article

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