A method for quantification of volatile organic compounds in blood by SPME-GC-MS/MS with broader application: From non-occupational exposure population to exposure studies

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 992, Issue , 2015, Pages 76-85

  Aranda Rodriguez, Rocio ^a   Cabecinha, Ashley ^a   Harvie, Jeromy ^a   Jin, Zhiyun ^a   Marchand, Axelle ^b   Tardif, Robert ^b   Nong, Andy ^a   Haddad, Sami ^b  

^a HEALTH CANADA   (Canada)

^b UNIVERSITÉ DE MONTRÉAL   (Canada)

Author keywords

Biomonitoring; Blood; Exposure studies; General population; Solid phase microextraction; Volatile organic compounds

Indexed keywords

BINARY MIXTURES; BLOOD; CHROMATOGRAPHY; ETHYLBENZENE; EXTRACTION; GAS CHROMATOGRAPHY; INDOOR AIR POLLUTION; ISOTOPES; MASS SPECTROMETRY; MATERIALS TESTING; ORGANIC CHEMICALS; ORGANIC COMPOUNDS; STYRENE; TERNARY SYSTEMS; TOLUENE; VOLATILE ORGANIC COMPOUNDS; XYLENE;

BIOMONITORING; EXPOSURE STUDIES; GENERAL POPULATION; HEAD-SPACE SOLID-PHASE MICROEXTRACTION; ISOTOPE DILUTION MASS SPECTROMETRY; NON-OCCUPATIONAL EXPOSURE; PHARMACOKINETIC STUDIES; SOLID-PHASE MICROEXTRACTION;

QUALITY CONTROL;

BENZENE; CHLOROFORM; ETHYLBENZENE; META XYLENE; ORTHO XYLENE; PARA XYLENE; STYRENE; TETRACHLOROETHYLENE; TOLUENE; TRICHLOROETHYLENE; TRIHALOMETHANE; VOLATILE ORGANIC COMPOUND;

ACCURACY; ARTICLE; BIOLOGICAL MONITORING; BLOOD LEVEL; CONTROLLED STUDY; GAS CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; LIMIT OF DETECTION; MALE; NORMAL HUMAN; POPULATION EXPOSURE; PRIORITY JOURNAL; QUALITY CONTROL; SOLID PHASE MICROEXTRACTION; TANDEM MASS SPECTROMETRY; ANALYSIS; BLOOD; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL MONITORING; PROCEDURES; REPRODUCIBILITY; STATISTICAL MODEL;

ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL MONITORING; HUMANS; LIMIT OF DETECTION; LINEAR MODELS; MALE; REPRODUCIBILITY OF RESULTS; SOLID PHASE MICROEXTRACTION; TANDEM MASS SPECTROMETRY; VOLATILE ORGANIC COMPOUNDS;

EID: 84928984446     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2015.04.020     Document Type: Article

References (39)

1. Chambers D.M., Ocariz J.M., McGuirk M.F., Blount B.C. Impact of cigarette smoking on Volatile Organic Compound (VOC) blood levels in the U.S. Population: NHANES 2003-2004. Environ. Int. 2011, 37:1321-1328.
2. Rumchev K., Spickett J., Bulsara M., Phillips M., Stick S. Association of domestic exposure to volatile organic compounds with asthma in young children. Thorax 2004, 59:746-751.
3. Zhang J., Smith K.R. Indoor air pollution: a global health concern. Br. Med. Bull. 2003, 68:209-225.
4. Agency for Toxic Substances and Disease Registry, (accessed 21.06.14). http://www.atsdr.cdc.gov/.
5. Zhu J., Wong S.L., Cakmak S. Nationally representative levels of selected volatile organic compounds in Canadian residential indoor air: population-based survey. Environ. Sci. Technol. 2013, 47:13276-13283.
6. Patry-Parisien J., Zhu J., Wong S.L. Implementation of the indoor air component of cycle 2 of the Canadian health measures survey. Health Rep. 2013, 24:3-10.
7. Sofuoglu S.C., Aslan G., Inal F., Sofuoglu A. An assessment of indoor air concentrations and health risks of volatile organic compounds in three primary schools. Int. J. Hyg. Environ. Health 2011, 214:36-46.
8. Zhou J., You Y., Bai Z., Hu Y., Zhang J., Zhang N. Health risk assessment of personal inhalation exposure to volatile organic compounds in Tianjin, China. Sci. Total Environ. 2011, 409:452-459.
9. Weisel C.P. Relationships of Indoor, Outdoor, and Personal Air (RIOPA). Part I. Collection methods and descriptive analyses. Research report 2005, Health Effects Institute.
10. Jia C., D'Souza J., Batterman S. Distributions of personal VOC exposures: a population-based analysis. Environ. Int. 2008, 34:922-931.
11. Ashley D.L., Bonin M.A., Cardinali F.L., McCraw J.M., Wooten J.V. Blood concentrations of volatile organic compounds in a nonoccupationally exposed US population and in groups with suspected exposure. Clin. Chem. 1994, 40:1401-1404.
12. Mathias P.I., B'Hymer C. A survey of liquid chromatographic-mass spectrometric analysis of mercapturic acid biomarkers in occupational and environmental exposure monitoring. J. Chromatogr. B: Anal. Technol. Biomed. Life Sci. 2014, 964:136-145.
13. Heinrich-Ramm R., Jakubowski M., Heinzow B., Christensen J.M., Olsen E., Hertel O. Biological monitoring for exposure to volatile organic compounds (VOCs) (IUPAC recommendations 2000). Pure Appl. Chem. 2000, 72:385-436.
14. Eckert E., Schmid K., Schaller B., Hiddemann-Koca K., Drexler H., Göen T. Mercapturic acids as metabolites of alkylating substances in urine samples of German inhabitants. Int. J. Hyg. Environ. Health 2011, 214:196-204.
15. Ashley D.L., Bonin M.A., Cardinali F.L., McCraw J.M., Wooten J.V. Measurement of volatile organic compounds in human blood. Environ. Health Perspect. 1996, 104:871-877.
16. Tremblay M., Wolfson M., Gorber S.C. Canadian Health Measures Survey: rationale, background and overview. Rapports sur la santé 2007, 18(Suppl.):7-20.
17. Exposure Science in the 21st Century: A Vision and a Strategy 2012, The National Academies Press.
18. Bonin M.A., Ashley D.L., Cardinali F.L., McGraw J.M., Patterson D.G. Importance of enhanced mass resolution in removing interferences when measuring volatile organic compounds in human blood by using purge-and-trap gas chromatography/mass spectrometry. J. Am. Soc. Mass Spectrom. 1992, 3:831-841.
19. Cardinali F.L., Ashley D.L., Wooten J.V., McCraw J.M., Lemire S.W. The use of solid-phase microextraction in conjunction with a benchtop quadrupole mass spectrometer for the analysis of volatile organic compounds in human blood at the low parts-per-trillion level. J. Chromatogr. Sci. 2000, 38:49-54.
20. Blount B.C., Kobelski R.J., McElprang D.O., Ashley D.L., Morrow J.C., Chambers D.M., Cardinali F.L. Quantification of 31 volatile organic compounds in whole blood using solid-phase microextraction and gas chromatography-mass spectrometry. J. Chromatogr. B. 2006, 832:292-301.
21. Chambers D.M., McElprang D.O., Waterhouse M.G., Blount B.C. An improved approach for accurate quantitation of benzene, toluene, ethylbenzene, xylene, and styrene in blood. Anal. Chem. 2006, 78:5375-5383.
22. Mochalski P., King J., Klieber M., Unterkofler K., Hinterhuber H., Baumann M., Amann A. Blood and breath levels of selected volatile organic compounds in healthy volunteers. Analyst 2013, 138:2134-2145.
23. Alonso M., Castellanos M., Sanchez J.M. Evaluation of matrix effects in the analysis of volatile organic compounds in whole blood with solid-phase microextraction. J. Sep. Sci. 2013, 36:3776-3782.
24. Gottzein A.K., Musshoff F., Madea B. Qualitative screening for volatile organic compounds in human blood using solid-phase microextraction and gas chromatography-mass spectrometry. J. Mass Spectrom. 2010, 45:391-397.
25. Alonso M., Castellanos M., Besalú E., Sanchez J.M. A headspace needle-trap method for the analysis of volatile organic compounds in whole blood. J. Chromatogr. A 2012, 1252:23-30.
26. Tardif R., Charest-Tardif G., Brodeur J., Krishnan K. Physiologically based pharmacokinetic modeling of a ternary mixture of alkyl benzenes in rats and humans. Toxicol. Appl. Pharmacol. 1997, 144:120-134.
27. Haddad S., Tardif R., Charest-Tardif G., Krishnan K. Physiological modeling of the toxicokinetic interactions in a quaternary mixture of aromatic hydrocarbons. Toxicol. Appl. Pharmacol. 1999, 161:249-257.
28. Sonne C., Gustavson K., Rigét F.F., Dietz R., Krüger T., Bonefeld-Jørgensen E.C. Physiologically based pharmacokinetic modeling of POPs in Greenlanders. Environ. Int. 2014, 64:91-97.
29. Ulaszewska M.M., Ciffroy P., Tahraoui F., Zeman F.A., Capri E., Brochot C. Interpreting PCB levels in breast milk using a physiologically based pharmacokinetic model to reconstruct the dynamic exposure of Italian women. J. Expos. Sci. Environ. Epidemiol. 2012, 22:601-609.
30. McNally K., Cotton R., Cocker J., Jones K., Bartels M., Rick D., Price P., Loizou G. Reconstruction of exposure to m-xylene from human biomonitoring data using PBPK modelling, bayesian inference, and Markov chain Monte Carlo simulation. J. Toxicol. 2012, 2012.
31. Redding L.E., Sohn M.D., McKone T.E., Chen J.-W., Wang S.-L., Hsieh D.P.H., Yang R.S.H. Population physiologically based pharmacokinetic modeling for the human lactational transfer of PCB-153 with consideration of worldwide human biomonitoring results. Environ. Health Perspect. 2008, 116:1629-1634.
32. Marchand A., Aranda-Rodriguez R., Tardif R., Nong A., Haddad S. Toxicol. Sci. 2015, 10.1093/toxsci/kfv009.
33. Cardinali F.L., McCraw J.M., Ashley D.L., Bonin M.A. Production of Blank water for the analysis of volatile organic compounds in human blood at the low parts-per-trillion level. Chromatogr. Sci. 1994, 32:41-45.
34. Chambers D.M., Blount B.C., McElprang D.O., Waterhouse M.G., Morrow J.C. Picogram measurement of volatile n-alkanes (n-hexane through n-dodecane) in blood using solid-phase microextraction to assess nonoccupational petroleum-based fuel exposure. Anal. Chem. 2008, 80:4666-4674.
35. Environmental Protection Agency, (accessed 20.06.14). http://www.gpo.gov/fdsys/granule/CFR-2011-title40-vol23/CFR-2011-title40-vol23-part136-appB/content-detail.html.
36. Colby B.N., McCaman M.W. A comparison of calculation procedures for isotope dilution determinations using gas chromatography mass spectrometry. Biomed. Mass Spectrom. 1979, 6:225-230.
37. Cardinali F.L., McCraw J.M., Ashley D.L., Bonin M., Wooten J. Treatment of vacutainers for use in the analysis of volatile organic compounds in human blood at the low parts-per-trillion level. J. Chromatogr. Sci. 1995, 33:557-560.
38. Fourth National Report on Human Exposure to Environmental Chemicals 2009, U.S. Department of Health and Human Services, Centers for Disease Control and Prevention.
39. Bonin M.A., Silva L.K., Smith M.M., Ashley D.L., Blount B.C. Measurement of trihalomethanes and methyl tert-butyl ether in whole blood using gas chromatography with high-resolution mass spectrometry. J. Anal. Toxicol. 2005, 29:81-89.