Interpreting PCB levels in breast milk using a physiologically based pharmacokinetic model to reconstruct the dynamic exposure of Italian women

Journal of Exposure Science and Environmental Epidemiology

Volumn 22, Issue 6, 2012, Pages 601-609

  Ulaszewska, Maria M ^a,b   Ciffroy, Philippe ^c   Tahraoui, Fazia ^a   Zeman, Florence A ^a   Capri, Ettore ^b   Brochot, Céline ^a  

^a INSTITUT NATIONAL DE L ENVIRONNEMENT INDUSTRIEL ET DES RISQUES INERIS   (France)

^b UNIVERSITÀ CATTOLICA DEL SACRO CUORE   (Italy)

^c EDF R AND D   (France)

Author keywords

breast milk monitoring; exposure assessment; PCB indicators; physiologically based pharmacokinetic modeling; reverse dosimetry

Indexed keywords

POLYCHLORINATED BIPHENYL;

ARTICLE; BREAST MILK; CHEMICAL MODEL; CHEMISTRY; FEMALE; HUMAN; ITALY;

FEMALE; HUMANS; ITALY; MILK, HUMAN; MODELS, CHEMICAL; POLYCHLORINATED BIPHENYLS;

EID: 84867902013     PISSN: 15590631     EISSN: 1559064X     Source Type: Journal    
DOI: 10.1038/jes.2012.36     Document Type: Article

References (52)

1. Cachada A., Lopes L.V., Hursthouse A.S., Biasioli M., Grcman H., and Otabbong E., et al. The variability of polychlorinated biphenyls levels in urban soils from five European cities. Environ Pollut 2009: 157(2): 511-518.
2. Grassi P., Fattore E., Generoso C., Fanelli R., Arvati M., and Zuccato E. Polychlorobiphenyls (PCBs), polychlorinated dibenzo-p-dioxins (PCDDs) and dibenzofurans (PCDFs) in fruit and vegetables from an industrial area in northern Italy. Chemosphere 2010: 79(3): 292-298.
3. Menichini E., Lacovella N., Monfredini F., and Turrio-Baldassarri L. Atmospheric pollution by PAHs, PCDD/Fs and PCBs simultaneously collected at a regional background site in central Italy and at an urban site in Rome. Chemosphere 2007: 69(3): 422-434. (Pubitemid 47247812)
4. Kelly B.C., Ikonomou M.G., Blair J.D., Morin A.E., and Gobas F. Food web-specific biomagnification of persistent organic pollutants. Science 2007: 317(5835): 236-239. (Pubitemid 47076197)
5. Cohn B.A., Cirillo P.M., Sholtz R.I., Ferrara A., Park J.S., and Schwingl P.J. Polychlorinated biphenyl (PCB) exposure in mothers and time to pregnancy in daughters. Reprod Toxicol 2011: 31(3): 290-296.
6. Kimbrough R.D. Polychlorinated-biphenyls (PCBs) and human health-an update. Crit Rev Toxicol 1995: 25(2): 133-163.
7. Lamb M.R., Taylor S., Liu X.H., Wolff M.S., Borrell L., and Matte T.D., et al. Prenatal exposure to polychlorinated biphenyls and postnatal growth: a structural analysis. Environ Health Perspect 2006: 114(5): 779-785.
8. McGlynn K.A., Guo X.G., Graubard B.I., Brock J.W., Klebanoff M.A., and Longnecker M.P. Maternal pregnancy levels of polychlorinated biphenyls and risk of hypospadias and cryptorchidism in male offspring. Environ Health Perspect 2009: 117(9): 1472-1476.
9. Stewart P.W., Lonky E., Reihman J., Pagano J., Gump B.B., and Darvill T. The relationship between prenatal PCB exposure and intelligence (IQ) in 9-year-old children. Environ Health Perspect 2008: 116(10): 1416-1422.
10. Toft G., Thulstrup A.M., Jonsson B.A., Pedersen H.S., Ludwicki J.K., and Zvezday V., et al. Fetal loss and maternal serum levels of 2,2 ',4,4 ',5,5 '-hexachlorbiphenyl (CB-153) and 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (p,p '-DDE) exposure: a cohort study in Greenland and two European populations. Environ Health 2010: 9: 5-6.
11. Weisglas-Kuperus N., Patandin S., Berbers G.A.M., Sas T.C.J., Mulder P.G.H., and Sauer P.J.J., et al. Immunologic effects of background exposure to polychlorinated biphenyls and dioxins in Dutch preschool children. Environm Health Perspect 2000: 108(12): 1203-1207. (Pubitemid 32049107)
12. Beaudouin R., Micallef S., and Brochot C. A stochastic whole-body physiologically based pharmacokinetic model to assess the impact of inter-individual variability on tissue dosimetry over the human lifespan. Regul Toxicol Pharmacol 2010: 57(1): 103-116.
13. Redding L.E., Sohn M.D., McKone T.E., Chen J.W., Wang S.L., and Hsieh D.P.H., et al. Population physiologically based pharmacokinetic modeling for the human lactational transfer of PCB-153 with consideration of worldwide human biomonitoring results. Environ Health Perspect 2008: 116(12): 1629-1634.
14. Verner M.A., Ayotte P., Muckle G., Charbonneau M., and Haddad S. A Physiologically based pharmacokinetic model for the assessment of infant exposure to persistent organic pollutants in epidemiologic studies. Environ Health Perspect 2009: 117(3): 481-487.
15. Quinn C.L., Wania F., Czub G., and Breivik K. Investigating intergenerational differences in human PCB exposure due to variable emissions and reproductive behaviors. Environ Health Perspect 2011: 119(5): 641-646.
16. Alcock R.E., Sweetman A.J., Juan C.Y., and Jones K.C. A generic model of human lifetime exposure to persistent organic contaminants: development and application to PCB-101. Environ Pollut 2000: 110(2): 253-265. (Pubitemid 30406932)
17. Moser G.A., and McLachlan M.S. Modeling digestive tract absorption and desorption of lipophilic organic contaminants in humans. Environ Sci Technol 2002: 36(15): 3318-3325. (Pubitemid 34851262)
18. Fensterheim R.J. Documenting temporal trends of polychlorinated-biphenyls in the environment. Regul Toxicol Pharmacol 1993: 18(2): 181-201.
19. Harrad S.J., Sewart A.P., Alcock R., Boumphrey R., Burnett V., and Duartedavidson R., et al. Polychlorinated-biphenyls (PCBs) in the British environment-Sinks, sources and temporal trends. Environ Pollut 1994: 85(2): 131-146. (Pubitemid 24113341)
20. Muir D.C.G., and Norstrom R.J. Geographical differences and time trends of persistent organic pollutants in the Arctic. Toxicol Lett 2000: 112: 93-101. (Pubitemid 30138109)
21. Noren K., and Meironyte D. Certain organochlorine and organobromine contaminants in Swedish human milk in perspective of past 20-30 years. Chemosphere 2000: 40(9-11): 1111-1123. (Pubitemid 30120720)
22. Sjodin A., Jones R.S., Focant J.F., Lapeza C., Wang R.Y., and McGahee E.E., et al. Retrospective time-trend study of polybrominated diphenyl ether and polybrominated and polychlorinated biphenyl levels in human serum from the United States. Environ Health Perspect 2004: 112(6): 654-658. (Pubitemid 38628392)
23. Ulaszewska M.M., Zuccato E., Capri E., Iovine R., Colombo A., and Rotella G., et al. The effect of waste combustion on the occurrence of polychlorinated dibenzo-pdioxins (PCDDs), polychlorinated dibenzofurans (PCDFs) and polychlorinated biphenyls (PCBs) in breast milk in Italy. Chemosphere 2011a: 82(1): 1-8.
24. Ulaszewska M.M., Zuccato E., and Davoli E. PCDD/Fs and dioxin-like PCBs in human milk and estimation of infants' daily intake: a review. Chemosphere 2011b: 83(6): 774-782.
25. Breivik K., Sweetman A., Pacyna J.M., and Jones K.C. Towards a global historical emission inventory for selected PCB congeners-a mass balance approach 2. Emissions. Sci Total Environ 2002: 290(1-3): 199-224. (Pubitemid 34460498)
26. Breivik K., Sweetman A., Pacyna J.M., and Jones K.C. Towards a global historical emission inventory for selected PCB congeners-a mass balance approach-3. An update. Sci Total Environt 2007: 377(2-3): 296-307. (Pubitemid 46662002)
27. Georgopoulos P.G., Sasso A.F., Isukapalli S.S., Lioy P.J., Vallero D.A., and Okino M., et al. Reconstructing population exposures to environmental chemicals from biomarkers: challenges and opportunities. J Expo Sci Environ Epidemiol 2009: 19(2): 149-171.
28. Lyons M.A., Yang R.S.H., Mayeno A.N., and Reisfeld B. Computational toxicology of chloroform: reverse dosimetry using Bayesian inference, Markov chain Monte Carlo simulation, and human biomonitoring data. Environ Health Perspect 2008: 116(8): 1040-1046.
29. Tan Y.M., Liao K.H., and Clewell H.J. Reverse dosimetry: interpreting trihalomethanes biomonitoring data using physiologically based pharmacokinetic modeling. J Expo Sci Environ Epidemiol 2007: 17(7): 591-603. (Pubitemid 350126884)
30. Abraham K., Papke O., Gross A., Kordonouri O., Wiegand S., and Wahn U., et al. Time course of PCDD/PCDF/PCB concentrations in breast-feeding mothers and their infants. Chemosphere 1998: 37(9-12): 1731-1741. (Pubitemid 28480043)
31. Thomas G.O., Smith K.E.C., Sweetman A.J., and Jones K.C. Further studies of the airpasture transfer of polychlorinated biphenyls. Environ Pollut 1998: 102(1): 119-128. (Pubitemid 28511260)
32. Fattore E, Fanelli R, Dellatte E, Turrini A, and di Domenico A Assessment of the dietary exposure to non-dioxin-like PCBs of the Italian general population. Chemosphere 2008: 73(1): S278-S283.
33. Leclercq C, Arcella D, Piccinelli R, Sette S, Le Donne C, and Turrini A The Italian National Food Consumption Survey INRAN-SCAI 2005-06: main results in terms of food consumption. Public Health Nutr 2009: 12(12): 2504-2532.
34. Verner M.A., Charbonneau M., Lopez-Carrillo L., and Haddad S. Physiologically based pharmacokinetic modeling of persistent organic pollutants for lifetime exposure assessment: a new tool in breast cancer epidemiologic studies. Environ Health Perspect 2008: 116(7): 886-892. (Pubitemid 351943895)
35. Johnson T.N., Rostami-Hodjegan A., and Tucker G.T. Prediction of the clearance of eleven drugs and associated variability in neonates, infants and children. Clin Pharmacokinet 2006: 45(9): 931-956. (Pubitemid 44299829)
36. Neville M.C., Keller R., Seacat J., Lutes V., Neifert M., and Casey C., et al. Studies in human lactation: milk volumes in lactating women during the onset of lactation and full lactation. Am J Clin Nutr 1988: 48(6): 1375-1386. (Pubitemid 19008568)
37. Parham F.M., Kohn M.C., Matthews H.B., DeRosa C., and Portier C.J. Using structural information to create physiologically based pharmacokinetic models for all polychlorinated biphenyls 1. Tissue:blood partition coefficients. Toxicol Appl Pharmacol 1997: 144(2): 340-347. (Pubitemid 27268356)
38. Arcus-Arth A., Krowech G., and Zeise L. Breast milk and lipid intake distributions for assessing cumulative exposure and risk. J Expo Anal Environ Epidemiol 2005: 15(4): 357-365. (Pubitemid 41140908)
39. Bitman J., Wood D.L., Mehta N.R., Hamosh P., and Hamosh M. Comparison of the phospholipid-composition of breast-milk from mothers of term and preterm infants during lactation. Am J Clin Nutr 1984: 40(5): 1103-1119. (Pubitemid 15210591)
40. Bitman J., Freed L.M., Neville M.C., Wood D.L., Hamosh P., and Hamosh M. Lipidcomposition of prepartum human mammary secretion and postpartum milk. JPGN 1986: 5(4): 608-615. (Pubitemid 17232807)
41. International Commission on Radiological Protection. Basic Anatomical and Physiological Data for Use in Radiological Protection: Reference Values vol. 32. J. Valentin: Stockholm, 2002.
42. Poulin P., and Theil F.P. Prediction of pharmacokinetics prior to in vivo studies. 1. Mechanism-based prediction of volume of distribution. J Pharm Sci 2002: 91(1): 129-156. (Pubitemid 34074473)
43. White D.R., Widdowson E.M., Woodard H.W., and Dickerson J.W.T. The composition of body-tissues 2. Fetus to young-adult. Brit J Radiol 1991: 64(758): 149-159.
44. Woodard H.Q., and White D.R. The composition of body-tissues. Brit J Radiol 1986: 59(708): 1209-1219.
45. Ritter R., Scheringer M., MacLeod M., Moeckel C., Jones K.C., and Hungerbuhler K. Intrinsic human elimination half-lives of polychlorinated biphenyls derived from the temporal evolution of cross-sectional biomonitoring data from the United Kingdom. Environ Health Perspect 2011: 119(2): 225-231.
46. Bois F.Y., and Maszle D. MCSim: a simulation program. J Stat Software 1997: 2(9). http://www.stat.ucla.edu/journals/jss/v02/i09 (software available online at www.toxi.ineris.fr).
47. Zuccato E., Calvarese S., Mariani G., Mangiapan S., Grasso P., and Guzzi A., et al. Level, sources and toxicity of polychlorinated biphenyls in the Italian diet. Chemosphere 1999: 38(12): 2753-2765. (Pubitemid 29134881)
48. Arnich N., Tard A., Leblanc J.C., Le Bizec B., Narbonne J.F., and Maximilien R. Dietary intake of non-dioxin-like PCBs (NDL-PCBs) in France, impact of maximum levels in some foodstuffs. Regul Toxicol Pharmacol 2009: 54(3): 287-293.
49. Aylward L.L., Brunet R.C., Starr T.B., Carrier G., Delzell E., and Cheng H., et al. Exposure reconstruction for the TCDD-exposed NIOSH cohort using a concentration-and age-dependent model of elimination. Risk Anal 2005: 25(4): 945-956. (Pubitemid 41565824)
50. Bergonzi R., Specchia C., Dinolfo M., Tomasi C., De Palma G., and Frusca T., et al. Distribution of persistent organochlorine pollutants in maternal and foetal tissues: data from an Italian polluted urban area. Chemosphere 2009: 76(6): 747-754.
51. Sahmel J., Devlin K., Paustenbach D., Hollins D., and Gaffney S. The role of exposure reconstruction in occupational human health risk assessment: current methods and a recommended framework. Crit Rev Toxicol 2010: 40(9): 799-843.
52. Ciffroy P., Tanaka T., Johansson E., and Brochot C. Linking fate model in freshwater and PBPK model to assess human internal dosimetry of B(a)P associated with drinking water. Environ Geochem Health 2011: 33(4): 371-387.