Human inhalation exposures to toluene, ethylbenzene, and m-xylene and physiologically based pharmacokinetic modeling of exposure biomarkers in exhaled air, blood, and urine

Toxicological Sciences

Volumn 144, Issue 2, 2015, Pages 414-424

  Marchand, Axelle ^a,b   Aranda Rodriguez, Rocio ^c   Tardif, Robert ^a   Nong, Andy ^c   Haddad, Sami ^a,b  

^a Department of Environmental and Occupational Health   (Canada)

^b UNIVERSITÉ DE MONTRÉAL   (Canada)

^c HEALTH CANADA   (Canada)

Author keywords

Biomarkers; Ethylbenzene; Inhalation; M xylene; PBPK modeling; Toluene

Indexed keywords

BIOLOGICAL MARKER; CYTOCHROME P450 1A2; ETHYLBENZENE; M XYLENE; MANDELIC ACID; ORTHO CRESOL; TOLUENE; UNCLASSIFIED DRUG; XYLENE; 3-XYLENE; BENZENE DERIVATIVE;

ADULT; ARTICLE; BLOOD; ENVIRONMENTAL EXPOSURE; EXPIRED AIR; HUMAN; INHALATION; MALE; NORMAL HUMAN; PHARMACOKINETICS; PHYSIOLOGICAL PROCESS; SIMULATION; STOICHIOMETRY; TOXICOKINETICS; URINARY EXCRETION; URINE; BIOLOGICAL MODEL; BREATH ANALYSIS; EXPOSURE;

ADULT; BENZENE DERIVATIVES; BIOMARKERS; BREATH TESTS; HUMANS; INHALATION EXPOSURE; MODELS, BIOLOGICAL; TOLUENE; XYLENES;

EID: 84926436294     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfv009     Document Type: Article

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