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Volumn 51, Issue 4, 2011, Pages 501-505

Neuregulin-1β for the treatment of systolic heart failure

Author keywords

Cardiac myocyte; ErbB2; ErbB4; Glial growth factor 2; Heregulin

Indexed keywords

CALCIUM; EPIDERMAL GROWTH FACTOR RECEPTOR 2; EPIDERMAL GROWTH FACTOR RECEPTOR 4; GLYCOSYLATED RECOMBINANT HUMAN NEUREGULIN 1BETA3; NEU DIFFERENTIATION FACTOR; NEUREGULIN 1BETA; RECOMBINANT NEUREGULIN 1BETA; UNCLASSIFIED DRUG;

EID: 80052807325     PISSN: 00222828     EISSN: 10958584     Source Type: Journal    
DOI: 10.1016/j.yjmcc.2011.06.016     Document Type: Review
Times cited : (40)

References (69)
  • 1
    • 0032994536 scopus 로고    scopus 로고
    • Growth hormone therapy in patients with dilated cardiomyopathy: preliminary observations of a pilot study
    • Jose V.J., Zechariah T.U., George P., Jonathan V. Growth hormone therapy in patients with dilated cardiomyopathy: preliminary observations of a pilot study. Indian Heart J Mar-Apr 1999, 51(2):183-185.
    • Indian Heart J
    • Jose, V.J.1    Zechariah, T.U.2    George, P.3    Jonathan, V.4
  • 2
    • 0037305044 scopus 로고    scopus 로고
    • Administration of growth hormone to patients with advanced cardiac heart failure: effects upon left ventricular function, exercise capacity, and neurohormonal status
    • Acevedo M., Corbalan R., Chamorro G., Jalil J., Nazzal C., Campusano C., et al. Administration of growth hormone to patients with advanced cardiac heart failure: effects upon left ventricular function, exercise capacity, and neurohormonal status. Int J Cardiol 2003, 87(2-3):185-191.
    • (2003) Int J Cardiol , vol.87 , Issue.2-3 , pp. 185-191
    • Acevedo, M.1    Corbalan, R.2    Chamorro, G.3    Jalil, J.4    Nazzal, C.5    Campusano, C.6
  • 3
    • 0030069728 scopus 로고    scopus 로고
    • Differential cardiac effects of growth hormone and insulin-like growth factor-1 in the rat. A combined in vivo and in vitro evaluation
    • Cittadini A., Stromer H., Katz S.E., Clark R., Moses A.C., Morgan J.P., et al. Differential cardiac effects of growth hormone and insulin-like growth factor-1 in the rat. A combined in vivo and in vitro evaluation. Circulation 1996, 93(4):800-809.
    • (1996) Circulation , vol.93 , Issue.4 , pp. 800-809
    • Cittadini, A.1    Stromer, H.2    Katz, S.E.3    Clark, R.4    Moses, A.C.5    Morgan, J.P.6
  • 4
    • 0037429649 scopus 로고    scopus 로고
    • Neuregulins: functions, forms, and signaling strategies
    • Falls D.L. Neuregulins: functions, forms, and signaling strategies. Exp Cell Res 2003, 284(1):14-30.
    • (2003) Exp Cell Res , vol.284 , Issue.1 , pp. 14-30
    • Falls, D.L.1
  • 5
    • 0028785406 scopus 로고
    • Aberrant neural and cardiac development in mice lacking the ErbB4 neuregulin receptor [see comments]
    • Gassmann M., Casagranda F., Orioli D., Simon H., Lai C., Klein R., et al. Aberrant neural and cardiac development in mice lacking the ErbB4 neuregulin receptor [see comments]. Nature 1995, 378(6555):390-394.
    • (1995) Nature , vol.378 , Issue.6555 , pp. 390-394
    • Gassmann, M.1    Casagranda, F.2    Orioli, D.3    Simon, H.4    Lai, C.5    Klein, R.6
  • 6
    • 0028914037 scopus 로고
    • Wortmannin inhibits insulin-stimulated but not contraction-stimulated glucose transport activity in skeletal muscle
    • Lee A.D., Hansen P.A., Holloszy J.O. Wortmannin inhibits insulin-stimulated but not contraction-stimulated glucose transport activity in skeletal muscle. FEBS Lett 1995, 361(1):51-54.
    • (1995) FEBS Lett , vol.361 , Issue.1 , pp. 51-54
    • Lee, A.D.1    Hansen, P.A.2    Holloszy, J.O.3
  • 7
    • 0028827104 scopus 로고
    • Multiple essential functions of neuregulin in development
    • Meyer D., Birchmeier C. Multiple essential functions of neuregulin in development. Nature 1995, 378(6555):386-390.
    • (1995) Nature , vol.378 , Issue.6555 , pp. 386-390
    • Meyer, D.1    Birchmeier, C.2
  • 8
    • 0032573183 scopus 로고    scopus 로고
    • Domain-specific gene disruption reveals critical regulation of neuregulin signaling by its cytoplasmic tail
    • Liu X., Hwang H., Cao L., Buckland M., Cunningham A., Chen J., et al. Domain-specific gene disruption reveals critical regulation of neuregulin signaling by its cytoplasmic tail. Proc Natl Acad Sci USA 1998, 95(22):13024-13029.
    • (1998) Proc Natl Acad Sci USA , vol.95 , Issue.22 , pp. 13024-13029
    • Liu, X.1    Hwang, H.2    Cao, L.3    Buckland, M.4    Cunningham, A.5    Chen, J.6
  • 9
    • 0028884413 scopus 로고
    • Requirement for neuregulin receptor erbB2 in neural and cardiac development
    • Lee K.F., Simon H., Chen H., Bates B., Hung M.C., Hauser C. Requirement for neuregulin receptor erbB2 in neural and cardiac development. Nature 1995, 378(6555):394-398.
    • (1995) Nature , vol.378 , Issue.6555 , pp. 394-398
    • Lee, K.F.1    Simon, H.2    Chen, H.3    Bates, B.4    Hung, M.C.5    Hauser, C.6
  • 10
    • 0032562770 scopus 로고    scopus 로고
    • Neuregulins promote survival and growth of cardiac myocytes. Persistence of ErbB2 and ErbB4 expression in neonatal and adult ventricular myocytes
    • Zhao Y.Y., Sawyer D.R., Baliga R.R., Opel D.J., Han X., Marchionni M.A., et al. Neuregulins promote survival and growth of cardiac myocytes. Persistence of ErbB2 and ErbB4 expression in neonatal and adult ventricular myocytes. J Biol Chem 1998, 273(17):10261-10269.
    • (1998) J Biol Chem , vol.273 , Issue.17 , pp. 10261-10269
    • Zhao, Y.Y.1    Sawyer, D.R.2    Baliga, R.R.3    Opel, D.J.4    Han, X.5    Marchionni, M.A.6
  • 11
    • 27344447301 scopus 로고    scopus 로고
    • Neuregulin-1alpha and beta isoform expression in cardiac microvascular endothelial cells and function in cardiac myocytes in vitro
    • Cote G.M., Miller T.A., Lebrasseur N.K., Kuramochi Y., Sawyer D.B. Neuregulin-1alpha and beta isoform expression in cardiac microvascular endothelial cells and function in cardiac myocytes in vitro. Exp Cell Res 2005, 311(1):135-146.
    • (2005) Exp Cell Res , vol.311 , Issue.1 , pp. 135-146
    • Cote, G.M.1    Miller, T.A.2    Lebrasseur, N.K.3    Kuramochi, Y.4    Sawyer, D.B.5
  • 12
    • 79955052182 scopus 로고    scopus 로고
    • Activation of the neuregulin/ErbB system during physiological ventricular remodeling in pregnancy
    • Lemmens K., Doggen K., De Keulenaer G.W. Activation of the neuregulin/ErbB system during physiological ventricular remodeling in pregnancy. Am J Physiol Heart Circ Physiol 2011, 300(3):H931-H942.
    • (2011) Am J Physiol Heart Circ Physiol , vol.300 , Issue.3
    • Lemmens, K.1    Doggen, K.2    De Keulenaer, G.W.3
  • 13
    • 10944236872 scopus 로고    scopus 로고
    • Cardiac endothelial cells regulate ROS-induced cardiomyocyte apoptosis through neuregulin-1beta /erbB4 signaling
    • Kuramochi Y., Cote G.M., Guo X., LeBrasseur N.K., Cui L., Liao R., et al. Cardiac endothelial cells regulate ROS-induced cardiomyocyte apoptosis through neuregulin-1beta /erbB4 signaling. J Biol Chem 2004, 279(49):51141-51147.
    • (2004) J Biol Chem , vol.279 , Issue.49 , pp. 51141-51147
    • Kuramochi, Y.1    Cote, G.M.2    Guo, X.3    LeBrasseur, N.K.4    Cui, L.5    Liao, R.6
  • 14
    • 0033393696 scopus 로고    scopus 로고
    • Neuregulin activation of ErbB receptors in vascular endothelium leads to angiogenesis
    • Russell K.S., Stern D.F., Polverini P.J., Bender J.R. Neuregulin activation of ErbB receptors in vascular endothelium leads to angiogenesis. Am J Physiol Heart Circ Physiol 1999, 277(6 Pt 2):H2205-H2211.
    • (1999) Am J Physiol Heart Circ Physiol , vol.277 , Issue.6 PART 2
    • Russell, K.S.1    Stern, D.F.2    Polverini, P.J.3    Bender, J.R.4
  • 15
    • 0035869407 scopus 로고    scopus 로고
    • Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2
    • Slamon D.J., Leyland-Jones B., Shak S., Fuchs H., Paton V., Bajamonde A., et al. Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. N Engl J Med 2001, 344(11):783-792.
    • (2001) N Engl J Med , vol.344 , Issue.11 , pp. 783-792
    • Slamon, D.J.1    Leyland-Jones, B.2    Shak, S.3    Fuchs, H.4    Paton, V.5    Bajamonde, A.6
  • 16
    • 0037172982 scopus 로고    scopus 로고
    • Conditional mutation of the ErbB2 (HER2) receptor in cardiomyocytes leads to dilated cardiomyopathy
    • Ozcelik C., Erdmann B., Pilz B., Wettschureck N., Britsch S., Hubner N., et al. Conditional mutation of the ErbB2 (HER2) receptor in cardiomyocytes leads to dilated cardiomyopathy. Proc Natl Acad Sci USA 2002, 99(13):8880-8885.
    • (2002) Proc Natl Acad Sci USA , vol.99 , Issue.13 , pp. 8880-8885
    • Ozcelik, C.1    Erdmann, B.2    Pilz, B.3    Wettschureck, N.4    Britsch, S.5    Hubner, N.6
  • 17
    • 0036099675 scopus 로고    scopus 로고
    • ErbB2 is essential in the prevention of dilated cardiomyopathy
    • Crone S.A., Zhao Y.Y., Fan L., Gu Y., Minamisawa S., Liu Y., et al. ErbB2 is essential in the prevention of dilated cardiomyopathy. Nat Med 2002, 8(5):459-465.
    • (2002) Nat Med , vol.8 , Issue.5 , pp. 459-465
    • Crone, S.A.1    Zhao, Y.Y.2    Fan, L.3    Gu, Y.4    Minamisawa, S.5    Liu, Y.6
  • 19
    • 0037007076 scopus 로고    scopus 로고
    • Modulation of anthracycline-induced myofibrillar disarray in rat ventricular myocytes by neuregulin-1beta and anti-erbB2: potential mechanism for trastuzumab-induced cardiotoxicity
    • Sawyer D.B., Zuppinger C., Miller T.A., Eppenberger H.M., Suter T.M. Modulation of anthracycline-induced myofibrillar disarray in rat ventricular myocytes by neuregulin-1beta and anti-erbB2: potential mechanism for trastuzumab-induced cardiotoxicity. Circulation 2002, 105(13):1551-1554.
    • (2002) Circulation , vol.105 , Issue.13 , pp. 1551-1554
    • Sawyer, D.B.1    Zuppinger, C.2    Miller, T.A.3    Eppenberger, H.M.4    Suter, T.M.5
  • 22
    • 68249087127 scopus 로고    scopus 로고
    • Neuregulin-1 beta is associated with disease severity and adverse outcomes in chronic heart failure
    • Ky B., Kimmel S.E., Safa R.N., Putt M.E., Sweitzer N.K., Fang J.C., et al. Neuregulin-1 beta is associated with disease severity and adverse outcomes in chronic heart failure. Circulation 2009, 120(4):310-317.
    • (2009) Circulation , vol.120 , Issue.4 , pp. 310-317
    • Ky, B.1    Kimmel, S.E.2    Safa, R.N.3    Putt, M.E.4    Sweitzer, N.K.5    Fang, J.C.6
  • 23
    • 10944236872 scopus 로고    scopus 로고
    • Cardiac endothelial cells regulate reactive oxygen species-induced cardiomyocyte apoptosis through neuregulin-1beta/erbB4 signaling
    • Kuramochi Y., Cote G.M., Guo X., Lebrasseur N.K., Cui L., Liao R., et al. Cardiac endothelial cells regulate reactive oxygen species-induced cardiomyocyte apoptosis through neuregulin-1beta/erbB4 signaling. J Biol Chem 2004, 279(49):51141-51147.
    • (2004) J Biol Chem , vol.279 , Issue.49 , pp. 51141-51147
    • Kuramochi, Y.1    Cote, G.M.2    Guo, X.3    Lebrasseur, N.K.4    Cui, L.5    Liao, R.6
  • 24
    • 34548132413 scopus 로고    scopus 로고
    • Role of neuregulin-1/ErbB signaling in cardiovascular physiology and disease: implications for therapy of heart failure
    • Lemmens K., Doggen K., De Keulenaer G.W. Role of neuregulin-1/ErbB signaling in cardiovascular physiology and disease: implications for therapy of heart failure. Circulation 2007, 116(8):954-960.
    • (2007) Circulation , vol.116 , Issue.8 , pp. 954-960
    • Lemmens, K.1    Doggen, K.2    De Keulenaer, G.W.3
  • 25
    • 57149098209 scopus 로고    scopus 로고
    • Ventricular ErbB2/ErbB4 activation and downstream signaling in pacing-induced heart failure
    • Doggen K., Ray L., Mathieu M., Mc Entee K., Lemmens K., De Keulenaer G.W. Ventricular ErbB2/ErbB4 activation and downstream signaling in pacing-induced heart failure. J Mol Cell Cardiol 2009, 46(1):33-38.
    • (2009) J Mol Cell Cardiol , vol.46 , Issue.1 , pp. 33-38
    • Doggen, K.1    Ray, L.2    Mathieu, M.3    Mc Entee, K.4    Lemmens, K.5    De Keulenaer, G.W.6
  • 26
    • 0033609458 scopus 로고    scopus 로고
    • Neuregulin in cardiac hypertrophy in rats with aortic stenosis. Differential expression of erbB2 and erbB4 receptors
    • Rohrbach S., Yan X., Weinberg E.O., Hasan F., Bartunek J., Marchionni M.A., et al. Neuregulin in cardiac hypertrophy in rats with aortic stenosis. Differential expression of erbB2 and erbB4 receptors. Circulation 1999, 100(4):407-412.
    • (1999) Circulation , vol.100 , Issue.4 , pp. 407-412
    • Rohrbach, S.1    Yan, X.2    Weinberg, E.O.3    Hasan, F.4    Bartunek, J.5    Marchionni, M.A.6
  • 27
    • 25144465666 scopus 로고    scopus 로고
    • Neuregulin receptors erbB2 and erbB4 in failing human myocardium - depressed expression and attenuated activation
    • Rohrbach S., Niemann B., Silber R.E., Holtz J. Neuregulin receptors erbB2 and erbB4 in failing human myocardium - depressed expression and attenuated activation. Basic Res Cardiol 2005, 100(3):240-249.
    • (2005) Basic Res Cardiol , vol.100 , Issue.3 , pp. 240-249
    • Rohrbach, S.1    Niemann, B.2    Silber, R.E.3    Holtz, J.4
  • 28
    • 70149110196 scopus 로고    scopus 로고
    • Preventive effects of heregulin-beta1 on macrophage foam cell formation and atherosclerosis
    • Xu G., Watanabe T., Iso Y., Koba S., Sakai T., Nagashima M., et al. Preventive effects of heregulin-beta1 on macrophage foam cell formation and atherosclerosis. Circ Res 2009, 105(5):500-510.
    • (2009) Circ Res , vol.105 , Issue.5 , pp. 500-510
    • Xu, G.1    Watanabe, T.2    Iso, Y.3    Koba, S.4    Sakai, T.5    Nagashima, M.6
  • 29
    • 34548055891 scopus 로고    scopus 로고
    • Neuregulin-1 genotype moderates the association between job strain and early atherosclerosis in young men
    • Hintsanen M., Elovainio M., Puttonen S., Kivimaki M., Raitakari O.T., Lehtimaki T., et al. Neuregulin-1 genotype moderates the association between job strain and early atherosclerosis in young men. Ann Behav Med 2007, 33(2):148-155.
    • (2007) Ann Behav Med , vol.33 , Issue.2 , pp. 148-155
    • Hintsanen, M.1    Elovainio, M.2    Puttonen, S.3    Kivimaki, M.4    Raitakari, O.T.5    Lehtimaki, T.6
  • 30
    • 33748929841 scopus 로고    scopus 로고
    • Neuregulin-1/erbB-activation improves cardiac function and survival in models of ischemic, dilated, and viral cardiomyopathy
    • Liu X., Gu X., Li Z., Li X., Li H., Chang J., et al. Neuregulin-1/erbB-activation improves cardiac function and survival in models of ischemic, dilated, and viral cardiomyopathy. J Am Coll Cardiol 2006, 48(7):1438-1447.
    • (2006) J Am Coll Cardiol , vol.48 , Issue.7 , pp. 1438-1447
    • Liu, X.1    Gu, X.2    Li, Z.3    Li, X.4    Li, H.5    Chang, J.6
  • 32
    • 33846588522 scopus 로고    scopus 로고
    • Effects of recombined human neuregulin on the contractibility of cardiac muscles of rhesus monkeys with pacing-induced heart failure
    • Li J., Gu X.H., Duan J.C., Zeng L., Li Y., Wang L. Effects of recombined human neuregulin on the contractibility of cardiac muscles of rhesus monkeys with pacing-induced heart failure. Sichuan Da Xue Xue Bao Yi Xue Ban 2007, 38(1):105-108.
    • (2007) Sichuan Da Xue Xue Bao Yi Xue Ban , vol.38 , Issue.1 , pp. 105-108
    • Li, J.1    Gu, X.H.2    Duan, J.C.3    Zeng, L.4    Li, Y.5    Wang, L.6
  • 33
    • 67650569135 scopus 로고    scopus 로고
    • Neuregulin1/ErbB4 signaling induces cardiomyocyte proliferation and repair of heart injury
    • Bersell K., Arab S., Haring B., Kuhn B. Neuregulin1/ErbB4 signaling induces cardiomyocyte proliferation and repair of heart injury. Cell 2009, 138(2):257-270.
    • (2009) Cell , vol.138 , Issue.2 , pp. 257-270
    • Bersell, K.1    Arab, S.2    Haring, B.3    Kuhn, B.4
  • 35
    • 0030009007 scopus 로고    scopus 로고
    • Neuregulins with an Ig-like domain are essential for mouse myocardial and neuronal development
    • Kramer R., Bucay N., Kane D.J., Martin L.E., Tarpley J.E., Theill L.E. Neuregulins with an Ig-like domain are essential for mouse myocardial and neuronal development. Proc Natl Acad Sci USA 1996, 93(10):4833-4838.
    • (1996) Proc Natl Acad Sci USA , vol.93 , Issue.10 , pp. 4833-4838
    • Kramer, R.1    Bucay, N.2    Kane, D.J.3    Martin, L.E.4    Tarpley, J.E.5    Theill, L.E.6
  • 36
    • 33749353121 scopus 로고    scopus 로고
    • The immunoglobulin-like domain is involved in interaction of Neuregulin1 with ErbB
    • Eto K., Eda K., Kanemoto S., Abe S. The immunoglobulin-like domain is involved in interaction of Neuregulin1 with ErbB. Biochem Biophys Res Commun 2006, 350(2):263-271.
    • (2006) Biochem Biophys Res Commun , vol.350 , Issue.2 , pp. 263-271
    • Eto, K.1    Eda, K.2    Kanemoto, S.3    Abe, S.4
  • 37
    • 1642458136 scopus 로고    scopus 로고
    • Neuregulin-1 induces a negative inotropic effect in cardiac muscle: role of nitric oxide synthase
    • Lemmens K., Fransen P., Sys S.U., Brutsaert D.L., De Keulenaer G.W. Neuregulin-1 induces a negative inotropic effect in cardiac muscle: role of nitric oxide synthase. Circulation 2004, 109(3):324-326.
    • (2004) Circulation , vol.109 , Issue.3 , pp. 324-326
    • Lemmens, K.1    Fransen, P.2    Sys, S.U.3    Brutsaert, D.L.4    De Keulenaer, G.W.5
  • 38
    • 4043110498 scopus 로고    scopus 로고
    • Neuregulins regulate cardiac parasympathetic activity: muscarinic modulation of beta-adrenergic activity in myocytes from mice with neuregulin-1 gene deletion
    • Okoshi K., Nakayama M., Yan X., Okoshi M.P., Schuldt A.J., Marchionni M.A., et al. Neuregulins regulate cardiac parasympathetic activity: muscarinic modulation of beta-adrenergic activity in myocytes from mice with neuregulin-1 gene deletion. Circulation 2004, 110(6):713-717.
    • (2004) Circulation , vol.110 , Issue.6 , pp. 713-717
    • Okoshi, K.1    Nakayama, M.2    Yan, X.3    Okoshi, M.P.4    Schuldt, A.J.5    Marchionni, M.A.6
  • 39
    • 33750347979 scopus 로고    scopus 로고
    • Neuregulin-1 beta attenuates doxorubicin-induced alterations of excitation-contraction coupling and reduces oxidative stress in adult rat cardiomyocytes
    • Timolati F., Ott D., Pentassuglia L., Giraud M.N., Perriard J.C., Suter T.M., et al. Neuregulin-1 beta attenuates doxorubicin-induced alterations of excitation-contraction coupling and reduces oxidative stress in adult rat cardiomyocytes. J Mol Cell Cardiol 2006, 41(5):845-854.
    • (2006) J Mol Cell Cardiol , vol.41 , Issue.5 , pp. 845-854
    • Timolati, F.1    Ott, D.2    Pentassuglia, L.3    Giraud, M.N.4    Perriard, J.C.5    Suter, T.M.6
  • 40
    • 78149338262 scopus 로고    scopus 로고
    • Neuregulin-1beta1 rapidly modulates nitric oxide synthesis and calcium handling in rat cardiomyocytes
    • Brero A., Ramella R., Fitou A., Dati C., Alloatti G., Gallo M.P., et al. Neuregulin-1beta1 rapidly modulates nitric oxide synthesis and calcium handling in rat cardiomyocytes. Cardiovasc Res 2010, 88(3):443-452.
    • (2010) Cardiovasc Res , vol.88 , Issue.3 , pp. 443-452
    • Brero, A.1    Ramella, R.2    Fitou, A.3    Dati, C.4    Alloatti, G.5    Gallo, M.P.6
  • 41
    • 77952317892 scopus 로고    scopus 로고
    • A Phase II, randomized, double-blind, multicenter, based on standard therapy, placebo-controlled study of the efficacy and safety of recombinant human neuregulin-1 in patients with chronic heart failure
    • Gao R., Zhang J., Cheng L., Wu X., Dong W., Yang X., et al. A Phase II, randomized, double-blind, multicenter, based on standard therapy, placebo-controlled study of the efficacy and safety of recombinant human neuregulin-1 in patients with chronic heart failure. J Am Coll Cardiol 2010, 55(18):1907-1914.
    • (2010) J Am Coll Cardiol , vol.55 , Issue.18 , pp. 1907-1914
    • Gao, R.1    Zhang, J.2    Cheng, L.3    Wu, X.4    Dong, W.5    Yang, X.6
  • 42
    • 78650412123 scopus 로고    scopus 로고
    • Parenteral administration of recombinant human neuregulin-1 to patients with stable chronic heart failure produces favourable acute and chronic haemodynamic responses
    • Jabbour A., Hayward C.S., Keogh A.M., Kotlyar E., McCrohon J.A., England J.F., et al. Parenteral administration of recombinant human neuregulin-1 to patients with stable chronic heart failure produces favourable acute and chronic haemodynamic responses. Eur J Heart Fail 2011, 13(1):83-92.
    • (2011) Eur J Heart Fail , vol.13 , Issue.1 , pp. 83-92
    • Jabbour, A.1    Hayward, C.S.2    Keogh, A.M.3    Kotlyar, E.4    McCrohon, J.A.5    England, J.F.6
  • 43
    • 80052791284 scopus 로고    scopus 로고
    • Clinical Trial to Evaluate the Efficacy and Safety of Recombinant Human Neuregulin-1 for Subcutaneous Administration in Patients With Chronic Systolic Heart Failure
    • Zensun Sci. and Tech.Co.L.
    • Zensun Sci., &, Tech.Co.L. Clinical Trial to Evaluate the Efficacy and Safety of Recombinant Human Neuregulin-1 for Subcutaneous Administration in Patients With Chronic Systolic Heart Failure. Clinical Trials Gov 2010.
    • (2010) Clinical Trials Gov
  • 44
    • 80052797620 scopus 로고    scopus 로고
    • Study of the Survival of Recombinant Human Neuregulin-1? in Chronic Heart Failure (CHF) Patients
    • Zensun Sci. and Tech.Co.L.
    • Zensun Sci., &, Tech.Co.L. Study of the Survival of Recombinant Human Neuregulin-1? in Chronic Heart Failure (CHF) Patients. Clinical Trials Gov 2010.
    • (2010) Clinical Trials Gov
  • 45
    • 80052795917 scopus 로고    scopus 로고
    • Efficacy and Safety of Human Neuregulin-1 to Treat Stable Chronic Heart Failure (ZS-01-210)
    • Zensun Sci. and Tech.Co.L.
    • Zensun Sci., &, Tech.Co.L. Efficacy and Safety of Human Neuregulin-1 to Treat Stable Chronic Heart Failure (ZS-01-210). Clinical Trials Gov 2010.
    • (2010) Clinical Trials Gov
  • 46
    • 80052819478 scopus 로고    scopus 로고
    • Single Ascending Doses of GGF2 in Patients With Left Ventricular Dysfunction and Symptomatic Heart Failure (GGF2-1101-1)
    • Therapeutics A. Single Ascending Doses of GGF2 in Patients With Left Ventricular Dysfunction and Symptomatic Heart Failure (GGF2-1101-1). Clinical Trials Gov 2010.
    • (2010) Clinical Trials Gov
    • Therapeutics, A.1
  • 47
    • 0035256698 scopus 로고    scopus 로고
    • Untangling the ErbB signalling network
    • Yarden Y., Sliwkowski M.X. Untangling the ErbB signalling network. Nat Rev Mol Cell Biol 2001, 2(2):127-137.
    • (2001) Nat Rev Mol Cell Biol , vol.2 , Issue.2 , pp. 127-137
    • Yarden, Y.1    Sliwkowski, M.X.2
  • 48
    • 70450236961 scopus 로고    scopus 로고
    • The NRG1 gene is frequently silenced by methylation in breast cancers and is a strong candidate for the 8p tumour suppressor gene
    • Chua Y.L., Ito Y., Pole J.C., Newman S., Chin S.F., Stein R.C., et al. The NRG1 gene is frequently silenced by methylation in breast cancers and is a strong candidate for the 8p tumour suppressor gene. Oncogene 2009, 28(46):4041-4052.
    • (2009) Oncogene , vol.28 , Issue.46 , pp. 4041-4052
    • Chua, Y.L.1    Ito, Y.2    Pole, J.C.3    Newman, S.4    Chin, S.F.5    Stein, R.C.6
  • 49
    • 0037226817 scopus 로고    scopus 로고
    • Heregulin is sufficient for the promotion of tumorigenicity and metastasis of breast cancer cells in vivo
    • Atlas E., Cardillo M., Mehmi I., Zahedkargaran H., Tang C., Lupu R. Heregulin is sufficient for the promotion of tumorigenicity and metastasis of breast cancer cells in vivo. Mol Cancer Res 2003, 1(3):165-175.
    • (2003) Mol Cancer Res , vol.1 , Issue.3 , pp. 165-175
    • Atlas, E.1    Cardillo, M.2    Mehmi, I.3    Zahedkargaran, H.4    Tang, C.5    Lupu, R.6
  • 50
    • 78650083166 scopus 로고    scopus 로고
    • Phenotypic characterization of transgenic mice overexpressing neuregulin-1
    • Kato T., Kasai A., Mizuno M., Fengyi L., Shintani N., Maeda S., et al. Phenotypic characterization of transgenic mice overexpressing neuregulin-1. PLoS One 2010, 5(12):e14185.
    • (2010) PLoS One , vol.5 , Issue.12
    • Kato, T.1    Kasai, A.2    Mizuno, M.3    Fengyi, L.4    Shintani, N.5    Maeda, S.6
  • 51
    • 0034466119 scopus 로고    scopus 로고
    • Neuregulin in neuron/glial interactions in the central nervous system. GGF2 diminishes autoimmune demyelination, promotes oligodendrocyte progenitor expansion, and enhances remyelination
    • Marchionni M.A., Cannella B., Hoban C., Gao Y.L., Garcia-Arenas R., Lawson D., et al. Neuregulin in neuron/glial interactions in the central nervous system. GGF2 diminishes autoimmune demyelination, promotes oligodendrocyte progenitor expansion, and enhances remyelination. Adv Exp Med Biol 1999, 468:283-295.
    • (1999) Adv Exp Med Biol , vol.468 , pp. 283-295
    • Marchionni, M.A.1    Cannella, B.2    Hoban, C.3    Gao, Y.L.4    Garcia-Arenas, R.5    Lawson, D.6
  • 52
    • 6044220229 scopus 로고    scopus 로고
    • Neuregulin-1 is neuroprotective and attenuates inflammatory responses induced by ischemic stroke
    • Xu Z., Jiang J., Ford G., Ford B.D. Neuregulin-1 is neuroprotective and attenuates inflammatory responses induced by ischemic stroke. Biochem Biophys Res Commun 2004, 322(2):440-446.
    • (2004) Biochem Biophys Res Commun , vol.322 , Issue.2 , pp. 440-446
    • Xu, Z.1    Jiang, J.2    Ford, G.3    Ford, B.D.4
  • 53
    • 77958082505 scopus 로고    scopus 로고
    • Glial growth factor 2 promotes functional recovery with treatment initiated up to 7days after permanent focal ischemic stroke
    • Iaci J.F., Ganguly A., Finklestein S.P., Parry T.J., Ren J., Saha S., et al. Glial growth factor 2 promotes functional recovery with treatment initiated up to 7days after permanent focal ischemic stroke. Neuropharmacology 2010, 59(7-8):640-649.
    • (2010) Neuropharmacology , vol.59 , Issue.7-8 , pp. 640-649
    • Iaci, J.F.1    Ganguly, A.2    Finklestein, S.P.3    Parry, T.J.4    Ren, J.5    Saha, S.6
  • 55
    • 0002820468 scopus 로고    scopus 로고
    • The glial growth factors deficiency and synaptic destabilization hypothesis of schizophrenia
    • Moises H.W., Zoega T., Gottesman I.I. The glial growth factors deficiency and synaptic destabilization hypothesis of schizophrenia. BMC Psychiatry 2002, 2:8.
    • (2002) BMC Psychiatry , vol.2 , pp. 8
    • Moises, H.W.1    Zoega, T.2    Gottesman, I.I.3
  • 56
    • 1842629561 scopus 로고    scopus 로고
    • Synergistic improvements in cell and axonal migration across sciatic nerve lesion gaps using bioresorbable filaments and heregulin-beta1
    • Cai J., Peng X., Nelson K.D., Eberhart R., Smith G.M. Synergistic improvements in cell and axonal migration across sciatic nerve lesion gaps using bioresorbable filaments and heregulin-beta1. J Biomed Mater Res A 2004, 69(2):247-258.
    • (2004) J Biomed Mater Res A , vol.69 , Issue.2 , pp. 247-258
    • Cai, J.1    Peng, X.2    Nelson, K.D.3    Eberhart, R.4    Smith, G.M.5
  • 57
    • 0034655960 scopus 로고    scopus 로고
    • RhGGF2 protects against cisplatin-induced neuropathy in the rat
    • ter Laak M.P., Hamers F.P., Kirk C.J., Gispen W.H. rhGGF2 protects against cisplatin-induced neuropathy in the rat. J Neurosci Res 2000, 60(2):237-244.
    • (2000) J Neurosci Res , vol.60 , Issue.2 , pp. 237-244
    • ter Laak, M.P.1    Hamers, F.P.2    Kirk, C.J.3    Gispen, W.H.4
  • 58
    • 0028895952 scopus 로고
    • Neuregulins are concentrated at nerve-muscle synapses and activate ACh- receptor gene expression
    • Jo S.A., Zhu X., Marchionni M.A., Burden S.J. Neuregulins are concentrated at nerve-muscle synapses and activate ACh- receptor gene expression. Nature 1995, 373(6510):158-161.
    • (1995) Nature , vol.373 , Issue.6510 , pp. 158-161
    • Jo, S.A.1    Zhu, X.2    Marchionni, M.A.3    Burden, S.J.4
  • 59
    • 0038054255 scopus 로고    scopus 로고
    • Differentiation-dependent regulation of skeletal myogenesis by neuregulin-1
    • Ford B.D., Han B., Fischbach G.D. Differentiation-dependent regulation of skeletal myogenesis by neuregulin-1. Biochem Biophys Res Commun 2003, 306(1):276-281.
    • (2003) Biochem Biophys Res Commun , vol.306 , Issue.1 , pp. 276-281
    • Ford, B.D.1    Han, B.2    Fischbach, G.D.3
  • 60
    • 0035947614 scopus 로고    scopus 로고
    • A novel role of neuregulin in skeletal muscle. Neuregulin stimulates glucose uptake, glucose transporter translocation, and transporter expression in muscle cells
    • Suarez E., Bach D., Cadefau J., Palacin M., Zorzano A., Guma A. A novel role of neuregulin in skeletal muscle. Neuregulin stimulates glucose uptake, glucose transporter translocation, and transporter expression in muscle cells. J Biol Chem 2001, 276(21):18257-18264.
    • (2001) J Biol Chem , vol.276 , Issue.21 , pp. 18257-18264
    • Suarez, E.1    Bach, D.2    Cadefau, J.3    Palacin, M.4    Zorzano, A.5    Guma, A.6
  • 61
    • 0029886737 scopus 로고    scopus 로고
    • Stimulation of myogenic differentiation by a neuregulin, glial growth factor 2. Are neuregulins the long-sought muscle trophic factors secreted by nerves?
    • Florini J.R., Samuel D.S., Ewton D.Z., Kirk C., Sklar R.M. Stimulation of myogenic differentiation by a neuregulin, glial growth factor 2. Are neuregulins the long-sought muscle trophic factors secreted by nerves?. J Biol Chem 1996, 271(22):12699-12702.
    • (1996) J Biol Chem , vol.271 , Issue.22 , pp. 12699-12702
    • Florini, J.R.1    Samuel, D.S.2    Ewton, D.Z.3    Kirk, C.4    Sklar, R.M.5
  • 62
    • 0037290636 scopus 로고    scopus 로고
    • Intracellular signals involved in the effects of insulin-like growth factors and neuregulins on myofibre formation
    • Zorzano A., Kaliman P., Guma A., Palacin M. Intracellular signals involved in the effects of insulin-like growth factors and neuregulins on myofibre formation. Cell Signal 2003, 15(2):141-149.
    • (2003) Cell Signal , vol.15 , Issue.2 , pp. 141-149
    • Zorzano, A.1    Kaliman, P.2    Guma, A.3    Palacin, M.4
  • 63
    • 0344924865 scopus 로고    scopus 로고
    • Neuregulin-1 protects ventricular myocytes from anthracycline-induced apoptosis via erbB4-dependent activation of PI3-kinase/Akt
    • Fukazawa R., Miller T.A., Kuramochi Y., Frantz S., Kim Y.D., Marchionni M.A., et al. Neuregulin-1 protects ventricular myocytes from anthracycline-induced apoptosis via erbB4-dependent activation of PI3-kinase/Akt. J Mol Cell Cardiol 2003, 35(12):1473-1479.
    • (2003) J Mol Cell Cardiol , vol.35 , Issue.12 , pp. 1473-1479
    • Fukazawa, R.1    Miller, T.A.2    Kuramochi, Y.3    Frantz, S.4    Kim, Y.D.5    Marchionni, M.A.6
  • 64
    • 9644310269 scopus 로고    scopus 로고
    • Inhibition of ErbB2 causes mitochondrial dysfunction in cardiomyocytes: implications for herceptin-induced cardiomyopathy
    • Grazette L.P., Boecker W., Matsui T., Semigran M., Force T.L., Hajjar R.J., et al. Inhibition of ErbB2 causes mitochondrial dysfunction in cardiomyocytes: implications for herceptin-induced cardiomyopathy. J Am Coll Cardiol 2004, 44(11):2231-2238.
    • (2004) J Am Coll Cardiol , vol.44 , Issue.11 , pp. 2231-2238
    • Grazette, L.P.1    Boecker, W.2    Matsui, T.3    Semigran, M.4    Force, T.L.5    Hajjar, R.J.6
  • 66
    • 33746048823 scopus 로고    scopus 로고
    • Neuregulin activates erbB2-dependent src/FAK signaling and cytoskeletal remodeling in isolated adult rat cardiac myocytes
    • Kuramochi Y., Guo X., Sawyer D.B. Neuregulin activates erbB2-dependent src/FAK signaling and cytoskeletal remodeling in isolated adult rat cardiac myocytes. J Mol Cell Cardiol 2006, 41(2):228-235.
    • (2006) J Mol Cell Cardiol , vol.41 , Issue.2 , pp. 228-235
    • Kuramochi, Y.1    Guo, X.2    Sawyer, D.B.3
  • 67
    • 77957270888 scopus 로고    scopus 로고
    • Neuregulin/ErbB signaling regulates cardiac subtype specification in differentiating human embryonic stem cells
    • Zhu W.Z., Xie Y., Moyes K.W., Gold J.D., Askari B., Laflamme M.A. Neuregulin/ErbB signaling regulates cardiac subtype specification in differentiating human embryonic stem cells. Circ Res 2010, 107(6):776-786.
    • (2010) Circ Res , vol.107 , Issue.6 , pp. 776-786
    • Zhu, W.Z.1    Xie, Y.2    Moyes, K.W.3    Gold, J.D.4    Askari, B.5    Laflamme, M.A.6


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