Deep Sequencing of the Trypanosoma cruzi GP63 Surface Proteases Reveals Diversity and Diversifying Selection among Chronic and Congenital Chagas Disease Patients

PLoS Neglected Tropical Diseases

Volumn 9, Issue 4, 2015, Pages

  Llewellyn, Martin S ^a,b   Messenger, Louisa A ^a   Luquetti, Alejandro O ^c   Garcia, Lineth ^d   Torrico, Faustino ^d   Tavares, Suelene B N ^c   Cheaib, Bachar ^e   Derome, Nicolas ^e   Delepine, Marc ^f   Baulard, Céline ^f   Deleuze, Jean Francois ^f   Sauer, Sascha ^g   Miles, Michael A ^a  

^a LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^b BANGOR UNIVERSITY   (United Kingdom)

^c FEDERAL UNIVERSITY OF GOIÁS   (Brazil)

^d UNIVERSIDAD MAYOR DE SAN SIMÓN   (Bolivia)

^e UNIVERSITÉ LAVAL   (Canada)

^f DIF   (France)

^g MAX PLANCK INSTITUTE FOR MOLECULAR GENETICS   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEINASE; SURFACE PROTEASE GP63; UNCLASSIFIED DRUG; PEPTIDE HYDROLASE; PROTOZOAL PROTEIN;

ADOLESCENT; ADULT; AGED; ARTICLE; CHAGAS DISEASE; CONTROLLED STUDY; DIVERSIFYING SELECTION; FEMALE; GENE FREQUENCY; GENOTYPE; GEOGRAPHIC DISTRIBUTION; HUMAN; INFANT; MAJOR CLINICAL STUDY; MALE; MICROBIAL DIVERSITY; MIDDLE AGED; NONHUMAN; PARASITE IDENTIFICATION; PARASITE ISOLATION; PARASITE TRANSMISSION; POLYMERASE CHAIN REACTION; SEQUENCE ALIGNMENT; SEQUENCE ANALYSIS; TRYPANOSOMA CRUZI; YOUNG ADULT; ANIMAL; BOLIVIA; BRAZIL; CHRONIC DISEASE; COHORT ANALYSIS; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETIC VARIATION; GENETICS; HIGH THROUGHPUT SEQUENCING; METABOLISM; PARASITOLOGY; VERTICAL TRANSMISSION;

ANIMALS; BOLIVIA; BRAZIL; CHAGAS DISEASE; CHRONIC DISEASE; COHORT STUDIES; FEMALE; GENE EXPRESSION REGULATION; GENETIC VARIATION; GENOTYPE; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; HUMANS; INFANT; INFECTIOUS DISEASE TRANSMISSION, VERTICAL; MALE; PEPTIDE HYDROLASES; PROTOZOAN PROTEINS; TRYPANOSOMA CRUZI;

EID: 84928901879     PISSN: 19352727     EISSN: 19352735     Source Type: Journal    
DOI: 10.1371/journal.pntd.0003458     Document Type: Article

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