Pooled deep sequencing of plasmodium falciparum isolates: An efficient and scalable tool to quantify prevailing malaria drug-resistance genotypes

Journal of Infectious Diseases

Volumn 208, Issue 12, 2013, Pages 1998-2006

  Taylor, Steve M ^a,d   Parobek, Christian M ^b   Aragam, Nash ^c   Ngasala, Billy E ^e   Mårtensson, Andreas ^f,g   Meshnick, Steven R ^a   Juliano, Jonathan J ^c  

^a University of North Carolina at Chapel Hill   (United States)

^b Department of Genetics ^*  (United States)

^c UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^d DUKE UNIVERSITY MEDICAL CENTER   (United States)

^e MUHIMBILI UNIVERSITY OF HEALTH AND ALLIED SCIENCES   (Tanzania)

^f KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^g KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Drug resistance; Molecular surveillance; Plasmodium falciparum; Tropical diseases

Indexed keywords

ARTEMETHER PLUS BENFLUMETOL; ANTIMALARIAL AGENT; PROTOZOAL DNA;

ALLELE; ARTICLE; COST CONTROL; DHFR GENE; DHPS GENE; GENE FREQUENCY; GENE MUTATION; GENE SEQUENCE; GENOTYPE; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MALARIA; MICROBIAL GENE; NONHUMAN; NUCLEOTIDE SEQUENCE; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; SANGER SEQUENCING; SEQUENCE ANALYSIS; TANZANIA; BLOOD; CHILD; CLASSIFICATION; DNA SEQUENCE; DRUG EFFECTS; DRUG RESISTANCE; GENETICS; HIGH THROUGHPUT SEQUENCING; ISOLATION AND PURIFICATION; MALARIA FALCIPARUM; MOLECULAR EPIDEMIOLOGY; MOLECULAR GENETICS; PARASITOLOGY; PROCEDURES; REPRODUCIBILITY; DRUG EFFECT; METHODOLOGY; MOLECULAR SURVEILLANCE; TROPICAL DISEASE;

ANTIMALARIALS; BASE SEQUENCE; CHILD; DNA, PROTOZOAN; DRUG RESISTANCE; GENE FREQUENCY; GENOTYPE; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; HUMANS; MALARIA, FALCIPARUM; MOLECULAR EPIDEMIOLOGY; MOLECULAR SEQUENCE DATA; PLASMODIUM FALCIPARUM; REPRODUCIBILITY OF RESULTS; SEQUENCE ANALYSIS, DNA; TANZANIA;

DRUG RESISTANCE; MOLECULAR SURVEILLANCE; PLASMODIUM FALCIPARUM; TROPICAL DISEASES;

EID: 84893985233     PISSN: 00221899     EISSN: 15376613     Source Type: Journal    
DOI: 10.1093/infdis/jit392     Document Type: Article

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