Culture adaptation alters transcriptional hierarchies among single human embryonic stem cells reflecting altered patterns of differentiation

PLoS ONE

Volumn 10, Issue 4, 2015, Pages

  Gokhale, Paul J ^a   Au Young, Janice K ^b   Dadi, SriVidya ^b   Keys, David N ^b   Harrison, Neil J ^a   Jones, Mark ^a   Soneji, Shamit ^c,d   Enver, Tariq ^c,e   Sherlock, Jon K ^b   Andrews, Peter W ^a  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

^b ThermoFisher   (United States)

^c UNIVERSITY OF OXFORD   (United Kingdom)

^d LUND UNIVERSITY   (Sweden)

^e UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

OCTAMER TRANSCRIPTION FACTOR 4; STAGE SPECIFIC EMBRYO ANTIGEN 3; HOMEODOMAIN PROTEIN; NANOG PROTEIN, HUMAN; POU5F1 PROTEIN, HUMAN; STAGE SPECIFIC EMBRYO ANTIGEN; STAGE-SPECIFIC EMBRYONIC ANTIGEN-3; TRANSCRIPTION FACTOR NANOG; TRANSCRIPTOME; TUMOR ANTIGEN;

ARTICLE; CELL COMPARTMENTALIZATION; CELL CULTURE; CELL DIFFERENTIATION; CELL GROWTH; CELL SURFACE; CONTROLLED STUDY; CULTURAL ANTHROPOLOGY; EMBRYONIC STEM CELL; EVOLUTIONARY ADAPTATION; FEMALE; GENE EXPRESSION; GENETIC TRANSCRIPTION; GENETIC VARIABILITY; HUMAN; HUMAN CELL; NANOG GENE; OCT4 GENE; PHENOTYPE; PROTEIN EXPRESSION; SINGLE CELL ANALYSIS; CLUSTER ANALYSIS; GENETICS; HUMAN EMBRYONIC STEM CELL; METABOLISM; REAL TIME POLYMERASE CHAIN REACTION;

ANTIGENS, TUMOR-ASSOCIATED, CARBOHYDRATE; CELL DIFFERENTIATION; CELLS, CULTURED; CLUSTER ANALYSIS; HOMEODOMAIN PROTEINS; HUMAN EMBRYONIC STEM CELLS; HUMANS; NANOG HOMEOBOX PROTEIN; OCTAMER TRANSCRIPTION FACTOR-3; REAL-TIME POLYMERASE CHAIN REACTION; STAGE-SPECIFIC EMBRYONIC ANTIGENS; TRANSCRIPTOME;

EID: 84928901485     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0123467     Document Type: Article

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