Discovery and structural characterization of an allosteric inhibitor of bacterial cis-prenyltransferase

Protein Science

Volumn 24, Issue 1, 2015, Pages 20-26

  Danley, Dennis E ^a   Baima, Eric T ^a,b   Mansour, Mahmoud ^a   Fennell, Kimberly F ^a   Chrunyk, Boris A ^a   Mueller, John P ^a,c   Liu, Shenping ^a   Qiu, Xiayang ^a  

^a PFIZER INC   (United States)

^b ZOETIS   (United States)

^c ASTRAZENECA   (United Kingdom)

Author keywords

antibiotic; cell wall; enzyme inhibitor; isopentenyl pyrophosphate chain; surface plasmon resonance; undecaprenyl pyrophosphate synthase; X ray crystallography

Indexed keywords

3 (2 CHLOROPHENYL) N (4 ISOPROPYLPHENYL 5 METHYLISOXAZOLE 4 CARBOXAMIDE); ANTIINFECTIVE AGENT; DIMETHYLALLYLTRANSFERASE; OXAZOLE DERIVATIVE; PYROPHOSPHATE; TRANS FARNESYL PYROPHOSPHATE; UNCLASSIFIED DRUG; UNDECAPRENYL PYROPHOSPHATE; CIS-PRENYL TRANSFERASE; ENZYME INHIBITOR; FARNESYL DIPHOSPHATE; ISOPRENOID PHOSPHATE; SESQUITERPENE; TRANSFERASE; UNDECAPRENYL PYROPHOSPHATE SYNTHETASE;

ARTICLE; BACTERIAL STRAIN; BINDING SITE; CHEMICAL STRUCTURE; CRYSTAL STRUCTURE; DRUG BINDING; DRUG STRUCTURE; IC50; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; STREPTOCOCCUS PNEUMONIAE; ALLOSTERISM; ANTAGONISTS AND INHIBITORS; CHEMISTRY; DRUG DEVELOPMENT; DRUG EFFECTS; ENZYMOLOGY; HUMAN; METABOLISM; MICROBIOLOGY; MOLECULAR DOCKING; PNEUMOCOCCAL INFECTIONS; X RAY CRYSTALLOGRAPHY;

BACTERIA (MICROORGANISMS); STREPTOCOCCUS PNEUMONIAE;

ALKYL AND ARYL TRANSFERASES; ALLOSTERIC REGULATION; ANTI-BACTERIAL AGENTS; CRYSTALLOGRAPHY, X-RAY; DRUG DISCOVERY; ENZYME INHIBITORS; HUMANS; MOLECULAR DOCKING SIMULATION; PNEUMOCOCCAL INFECTIONS; POLYISOPRENYL PHOSPHATES; SESQUITERPENES; STREPTOCOCCUS PNEUMONIAE; TRANSFERASES;

EID: 84928891154     PISSN: 09618368     EISSN: 1469896X     Source Type: Journal    
DOI: 10.1002/pro.2579     Document Type: Article

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